Title: 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.
Journal: Journal of medicinal chemistry20121011
Title: N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region.
Journal: Bioorganic & medicinal chemistry20120101
Title: The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation.
Journal: The Journal of biological chemistry20111111
Title: TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells.
Journal: Investigative ophthalmology & visual science20110101
Title: Silicon switch approach in TRPV1 antagonist MK-056 and its analogues.
Journal: Bioorganic & medicinal chemistry20100101
Title: Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder.
Journal: The Journal of urology20090801
Title: Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats.
Journal: Neuroscience20090630
Title: Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists.
Journal: Bioorganic & medicinal chemistry20090515
Title: The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis.
Journal: Neuroscience20070921
Title: Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists.
Journal: Bioorganic & medicinal chemistry20070915
Title: The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20070328
Title: Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.
Journal: Bioorganic & medicinal chemistry letters20050915
Title: Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.
Journal: Bioorganic & medicinal chemistry letters20050915
Title: Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents.
Journal: Journal of medicinal chemistry20050908
Title: Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat.
Journal: European journal of pharmacology20050704
Title: Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse?
Journal: Journal of medicinal chemistry20040520
Title: N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Journal: Bioorganic & medicinal chemistry letters20040405
Title: Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
Journal: Bioorganic & medicinal chemistry letters20031215
Title: High affinity antagonists of the vanilloid receptor.
Journal: Molecular pharmacology20021001
Title: Jakab B, et al. Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. Eur J Pharmacol. 2005 Jul 4;517(1-2):35-44.
