[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2008/51440,2008,A1Locationinpatent:Page/Pagecolumn14-15
[2]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2008/51440,2008,A1Locationinpatent:Page/Pagecolumn16
[3]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2008/51440,2008,A1Locationinpatent:Page/Pagecolumn16
[4]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2008/51440,2008,A1Locationinpatent:Page/Pagecolumn15-16
[5]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2008/51440,2008,A1Locationinpatent:Page/Pagecolumn15
[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2008/112479,2008,A1Locationinpatent:Page/Pagecolumn8-9
[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2008/112479,2008,A1Locationinpatent:Page/Pagecolumn8
[1]JournalofMedicinalChemistry,2009,vol.52,p.6193-6196
[2]JournalofMedicinalChemistry,2011,vol.54,p.6028-6039
[1]JournalofMedicinalChemistry,2011,vol.54,p.6028-6039
Title: Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150501
Title: Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.
Journal: Journal of medicinal chemistry 20150108
Title: Effects of sotrastaurin, mycophenolic acid and everolimus on human B-lymphocyte function and activation.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20121001
Title: Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.
Journal: Blood 20120628
Title: Validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of Sotrastaurin and its metabolite N-desmethyl-sotrastaurin in human blood.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120515
Title: PKCθ: a new target for selective immunosuppression.
Journal: Expert review of clinical immunology 20120301
Title: Sotrastaurin, a new selective protein kinase C inhibitor, on the way.
Journal: Transplantation 20120127
Title: Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts.
Journal: Transplantation 20120127
Title: Kinase inhibitors in the treatment of immune-mediated disease.
Journal: F1000 medicine reports 20120101
Title: Immunological aspects of allogeneic and autologous mesenchymal stem cell therapies.
Journal: Human gene therapy 20111201
Title: The effects of AEB071 (sotrastaurin) with tacrolimus on rat heterotopic cardiac allograft rejection and survival.
Journal: The Journal of surgical research 20111101
Title: Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20111101
Title: Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Journal: Journal of medicinal chemistry 20110908
Title: Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110701
Title: The search for CNI-free immunosuppression: no free lunch.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110701
Title: The emerging role of Brazil in clinical trial conduct for transplantation.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110701
Title: Current landscape for T-cell targeting in autoimmunity and transplantation.
Journal: Immunotherapy 20110701
Title: Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.
Journal: Cancer research 20110401
Title: Frontiers in immunosuppression.
Journal: Transplantation proceedings 20110401
Title: Sotrastaurin single-dose pharmacokinetics in de novo liver transplant recipients.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20110301
Title: Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients.
Journal: Transplantation 20110215
Title: Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation.
Journal: Expert opinion on drug metabolism & toxicology 20110101
Title: Discovery of novel small molecule activators of β-catenin signaling.
Journal: PloS one 20110101
Title: Combination therapy: the next opportunity and challenge of medicine.
Journal: Journal of translational medicine 20110101
Title: The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus.
Journal: PloS one 20110101
Title: AEB071 (sotrastaurin) does not exhibit toxic effects on human islets in vitro, nor after transplantation into immunodeficient mice.
Journal: Islets 20110101
Title: Sotrastaurin and tacrolimus coadministration: effects on pharmacokinetics and biomarker responses.
Journal: Journal of clinical pharmacology 20101101
Title: Overview of sotrastaurin clinical pharmacokinetics.
Journal: Therapeutic drug monitoring 20101001
Title: Effects of the new immunosuppressive agent AEB071 on human immune cells.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100701
Title: Sotrastaurin and cyclosporine drug interaction study in healthy subjects.
Journal: Biopharmaceutics & drug disposition 20100701
Title: Probing the probes: fitness factors for small molecule tools.
Journal: Chemistry & biology 20100625
Title: Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20100501
Title: Novel immunosuppressive agents in kidney transplantation.
Journal: Clinical nephrology 20100501
Title: beta-Galactosidase enzyme fragment complementation for the measurement of Wnt/beta-catenin signaling.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100401
Title: AEB-071 versus tacrolimus monotherapy to prevent acute cardiac allograft rejection in the rat: a preliminary report.
Journal: Transplantation proceedings 20100401
Title: Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20100301
Title: Sotrastaurin and everolimus pharmacokinetics after single-dose coadministration.
Journal: International journal of clinical pharmacology and therapeutics 20100201
Title: AEB071--a promising immunosuppressive agent.
Journal: Clinical transplantation 20091201
Title: Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Journal: Current opinion in investigational drugs (London, England : 2000) 20091101
Title: Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Journal: Journal of medicinal chemistry 20091022
Title: The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.
Journal: The Journal of pharmacology and experimental therapeutics 20090901
Title: The effect on sotrastaurin pharmacokinetics of strong CYP3A inhibition by ketoconazole.
Journal: British journal of clinical pharmacology 20090901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080401
Title: Evenou JP, et al. The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801.
Title: Musi E, et al. The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells. Mol Cancer Ther. 2014 May;13(5):1044-53
Title: Kamo N, et al. Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11(11):2499-507.
