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269718-83-4,MFCD09833663
Catalog No.:AA00BF3M

269718-83-4 | 2(3H)-BENZOXAZOLONE, 7-(4-METHYL-1-PIPERAZINYL)-, MONOHYDROCHLORIDE

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1mg
≥98%
in stock  
$53.00   $37.00
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5mg
≥98%
in stock  
$230.00   $161.00
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10mg
98+%
in stock  
$375.00   $263.00
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25mg
98+%
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$675.00   $472.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BF3M
Chemical Name:
2(3H)-BENZOXAZOLONE, 7-(4-METHYL-1-PIPERAZINYL)-, MONOHYDROCHLORIDE
CAS Number:
269718-83-4
Molecular Formula:
C12H16ClN3O2
Molecular Weight:
269.7273
MDL Number:
MFCD09833663
SMILES:
CN1CCN(CC1)c1cccc2c1oc(n2)O.Cl
Properties
Computed Properties
 
Complexity:
302  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  

Literature

Title: Pardoprunox as adjunct therapy to levodopa in patients with Parkinson's disease experiencing motor fluctuations: results of a double-blind, randomized, placebo-controlled, trial.

Journal: Parkinsonism & related disorders 20120501

Title: Temporal stability of the Unified Dyskinesia Rating Scale.

Journal: Movement disorders : official journal of the Movement Disorder Society 20111201

Title: In vivo effects of pardoprunox (SLV308), a partial D₂/D₃ receptor and 5-HT1A receptor agonist, on rat dopamine and serotonin neuronal activity.

Journal: Synapse (New York, N.Y.) 20111001

Title: Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Journal: Journal of medicinal chemistry 20110714

Title: Pardoprunox in early Parkinson's disease: results from 2 large, randomized double-blind trials.

Journal: Movement disorders : official journal of the Movement Disorder Society 20110701

Title: The partial dopamine agonist pardoprunox (SLV308) administered in combination with l-dopa improves efficacy and decreases dyskinesia in MPTP treated common marmosets.

Journal: Experimental neurology 20101201

Title: Pardoprunox reverses motor deficits but induces only mild dyskinesia in MPTP-treated common marmosets.

Journal: Movement disorders : official journal of the Movement Disorder Society 20101015

Title: An in vivo pharmacological evaluation of pardoprunox (SLV308)--a novel combined dopamine D(2)/D(3) receptor partial agonist and 5-HT(1A) receptor agonist with efficacy in experimental models of Parkinson's disease.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100801

Title: Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society 20100430

Title: Safety and tolerability of pardoprunox, a new partial dopamine agonist, in a randomized, controlled study of patients with advanced Parkinson's disease.

Journal: European neurology 20090101

Title: In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.

Journal: Synapse (New York, N.Y.) 20061215

Title: SLV-308. Solvay.

Journal: Current opinion in investigational drugs (London, England : 2000) 20030701

Title: Glennon JC, et al. In vitro characterization of SLV308 (7--methyl-1-piperazinyl-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608.

Title: Jones CA, et al. An in vivo pharmacological evaluation of pardoprunox (SLV308)--a novel combined dopamine D(2)/D(3) receptor partial agonist and 5-HT(1A) receptor agonist with efficacy in experimental models of Parkinson's disease. Eur Neuropsychopharmacol. 2010 Aug;20(8):582-593.

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Tags:269718-83-4 Molecular Formula|269718-83-4 MDL|269718-83-4 SMILES|269718-83-4 2(3H)-BENZOXAZOLONE, 7-(4-METHYL-1-PIPERAZINYL)-, MONOHYDROCHLORIDE