2158-02-3,MFCD00085717
Catalog No.:AA00BV29

2158-02-3 | Morpholine-4-carboxamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
96%
in stock  
$91.00   $64.00
- +
5g
96%
in stock  
$250.00   $175.00
- +
10g
96%
in stock  
$408.00   $286.00
- +
25g
96%
in stock  
$726.00 $508.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BV29
Chemical Name:
Morpholine-4-carboxamide
CAS Number:
2158-02-3
Molecular Formula:
C5H10N2O2
Molecular Weight:
130.1451
MDL Number:
MFCD00085717
SMILES:
NC(=O)N1CCOCC1
NSC Number:
10542
Properties
Computed Properties
 
Complexity:
110  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-1.2  

Downstream Synthesis Route

[1]Schroth,W.;Kluge,H.;Frach,R.;Hodek,W.;Schaedler,H.D.[JournalfurpraktischeChemie(Leipzig1954),1983,vol.325,#5,p.787-802]

[2]Schroth,Werner;Kluge,Helmut;Matthias,Michael;Krieg,Reimar;Schaedler,Hans-Dieter[ZeitschriftfurChemie,1981,vol.21,#1,p.25-27]

[1]BioorganicandMedicinalChemistry,2005,vol.13,p.3705-3720

[1]Patent:US2012/172320,2012,A1

2158-02-3    13089-11-7   
methyl3,3,3-trifluoro-2-(morpholin-4-ylcarbonyl)iminopropanoate 

[1]Aksinenko,AlexeyYu.;Goreva,TatyanaV.;Epishina,TatyanaA.;Trepalin,SergeyV.;Sokolov,VladimirB.[JournalofFluorineChemistry,2017,vol.201,p.19-23]

[1]Álvarez,Daniel;Cadierno,Victorio;Crochet,Pascale;González-Fernández,Rebeca;López,Ramón;Menéndez,M.Isabel[Catalysisscienceandtechnology,2020,vol.10,#12,p.4084-4098]

Literature

Title: Synthesis, antitumor, antitrypanosomal and antileishmanial activities of benzo[4,5]canthin-6-ones bearing the N'-(Substituted benzylidene)-carbohydrazide and N-Alkylcarboxamide groups at C-2.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: Asymmetric synthesis of (+)-galbelgin, (-)-kadangustin J, (-)-cyclogalgravin and (-)-pycnanthulignenes A and B, three structurally distinct lignan classes, using a common chiral precursor.

Journal: The Journal of organic chemistry 20110819

Title: New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosis.

Journal: PloS one 20110101

Title: Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.

Journal: PloS one 20110101

Title: The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.

Journal: International journal of endocrinology 20110101

Title: Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

Journal: Journal of molecular biology 20101119

Title: In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB(2)) in rat liver microsomes.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100911

Title: BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080401

Title: Lewis base activation of Lewis acids: catalytic, enantioselective vinylogous aldol addition reactions.

Journal: The Journal of organic chemistry 20070720

Title: Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors.

Journal: Calcified tissue international 20070101

Title: Lewis base activation of Lewis acids. Vinylogous aldol addition reactions of conjugated N,O-silyl ketene acetals to aldehydes.

Journal: Journal of the American Chemical Society 20060201

Title: Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.

Journal: Journal of medicinal chemistry 20040408

Title: Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.

Journal: British journal of pharmacology 20030601

Title: BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates.

Journal: FEBS letters 20030211

Title: Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

Journal: Journal of medicinal chemistry 20010802

Title: Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids.

Journal: Journal of cellular biochemistry 20010101

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SDS
Tags:2158-02-3 Molecular Formula|2158-02-3 MDL|2158-02-3 SMILES|2158-02-3 Morpholine-4-carboxamide
Catalog No.: AA00BV29
2158-02-3,MFCD00085717
2158-02-3 | Morpholine-4-carboxamide
Pack Size: 1g
Purity: 96%
in stock
$91.00 $64.00
Pack Size: 5g
Purity: 96%
in stock
$250.00 $175.00
Pack Size: 10g
Purity: 96%
in stock
$408.00 $286.00
Pack Size: 25g
Purity: 96%
in stock
$726.00 $508.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BV29
Chemical Name: Morpholine-4-carboxamide
CAS Number: 2158-02-3
Molecular Formula: C5H10N2O2
Molecular Weight: 130.1451
MDL Number: MFCD00085717
SMILES: NC(=O)N1CCOCC1
NSC Number: 10542
Properties
Complexity: 110  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 9  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -1.2  
Downstream Synthesis Route
2158-02-3    1530-89-8 

[1]Schroth,W.;Kluge,H.;Frach,R.;Hodek,W.;Schaedler,H.D.[JournalfurpraktischeChemie(Leipzig1954),1983,vol.325,#5,p.787-802]

[2]Schroth,Werner;Kluge,Helmut;Matthias,Michael;Krieg,Reimar;Schaedler,Hans-Dieter[ZeitschriftfurChemie,1981,vol.21,#1,p.25-27]

2158-02-3    87005-15-0    265107-05-9 

[1]BioorganicandMedicinalChemistry,2005,vol.13,p.3705-3720

110-91-8    1103738-17-5    2158-02-3 

[1]Patent:US2012/172320,2012,A1

2158-02-3    13089-11-7   
methyl3,3,3-trifluoro-2-(morpholin-4-ylcarbonyl)iminopropanoate 

[1]Aksinenko,AlexeyYu.;Goreva,TatyanaV.;Epishina,TatyanaA.;Trepalin,SergeyV.;Sokolov,VladimirB.[JournalofFluorineChemistry,2017,vol.201,p.19-23]

1530-89-8    2158-02-3 

[1]Álvarez,Daniel;Cadierno,Victorio;Crochet,Pascale;González-Fernández,Rebeca;López,Ramón;Menéndez,M.Isabel[Catalysisscienceandtechnology,2020,vol.10,#12,p.4084-4098]

Literature fold

Title: Synthesis, antitumor, antitrypanosomal and antileishmanial activities of benzo[4,5]canthin-6-ones bearing the N'-(Substituted benzylidene)-carbohydrazide and N-Alkylcarboxamide groups at C-2.

Journal: Chemical & pharmaceutical bulletin20120101

Title: Asymmetric synthesis of (+)-galbelgin, (-)-kadangustin J, (-)-cyclogalgravin and (-)-pycnanthulignenes A and B, three structurally distinct lignan classes, using a common chiral precursor.

Journal: The Journal of organic chemistry20110819

Title: New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosis.

Journal: PloS one20110101

Title: Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.

Journal: PloS one20110101

Title: The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.

Journal: International journal of endocrinology20110101

Title: Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

Journal: Journal of molecular biology20101119

Title: In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB(2)) in rat liver microsomes.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20100911

Title: BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20080401

Title: Lewis base activation of Lewis acids: catalytic, enantioselective vinylogous aldol addition reactions.

Journal: The Journal of organic chemistry20070720

Title: Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors.

Journal: Calcified tissue international20070101

Title: Lewis base activation of Lewis acids. Vinylogous aldol addition reactions of conjugated N,O-silyl ketene acetals to aldehydes.

Journal: Journal of the American Chemical Society20060201

Title: Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.

Journal: Journal of medicinal chemistry20040408

Title: Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.

Journal: British journal of pharmacology20030601

Title: BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates.

Journal: FEBS letters20030211

Title: Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

Journal: Journal of medicinal chemistry20010802

Title: Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids.

Journal: Journal of cellular biochemistry20010101

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