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Home Other Building Blocks 41451-75-6
41451-75-6,MFCD00866510
Catalog No.:AA00C6CA

41451-75-6 | Bruceantin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$203.00   $142.00
- +
5mg
≥95%
in stock  
$635.00   $444.00
- +
10mg
≥95%
in stock  
$1,142.00   $799.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6CA
Chemical Name:
Bruceantin
CAS Number:
41451-75-6
Molecular Formula:
C28H36O11
Molecular Weight:
548.5788
MDL Number:
MFCD00866510
SMILES:
COC(=O)[C@@]12OC[C@]34[C@H]2[C@@H](OC(=O)/C=C(/C(C)C)\C)C(=O)O[C@@H]4C[C@@H]2[C@]([C@H]3[C@H]([C@@H]1O)O)(C)CC(=O)C(=C2C)O
NSC Number:
165563
Properties
Computed Properties
 
Complexity:
1200  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
1.7  

Literature

Title: Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.

Journal: Journal of natural products 20100924

Title: NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species.

Journal: Anticancer research 20100901

Title: U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.

Journal: Journal of molecular biology 20090529

Title: Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.

Journal: Journal of natural products 20090327

Title: Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam.

Journal: Bioorganic & medicinal chemistry 20090315

Title: Altering chemosensitivity by modulating translation elongation.

Journal: PloS one 20090101

Title: Synthesis of A/B-ring partial analogs of bruceantin as potential antimalarial agents.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20050101

Title: Multiple myeloma regression mediated by bruceantin.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201

Title: Antitumor activity of bruceantin: an old drug with new promise.

Journal: Journal of natural products 20040201

Title: Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.

Journal: Journal of natural products 20011201

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Cuendet M, et al. Multiple myeloma regression mediated by bruceantin. Clin Cancer Res. 2004 Feb 1;10(3):1170-9.

Title: Cuendet M, et al. Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod. 2004 Feb;67(2):269-72.

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SDS
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