Title: Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats.
Journal: Alcoholism, clinical and experimental research20121001
Title: Positive allosteric modulation of the GABA(B) receptor by GS39783 attenuates the locomotor stimulant actions of ethanol and potentiates the induction of locomotor sensitization.
Journal: Alcohol (Fayetteville, N.Y.)20120801
Title: Positive allosteric modulators at GABAB receptors exert intrinsic actions and enhance the influence of baclofen on light-induced phase shifts of hamster circadian activity rhythms.
Journal: Pharmacology, biochemistry, and behavior20111001
Title: Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
Journal: The Journal of pharmacology and experimental therapeutics20110901
Title: The GABA-B positive modulator GS39783 decreases psychostimulant conditioned-reinforcement and conditioned-reward.
Journal: Addiction biology20110701
Title: The GABA B receptor agonist CGP44532 and the positive modulator GS39783 reverse some behavioural changes related to positive syndromes of psychosis in mice.
Journal: British journal of pharmacology20110701
Title: Administration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference.
Journal: Behavioural brain research20110101
Title: In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE).
Journal: Neuropharmacology20110101
Title: Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression.
Journal: PloS one20110101
Title: Role of the GABA(B) receptor in alcohol-seeking and drinking behavior.
Journal: Alcohol (Fayetteville, N.Y.)20091101
Title: Changes in the properties of allosteric and orthosteric GABAB receptor ligands after a continuous, desensitizing agonist pretreatment.
Journal: European journal of pharmacology20090128
Title: Receptor activation involving positive allosteric modulation, unlike full agonism, does not result in GABAB receptor desensitization.
Journal: Neuropharmacology20081201
Title: Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen.
Journal: Alcoholism, clinical and experimental research20080901
Title: Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.
Journal: The Journal of pharmacology and experimental therapeutics20080701
Title: Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.
Journal: Bioorganic & medicinal chemistry letters20071115
Title: Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.
Journal: Current neuropharmacology20070901
Title: Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats.
Journal: Psychopharmacology20070801
Title: GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation.
Journal: The Journal of pharmacology and experimental therapeutics20070401
Title: GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20070201
Title: Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit.
Journal: Molecular pharmacology20061201
Title: The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo.
Journal: Journal of neurochemistry20060301
Title: Reducing effect of the positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats.
Journal: European journal of pharmacology20051121
Title: The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20051101
Title: Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties.
Journal: Neuropharmacology20050301
Title: GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent.
Journal: The Journal of pharmacology and experimental therapeutics20050101
Title: Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.
Journal: The Journal of pharmacology and experimental therapeutics20040901
Title: Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20040601
Title: Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats.
Journal: Psychopharmacology20040401
