Home Amines 220201-34-3
220201-34-3,MFCD26960899
Catalog No.:AA00BF20

220201-34-3 | Tetrasodium (2S)-2-((((7S,8S)-3-carboxylato-7-(2-carboxylatoethyl)-13-ethenyl-18-ethyl-2,8,12,17-tetramethyl-7,8-dihydroporphyrin-5-yl)acetyl)amino)butanedioate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$128.00   $89.00
- +
10mg
≥95%
in stock  
$203.00   $142.00
- +
25mg
≥95%
in stock  
$476.00   $333.00
- +
50mg
≥95%
in stock  
$889.00   $622.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BF20
Chemical Name:
Tetrasodium (2S)-2-((((7S,8S)-3-carboxylato-7-(2-carboxylatoethyl)-13-ethenyl-18-ethyl-2,8,12,17-tetramethyl-7,8-dihydroporphyrin-5-yl)acetyl)amino)butanedioate
CAS Number:
220201-34-3
Molecular Formula:
C38H37N5Na4O9
Molecular Weight:
799.6876
MDL Number:
MFCD26960899
SMILES:
CCC1=C(C)C2=N/C/1=C\c1[nH]c(c(c1C)C(=O)[O-])/C(=C/1\N=C(/C=c/3\[nH]/c(=C\2)/c(C=C)c3C)[C@H]([C@@H]1CCC(=O)[O-])C)/CC(=O)N[C@H](C(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
1340  
Covalently-Bonded Unit Count:
5  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
56  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  

Downstream Synthesis Route
220201-34-3   
(S)-2-{2-(4Z,10Z,15Z,19Z)-(2S,3S)-3-(2-Carboxy-ethyl)-12-ethyl-2,8,13,18-tetramethyl-17-vinyl-2,3,22,24-tetrahydro-porphin-5-yl-acetylamino}-succinicacid 

[1]Gomi,Shuichi;Nishizuka,Toshio;Ushiroda,Osamu;Uchida,Naoki;Takahashi,Hirotada;Sumi,Shinjiro[Heterocycles,1998,vol.48,#11,p.2231-2244]

220201-34-3   
C37H38N5O7(3-)*3Na(1+) 

[1]Gomi,Shuichi;Nishizuka,Toshio;Ushiroda,Osamu;Uchida,Naoki;Takahashi,Hirotada;Sumi,Shinjiro[Heterocycles,1998,vol.48,#11,p.2231-2244]

220201-34-3    74-88-4   
talaporfintetramethylester 

[1]Gomi,Shuichi;Nishizuka,Toshio;Ushiroda,Osamu;Uchida,Naoki;Takahashi,Hirotada;Sumi,Shinjiro[Heterocycles,1998,vol.48,#11,p.2231-2244]

chlorinee6anhydride 
 
L-asparticaciddisodiumsalt 
  220201-34-3 

[1]CurrentPatentAssignee:LIGHTSCIENCESONCOLOGYINC-WO2008/5308,2008,A2Locationinpatent:Page/Pagecolumn34

Literature

Title: Preclinical in vivo evaluation of NPe6-mediated photodynamic therapy on normal vasculature.

Journal: Lasers in surgery and medicine 20120201

Title: Tissue damage in the canine normal esophagus by photoactivation with talaporfin sodium (laserphyrin): a preclinical study.

Journal: PloS one 20120101

Title: Myocardial electrical conduction block induced by photosensitization reaction in exposed porcine hearts in vivo.

Journal: Lasers in surgery and medicine 20111201

Title: Inhibition of endocytic processes by photodynamic therapy.

Journal: Lasers in surgery and medicine 20110901

Title: Molecular determinants of photodynamic therapy for lung cancers.

Journal: Lasers in surgery and medicine 20110901

Title: New aspects of photodynamic therapy for central type early stage lung cancer.

Journal: Lasers in surgery and medicine 20110901

Title: Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma.

Journal: Journal of hepato-biliary-pancreatic sciences 20110701

Title: Cell death via mitochondrial apoptotic pathway due to activation of Bax by lysosomal photodamage.

Journal: Free radical biology & medicine 20110701

Title: Sonodynamic cancer therapy: a non-invasive and repeatable approach using low-intensity ultrasound with a sonosensitizer.

Journal: Anticancer research 20110701

Title: Effects of endosomal photodamage on membrane recycling and endocytosis.

Journal: Photochemistry and photobiology 20110501

Title: Determination of the tumor tissue optical properties during and after photodynamic therapy using inverse Monte Carlo method and double integrating sphere between 350 and 1000 nm.

Journal: Journal of biomedical optics 20110501

Title: Effects of photodynamic therapy on the endocytic pathway.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110430

Title: Characterization of cutaneous photosensitivity in healthy volunteers receiving talaporfin sodium.

Journal: Photodermatology, photoimmunology & photomedicine 20110401

Title: Sonodynamically-induced antitumor effect of mono-l-aspartyl chlorin e6 (NPe6).

Journal: Anticancer research 20110201

Title: Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization.

Journal: Free radical biology & medicine 20110115

Title: Photosensitization reaction-induced acute electrophysiological cell response of rat myocardial cells in short loading periods of talaporfin sodium or porfimer sodium.

Journal: Photochemistry and photobiology 20110101

Title: Evaluation of oxygen consumption of culture medium and in vitro photodynamic effect of talaporfin sodium in lung tumor cells.

Journal: Photomedicine and laser surgery 20100601

Title: Photodynamic therapy induces microRNA-210 and -296 expression in HeLa cells.

Journal: Journal of biophotonics 20100601

Title: Novel photodynamic therapy against biliary tract carcinoma using mono-L: -aspartyl chlorine e6: basic evaluation for its feasibility and efficacy.

Journal: Journal of hepato-biliary-pancreatic sciences 20100501

Title: Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways >1.0 cm in diameter.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100401

Title: Breast cancer resistant protein (BCRP) is a molecular determinant of the outcome of photodynamic therapy (PDT) for centrally located early lung cancer.

Journal: Lung cancer (Amsterdam, Netherlands) 20100201

Title: The myocardial electrical blockade induced by photosensitization reaction.

Journal: IEEE transactions on bio-medical engineering 20100201

Title: Talaporfin-mediated photodynamic therapy for peritoneal metastasis of gastric cancer in an in vivo mouse model: drug distribution and efficacy studies.

Journal: International journal of oncology 20100201

Title: Management of multiple primary lung cancer in patients with centrally located early cancer lesions.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20100101

Title: Talaporfin sodium.

Journal: Expert opinion on pharmacotherapy 20100101

Title: Histological responses of cutaneous vascular lesions following photodynamic therapy with talaporfin sodium: a chicken comb model.

Journal: The Keio journal of medicine 20090901

Title: Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model.

Journal: Oncology reports 20090701

Title: [Clinical photodynamic diagnosis and therapy efficiency in oropharyngeal cancer].

Journal: Nihon Jibiinkoka Gakkai kaiho 20090501

Title: The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema--in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium.

Journal: Photodiagnosis and photodynamic therapy 20090301

Title: Amelioration of airway stenosis in rabbit models by photodynamic therapy with talaporfin sodium (NPe6).

Journal: Photochemistry and photobiology 20090101

Title: Therapeutic effects of a new photosensitizer for photodynamic therapy of early head and neck cancer in relation to tissue concentration.

Journal: Auris, nasus, larynx 20081201

Title: Time-dependent interactions of the two porphyrinic compounds chlorin e6 and mono-L-aspartyl-chlorin e6 with phospholipid vesicles probed by NMR spectroscopy.

Journal: Langmuir : the ACS journal of surfaces and colloids 20081104

Title: Differential effects of photodynamic therapy on morphologically distinct tumor cells derived from a single precursor cell.

Journal: Cancer letters 20080918

Title: Photodynamic therapy of C6-implanted glioma cells in the rat brain employing second-generation photosensitizer talaporfin sodium.

Journal: Photodiagnosis and photodynamic therapy 20080901

Title: Uptake and retention of the photosensitizer mono-L-asparthyl chlorine e6 in experimental malignant glioma.

Journal: Lasers in medical science 20080701

Title: Photodynamic therapy using talaporfin sodium for synovial membrane from rheumatoid arthritis patients and collagen-induced arthritis rats.

Journal: Clinical rheumatology 20080601

Title: In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6.

Journal: Neoplasia (New York, N.Y.) 20080501

Title: High expression of GADD-45alpha and VEGF induced tumor recurrence via upregulation of IL-2 after photodynamic therapy using NPe6.

Journal: International journal of oncology 20080201

Title: Sonodynamically-induced apoptosis, necrosis, and active oxygen generation by mono-l-aspartyl chlorin e6.

Journal: Cancer science 20080101

Title: Bid is required in NPe6-PDT-induced apoptosis.

Journal: Photochemistry and photobiology 20080101

Title: Photosensitization reaction-induced electrical blockade in myocardial tissue.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20080101

Title: Photodynamic therapy for lung cancers based on novel photodynamic diagnosis using talaporfin sodium (NPe6) and autofluorescence bronchoscopy.

Journal: Lung cancer (Amsterdam, Netherlands) 20071201

Title: A Phase II safety and effect on time to tumor progression study of intratumoral light infusion technology using talaporfin sodium in patients with metastatic colorectal cancer.

Journal: Journal of surgical oncology 20071101

Title: Expression of vascular endothelial growth factor by photodynamic therapy with mono-L-aspartyl chlorin e6 (NPe6) in oral squamous cell carcinoma.

Journal: Oral oncology 20070701

Title: Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response.

Journal: Cancer research 20070515

Title: Index-of-refraction-dependent subcellular light scattering observed with organelle-specific dyes.

Journal: Journal of biomedical optics 20070101

Title: Intraocular biodistribution of mono-L-aspartyl chlorin e6 in a primate choroidal neovascularization model.

Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20070101

Title: Mono-(L)-aspartylchlorin-e6.

Journal: Photochemistry and photobiology 20070101

Title: In vitro behavior of Porfimer sodium and Talaporfin sodium with high intensity pulsed irradiation.

Journal: Lasers in medical science 20061201

Title: Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital.

Journal: Lasers in surgery and medicine 20060601

Title: Photodynamic therapy with mono-L-aspartyl chlorin e6 can cause necrosis of squamous cell carcinoma of tongue: experimental study on an animal model of nude mouse.

Journal: Oral oncology 20060101

Title: Tumor viability using real-time spectral images.

Journal: Surgery today 20060101

Title: Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy.

Journal: The Biochemical journal 20051201

Title: Long-term inhibition of intimal hyperplasia using vascular photodynamic therapy in balloon-injured carotid arteries.

Journal: Medical molecular morphology 20051201

Title: Laser photocoagulation and, to a lesser extent, photodynamic therapy target and enhance adenovirus vector-mediated gene transfer in the rat retina.

Journal: Investigative ophthalmology & visual science 20051001

Title: Pharmacokinetics and clinical effects of mono-L-aspartyl chlorin e6 (NPe6) photodynamic therapy in adult patients with primary or secondary cancer of the skin and mucosal surfaces.

Journal: Photodermatology, photoimmunology & photomedicine 20050401

Title: Killing tumor cells: the effect of photodynamic therapy using mono-L-aspartyl chlorine and NS-398.

Journal: American journal of surgery 20050301

Title: Effects of photodynamic therapy using a fractionated dosing of mono-L-aspartyl chlorin e6 in a murine tumor.

Journal: Journal of photochemistry and photobiology. B, Biology 20050201

Title: Detection of photodynamic therapy-induced early apoptosis in human salivary gland tumor cells in vitro and in a mouse tumor model.

Journal: Oral oncology 20040901

Title: [Development of a novel photosensitizer, talaporfin sodium, for the photodynamic therapy (PDT)].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040601

Title: Photodynamic therapy upregulates expression of Mac-1 and generation of leukotriene B(4) by human polymorphonuclear leukocytes.

Journal: Oral oncology 20040501

Title: Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents.

Journal: Molecular pharmacology 20040401

Title: CHOP activation by photodynamic therapy increases treatment induced photosensitization.

Journal: Lasers in surgery and medicine 20040101

Title: Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung.

Journal: Lung cancer (Amsterdam, Netherlands) 20031001

Title: Pilot study of topical delivery of mono-L-aspartyl chlorin e6 (NPe6): implication of topical NPe6-photodynamic therapy.

Journal: Journal of pharmacological sciences 20031001

Title: In vitro photodynamic diagnosis of atherosclerotic wall changes with the use of mono-l-aspartyl chlorin e6. A preliminary report.

Journal: Kardiologia polska 20031001

Title: Talaporfin sodium. LS 11, ME 2906, mono-L-aspartyl chlorine e6, NP e6, NPE 6, taporfin sodium.

Journal: Drugs in R&D 20030101

Title: Photodynamic therapy of intestinal tumors with mono-L-aspartyl chlorin e6 (NPe6): a basic study.

Journal: Anticancer research 20030101

Title: Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage.

Journal: Cell death and differentiation 20020901

Title: Phase-resolved fluorescence study of mono-L-aspartyl chlorin E6.

Journal: Journal of photochemistry and photobiology. B, Biology 20020501

Title: Morphologic evaluation of the antitumor activity of photodynamic therapy (PDT) using mono-L-aspartyl chlorin e6 (NPe6) against uterine cervical carcinoma cell lines.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20020101

Title: New technology for deep light distribution in tissue for phototherapy.

Journal: Cancer journal (Sudbury, Mass.) 20020101

Title: Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis.

Journal: International journal of cancer 20010815

Title: Endovascular photodynamic therapy using mono-L-aspartyl-chlorin e6 to inhibit Intimal hyperplasia in balloon-injured rabbit arteries.

Journal: Lasers in surgery and medicine 20010101

Title: Toxicity of the photosensitizer NPe6 following intravitreal injection.

Journal: Ophthalmic surgery and lasers 20010101

Title: Retreatment effect of NPe6 photodynamic therapy on the normal primate macula.

Journal: Retina (Philadelphia, Pa.) 20010101

Title: Photodynamic therapy of experimental choroidal neovascularization with a hydrophilic photosensitizer: mono-L-aspartyl chlorin e6.

Journal: Retina (Philadelphia, Pa.) 20010101

Title: http://journals.lww.com/jto/Fulltext/2006/06000/Photodynamic_Therapy__PDT__for_Lung_Cancers.18.aspx

Title: http://meeting.ascopubs.org/cgi/content/abstract/24/18_suppl/7229

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:220201-34-3 Molecular Formula|220201-34-3 MDL|220201-34-3 SMILES|220201-34-3 Tetrasodium (2S)-2-((((7S,8S)-3-carboxylato-7-(2-carboxylatoethyl)-13-ethenyl-18-ethyl-2,8,12,17-tetramethyl-7,8-dihydroporphyrin-5-yl)acetyl)amino)butanedioate