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32828-81-2,MFCD00866792
Catalog No.:AA00C0HV

32828-81-2 | 4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C0HV
Chemical Name:
4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
CAS Number:
32828-81-2
Molecular Formula:
C21H20N4O3
Molecular Weight:
376.4085
MDL Number:
MFCD00866792
SMILES:
COc1ccc(cc1C(=O)NCc1cccnc1)C(=O)NCc1cccnc1
NSC Number:
304384
Properties
Computed Properties
 
Complexity:
516  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
1.3  

Downstream Synthesis Route
zinc(II)nitratehexahydrate 
  32828-81-2    586-91-4   
4C14H9N2O4(1-)*2Zn(2+)*2C21H20N4O3 

[1]Yang,LiXiao;Feng,XueFeng;Yin,WenHui;Tao,Yuan;Wu,HuiQiong;Li,JianQiang;Ma,LuFang;Luo,Feng[JournalofSolidStateChemistry,2018,vol.265,p.148-154]

[1]CurrentPatentAssignee:CHANGZHOUVOCATIONALINSTITUTEOFENGINEERING-CN112159347,2021,A

Literature

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Journal: Cardiology research and practice 20120101

Title: Aging-shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders.

Journal: Journal of aging research 20120101

Title: Antiplatelet therapy in peripheral artery disease.

Journal: Handbook of experimental pharmacology 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Antiplatelet agents for intermittent claudication.

Journal: The Cochrane database of systematic reviews 20111109

Title: NADPH oxidase 1 mediates upregulation of thromboxane A2 synthase in human vascular smooth muscle cells: inhibition with iloprost.

Journal: European journal of pharmacology 20110511

Title: Recurrent episodes of very late stent thrombosis in a patient with aspirin hypersensitivity, stent fracture and malapposition.

Journal: Acute cardiac care 20110301

Title: Diabetes mellitus and cardiovascular prevention: the role and the limitations of currently available antiplatelet drugs.

Journal: International journal of vascular medicine 20110101

Title: Optimal management of peripheral arterial disease for the non-specialist.

Journal: The Ulster medical journal 20110101

Title: 8-isoprostane F2α up-regulates the expression of type 5 phosphodiesterase in cavernosal vascular smooth muscle cells: inhibition with sildenafil, iloprost, nitric oxide and picotamide.

Journal: BJU international 20101201

Title: 2009 World Congress on the Insulin Resistance Syndrome: cardiovascular disease concepts.

Journal: Diabetes care 20100701

Title: Antiplatelet drugs--do we need new options? With a reappraisal of direct thromboxane inhibitors.

Journal: Drugs 20100507

Title: Comparison of efficacy of antiplatelet treatments for patients with claudication. A meta-analysis.

Journal: Thrombosis and haemostasis 20100401

Title: The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1.

Journal: Brain, behavior, and immunity 20100301

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

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Journal: Diabetes care 20090401

Title: Medical management and cardiovascular risk reduction in peripheral arterial disease.

Journal: Experimental and clinical cardiology 20080101

Title: Antithrombotic treatment for peripheral arterial disease.

Journal: Heart (British Cardiac Society) 20070301

Title: A review of picotamide in the reduction of cardiovascular events in diabetic patients.

Journal: Vascular health and risk management 20070201

Title: Approaches to prevention of cardiovascular complications and events in diabetes mellitus.

Journal: Drugs 20070101

Title: Medical management of peripheral arterial disease.

Journal: JAMA 20060705

Title: Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vascular preparations.

Journal: The Journal of pharmacology and experimental therapeutics 20060501

Title: Treatment of aura: solving the puzzle.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20060501

Title: Masterclass series in peripheral arterial disease. Antiplatelet therapy for peripheral arterial disease and claudication.

Journal: Vascular medicine (London, England) 20060201

Title: Migraine with aura from pathophysiology to treatment: therapeutic strategies.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20050501

Title: Picotamide reduced all-cause mortality more than aspirin in type 2 diabetes mellitus and peripheral arterial disease.

Journal: ACP journal club 20050101

Title: Picotamide versus aspirin in diabetic patients with peripheral arterial disease: has David defeated Goliath?

Journal: European heart journal 20041001

Title: Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study.

Journal: European heart journal 20041001

Title: Picotamide in migraine aura prevention: a pilot study.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001

Title: Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure.

Journal: Journal of the American College of Cardiology 20030702

Title: Evaluation of the effects of anti-thromboxane agents in platelet-vessel wall interaction.

Journal: European journal of pharmacology 20020517

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20010801

Title: NQ-Y15 inhibits the calcium mobilization by elevation of cyclic AMP in rat platelets.

Journal: Biological & pharmaceutical bulletin 20010501

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Tags:32828-81-2 Molecular Formula|32828-81-2 MDL|32828-81-2 SMILES|32828-81-2 4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide