Home Amines 40312-34-3
40312-34-3,MFCD00451472
Catalog No.:AA00D6CT

40312-34-3 | (2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone

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5mg
95%
in stock  
$581.00   $407.00
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25mg
95%
in stock  
$1,915.00   $1,340.00
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50mg
95%
in stock  
$2,415.00   $1,690.00
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100mg
95%
in stock  
$3,040.00   $2,128.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00D6CT
Chemical Name:
(2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone
CAS Number:
40312-34-3
Molecular Formula:
C15H14ClNOS
Molecular Weight:
291.7958
MDL Number:
MFCD00451472
SMILES:
Clc1ccc(cc1)C(=O)c1c(N)sc2c1CCCC2
Properties
Computed Properties
 
Complexity:
343  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
5  

Literature

Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury.

Journal: Anesthesiology 20040501

Title: Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.

Journal: Anesthesiology 20040401

Title: Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: 2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors.

Journal: Journal of medicinal chemistry 20020117

Title: Obata H, et al. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004 May;100(5):1258-62.

Title: Li X, et al. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun;305(3):950-5.

Title: Soudijn W, et al. Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov Today. 2004 Sep 1;9(17):752-8.

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Tags:40312-34-3 Molecular Formula|40312-34-3 MDL|40312-34-3 SMILES|40312-34-3 (2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone