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405060-95-9,MFCD00548612
Catalog No.:AA00BXB4

405060-95-9 | Salubrinal

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1mg
98%
in stock  
$12.00   $8.00
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5mg
98%
in stock  
$26.00   $18.00
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10mg
98%
in stock  
$38.00   $27.00
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25mg
98%
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$64.00   $45.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BXB4
Chemical Name:
Salubrinal
CAS Number:
405060-95-9
Molecular Formula:
C21H17Cl3N4OS
Molecular Weight:
479.8099
MDL Number:
MFCD00548612
SMILES:
O=C(NC(C(Cl)(Cl)Cl)NC(=S)Nc1cccc2c1nccc2)/C=C/c1ccccc1
Properties
Properties
 
Form:
Solid  
MP:
>160°C (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
622  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.2  

Literature

Title: Eukaryotic translation initiation factor 2 subunit α (eIF2α) inhibitor salubrinal attenuates paraquat-induced human lung epithelial-like A549 cell apoptosis by regulating the PERK-eIF2α signaling pathway.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201

Title: Endoplasmic reticulum stress restrains hepatocyte growth factor expression in hepatic stellate cells and rat acute liver failure model.

Journal: Chemico-biological interactions 20171101

Title: Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20161201

Title: Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons.

Journal: Molecular neurobiology 20160101

Title: Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.

Journal: Chemical research in toxicology 20150615

Title: Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.

Journal: The FEBS journal 20150301

Title: Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNA.

Journal: Blood 20141023

Title: The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cells.

Journal: Neurotoxicology 20140901

Title: Arsenic trioxide induces unfolded protein response in vascular endothelial cells.

Journal: Archives of toxicology 20140201

Title: Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.

Journal: Toxicology and applied pharmacology 20131101

Title: Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130801

Title: Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.

Journal: Blood 20130725

Title: Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 20130401

Title: Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction.

Journal: Free radical biology & medicine 20120901

Title: Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120801

Title: Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells.

Journal: Journal of periodontal research 20120601

Title: Sustained translational repression by eIF2α-P mediates prion neurodegeneration.

Journal: Nature 20120506

Title: Salubrinal, an endoplasmic reticulum stress blocker, modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons.

Journal: Neuroscience 20120503

Title: Β-adrenergic receptor stimulation induces endoplasmic reticulum stress in adult cardiac myocytes: role in apoptosis.

Journal: Molecular and cellular biochemistry 20120501

Title: Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways.

Journal: Journal of cellular physiology 20120301

Title: Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.

Journal: Autophagy 20120301

Title: A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

Journal: Toxicology and applied pharmacology 20120115

Title: Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells.

Journal: Archives of toxicology 20120101

Title: Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.

Journal: Progress in molecular biology and translational science 20120101

Title: Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells.

Journal: Cancer letters 20111227

Title: Endoplasmic reticulum stress causes EBV lytic replication.

Journal: Blood 20111117

Title: Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20110901

Title: Mechanism of pyrethroid pesticide-induced apoptosis: role of calpain and the ER stress pathway.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110801

Title: Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model.

Journal: Free radical biology & medicine 20110801

Title: Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema.

Journal: Journal of molecular medicine (Berlin, Germany) 20110601

Title: Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110301

Title: ASK1 overexpression accelerates paraquat-induced autophagy via endoplasmic reticulum stress.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110101

Title: Homocysteine-induced caspase-3 activation by endoplasmic reticulum stress in endothelial progenitor cells from patients with coronary heart disease and healthy donors.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20101215

Title: Homocysteine induces caspase activation by endoplasmic reticulum stress in platelets from type 2 diabetics and healthy donors.

Journal: Thrombosis and haemostasis 20100501

Title: The role of endoplasmic reticulum stress-related unfolded protein response in the radiocontrast medium-induced renal tubular cell injury.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100401

Title: Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

Journal: The Journal of clinical endocrinology and metabolism 20100301

Title: Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats.

Journal: Neurotoxicity research 20100201

Title: Phosphatase inhibitors with anti-angiogenic effect in vitro.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20100101

Title: Activation of PERK signaling attenuates Abeta-mediated ER stress.

Journal: PloS one 20100101

Title: Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis.

Journal: PloS one 20100101

Title: Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones.

Journal: Cellular immunology 20100101

Title: Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells.

Journal: Toxicology letters 20091215

Title: Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.

Journal: Cancer chemotherapy and pharmacology 20091101

Title: Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.

Journal: Journal of molecular neuroscience : MN 20090901

Title: Lopinavir co-induces insulin resistance and ER stress in human adipocytes.

Journal: Biochemical and biophysical research communications 20090814

Title: A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice.

Journal: Nature neuroscience 20090501

Title: Salubrinal, an inhibitor of protein synthesis, promotes deep slow wave sleep.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090101

Title: Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death.

Journal: American journal of physiology. Renal physiology 20090101

Title: Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.

Journal: PloS one 20090101

Title: Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20081101

Title: Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.

Journal: The American journal of pathology 20081101

Title: ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.

Journal: Virology 20080930

Title: Arsenite-induced cytotoxicity in dorsal root ganglion explants.

Journal: Free radical biology & medicine 20080415

Title: Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins.

Journal: Experimental cell research 20080310

Title: A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.

Journal: Cell death and differentiation 20080301

Title: Eif-2a protects brainstem motoneurons in a murine model of sleep apnea.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080227

Title: Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.

Journal: Cell death and differentiation 20070801

Title: Mechanism of attenuation of angiotensin-II-induced protein degradation by insulin-like growth factor-I (IGF-I).

Journal: Cellular signalling 20070701

Title: Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.

Journal: Cell 20070406

Title: Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Journal: The Journal of biological chemistry 20070209

Title: Calreticulin exposure dictates the immunogenicity of cancer cell death.

Journal: Nature medicine 20070101

Title: Protection of Bcl-2 by salubrinal.

Journal: Biochemical and biophysical research communications 20060811

Title: Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.

Journal: Bioorganic & medicinal chemistry letters 20050901

Title: A new pharmacology--drugging stressed folding pathways.

Journal: Trends in molecular medicine 20050801

Title: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

Journal: Science (New York, N.Y.) 20050211

Title: Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development.

Journal: Molecular endocrinology (Baltimore, Md.)

Title: Drexler HC. Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors. PLoS One. 2009;4(1):e4161.

Title: Hamamura K, et al. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015 Apr;27(4):828-35.

Title: Bryant KF, et al. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30;379(2):197-204.

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