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220355-63-5,MFCD30343853
Catalog No.:AA00BF5A

220355-63-5 | UKI-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
96%
1 week  
$336.00   $235.00
- +
5mg
96%
1 week  
$717.00   $502.00
- +
10mg
96%
1 week  
$1,003.00   $702.00
- +
50mg
96%
1 week  
$2,908.00   $2,035.00
- +
100mg
96%
1 week  
$4,050.00   $2,835.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BF5A
Chemical Name:
UKI-1
CAS Number:
220355-63-5
Molecular Formula:
C32H47N5O5S
Molecular Weight:
613.8111
MDL Number:
MFCD30343853
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)[C@@H](NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C)Cc1cccc(c1)C(=N)N
Properties
Computed Properties
 
Complexity:
1030  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
12  
XLogP3:
4.8  

Literature

Title: Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA).

Journal: Bioorganic & medicinal chemistry 20120215

Title: Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.

Journal: Journal of medicinal chemistry 20080124

Title: Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.

Journal: Journal of medicinal chemistry 20060713

Title: Suppression of rat breast cancer metastasis and reduction of primary tumour growth by the small synthetic urokinase inhibitor WX-UK1.

Journal: Thrombosis and haemostasis 20050401

Title: Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system.

Journal: International journal of cancer 20040720

Title: 3-Amidinophenylalanine-based inhibitors of urokinase.

Journal: Bioorganic & medicinal chemistry letters 19991101

Title: Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24.

Title: Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75.

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