Name: Name:GRA Ex-25
Brand: AABLOCKS
SKU: AA00BJWP
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00BJWP

Chemical Name: GRA Ex-25

CAS Number: 307983-31-9

Molecular Formula: C29H36F3N3O5

Molecular Weight: 563.6084

MDL Number: MFCD11977277

SMILES: OC(=O)CCNC(=O)c1ccc(cc1)CN(C(=O)Nc1ccc(cc1)OC(F)(F)F)[C@@H]1CC[C@H](CC1)C(C)(C)C

Properties

Complexity: 839

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 40

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 3

Rotatable Bond Count: 10

XLogP3: 5.8

Literature fold

Title: Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.

Journal: Bioorganic & medicinal chemistry letters20110101

Title: Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

Journal: Journal of medicinal chemistry20080911

Title: New beta-alanine derivatives are orally available glucagon receptor antagonists.

Journal: Journal of medicinal chemistry20070111

Title: Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters20051015

Title: Biaryl amide glucagon receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters20040503

Title: Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50.

Title: Lau J, et al. New beta-alanine derivatives are orally available glucagon receptor antagonists. J Med Chem. 2007 Jan 11;50(1):113-28.

307983-31-9 | GRA Ex-25