Home Other Building Blocks 36075-44-2
36075-44-2,MFCD01219546
Catalog No.:AA00C851

36075-44-2 | 4-Hydrazinoquinazoline

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C851
Chemical Name:
4-Hydrazinoquinazoline
CAS Number:
36075-44-2
Molecular Formula:
C8H8N4
Molecular Weight:
160.1759
MDL Number:
MFCD01219546
SMILES:
NNc1ncnc2c1cccc2
Properties
Computed Properties
 
Complexity:
150  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1.7  

Downstream Synthesis Route

[1]Locationinpatent:experimentalpartHe,Junbo;Wang,Xiaoguo;Zhao,Xiaoqin;Liang,Yongju;He,Hongwu;Fu,Liwu[EuropeanJournalofMedicinalChemistry,2012,vol.54,p.925-930]

[2]Liu,Lingfeng;Qiao,Chunhua;Shen,Bei;Xu,Yiwen[TetrahedronLetters,2020]

[3]Dewar[JournaloftheChemicalSociety,1944,p.619,622]Claesen;Vanderhaeghe[BulletindesSocietesChimiquesBelges,1959,vol.68,p.220,222]Kumadaetal.[YakugakuKenkyu,1958,vol.30,p.635,640][Chem.Abstr.,1959,p.20554]

[1]AnalyticalChemistry,1984,vol.56,p.2860-2862

36075-44-2    21599-37-1   
7,7-Dimethyl-5-(quinazolin-4-yl-hydrazono)-5,6,7,8-tetrahydro-quinazolin-2-ylamine 

[1]Strakov;Krasnova;Petrova[ChemistryofHeterocyclicCompounds,1996,vol.32,#1,p.72-74]

[1]JournalofMedicinalChemistry,2005,vol.48,p.6409-6422

[1]Locationinpatent:experimentalpartKarpenko,AlexanderV.;Kovalenko,SergeyI.;Shishkin,OlegV.[Tetrahedron,2009,vol.65,#31,p.5964-5972]

Literature

Title: Reactivity of 2-ethoxyquinazolin- 4-yl hydrazine and its use in synthesis of novel quinazoline derivatives of antimicrobial activity.

Journal: Global journal of health science 20120101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

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