Home Other Building Blocks 338967-87-6
338967-87-6,MFCD00974506
Catalog No.:AA00C0UI

338967-87-6 | Mdivi-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$25.00   $18.00
- +
10mg
98%
in stock  
$36.00   $25.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C0UI
Chemical Name:
Mdivi-1
CAS Number:
338967-87-6
Molecular Formula:
C15H10Cl2N2O2S
Molecular Weight:
353.2231
MDL Number:
MFCD00974506
SMILES:
COc1cc(c(cc1Cl)Cl)n1c(S)nc2c(c1=O)cccc2
Properties
Properties
 
Form:
Solid  
MP:
281 - 283°C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
465  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
4  

Literature

Title: Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells.

Journal: Environmental toxicology and pharmacology 20160701

Title: Characterization of mitophagy in the 6-hydoxydopamine Parkinson's disease model.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20121001

Title: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

Journal: Circulation research 20120525

Title: The actions of mdivi-1, an inhibitor of mitochondrial fission, on rapidly activating delayed-rectifier K⁺ current and membrane potential in HL-1 murine atrial cardiomyocytes.

Journal: European journal of pharmacology 20120515

Title: Mitochondrial division/mitophagy inhibitor (Mdivi) ameliorates pressure overload induced heart failure.

Journal: PloS one 20120101

Title: Role of Drp1, a key mitochondrial fission protein, in neuropathic pain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803

Title: A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina.

Journal: Investigative ophthalmology & visual science 20110401

Title: Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.

Journal: Chemistry & biology 20100625

Title: Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury.

Journal: Circulation 20100511

Title: Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.

Journal: The Journal of biological chemistry 20100409

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Cassidy-Stone A, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb;14(2):193-204.

Title: Tanaka A, et al. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 2008 Feb 29;29(4):409-10.

Title: Park SW, et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr 27;52(5):2837-43.

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SDS
Tags:338967-87-6 Molecular Formula|338967-87-6 MDL|338967-87-6 SMILES|338967-87-6 Mdivi-1