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376638-65-2,MFCD25976913
Catalog No.:AA00CJG4

376638-65-2 | 2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-n,n-diethylacetamide

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Purity
Availability
Price(USD)
Quantity
  
5mg
98% by HPLC
in stock  
$179.00   $125.00
- +
25mg
95%
in stock  
$198.00   $139.00
- +
100mg
95%
in stock  
$516.00   $361.00
- +
250mg
95%
in stock  
$998.00   $699.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CJG4
Chemical Name:
2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-n,n-diethylacetamide
CAS Number:
376638-65-2
Molecular Formula:
C16H20ClN3O3S2
Molecular Weight:
401.9313
MDL Number:
MFCD25976913
SMILES:
CCN(C(=O)Cc1csc(n1)NS(=O)(=O)c1cccc(c1C)Cl)CC
Properties
Computed Properties
 
Complexity:
551  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
3  

Literature

Title: Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100301

Title: Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes.

Journal: Journal of medicinal chemistry 20080828

Title: Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

Journal: Journal of medicinal chemistry 20020829

Title: Barf T, et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2002 Aug 29;45(18):3813-5.

Title: Vicker N, et al. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9.

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SDS
Tags:376638-65-2 Molecular Formula|376638-65-2 MDL|376638-65-2 SMILES|376638-65-2 2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-n,n-diethylacetamide