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3546-41-6,MFCD00010090
Catalog No.:AA00BY87

3546-41-6 | PYRVINIUM PAMOATE

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1mg
99%
in stock  
$7.00   $5.00
- +
10mg
99%
in stock  
$12.00   $8.00
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25mg
98%(HPLC)
in stock  
$24.00   $17.00
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50mg
99%
in stock  
$27.00   $19.00
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100mg
99%
in stock  
$44.00   $31.00
- +
250mg
98%(HPLC)
in stock  
$85.00   $59.00
- +
1g
98%(HPLC)
in stock  
$210.00   $147.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BY87
Chemical Name:
PYRVINIUM PAMOATE
CAS Number:
3546-41-6
Molecular Formula:
C75H70N6O6
Molecular Weight:
1151.3949
MDL Number:
MFCD00010090
SMILES:
[O-]C(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)[O-].CN(c1ccc2c(c1)ccc([n+]2C)C=Cc1cc(n(c1C)c1ccccc1)C)C.CN(c1ccc2c(c1)ccc([n+]2C)C=Cc1cc(n(c1C)c1ccccc1)C)C
Properties
Computed Properties
 
Complexity:
1120  
Covalently-Bonded Unit Count:
3  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
87  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  

Downstream Synthesis Route
2136666-28-7   
CASUnavailable 
  3546-41-6 

[1]CurrentPatentAssignee:URIACHS.A.-WO2017/178524,2017,A1Locationinpatent:Page/Pagecolumn18;19

[1]Adhikari,Navin;Gaikwad,VikasR.;Govindarajalu,Gokulapriya;Karale,UttamB.;Krishna,E.Vamshi;Krishna,VagoluSiva;Misra,Sunil;Rode,HaridasB.;Sijwali,PuranSigh;Sriram,Dharmarajan[Bioorganicandmedicinalchemistryletters,2020]

CASUnavailable 
  35648-29-4    3546-41-6 

[1]Adhikari,Navin;Gaikwad,VikasR.;Govindarajalu,Gokulapriya;Karale,UttamB.;Krishna,E.Vamshi;Krishna,VagoluSiva;Misra,Sunil;Rode,HaridasB.;Sijwali,PuranSigh;Sriram,Dharmarajan[Bioorganicandmedicinalchemistryletters,2020]

92-99-9   
pyrviniumpamoate 

[1]Bioorganicandmedicinalchemistryletters,2020

Literature

Title: Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

Journal: PloS one 20140101

Title: Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.

Journal: Journal of medicinal chemistry 20130808

Title: An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system--a unique mitochondrial energy metabolism in tumour microenvironments.

Journal: Journal of biochemistry 20120801

Title: Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3.

Journal: Cancer letters 20120601

Title: Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs).

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20120101

Title: Protein kinase CK1α regulates erythrocyte survival.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Effect of casein kinase 1α activator pyrvinium pamoate on erythrocyte ion channels.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Exposure to mebendazole and pyrvinium during pregnancy: a Danish nationwide cohort study.

Journal: Infectious diseases in obstetrics and gynecology 20120101

Title: Pinworm and TNKS inhibitors, an eccentric duo to derail the oncogenic WNT pathway.

Journal: Clinics and research in hepatology and gastroenterology 20110901

Title: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Journal: Nature chemical biology 20101101

Title: The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments.

Journal: Annals of the New York Academy of Sciences 20100701

Title: Order of functionality loss during photodegradation of aquatic humic substances.

Journal: Journal of environmental quality 20100101

Title: Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.

Journal: PloS one 20100101

Title: In vitro activity of pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis using radiolabelled thymidine incorporation and an SYBR Green I-based fluorescence assay.

Journal: The Journal of antimicrobial chemotherapy 20091001

Title: Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy.

Journal: PloS one 20080101

Title: Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors.

Journal: Parasitology research 20070301

Title: [The (children's) parasitic worms].

Journal: Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20041201

Title: Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation.

Journal: Cancer science 20040801

Title: Xu L, et al. WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells. Int J Oncol. 2016 Mar;48(3):1175-86.

Title: Wiegering A, et al. The impact of pyrvinium pamoate on colon cancer cell viability. Int J Colorectal Dis. 2014 Oct;29(10):1189-98.

Title: Venerando A, et al. Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation. Biochem J. 2013 May 15;452(1):131-7.

Title: Murakoshi M, et al. An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction. PLoS One. 2013 Nov 4;8(11):e79374.

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