25406-64-8,MFCD00210532
Catalog No.:AA00C1GC

25406-64-8 | Morroniside

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$14.00   $10.00
- +
10mg
95%
in stock  
$51.00   $36.00
- +
25mg
95%
in stock  
$86.00   $61.00
- +
50mg
95%
in stock  
$145.00   $102.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00C1GC
Chemical Name:
Morroniside
CAS Number:
25406-64-8
Molecular Formula:
C17H26O11
Molecular Weight:
406.3817
MDL Number:
MFCD00210532
SMILES:
OC[C@H]1O[C@@H](O[C@@H]2OC=C([C@@H]3[C@H]2[C@H](C)O[C@H](C3)O)C(=O)OC)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
596  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-1.8  

Downstream Synthesis Route

[1]Chemicalandpharmaceuticalbulletin,1976,vol.24,p.1393-1397

C17H25(2)HO11 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

C17H25(2)HO11 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

(1S,4aS,6R,7R,7aS)-7-Methyl-6-(toluene-4-sulfonyloxy)-1-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-1,4a,5,6,7,7a-hexahydro-cyclopentacpyran-4-carboxylicacidmethylester 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

<7-O-tosyl-7-epi-(2)H>loganintetraacetate 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

[2]Phytochemistry,1989,vol.28,p.2971-2980

Literature

Title: Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215

Title: [Studies on the chemical constituents from stems and leaves of Lonicera macranthoides].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110201

Title: Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice.

Journal: Biological & pharmaceutical bulletin 20110101

Title: [Study on the best concentration of combination of the effects of the four original constituents of liu-wei di-huang pill on the proliferation and differentiation of rat preadipocyte].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101201

Title: Neuroprotective effect of morroniside on focal cerebral ischemia in rats.

Journal: Brain research bulletin 20101030

Title: The pharmacological effects of morroniside and loganin isolated from Liuweidihuang Wan, on MC3T3-E1 cells.

Journal: Molecules (Basel, Switzerland) 20101021

Title: Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice.

Journal: The Journal of pharmacy and pharmacology 20100301

Title: The beneficial effects of morroniside on the inflammatory response and lipid metabolism in the liver of db/db mice.

Journal: Biological & pharmaceutical bulletin 20091001

Title: Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats.

Journal: Brain research bulletin 20090406

Title: Iodine-catalyzed etherification of morroniside.

Journal: Chemical & pharmaceutical bulletin 20090101

Title: Preparative purification of morroniside and loganin from Fructus corni by combination of macroporous absorption resin and HSCCC.

Journal: Journal of chromatographic science 20090101

Title: Simultaneous determination of six active components in crude and processed Fructus Corni by high performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20080910

Title: [Promoting effect of constituents in plasma after oral administration of liuwei dihuangwan on proliferation of rat osteoblast].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Title: Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats.

Journal: Biological & pharmaceutical bulletin 20080701

Title: Morroniside prevents peroxide-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells.

Journal: Cellular and molecular neurobiology 20080201

Title: Simultaneous determination of four bioactive constituents in Liuwei Dihuang Pills by micellar electrokinetic chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20070903

Title: [Studies on the chemical constituents of Adina pilulifera].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070901

Title: Morroniside and loganin extracted from Cornus officinalis have protective effects on rat mesangial cell proliferation exposed to advanced glycation end products by preventing oxidative stress.

Journal: Canadian journal of physiology and pharmacology 20061201

Title: [Function of getting rid of cores of Cornus officinalis Sieb. et Zucc. and studies on method of processing in producing area].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060101

Title: Morroniside protects cultured human umbilical vein endothelial cells from damage by high ambient glucose.

Journal: Acta pharmacologica Sinica 20040401

Title: Zeng G, et al. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16(3):2229-2234.

Title: Park CH, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34(10):1559-65.

Title: Huan Yu, et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10;266:113447.

Quotation Request
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Additional Info:
SDS
Tags:25406-64-8 Molecular Formula|25406-64-8 MDL|25406-64-8 SMILES|25406-64-8 Morroniside
Catalog No.: AA00C1GC
25406-64-8,MFCD00210532
25406-64-8 | Morroniside
Pack Size: 1mg
Purity: 95%
in stock
$14.00 $10.00
Pack Size: 10mg
Purity: 95%
in stock
$51.00 $36.00
Pack Size: 25mg
Purity: 95%
in stock
$86.00 $61.00
Pack Size: 50mg
Purity: 95%
in stock
$145.00 $102.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00C1GC
Chemical Name: Morroniside
CAS Number: 25406-64-8
Molecular Formula: C17H26O11
Molecular Weight: 406.3817
MDL Number: MFCD00210532
SMILES: OC[C@H]1O[C@@H](O[C@@H]2OC=C([C@@H]3[C@H]2[C@H](C)O[C@H](C3)O)C(=O)OC)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Complexity: 596  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 9  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: -1.8  
Downstream Synthesis Route
4993-84-4    108-24-7    25406-64-8    60706-94-7    60706-94-7 

[1]Chemicalandpharmaceuticalbulletin,1976,vol.24,p.1393-1397

C17H25(2)HO11 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

C17H25(2)HO11 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

(1S,4aS,6R,7R,7aS)-7-Methyl-6-(toluene-4-sulfonyloxy)-1-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-1,4a,5,6,7,7a-hexahydro-cyclopentacpyran-4-carboxylicacidmethylester 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

<7-O-tosyl-7-epi-(2)H>loganintetraacetate 
  25406-64-8 

[1]Phytochemistry,1989,vol.28,p.2971-2980

[2]Phytochemistry,1989,vol.28,p.2971-2980

Literature fold

Title: Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20120215

Title: [Studies on the chemical constituents from stems and leaves of Lonicera macranthoides].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20110201

Title: Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice.

Journal: Biological & pharmaceutical bulletin20110101

Title: [Study on the best concentration of combination of the effects of the four original constituents of liu-wei di-huang pill on the proliferation and differentiation of rat preadipocyte].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20101201

Title: Neuroprotective effect of morroniside on focal cerebral ischemia in rats.

Journal: Brain research bulletin20101030

Title: The pharmacological effects of morroniside and loganin isolated from Liuweidihuang Wan, on MC3T3-E1 cells.

Journal: Molecules (Basel, Switzerland)20101021

Title: Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice.

Journal: The Journal of pharmacy and pharmacology20100301

Title: The beneficial effects of morroniside on the inflammatory response and lipid metabolism in the liver of db/db mice.

Journal: Biological & pharmaceutical bulletin20091001

Title: Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats.

Journal: Brain research bulletin20090406

Title: Iodine-catalyzed etherification of morroniside.

Journal: Chemical & pharmaceutical bulletin20090101

Title: Preparative purification of morroniside and loganin from Fructus corni by combination of macroporous absorption resin and HSCCC.

Journal: Journal of chromatographic science20090101

Title: Simultaneous determination of six active components in crude and processed Fructus Corni by high performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20080910

Title: [Promoting effect of constituents in plasma after oral administration of liuwei dihuangwan on proliferation of rat osteoblast].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20080901

Title: Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats.

Journal: Biological & pharmaceutical bulletin20080701

Title: Morroniside prevents peroxide-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells.

Journal: Cellular and molecular neurobiology20080201

Title: Simultaneous determination of four bioactive constituents in Liuwei Dihuang Pills by micellar electrokinetic chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20070903

Title: [Studies on the chemical constituents of Adina pilulifera].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20070901

Title: Morroniside and loganin extracted from Cornus officinalis have protective effects on rat mesangial cell proliferation exposed to advanced glycation end products by preventing oxidative stress.

Journal: Canadian journal of physiology and pharmacology20061201

Title: [Function of getting rid of cores of Cornus officinalis Sieb. et Zucc. and studies on method of processing in producing area].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20060101

Title: Morroniside protects cultured human umbilical vein endothelial cells from damage by high ambient glucose.

Journal: Acta pharmacologica Sinica20040401

Title: Zeng G, et al. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16(3):2229-2234.

Title: Park CH, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34(10):1559-65.

Title: Huan Yu, et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10;266:113447.

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