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27113-22-0,MFCD01736103
Catalog No.:AA00BF1I

27113-22-0 | Paradol

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Purity
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1mg
98%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$35.00   $25.00
- +
25mg
≥98%
in stock  
$139.00   $97.00
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50mg
≥98%
in stock  
$263.00   $184.00
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100mg
≥98%
in stock  
$495.00   $346.00
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250mg
≥98%
in stock  
$1,098.00   $768.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BF1I
Chemical Name:
Paradol
CAS Number:
27113-22-0
Molecular Formula:
C17H26O3
Molecular Weight:
278.3865
MDL Number:
MFCD01736103
SMILES:
CCCCCCCC(=O)CCc1ccc(c(c1)OC)O
FEMA Number:
4665
Properties
Properties
 
BP:
406.5±30.0°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
265  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
3.8  

Upstream Synthesis Route

[1]Patent:CN106866393,2017,A,.Locationinpatent:Paragraph0045;0046;0047;0048

[2]JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999),1972,p.3001-3006

[1]Patent:US9272994,2016,B1,.Locationinpatent:Page/Pagecolumn51

[1]EuropeanJournalofOrganicChemistry,2017,vol.2017,#48,p.7295-7299

[1]JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999),1972,p.3001-3006

[1]JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999),1972,p.3001-3006

Literature

Title: Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta.

Journal: Journal of natural products 20120727

Title: Metabolism of [6]-shogaol in mice and in cancer cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401

Title: Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats.

Journal: Autonomic neuroscience : basic & clinical 20110426

Title: Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale).

Journal: Fitoterapia 20110101

Title: Chemopreventive and antioxidant efficacy of (6)-paradol in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.

Journal: Pharmacological reports : PR 20100101

Title: Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.

Journal: British journal of pharmacology 20090801

Title: Modulation of macrophage functions by compounds isolated from Zingiber officinale.

Journal: Planta medica 20090201

Title: Herbal compounds and toxins modulating TRP channels.

Journal: Current neuropharmacology 20080301

Title: Cancer preventive properties of ginger: a brief review.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070501

Title: Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells.

Journal: Cancer letters 20020308

Title: Antioxidative and antitumor promoting effects of [6]-paradol and its homologs.

Journal: Mutation research 20010920

Title: Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol.

Journal: Cancer research 20010201

Title: van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43.

Title: Keum YS, et al. Induction of apoptosis and caspase-3 activation by chemopreventive -paradol and structurally related compounds in KB cells. Cancer Lett. 2002 Mar 8;177(1):41-7.

Title: Gaire BP, et al. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10(3):e0120203.

Title: Setoguchi S, et al. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64(9):1932-7.

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SDS
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