Title: Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120501
Title: Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.
Journal: Molecular pharmacology 20080301
Title: Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652.
Journal: Antimicrobial agents and chemotherapy 20070201
Title: Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity.
Journal: Journal of medicinal chemistry 20060504
Title: Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist.
Journal: Antimicrobial agents and chemotherapy 20050801
Title: Takashima K, et al. Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist. Antimicrob Agents Chemother. 2005 Aug;49(8):3474-82.
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