212329-37-8,MFCD03787977
Catalog No.:AA00BJVK

212329-37-8 | MRS 1523

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$80.00   $56.00
- +
5mg
≥98%
in stock  
$269.00   $188.00
- +
10mg
98%
in stock  
$450.00   $315.00
- +
50mg
98%
in stock  
$1,550.00   $1,085.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BJVK
Chemical Name:
MRS 1523
CAS Number:
212329-37-8
Molecular Formula:
C23H29NO3S
Molecular Weight:
399.5463
MDL Number:
MFCD03787977
SMILES:
CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC
Properties
Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
6.2  

Literature

Title: Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes.

Journal: Journal of molecular and cellular cardiology 20121101

Title: NADPH oxidase pathway is involved in aortic contraction induced by A3 adenosine receptor in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20110801

Title: Control of enteric neuromuscular functions by purinergic A(3) receptors in normal rat distal colon and experimental bowel inflammation.

Journal: British journal of pharmacology 20101001

Title: Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20100201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.

Journal: Purinergic signalling 20090301

Title: Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.

Journal: American journal of physiology. Heart and circulatory physiology 20070101

Title: Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells.

Journal: Neuroscience letters 20060320

Title: A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.

Journal: British journal of pharmacology 20060301

Title: Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics 20050101

Title: An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B.

Journal: Oncogene 20040401

Title: Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.

Journal: British journal of pharmacology 20030901

Title: Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030601

Title: Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration.

Journal: Cellular and molecular neurobiology 20030601

Title: Activation of A(3) receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons.

Journal: Restorative neurology and neuroscience 20030101

Title: Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Journal: Journal of medicinal chemistry 20020926

Title: Mechanisms of apoptosis induced by purine nucleosides in astrocytes.

Journal: Glia 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA.

Journal: Biochemical pharmacology 20020301

Title: Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity.

Journal: Journal of molecular and cellular cardiology 20010601

Title: Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.

Journal: Molecular and cellular biochemistry 20010101

Title: Induction of apoptosis in rat cardiocytes by A3 adenosine receptor activation and its suppression by isoproterenol.

Journal: Experimental cell research 20000525

Title: Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 19980813

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Related Products of 212329-37-8
Tags:212329-37-8 Molecular Formula|212329-37-8 MDL|212329-37-8 SMILES|212329-37-8 MRS 1523
Catalog No.: AA00BJVK
212329-37-8,MFCD03787977
212329-37-8 | MRS 1523
Pack Size: 1mg
Purity: ≥98%
in stock
$80.00 $56.00
Pack Size: 5mg
Purity: ≥98%
in stock
$269.00 $188.00
Pack Size: 10mg
Purity: 98%
in stock
$450.00 $315.00
Pack Size: 50mg
Purity: 98%
in stock
$1,550.00 $1,085.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00BJVK
Chemical Name: MRS 1523
CAS Number: 212329-37-8
Molecular Formula: C23H29NO3S
Molecular Weight: 399.5463
MDL Number: MFCD03787977
SMILES: CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC
Properties
Complexity: 492  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 11  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 6.2  
Literature fold

Title: Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes.

Journal: Journal of molecular and cellular cardiology20121101

Title: NADPH oxidase pathway is involved in aortic contraction induced by A3 adenosine receptor in mice.

Journal: The Journal of pharmacology and experimental therapeutics20110801

Title: Control of enteric neuromuscular functions by purinergic A(3) receptors in normal rat distal colon and experimental bowel inflammation.

Journal: British journal of pharmacology20101001

Title: Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.

Journal: American journal of physiology. Heart and circulatory physiology20100201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.

Journal: Purinergic signalling20090301

Title: Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.

Journal: American journal of physiology. Heart and circulatory physiology20071201

Title: The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.

Journal: American journal of physiology. Heart and circulatory physiology20070101

Title: Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.

Journal: The Journal of pharmacology and experimental therapeutics20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells.

Journal: Neuroscience letters20060320

Title: A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.

Journal: British journal of pharmacology20060301

Title: Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics20050101

Title: An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B.

Journal: Oncogene20040401

Title: Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.

Journal: British journal of pharmacology20030901

Title: Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model.

Journal: American journal of physiology. Lung cellular and molecular physiology20030601

Title: Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration.

Journal: Cellular and molecular neurobiology20030601

Title: Activation of A(3) receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons.

Journal: Restorative neurology and neuroscience20030101

Title: Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Journal: Journal of medicinal chemistry20020926

Title: Mechanisms of apoptosis induced by purine nucleosides in astrocytes.

Journal: Glia20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA.

Journal: Biochemical pharmacology20020301

Title: Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity.

Journal: Journal of molecular and cellular cardiology20010601

Title: Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.

Journal: Molecular and cellular biochemistry20010101

Title: Induction of apoptosis in rat cardiocytes by A3 adenosine receptor activation and its suppression by isoproterenol.

Journal: Experimental cell research20000525

Title: Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry19980813

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