Name: Name:H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
Brand: AABLOCKS
SKU: AA00BEOL
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00BEOL

Chemical Name: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

CAS Number: 249537-73-3

Molecular Formula: C75H118N20O22S

Molecular Weight: 1683.9252

MDL Number: MFCD02683959

SMILES: CSCCC(C(=O)NC(C(=O)NCC(=O)N1CCCC1C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CCC(=O)O)CCC(=O)O)Cc1[nH]cnc1)C(O)C)C(CC)C)C(C)C)C(CC)C)C(C)C)Cc1[nH]cnc1)C)N

Properties

Complexity: 3550

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 17

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 118

Hydrogen Bond Acceptor Count: 26

Hydrogen Bond Donor Count: 19

Isotope Atom Count: 0

Rotatable Bond Count: 48

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: -3.6

Literature fold

Title: NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect.

Journal: PloS one20130101

Title: Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation.

Journal: Biochemical and biophysical research communications20121019

Title: Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.

Journal: Molecular endocrinology (Baltimore, Md.)20110801

Title: NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society20081201

Title: NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis.

Journal: The Journal of biological chemistry20080926

Title: Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080319

Title: Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells.

Journal: Journal of immunology (Baltimore, Md. : 1950)20070301

Title: Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders.

Journal: Cardiovascular drug reviews20070101

Title: Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent.

Journal: Arteriosclerosis, thrombosis, and vascular biology20060701

Title: Calcium-dependent expression of TNF-alpha in neural cells is mediated by the calcineurin/NFAT pathway.

Journal: Molecular and cellular neurosciences20060401

Title: Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model.

Journal: The Journal of biological chemistry20050415

Title: A new cell-permeable peptide allows successful allogeneic islet transplantation in mice.

Journal: Nature medicine20040301

Title: Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.

Journal: American journal of physiology. Cell physiology20030701

Title: Intracellular delivery of glutathione S-transferase into mammalian cells.

Journal: Biochemical and biophysical research communications20030606

Title: NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro.

Journal: Circulation research20030418

249537-73-3 | H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH