[1]CurrentPatentAssignee:SUZHOUFUSHILAIPHARMACEUTICAL-CN105017061,2017,BLocationinpatent:Paragraph0041
[2]Linton,StevenD.;Aja,Teresa;Armstrong,RobertA.;Bai,Xu;Chen,Long-Shiuh;Chen,Ning;Ching,Brett;Contreras,Patricia;Diaz,Jose-Luis;Fisher,CraigD.;Fritz,LawrenceC.;Gladstone,Patricia;Groessl,Todd;Gu,Xin;Herrmann,Julia;Hirakawa,BradP.;Hoglen,NielC.;Jahangiri,KathyG.;Kalish,VincentJ.;Karanewsky,DonaldS.;Kodandapani,Lalitha;Krebs,Joseph;McQuiston,Jeff;Meduna,StevenP.;Nalley,Kip;Robinson,EdwardD.;Sayers,RobertO.;Sebring,Kristen;Spada,AlfredP.;Ternansky,RobertJ.;Tomaselli,KevinJ.;Ullman,BrettR.;Valentino,KarenL.;Weeks,Suzanne;Winn,David;Wu,JoeC.;Yeo,Pauline;Zhang,Cheng-Zhi[JournalofMedicinalChemistry,2005,vol.48,#22,p.6779-6782]
[3]CurrentPatentAssignee:HISTOGENINC-US2016/213736,2016,A1Locationinpatent:Paragraph0166
[4]CurrentPatentAssignee:HISTOGENINC-WO2017/117478,2017,A1Locationinpatent:Paragraph00165
[1]Linton,StevenD.;Aja,Teresa;Armstrong,RobertA.;Bai,Xu;Chen,Long-Shiuh;Chen,Ning;Ching,Brett;Contreras,Patricia;Diaz,Jose-Luis;Fisher,CraigD.;Fritz,LawrenceC.;Gladstone,Patricia;Groessl,Todd;Gu,Xin;Herrmann,Julia;Hirakawa,BradP.;Hoglen,NielC.;Jahangiri,KathyG.;Kalish,VincentJ.;Karanewsky,DonaldS.;Kodandapani,Lalitha;Krebs,Joseph;McQuiston,Jeff;Meduna,StevenP.;Nalley,Kip;Robinson,EdwardD.;Sayers,RobertO.;Sebring,Kristen;Spada,AlfredP.;Ternansky,RobertJ.;Tomaselli,KevinJ.;Ullman,BrettR.;Valentino,KarenL.;Weeks,Suzanne;Winn,David;Wu,JoeC.;Yeo,Pauline;Zhang,Cheng-Zhi[JournalofMedicinalChemistry,2005,vol.48,#22,p.6779-6782]
[1]Linton,StevenD.;Aja,Teresa;Armstrong,RobertA.;Bai,Xu;Chen,Long-Shiuh;Chen,Ning;Ching,Brett;Contreras,Patricia;Diaz,Jose-Luis;Fisher,CraigD.;Fritz,LawrenceC.;Gladstone,Patricia;Groessl,Todd;Gu,Xin;Herrmann,Julia;Hirakawa,BradP.;Hoglen,NielC.;Jahangiri,KathyG.;Kalish,VincentJ.;Karanewsky,DonaldS.;Kodandapani,Lalitha;Krebs,Joseph;McQuiston,Jeff;Meduna,StevenP.;Nalley,Kip;Robinson,EdwardD.;Sayers,RobertO.;Sebring,Kristen;Spada,AlfredP.;Ternansky,RobertJ.;Tomaselli,KevinJ.;Ullman,BrettR.;Valentino,KarenL.;Weeks,Suzanne;Winn,David;Wu,JoeC.;Yeo,Pauline;Zhang,Cheng-Zhi[JournalofMedicinalChemistry,2005,vol.48,#22,p.6779-6782]
[2]CurrentPatentAssignee:HISTOGENINC-US2016/213736,2016,A1
[3]CurrentPatentAssignee:HISTOGENINC-WO2017/117478,2017,A1
[1]Linton,StevenD.;Aja,Teresa;Armstrong,RobertA.;Bai,Xu;Chen,Long-Shiuh;Chen,Ning;Ching,Brett;Contreras,Patricia;Diaz,Jose-Luis;Fisher,CraigD.;Fritz,LawrenceC.;Gladstone,Patricia;Groessl,Todd;Gu,Xin;Herrmann,Julia;Hirakawa,BradP.;Hoglen,NielC.;Jahangiri,KathyG.;Kalish,VincentJ.;Karanewsky,DonaldS.;Kodandapani,Lalitha;Krebs,Joseph;McQuiston,Jeff;Meduna,StevenP.;Nalley,Kip;Robinson,EdwardD.;Sayers,RobertO.;Sebring,Kristen;Spada,AlfredP.;Ternansky,RobertJ.;Tomaselli,KevinJ.;Ullman,BrettR.;Valentino,KarenL.;Weeks,Suzanne;Winn,David;Wu,JoeC.;Yeo,Pauline;Zhang,Cheng-Zhi[JournalofMedicinalChemistry,2005,vol.48,#22,p.6779-6782]
[2]CurrentPatentAssignee:HISTOGENINC-US2016/213736,2016,A1
[3]CurrentPatentAssignee:HISTOGENINC-WO2017/117478,2017,A1
[1]Linton,StevenD.;Aja,Teresa;Armstrong,RobertA.;Bai,Xu;Chen,Long-Shiuh;Chen,Ning;Ching,Brett;Contreras,Patricia;Diaz,Jose-Luis;Fisher,CraigD.;Fritz,LawrenceC.;Gladstone,Patricia;Groessl,Todd;Gu,Xin;Herrmann,Julia;Hirakawa,BradP.;Hoglen,NielC.;Jahangiri,KathyG.;Kalish,VincentJ.;Karanewsky,DonaldS.;Kodandapani,Lalitha;Krebs,Joseph;McQuiston,Jeff;Meduna,StevenP.;Nalley,Kip;Robinson,EdwardD.;Sayers,RobertO.;Sebring,Kristen;Spada,AlfredP.;Ternansky,RobertJ.;Tomaselli,KevinJ.;Ullman,BrettR.;Valentino,KarenL.;Weeks,Suzanne;Winn,David;Wu,JoeC.;Yeo,Pauline;Zhang,Cheng-Zhi[JournalofMedicinalChemistry,2005,vol.48,#22,p.6779-6782]
[2]CurrentPatentAssignee:HISTOGENINC-US2016/213736,2016,A1
[3]CurrentPatentAssignee:HISTOGENINC-WO2017/117478,2017,A1
Title: Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.
Journal: Nature medicine 20161001
Title: Caspase inhibitor IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model.
Journal: Transplantation 20120715
Title: Synthesis and evaluation of novel prodrugs of caspase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice.
Journal: Surgery 20110701
Title: Clinical trial: the efficacy and safety of oral PF-03491390, a pancaspase inhibitor - a randomized placebo-controlled study in patients with chronic hepatitis C.
Journal: Alimentary pharmacology & therapeutics 20100501
Title: Orally-administered caspase inhibitor PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.
Journal: Journal of pharmacological sciences 20071001
Title: Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C.
Journal: Hepatology (Baltimore, Md.) 20070801
Title: A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia.
Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301
Title: New therapies: oral inhibitors and immune modulators.
Journal: Clinics in liver disease 20061101
Title: Thiol proteases: inhibitors and potential therapeutic targets.
Journal: Current medicinal chemistry 20060101
Title: First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Journal: Journal of medicinal chemistry 20051103
Title: Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor.
Journal: The Journal of pharmacology and experimental therapeutics 20040501
Title: Gracia-Sancho J, et al. Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism. Hepatol Commun. 2019 Apr 22;3(7):987-1000.
Title: Barreyro FJ, et al. The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. Liver Int. 2015 Mar;35(3):953-66.
Title: Hoglen NC, et al. Characterization of IDN-6556 (3--(2-tert-butyl-phenylaminooxalyl)-amino-propionylamino-4-oxo-5-(2,3,5,6-te trafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor. J Pharmacol Exp Ther. 2004 May;309(2):634-40.
Title: McCall M, et al. The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice. Surgery. 2011 Jul;150(1):48-55.
Title: Tian J, et al. Combination of Emricasan with AP24534 Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis. Transl Stroke Res. 2017 Nov 4.
Title: Xu M, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016 Oct;22(10):1101-1107.
