Title: Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans.
Journal: Molecular biology of the cell 20100315
Title: Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies.
Journal: Bioorganic & medicinal chemistry letters 20100301
Title: Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues.
Journal: Journal of medicinal chemistry 20090122
Title: Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin.
Journal: International journal of cancer 20080515
Title: Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin.
Journal: World journal of gastroenterology 20061114
Title: Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin.
Journal: Biochemistry 20050510
Title: Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.
Journal: Biochemistry 20041109
Title: Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
Journal: Molecular cancer therapeutics 20041001
Title: Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Journal: Journal of medicinal chemistry 20040909
Title: Probing the interaction of HTI-286 with tubulin using a stilbene analogue.
Journal: Journal of the American Chemical Society 20040818
Title: D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20040816
Title: Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents.
Journal: Cancer biology & therapy 20040301
Title: Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules.
Journal: Biochemistry 20031125
Title: HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
Journal: Cancer research 20030415
