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501919-59-1,MFCD09907564
Catalog No.:AA00DB4A

501919-59-1 | S3I-201

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Purity
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Price(USD)
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1mg
98+%
in stock  
$11.00   $8.00
- +
5mg
98+%
in stock  
$25.00   $18.00
- +
10mg
98+%
in stock  
$36.00   $25.00
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50mg
98+%
in stock  
$96.00   $68.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB4A
Chemical Name:
S3I-201
CAS Number:
501919-59-1
Molecular Formula:
C16H15NO7S
Molecular Weight:
365.3578
MDL Number:
MFCD09907564
SMILES:
O=C(Nc1ccc(c(c1)O)C(=O)O)COS(=O)(=O)c1ccc(cc1)C
NSC Number:
74859
Properties
Computed Properties
 
Complexity:
578  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3  

Literature

Title: Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.

Journal: The Journal of pharmacology and experimental therapeutics 20150401

Title: Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.

Journal: Toxicology letters 20150122

Title: Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3.

Journal: Chemico-biological interactions 20140425

Title: Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells.

Journal: Leukemia research 20131201

Title: Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

Journal: Cell cycle (Georgetown, Tex.) 20120115

Title: NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20120101

Title: A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

Journal: PloS one 20120101

Title: Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.

Journal: Human molecular genetics 20111101

Title: α4β2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling.

Journal: Molecular pharmacology 20110101

Title: Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma.

Journal: BMC cancer 20110101

Title: STAT3 activation in monocytes accelerates liver cancer progression.

Journal: BMC cancer 20110101

Title: A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes.

Journal: Biochemical pharmacology 20100515

Title: A novel method in order to evaluate the efficacies and the safeties of new drugs for hepatocellular carcinoma with loss of transforming growth factor-beta signaling.

Journal: Hepatology (Baltimore, Md.) 20091201

Title: Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

Journal: Chembiochem : a European journal of chemical biology 20090817

Title: The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling.

Journal: Oncogene 20090219

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6.

Title: Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling. Oncogene. 2009 Feb 19;28(7):961-72.

Title: Zhou C, et al. STAT3 upregulation in pituitary somatotroph adenomas induces hypersecretion. J Clin Invest. 2015 Apr;125(4):1692-702

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