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50908-62-8,MFCD00055130
Catalog No.:AA00D9WK

50908-62-8 | 5'-(N-CYCLOPROPYL)CARBOXAMIDOADENOSINE

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5mg
≥95%
in stock  
$72.00   $50.00
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10mg
≥95%
in stock  
$135.00   $94.00
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25mg
≥95%
in stock  
$246.00   $172.00
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50mg
≥95%
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$453.00   $317.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00D9WK
Chemical Name:
5'-(N-CYCLOPROPYL)CARBOXAMIDOADENOSINE
CAS Number:
50908-62-8
Molecular Formula:
C13H16N6O4
Molecular Weight:
320.3039
MDL Number:
MFCD00055130
SMILES:
O=C([C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N)NC1CC1
Properties
Computed Properties
 
Complexity:
477  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
-0.5  

Literature

Title: The effects of A1 and A2A adenosine receptor agonists on kainic acid excitotoxicity in the guinea pig cochlea.

Journal: Neuroscience letters 20120614

Title: Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.

Journal: Journal of medicinal chemistry 20120510

Title: Combined contribution of endothelial relaxing autacoides in the rat femoral artery response to CPCA: an adenosine A2 receptor agonist.

Journal: TheScientificWorldJournal 20120101

Title: Effects of adenosine A(2A) and A(2B) receptor activation on signaling pathways and cytokine production in human uroepithelial cells.

Journal: Pharmacology 20100101

Title: NK cell-mediated cytotoxicity modulation by A(2) adenosine receptor agonist in different mammalian species.

Journal: Folia microbiologica 20090101

Title: Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.

Journal: Journal of medicinal chemistry 20080410

Title: Involvement of guanylate cyclase in the cardiovascular response induced by adenosine A2B receptor stimulation in the posterior hypothalamus of the anesthetized rats.

Journal: Autonomic neuroscience : basic & clinical 20070731

Title: Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung.

Journal: European journal of anaesthesiology 20070301

Title: Characterization of adenosine receptors in the human bladder carcinoma T24 cell line.

Journal: European journal of pharmacology 20060424

Title: Adenosine postsynaptically modulates supraoptic neuronal excitability.

Journal: Journal of neurophysiology 20050101

Title: ATP-sensitive potassium channels are involved in adenosine-induced reduction of blood pressure variability in spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20040701

Title: Modification of cardiovascular response of posterior hypothalamic adenosine A(2) receptor stimulation by adenylate cylase, guanylate cyclase and by K(ATP) channel blockade in anesthetized rats.

Journal: Neuroscience letters 20030619

Title: Seizure suppression by adenosine A(2A) receptor activation in a rat model of audiogenic brainstem epilepsy.

Journal: Neuroscience letters 20020906

Title: The involvement of nitric oxide on the adenosine A(2) receptor-induced cardiovascular inhibitory responses in the posterior hypothalamus of rats.

Journal: Neuroscience letters 20020621

Title: Vasodilator responses to adenosine and hyperemia are mediated by A(1) and A(2) receptors in the cat vascular bed.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020601

Title: Mechanisms of glutamate release in the rat spinal cord slices during metabolic inhibition.

Journal: Journal of neurotrauma 20020201

Title: Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.

Journal: Journal of medicinal chemistry 20010118

Title: Adenosine A2 receptors modulate haloperidol-induced catalepsy in rats.

Journal: European journal of pharmacology 19970611

Title: Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.

Journal: Journal of medicinal chemistry 19940304

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