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289715-28-2,MFCD18782720
Catalog No.:AA00BF02

289715-28-2 | Cb-300919

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
1 week  
$530.00   $371.00
- +
10mg
98%
1 week  
$908.00   $635.00
- +
50mg
98%
1 week  
$2,908.00   $2,035.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BF02
Chemical Name:
Cb-300919
CAS Number:
289715-28-2
Molecular Formula:
C32H34ClN7O2
Molecular Weight:
584.1111
MDL Number:
MFCD18782720
SMILES:
C#CCN(c1ccc(cc1)C(=O)NCc1cccnc1)Cc1cc2c(cc1Cl)nc(n(c2=O)C)CN1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
1010  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
2.8  

Literature

Title: Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt).

Journal: Journal of medicinal chemistry 20101223

Title: The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent.

Journal: Journal of medicinal chemistry 20020815

Title: Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-8746

Title: Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.

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