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228559-41-9,MFCD09971092
Catalog No.:AA00BF17

228559-41-9 | Ki8751

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$8.00   $6.00
- +
5mg
98+%
in stock  
$13.00   $9.00
- +
10mg
98+%
in stock  
$17.00   $12.00
- +
50mg
98+%
in stock  
$55.00   $38.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BF17
Chemical Name:
Ki8751
CAS Number:
228559-41-9
Molecular Formula:
C24H18F3N3O4
Molecular Weight:
469.4126
MDL Number:
MFCD09971092
SMILES:
COc1cc2nccc(c2cc1OC)Oc1ccc(c(c1)F)NC(=O)Nc1ccc(cc1F)F
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
677  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.5  

Literature

Title: Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment.

Journal: The American journal of pathology 20120301

Title: Hypoxylonols C-F, benzo[j]fluoranthenes from Hypoxylon truncatum.

Journal: Journal of natural products 20120127

Title: Acquired drug resistance to vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor in human vascular endothelial cells.

Journal: Anticancer research 20110901

Title: Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.

Journal: Journal of medicinal chemistry 20050310

Title: Kubo K, et al. Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas. J Med Chem, 2005, 48(5), 1359-1366.

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SDS
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Tags:228559-41-9 Molecular Formula|228559-41-9 MDL|228559-41-9 SMILES|228559-41-9 Ki8751
Catalog No.: AA00BF17
228559-41-9,MFCD09971092
228559-41-9 | Ki8751
Pack Size： 1mg
Purity： 98+%
in stock
$8.00 $6.00
Pack Size： 5mg
Purity： 98+%
in stock
$13.00 $9.00
Pack Size： 10mg
Purity： 98+%
in stock
$17.00 $12.00
Pack Size： 50mg
Purity： 98+%
in stock
$55.00 $38.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00BF17
Chemical Name: Ki8751
CAS Number: 228559-41-9
Molecular Formula: C24H18F3N3O4
Molecular Weight: 469.4126
MDL Number: MFCD09971092
SMILES: COc1cc2nccc(c2cc1OC)Oc1ccc(c(c1)F)NC(=O)Nc1ccc(cc1F)F
Properties
Form: Solid  
Storage: Keep in dry area;-20 ℃;  
Complexity: 677  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 34  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.5  
Literature fold

Title: Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment.

Journal: The American journal of pathology20120301

Title: Hypoxylonols C-F, benzo[j]fluoranthenes from Hypoxylon truncatum.

Journal: Journal of natural products20120127

Title: Acquired drug resistance to vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor in human vascular endothelial cells.

Journal: Anticancer research20110901

Title: Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.

Journal: Journal of medicinal chemistry20050310

Title: Kubo K, et al. Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas. J Med Chem, 2005, 48(5), 1359-1366.

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