3303-31-9,MFCD00065185
Catalog No.:AA00BY75

3303-31-9 | H-Leu-leu-oh

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%(HPLC)
in stock  
$50.00   $35.00
- +
5g
95%
in stock  
$62.00   $43.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BY75
Chemical Name:
H-Leu-leu-oh
CAS Number:
3303-31-9
Molecular Formula:
C12H24N2O3
Molecular Weight:
244.3306
MDL Number:
MFCD00065185
SMILES:
CC(CC(C(=O)NC(C(=O)O)CC(C)C)N)C
Properties
Computed Properties
 
Complexity:
265  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-1.5  

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.4686,4689

[2]JournaloftheAmericanChemicalSociety,1957,vol.79,p.4686,4689

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.639,642

[1]JournalofOrganicChemistry,1950,vol.15,p.108,115

[1]JournalofBiologicalChemistry,1952,vol.199,p.801,808

[2]Tetrahedron,1963,vol.19,p.95-105

[3]BulletinoftheChemicalSocietyofJapan,1973,vol.46,p.2190-2193

[4]BioorganicandMedicinalChemistryLetters,2004,vol.14,p.1965-1968

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.639,642

[2]JournaloftheAmericanChemicalSociety,1957,vol.79,p.639,642

Literature

Title: Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Journal: Nature chemical biology 20090101

Title: Utilization of amino acids and dipeptides by Lactobacillus plantarum from orange in nutritionally stressed conditions.

Journal: Journal of applied microbiology 20080601

Title: Incorporation of the herpes simplex virus type 1 tegument protein VP22 into the virus particle is independent of interaction with VP16.

Journal: Virology 20071220

Title: A dileucine motif in its cytoplasmic domain directs beta-catenin-uncoupled E-cadherin to the lysosome.

Journal: Journal of cell science 20071215

Title: Dileucine motif is sufficient for internalization and synaptic vesicle targeting of vesicular acetylcholine transporter.

Journal: Traffic (Copenhagen, Denmark) 20070501

Title: Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.

Journal: Journal of medicinal chemistry 20060615

Title: ThPTR2, a di/tri-peptide transporter gene from Trichoderma harzianum.

Journal: Fungal genetics and biology : FG & B 20060401

Title: Simple estimation of absolute free energies for biomolecules.

Journal: The Journal of chemical physics 20060314

Title: New triorganotin (IV) derivatives of dipeptides as models for metal-protein interactions: synthesis, structural characterization and biological studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060101

Title: Effect of dipeptides on the growth of Oenococcus oeni in synthetic medium deprived of amino acids.

Journal: Current microbiology 20041101

Title: Addition of a peptide fragment on an alpha-helical depsipeptide induces alpha/3(10)-conjugated helix: synthesis, crystal structure, and CD spectra of Boc-Leu-Leu-Ala-(Leu-Leu-Lac)3-Leu-Leu-OEt.

Journal: Biopolymers 20041015

Title: Enantioselective molecular recognition between beta-sheets.

Journal: Journal of the American Chemical Society 20040317

Title: A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

Journal: Science (New York, N.Y.) 20030919

Title: Development of HIV-1 Nef vaccine components: immunogenicity study of Nef mutants lacking myristoylation and dileucine motif in mice.

Journal: Vaccine 20020910

Title: Cell biology. GGAs tie up the loose ends.

Journal: Science (New York, N.Y.) 20010601

Title: Sorting of mannose 6-phosphate receptors mediated by the GGAs.

Journal: Science (New York, N.Y.) 20010601

Title: Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.

Journal: Science (New York, N.Y.) 20010601

Title: Preferential utilization of dipeptides by Porphyromonas gingivalis.

Journal: Journal of dental research 20010501

Title: Transpeptidation by porcine pepsin catalyzed by a noncovalent intermediate unique to its iso-mechanism.

Journal: The Journal of biological chemistry 19980918

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Additional Info:
SDS
Tags:3303-31-9 Molecular Formula|3303-31-9 MDL|3303-31-9 SMILES|3303-31-9 H-Leu-leu-oh
Catalog No.: AA00BY75
3303-31-9,MFCD00065185
3303-31-9 | H-Leu-leu-oh
Pack Size: 1g
Purity: 98%(HPLC)
in stock
$50.00 $35.00
Pack Size: 5g
Purity: 95%
in stock
$62.00 $43.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BY75
Chemical Name: H-Leu-leu-oh
CAS Number: 3303-31-9
Molecular Formula: C12H24N2O3
Molecular Weight: 244.3306
MDL Number: MFCD00065185
SMILES: CC(CC(C(=O)NC(C(=O)O)CC(C)C)N)C
Properties
Complexity: 265  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -1.5  
Downstream Synthesis Route
73401-65-7    3303-31-9 

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.4686,4689

[2]JournaloftheAmericanChemicalSociety,1957,vol.79,p.4686,4689

109068-10-2    3303-31-9 

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.639,642

3504-37-8    3303-31-9 

[1]JournalofOrganicChemistry,1950,vol.15,p.108,115

7801-71-0    3303-31-9 

[1]JournalofBiologicalChemistry,1952,vol.199,p.801,808

[2]Tetrahedron,1963,vol.19,p.95-105

[3]BulletinoftheChemicalSocietyofJapan,1973,vol.46,p.2190-2193

[4]BioorganicandMedicinalChemistryLetters,2004,vol.14,p.1965-1968

7474-68-2    3303-31-9 

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.639,642

[2]JournaloftheAmericanChemicalSociety,1957,vol.79,p.639,642

Literature fold

Title: Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Journal: Nature chemical biology20090101

Title: Utilization of amino acids and dipeptides by Lactobacillus plantarum from orange in nutritionally stressed conditions.

Journal: Journal of applied microbiology20080601

Title: Incorporation of the herpes simplex virus type 1 tegument protein VP22 into the virus particle is independent of interaction with VP16.

Journal: Virology20071220

Title: A dileucine motif in its cytoplasmic domain directs beta-catenin-uncoupled E-cadherin to the lysosome.

Journal: Journal of cell science20071215

Title: Dileucine motif is sufficient for internalization and synaptic vesicle targeting of vesicular acetylcholine transporter.

Journal: Traffic (Copenhagen, Denmark)20070501

Title: Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.

Journal: Journal of medicinal chemistry20060615

Title: ThPTR2, a di/tri-peptide transporter gene from Trichoderma harzianum.

Journal: Fungal genetics and biology : FG & B20060401

Title: Simple estimation of absolute free energies for biomolecules.

Journal: The Journal of chemical physics20060314

Title: New triorganotin (IV) derivatives of dipeptides as models for metal-protein interactions: synthesis, structural characterization and biological studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20060101

Title: Effect of dipeptides on the growth of Oenococcus oeni in synthetic medium deprived of amino acids.

Journal: Current microbiology20041101

Title: Addition of a peptide fragment on an alpha-helical depsipeptide induces alpha/3(10)-conjugated helix: synthesis, crystal structure, and CD spectra of Boc-Leu-Leu-Ala-(Leu-Leu-Lac)3-Leu-Leu-OEt.

Journal: Biopolymers20041015

Title: Enantioselective molecular recognition between beta-sheets.

Journal: Journal of the American Chemical Society20040317

Title: A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

Journal: Science (New York, N.Y.)20030919

Title: Development of HIV-1 Nef vaccine components: immunogenicity study of Nef mutants lacking myristoylation and dileucine motif in mice.

Journal: Vaccine20020910

Title: Cell biology. GGAs tie up the loose ends.

Journal: Science (New York, N.Y.)20010601

Title: Sorting of mannose 6-phosphate receptors mediated by the GGAs.

Journal: Science (New York, N.Y.)20010601

Title: Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.

Journal: Science (New York, N.Y.)20010601

Title: Preferential utilization of dipeptides by Porphyromonas gingivalis.

Journal: Journal of dental research20010501

Title: Transpeptidation by porcine pepsin catalyzed by a noncovalent intermediate unique to its iso-mechanism.

Journal: The Journal of biological chemistry19980918

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