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199798-84-0,MFCD09954119
Catalog No.:AA00BFE6

199798-84-0 | ELOCALCITOL

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1mg
≥98%
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$255.00   $178.00
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5mg
≥98%
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$758.00   $530.00
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  • Technical Information
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Technical Information
Catalog Number:
AA00BFE6
Chemical Name:
ELOCALCITOL
CAS Number:
199798-84-0
Molecular Formula:
C29H43FO2
Molecular Weight:
442.6489
MDL Number:
MFCD09954119
SMILES:
CCC(/C=C/C[C@@H](C1=CC[C@@H]2[C@]1(C)CCC/C/2=C\C=C/1\C[C@@H](O)C[C@@H](C1=C)F)C)(CC)O
Properties
Computed Properties
 
Complexity:
813  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
5.7  

Literature

Title: Effects on bladder function of combining elocalcitol and tolterodine in rats with outflow obstruction.

Journal: BJU international 20120701

Title: Phase IIb, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to determine effects of elocalcitol in women with overactive bladder and idiopathic detrusor overactivity.

Journal: Urology 20120701

Title: Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation.

Journal: Journal of endocrinological investigation 20101101

Title: Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20100901

Title: Chronic inflammation in the pathogenesis of benign prostatic hyperplasia.

Journal: International journal of andrology 20100601

Title: Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility.

Journal: IDrugs : the investigational drugs journal 20090601

Title: The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.

Journal: The Prostate 20090401

Title: Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells.

Journal: Endocrinology 20080701

Title: The vitamin D receptor agonist elocalcitol upregulates L-type calcium channel activity in human and rat bladder.

Journal: American journal of physiology. Cell physiology 20080501

Title: Atorvastatin but not elocalcitol increases sildenafil responsiveness in spontaneously hypertensive rats by regulating the RhoA/ROCK pathway.

Journal: Journal of andrology 20080101

Title: Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol).

Journal: The Journal of steroid biochemistry and molecular biology 20070301

Title: BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder.

Journal: The Prostate 20070215

Title: Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20061215

Title: Effects of a vitamin D(3) analogue in a rat model of bladder outlet obstruction.

Journal: BJU international 20060901

Title: The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells.

Journal: Journal of cancer research and clinical oncology 20060601

Title: Non-genomic effects of the androgen receptor and vitamin D agonist are involved in suppressing invasive phenotype of prostate cancer cells.

Journal: Steroids 20060401

Title: Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis.

Journal: BJU international 20060301

Title: Emerging drug therapies for benign prostatic hyperplasia.

Journal: Expert opinion on emerging drugs 20060301

Title: BXL628, a novel vitamin D3 analog arrests prostate growth in patients with benign prostatic hyperplasia: a randomized clinical trial.

Journal: European urology 20060101

Title: Pre-clinical evidence and clinical translation of benign prostatic hyperplasia treatment by the vitamin D receptor agonist BXL-628 (Elocalcitol).

Journal: Journal of endocrinological investigation 20060101

Title: Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist.

Journal: Transplantation 20050715

Title: Human bladder as a novel target for vitamin D receptor ligands.

Journal: The Journal of clinical endocrinology and metabolism 20050201

Title: Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia.

Journal: European journal of endocrinology 20040401

Title: Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic rats.

Journal: Endocrinology 20020501

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