Name: Name:Bi-d1870
Brand: AABLOCKS
SKU: AA00D7XI
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00D7XI

Chemical Name: Bi-d1870

CAS Number: 501437-28-1

Molecular Formula: C19H23F2N5O2

Molecular Weight: 391.4150

MDL Number: MFCD11223662

SMILES: CC(CCN1C(C)C(=O)N(c2c1nc(nc2)Nc1cc(F)c(c(c1)F)O)C)C

NSC Number: 747342

Properties

Complexity: 542

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 28

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 5

Undefined Atom Stereocenter Count: 1

Undefined Bond Stereocenter Count: 0

XLogP3: 3.6

Literature fold

Title: Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

Journal: Neoplasia (New York, N.Y.)20140901

Title: PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium.

Journal: Archives of toxicology20140201

Title: Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

Journal: European journal of medicinal chemistry20121001

Title: Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.

Journal: The Journal of biological chemistry20110805

Title: SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.

Journal: Journal of medicinal chemistry20110526

Title: SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.

Journal: Genes to cells : devoted to molecular & cellular mechanisms20110501

Title: Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes.

Journal: Cellular signalling20091201

Title: The selectivity of protein kinase inhibitors: a further update.

Journal: The Biochemical journal20071215

Title: BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

Journal: The Biochemical journal20070101

Title: Sapkota GP, et al. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38.

Title: Ciceri P, et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014 Mar 2.

Title: Takada I, et al. The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice. Immunobiology. 2016 Feb;221(2):188-92.

Title: Roffe M, et al. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015 Aug;27(8):1630-42.

Title: Chiu CF, et al. Antitumor effects of BI-D1870 on human oral squamous cell carcinoma. Cancer Chemother Pharmacol. 2014 Feb;73(2):237-47.

501437-28-1 | Bi-d1870