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474391-66-7,MFCD12912353
Catalog No.:AA00DA7F

474391-66-7 | 8-isoprostaglandin A2

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1mg
≥98%
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$242.00   $169.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00DA7F
Chemical Name:
8-isoprostaglandin A2
CAS Number:
474391-66-7
Molecular Formula:
C20H30O4
Molecular Weight:
334.4498
MDL Number:
MFCD12912353
SMILES:
CCCCC[C@@H](/C=C/[C@H]1C=CC(=O)[C@H]1C/C=C\CCCC(=O)O)O
Properties
Computed Properties
 
Complexity:
476  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  
XLogP3:
3.6  

Literature

Title: Effects of a carrot juice intervention on plasma carotenoids, oxidative stress, and inflammation in overweight breast cancer survivors.

Journal: Nutrition and cancer 20120101

Title: Effects of atorvastatin and rosuvastatin on thromboxane-dependent platelet activation and oxidative stress in hypercholesterolemia.

Journal: Atherosclerosis 20110101

Title: Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

Journal: Journal of medicinal chemistry 20100722

Title: Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury.

Journal: Free radical biology & medicine 20091115

Title: Determinants of platelet activation in hypertensives with microalbuminuria.

Journal: Free radical biology & medicine 20090401

Title: Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: protection by chronic oral intake of resveratrol.

Journal: Free radical biology & medicine 20090315

Title: Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.

Journal: Chemical research in toxicology 20090101

Title: Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis.

Journal: Circulation research 20081024

Title: Antiinflammatory effects of the cyclopentenone isoprostane 15-A(2)-IsoP in human gestational tissues.

Journal: Free radical biology & medicine 20070615

Title: Effect of short-term fasting on urinary excretion of primary lipid peroxidation products and on markers of oxidative DNA damage in healthy women.

Journal: Carcinogenesis 20060701

Title: Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration.

Journal: Journal of neurochemistry 20060601

Title: Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease.

Journal: Respiratory medicine 20060401

Title: Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.

Journal: The Biochemical journal 20040301

Title: Exhaled breath condensate eicosanoids and sputum eosinophils in asthmatic children: a pilot study.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20040201

Title: The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione.

Journal: Chemical research in toxicology 20040101

Title: Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20031101

Title: The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4.

Journal: Chemical research in toxicology 20020901

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