[1]Prashad;Prasad;Repic[NucleosidesandNucleotides,1994,vol.13,#4,p.945-952]
[1]Prashad;Prasad;Repic[NucleosidesandNucleotides,1994,vol.13,#4,p.945-952]
[1]Prashad;Prasad;Repic[NucleosidesandNucleotides,1994,vol.13,#4,p.945-952]
[1]Prashad;Prasad;Repic[NucleosidesandNucleotides,1994,vol.13,#4,p.945-952]
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[3]Bressi;Choe;HoughHough;Buckner;VanVoorhis;Verlinde;Hol;Gelb[JournalofMedicinalChemistry,2000,vol.43,#22,p.4135-4150]
[4]Lin;Jiang;Schultz;Gray[JournaloftheAmericanChemicalSociety,2001,vol.123,#47,p.11608-11613]
[5]CurrentPatentAssignee:ROCKETPHARMACEUTICALSINC-WO2010/127210,2010,A1Locationinpatent:Page/Pagecolumn31
[6]CurrentPatentAssignee:ROCKETPHARMACEUTICALSINC-US2014/275128,2014,A1Locationinpatent:Paragraph0166
Title: Activation of adenosine₁ receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats.
Journal: The Journal of pharmacology and experimental therapeutics 20120501
Title: Involvement of NMDA receptors in the antidepressant-like action of adenosine.
Journal: Pharmacological reports : PR 20120101
Title: Adenosine A₂A and A₂B receptors are both required for adenosine A₁ receptor-mediated cardioprotection.
Journal: American journal of physiology. Heart and circulatory physiology 20110901
Title: Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A(1) receptors.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727
Title: Endogenous adenosine A1 receptor activation underlies the transient post-ischemic rhythmic delta EEG activity.
Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20110601
Title: Adenosine reduces GABAergic IPSC frequency via presynaptic A₁ receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla.
Journal: Neuroscience letters 20110218
Title: Adenosine regulates Sertoli cell function by activating AMPK.
Journal: Molecular and cellular endocrinology 20101215
Title: Analysis of adenosine A₂a receptor stability: effects of ligands and disulfide bonds.
Journal: Biochemistry 20101102
Title: Adenosine A(1) receptor agonist N(6)-cyclohexyl-adenosine induced phosphorylation of delta opioid receptor and desensitization of its signaling.
Journal: Acta pharmacologica Sinica 20100701
Title: The interaction of intrathecal neostigmine and N-cyclohexyladenosine on anti-allodynic effects in rats with a nerve ligation injury.
Journal: Korean journal of anesthesiology 20100701
Title: Adenosine receptor agonists affect taurine release from mouse brain stem slices in ischemia.
Journal: Amino acids 20100501
Title: Altered thermoregulation via sensitization of A1 adenosine receptors in dietary-restricted rats.
Journal: Psychopharmacology 20100401
Title: Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201
Title: Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
Journal: Journal of medicinal chemistry 20091008
Title: Reduced expression and desensitization of adenosine A1 receptor/adenylyl cyclase pathway after chronic (-)N6-phenylisopropyladenosine intake during pregnancy.
Journal: Neuroscience 20091006
Title: Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.
Journal: Neuropharmacology 20090601
Title: Contribution of NO, ATP-sensitive K+ channels and prostaglandins to adenosine receptor agonists-induced relaxation of the rat tail artery.
Journal: Pharmacological reports : PR 20090101
Title: Modulation of insulin release by adenosine A1 receptor agonists and antagonists in INS-1 cells: the possible contribution of 86Rb+ efflux and 45Ca2+ uptake.
Journal: Cell biochemistry and function 20081201
Title: Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080901
Title: Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.
Journal: Journal of medicinal chemistry 20080724
Title: Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons.
Journal: Brain research 20080605
Title: Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.
Journal: American journal of physiology. Heart and circulatory physiology 20080601
Title: Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test.
Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080515
Title: The role of piriform cortex adenosine A1 receptors on hippocampal kindling.
Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20080501
Title: Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.
Journal: Journal of medicinal chemistry 20080410
Title: Adenosine receptor ligands protect against a combination of apoptotic and necrotic cell death in cerebellar granule neurons.
Journal: Experimental brain research 20080301
Title: Alcohol related changes in regulation of NMDA receptor functions.
Journal: Current neuropharmacology 20080301
Title: C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus.
Journal: Neuropharmacology 20071201
Title: Up-regulation of adenosine A1 receptors in frontal cortex from Pick's disease cases.
Journal: The European journal of neuroscience 20071201
Title: Intracellular signalling pathways in the vasoconstrictor response of mouse afferent arterioles to adenosine.
Journal: Acta physiologica (Oxford, England) 20071001
Title: The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Journal: Pharmacological research 20070801
Title: Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney.
Journal: American journal of physiology. Renal physiology 20070701
Title: Changes in neuromodulatory effect of adenosine A1 receptors on piriform cortex field potentials in amygdala kindled rats.
Journal: European journal of pharmacology 20070622
Title: Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled rats.
Journal: Canadian journal of physiology and pharmacology 20070601
Title: Adenosine and sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain.
Journal: Journal of neurochemistry 20070301
Title: Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus.
Journal: Neuropharmacology 20070201
Title: Mechanisms linking adenosine A1 receptors and extracellular signal-regulated kinase 1/2 activation in human trabecular meshwork cells.
Journal: The Journal of pharmacology and experimental therapeutics 20070101
Title: Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium.
Journal: Pflugers Archiv : European journal of physiology 20070101
Title: Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine.
Journal: Experimental physiology 20070101
Title: Adenosine arrests apoptosis in lymphocytes but not in phagocytes from primary leucocyte cultures of the teleost fish, Sparus aurata L.
Journal: Developmental and comparative immunology 20070101
Title: Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systems.
Journal: Brain research bulletin 20061211
Title: Transcriptional activation of c-Fos by constitutively active Galpha(16)QL through a STAT1-dependent pathway.
Journal: Cellular signalling 20061201
Title: Anticonvulsant effects of N6-cyclohexyladenosine microinjected into the CA1 region of the hippocampus on entorhinal cortex-kindled seizures in rats.
Journal: Epileptic disorders : international epilepsy journal with videotape 20061201
Title: The impact of adenosine and A(2B) receptors on glucose homoeostasis.
Journal: The Journal of pharmacy and pharmacology 20061201
Title: Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPase.
Journal: Journal of the American Society of Nephrology : JASN 20060901
Title: A(1) adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death.
Journal: Neurotoxicology 20060701
Title: N6-Cyclohexyl-adenosine but not adenosine is a modulator of teleost fish innate immune activities.
Journal: Developmental and comparative immunology 20060101
Title: Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats.
Journal: Seizure 20060101
Title: Amygdala adenosine A1 receptors have no anticonvulsant effect on piriform cortex-kindled seizures in rat.
Journal: Canadian journal of physiology and pharmacology 20060101
Title: Effects of urea pretreatment on the binding properties of adenosine A1 receptors.
Journal: British journal of pharmacology 20051201
Title: Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone.
Journal: Brain research 20051109
Title: Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine.
Journal: Investigative ophthalmology & visual science 20051001
Title: The role of adenosine A(1) receptors in the interaction between amygdala and entorhinal cortex of kindled rats.
Journal: Epilepsy research 20050601
Title: Characterization of N(6)-cyclohexyladenosine-induced hypothermia in Syrian hamsters.
Journal: Journal of pharmacological sciences 20050301
Title: A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050115
Title: Adenosine postsynaptically modulates supraoptic neuronal excitability.
Journal: Journal of neurophysiology 20050101
Title: Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain.
Journal: Neuroscience 20050101
Title: G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling.
Journal: The Journal of biological chemistry 20041217
Title: Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb.
Journal: American journal of physiology. Renal physiology 20041101
Title: Multiple actions of extracellular ATP and adenosine on calcium currents mediated by various purinoceptors in neurons of nucleus tractus solitarius.
Journal: Neuroscience research 20041101
Title: Clearance of cyclopentyladenosine and cyclohexyladenosine in rats following a single subcutaneous dose.
Journal: Pharmacological research 20040901
Title: Role of adenosine A2A receptor in the regulation of gastric somatostatin release.
Journal: The Journal of pharmacology and experimental therapeutics 20040501
Title: 1,2,4-Triazolo[1,5-a]quinoxaline derivatives: synthesis and biological evaluation as adenosine receptor antagonists.
Journal: Farmaco (Societa chimica italiana : 1989) 20040201
Title: Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists.
Journal: Archiv der Pharmazie 20040101
Title: A(2A) adenosine receptor ligands and proinflammatory cytokines induce PC 12 cell death through apoptosis.
Journal: Biochemical pharmacology 20031115
Title: Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031101
Title: Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers.
Journal: Experimental neurology 20031101
Title: Adenosine induces vasoconstriction through Gi-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice.
Journal: Journal of the American Society of Nephrology : JASN 20031001
Title: Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030801
Title: Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation.
Journal: British journal of pharmacology 20030501
Title: Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis.
Journal: Neuroscience letters 20030410
Title: Opposing facilitatory and inhibitory modulation of glutamate release elicited by cAMP production in cerebrocortical nerve terminals (synaptosomes).
Journal: Neuropharmacology 20030401
Title: Adenosine A1 receptors regulate the response of the mouse circadian clock to light.
Journal: Brain research 20030117
Title: Characterization of N-methyl-D-aspartate-evoked taurine release in the developing and adult mouse hippocampus.
Journal: Amino acids 20030101
Title: [Protective effect of A-agonists in a minimum invasive model of spinal cord ischemia in rats].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101
Title: Adenosine suppresses the response of neurons to gaba in the superficial laminae of the rat spinal dorsal horn.
Journal: Neuroscience 20030101
Title: Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats.
Journal: Neuroscience 20030101
Title: Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells.
Journal: American journal of physiology. Renal physiology 20021201
Title: Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis.
Journal: Arthritis and rheumatism 20021101
Title: Lack of central effects of peripherally administered adenosine A(1) agonists on synaptic transmission in the rat hippocampus.
Journal: Brain research 20020927
Title: Presynaptic adenosine A1 receptors regulate retinohypothalamic neurotransmission in the hamster suprachiasmatic nucleus.
Journal: Journal of neurobiology 20020905
Title: Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020901
Title: Adenosine A1 receptor modulation of MMP-2 secretion by trabecular meshwork cells.
Journal: Investigative ophthalmology & visual science 20020901
Title: The effects of adenosine receptor agonists and antagonists on morphine state-dependent memory of passive avoidance.
Journal: Neurobiology of learning and memory 20020901
Title: Adenosine-mediated activation of Akt/protein kinase B in the rat hippocampus in vitro and in vivo.
Journal: Neuroscience letters 20020809
Title: Temperature dependence of the affinity enhancement of selective adenosine A1 receptor agonism: a thermodynamic analysis.
Journal: European journal of pharmacology 20020719
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts.
Journal: American journal of physiology. Heart and circulatory physiology 20020401
Title: Effects of temperature on adenosine A1 receptor activation in guinea pig hippocampus in vitro.
Journal: Pflugers Archiv : European journal of physiology 20020301
Title: Interaction of angiotensin II and III with adenosine A(1) receptor-related drugs in passive avoidance conditioning in rats.
Journal: Behavioural brain research 20020201
Title: Functional characterization of an endogenous Xenopus oocyte adenosine receptor.
Journal: British journal of pharmacology 20020101
Title: Effects of adenosine receptor agonists and antagonists on pentylenetetrazole-induced amnesia.
Journal: European journal of pharmacology 20011102
Title: Anticonvulsant effect of bilateral injection of N6-cyclohexyladenosine into the CA1 region of the hippocampus in amygdala-kindled rats.
Journal: Epilepsy research 20011101
Title: Adenosine and caffeine modulate circadian rhythms in the Syrian hamster.
Journal: Neuroreport 20010917
Title: Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
Journal: Brain research bulletin 20010915
Title: Intraocular pressure responses to the adenosine agonist cyclohexyladenosine: evidence for a dual mechanism of action.
Journal: Investigative ophthalmology & visual science 20010701
Title: Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor.
Journal: Brain research bulletin 20010701
Title: Involvement of the cerebellar adenosine A(1) receptor in cannabinoid-induced motor incoordination in the acute and tolerant state in mice.
Journal: Brain research 20010629
Title: Adenosine A1 receptors regulate the response of the hamster circadian clock to light.
Journal: European journal of pharmacology 20010223
Title: Adenosine enhances glial glutamate efflux via A2a adenosine receptors.
Journal: Life sciences 20010209
Title: K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus.
Journal: Brain research 20010119
Title: Adenosine activates aromatic L-amino acid decarboxylase activity in the kidney and increases dopamine.
Journal: Journal of the American Society of Nephrology : JASN 20010101
Title: N6-cyclohexyladenosine and 3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid enhance the effect of antiepileptic drugs against induced seizures in mice.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20010101
Title: [Comparative characteristics of A1-receptor agonists as neuroprotective agents].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101
Title: Modification of cardiovascular responses to adenosine A1 receptor stimulation in the posterior hypothalamus of anaesthetized rats by cAMP and by GABA(B) receptor blockade.
Journal: Journal of autonomic pharmacology 20010101
Title: Repeated adenosine pre-treatment potentiates the acute effect of methamphetamine in rats.
Journal: Japanese journal of pharmacology 20000901
Title: Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse.
Journal: Brain research 20000512
Title: N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.
Journal: Journal of medicinal chemistry 20000127
Title: Mechanisms of inhibitory effects of zinc and cadmium ions on agonist binding to adenosine A1 receptors in rat brain.
Journal: Biochemical pharmacology 19990815
Title: Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors.
Journal: Biochemical pharmacology 19990101
Title: K(ATP)-channel activation: effects on myocardial recovery from ischaemia and role in the cardioprotective response to adenosine A1-receptor stimulation.
Journal: British journal of pharmacology 19980601
Title: 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
Journal: Journal of medicinal chemistry 19980507
Title: Effect of adenosine receptor agonists and antagonists on morphine-induced catalepsy in mice.
Journal: European journal of pharmacology 19971029
Title: Therapeutic doses of theophylline exert proconvulsant effects in developing mice.
Journal: Brain & development 19970901
Title: Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261.
Journal: British journal of pharmacology 19970501
Title: Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.
Journal: Journal of immunology (Baltimore, Md. : 1950) 19960501
Title: Selective adenosine A2A receptor/dopamine D2 receptor interactions in animal models of schizophrenia.
Journal: European journal of pharmacology 19960111
Title: Effects of adenosine analogues on apomorphine-induced penile erection in rats.
Journal: General pharmacology 19951201
Title: Intrastriatal Ro15-4513 functionally antagonizes ethanol-induced motor incoordination and striatal adenosinergic modulation of ethanol-induced motor incoordination in rats.
Journal: The Journal of pharmacology and experimental therapeutics 19941001
Title: A binding site model and structure-activity relationships for the rat A3 adenosine receptor.
Journal: Molecular pharmacology 19940601
Title: Adenosine receptors are not involved in theophylline-induced seizures.
Journal: Journal of toxicology. Clinical toxicology 19940101
Title: Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors.
Journal: Pharmacology 19930101
Title: Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes.
Journal: Molecular pharmacology 19901201
Title: Binding of the adenosine A2 receptor ligand [3H]CGS 21680 to human and rat brain: evidence for multiple affinity sites.
Journal: Journal of neurochemistry 19901101
Title: Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Journal: Pharmacology, biochemistry, and behavior 19900801
Title: Caffeine-induced seizures: apparent proconvulsant action of N-ethyl carboxamidoadenosine (NECA).
Journal: Life sciences 19900101
Title: Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Journal: Life sciences 19890101
Title: Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors.
Journal: Archives internationales de pharmacodynamie et de therapie 19880101
Title: Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice.
Journal: Psychopharmacology 19840101
Title: Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists.
Journal: Canadian journal of physiology and pharmacology 19800601
Title: Asghari AA, et al. Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J Neurol Sci. 2013 Feb 15;3
