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371942-69-7,MFCD16038303
Catalog No.:AA00BYF0

371942-69-7 | YM-201636

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$52.00   $36.00
- +
2mg
98%
in stock  
$77.00   $54.00
- +
10mg
98
in stock  
$361.00   $253.00
- +
50mg
98
in stock  
$1,209.00   $847.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BYF0
Chemical Name:
YM-201636
CAS Number:
371942-69-7
Molecular Formula:
C24H19N7O3
Molecular Weight:
453.4528
MDL Number:
MFCD16038303
SMILES:
Nc1ccc(cn1)C(=O)Nc1cccc(c1)c1nc(N2CCOC2)c2c(n1)c1cccnc1o2
Properties
Properties
 
Form:
Solid  
MP:
>226°C (dec.)  
Storage:
Light sensitive;Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
738  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.5  

Literature

Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Journal: Journal of medicinal chemistry 20121108

Title: The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.

Journal: PloS one 20120101

Title: Identification of a novel signaling pathway and its relevance for GluA1 recycling.

Journal: PloS one 20120101

Title: Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.

Journal: PLoS genetics 20111001

Title: Phosphoinositides direct equine infectious anemia virus gag trafficking and release.

Journal: Traffic (Copenhagen, Denmark) 20110401

Title: Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.

Journal: The EMBO journal 20100421

Title: YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.

Journal: Biochemical and biophysical research communications 20090508

Title: A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.

Journal: EMBO reports 20080201

Title: Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9(2), 164-170.

Title: Ikonomov OC, et al. YM-201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.

Title: Sbrissa D, et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46.

Title: Dukes JD, et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012;7(3):e28659.

Title: Ikonomov OC, et al. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.

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