Home Other Building Blocks 345627-80-7
345627-80-7,MFCD09833875
Catalog No.:AA00C6EX

345627-80-7 | Sns-032

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$16.00   $11.00
- +
5mg
99%
in stock  
$53.00   $37.00
- +
10mg
99%
in stock  
$78.00   $55.00
- +
50mg
≥98%
in stock  
$349.00   $244.00
- +
100mg
99%
in stock  
$353.00   $247.00
- +
250mg
99%
in stock  
$540.00   $378.00
- +
1g
99%
in stock  
$1,358.00   $951.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6EX
Chemical Name:
Sns-032
CAS Number:
345627-80-7
Molecular Formula:
C17H24N4O2S2
Molecular Weight:
380.5281
MDL Number:
MFCD09833875
SMILES:
O=C(C1CCNCC1)Nc1ncc(s1)SCc1ncc(o1)C(C)(C)C
Properties
Computed Properties
 
Complexity:
454  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
3  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.

Journal: Journal of medicinal chemistry 20130214

Title: Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120401

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

Journal: European journal of medicinal chemistry 20110601

Title: The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.

Journal: Leukemia 20110301

Title: Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.

Journal: Blood 20110106

Title: Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

Journal: Leukemia 20110101

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.

Journal: Cancer research 20100815

Title: Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100620

Title: The small-molecule CDK inhibitor, SNS-032, enhances cellular radiosensitivity in quiescent and hypoxic non-small cell lung cancer cells.

Journal: Lung cancer (Amsterdam, Netherlands) 20091001

Title: SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.

Journal: Cancer chemotherapy and pharmacology 20090901

Title: Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032.

Journal: Cancer prevention research (Philadelphia, Pa.) 20090901

Title: Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.

Journal: Blood 20090507

Title: SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression.

Journal: International journal of oncology 20090401

Title: Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked.

Journal: Cell cycle (Georgetown, Tex.) 20081215

Title: Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.

Journal: Bioorganic & medicinal chemistry letters 20081201

Title: A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.

Journal: Bioorganic & medicinal chemistry letters 20081101

Title: A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors.

Journal: Investigational new drugs 20080201

Title: A quantitative analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20080101

Title: Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity.

Journal: Oncogene 20070524

Title: SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor.

Journal: Neoplasia (New York, N.Y.) 20070501

Title: The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells.

Journal: Cancer research 20060201

Title: Drugging cell cycle kinases in cancer therapy.

Journal: Current drug targets 20050501

Title: P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.

Journal: Cancer chemotherapy and pharmacology 20050201

Title: E2F4 deficiency promotes drug-induced apoptosis.

Journal: Cancer biology & therapy 20041201

Title: N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Journal: Journal of medicinal chemistry 20040325

Title: Chen R, et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45.

Title: Ali MA, et al. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia. 2007 May;9(5):370-81.

Title: Conroy A, et al. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32.

Title: Wu Y, et al. Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.Clin Cancer Res. 2012 Apr 1;18(7):1966-78. Epub 2012 Mar 23.

Title: Walsby E, et al. The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells. Leukemia. 2011 Mar;25(3):411-9. Epub 2011 Jan 7.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 345627-80-7
Tags:345627-80-7 Molecular Formula|345627-80-7 MDL|345627-80-7 SMILES|345627-80-7 Sns-032