Name: Name:2-[[(2,3-Difluorophenyl)methyl]thio]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1(4H)-quinolineacetamide
Brand: AABLOCKS
SKU: AA00CL7R
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00CL7R

Chemical Name: 2-[[(2,3-Difluorophenyl)methyl]thio]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1(4H)-quinolineacetamide

CAS Number: 412950-08-4

Molecular Formula: C40H38F5N3O3S

Molecular Weight: 735.8050

MDL Number: MFCD13195581

SMILES: COCCN1CCC(CC1)N(C(=O)Cn1c(SCc2cccc(c2F)F)cc(=O)c2c1cccc2)Cc1ccc(cc1)c1ccc(cc1)C(F)(F)F

Properties

Storage: -20 ℃;

Complexity: 1200

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 52

Hydrogen Bond Acceptor Count: 11

Rotatable Bond Count: 12

XLogP3: 8.1

Literature fold

Title: Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study.

Journal: Ophthalmology20150501

Title: Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study.

Journal: Atherosclerosis20140801

Title: Plasma lipoprotein-associated phospholipase A2 activity in Alzheimer's disease, amnestic mild cognitive impairment, and cognitively healthy elderly subjects: a cross-sectional study.

Journal: Alzheimer's research & therapy20120101

Title: Lipoprotein-associated phospholipase A(2) and atherosclerosis.

Journal: Current opinion in lipidology20091001

Title: Anti-inflammatory properties of a platelet-activating factor acetylhydrolase.

Journal: Nature19950406

Title: Shaddinger BC, et al. Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials. PLoS One. 2014 Jan 27;9(1):e83094.

Title: Athanasios Papakyriakou, et al. Computational Investigation of Darapladib and Rilapladib Binding to Platelet Activating Factor Receptor. A Possible Mechanism of Their Involvement in Atherosclerosis. International Journal of Chemistry; Vol. 6, No. 1; 2014.

412950-08-4 | 2-[[(2,3-Difluorophenyl)methyl]thio]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1(4H)-quinolineacetamide