Home Other Building Blocks 465-16-7
465-16-7,MFCD26960889
Catalog No.:AA00DB8A

465-16-7 | OLEANDRIN

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$262.00   $183.00
- +
10mg
≥98%
in stock  
$428.00   $299.00
- +
25mg
≥98%
in stock  
$762.00   $533.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB8A
Chemical Name:
OLEANDRIN
CAS Number:
465-16-7
Molecular Formula:
C32H48O9
Molecular Weight:
576.7181
MDL Number:
MFCD26960889
SMILES:
CO[C@H]1C[C@H](O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]2[C@@H]3CC[C@]3([C@]2(O)C[C@@H]([C@@H]3C2=CC(=O)OC2)OC(=O)C)C)C)O[C@H]([C@@H]1O)C
Properties
Computed Properties
 
Complexity:
1080  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
13  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.4  

Literature

Title: Identification of anti-viral activity of the cardenolides, Na(+)/K(+)-ATPase inhibitors, against porcine transmissible gastroenteritis virus.

Journal: Toxicology and applied pharmacology 20171001

Title: Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors.

Journal: British journal of pharmacology 20140701

Title: Flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium oleander and evaluation of cytotoxicity.

Journal: Phytochemistry 20120501

Title: [A non-fatal Nerium oleander self-poisoning: case report and discussion].

Journal: Annales de cardiologie et d'angeiologie 20120401

Title: Unexpected double lethal oleander poisoning.

Journal: The American journal of forensic medicine and pathology 20120301

Title: 'The Lower Threshold' phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis?

Journal: Journal of carcinogenesis 20120101

Title: Autophagic cell death is induced by acetone and ethyl acetate extracts from Eupatorium odoratum in vitro: effects on MCF-7 and vero cell lines.

Journal: TheScientificWorldJournal 20120101

Title: Radiation, inflammation, and immune responses in cancer.

Journal: Frontiers in oncology 20120101

Title: In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.

Journal: Journal of neurochemistry 20111101

Title: Ex vivo activity of cardiac glycosides in acute leukaemia.

Journal: PloS one 20110101

Title: Rapid detection of oleander poisoning by Dimension Vista digoxin assay (Flex Reagent Cartridge).

Journal: Journal of clinical laboratory analysis 20110101

Title: β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis.

Journal: BMC cancer 20110101

Title: Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986) points to its role in chronic persistence.

Journal: PloS one 20110101

Title: Detoxification of Nerium indicum roots based on Indian system of medicine: phytochemical and toxicity evaluations.

Journal: Acta poloniae pharmaceutica 20110101

Title: Influence of fungal elicitation on glycyrrhizin production in transformed cell cultures of Abrus precatorius Linn.

Journal: Pharmacognosy magazine 20110101

Title: Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

Journal: Toxins 20101001

Title: A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning.

Journal: Toxicon : official journal of the International Society on Toxinology 20100901

Title: Na, K-ATPase: Ubiquitous Multifunctional Transmembrane Protein and its Relevance to Various Pathophysiological Conditions.

Journal: Journal of clinical medicine research 20100201

Title: Human tumor cell sensitivity to oleandrin is dependent on relative expression of Na+, K+ -ATPase subunitst.

Journal: Journal of experimental therapeutics & oncology 20100101

Title: Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning.

Journal: Heart views : the official journal of the Gulf Heart Association 20100101

Title: A case of non-fatal oleander poisoning.

Journal: BMJ case reports 20100101

Title: Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.

Journal: Journal of natural products 20091101

Title: Oleander intoxication in New World camelids: 12 cases (1995-2006).

Journal: Journal of the American Veterinary Medical Association 20090801

Title: Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets.

Journal: Molecular cancer therapeutics 20090801

Title: In vitro study of the effectiveness of three commercial adsorbents for binding oleander toxins.

Journal: Clinical toxicology (Philadelphia, Pa.) 20090301

Title: Cancer is a preventable disease that requires major lifestyle changes.

Journal: Pharmaceutical research 20080901

Title: The inhibitory effect of quercitrin gallate on iNOS expression induced by lipopolysaccharide in Balb/c mice.

Journal: Journal of veterinary science 20080901

Title: A fatal case of oleandrin poisoning.

Journal: Forensic science international 20080806

Title: Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity.

Journal: Molecular cancer therapeutics 20080501

Title: Rapid detection of oleander poisoning by Digoxin III, a new Digoxin assay: impact on serum Digoxin measurement.

Journal: American journal of clinical pathology 20080401

Title: The prince and the pauper. A tale of anticancer targeted agents.

Journal: Molecular cancer 20080101

Title: Determinants of human and mouse melanoma cell sensitivities to oleandrin.

Journal: Journal of experimental therapeutics & oncology 20080101

Title: Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

Journal: Integrative cancer therapies 20071201

Title: Stability of oleander extract and oleandrin in sera stored in plastic serum separator tubes.

Journal: Annals of clinical biochemistry 20070901

Title: Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

Journal: American journal of physiology. Cell physiology 20070801

Title: Oleandrin produces changes in intracellular calcium levels in isolated cardiomyocytes: a real-time fluorescence imaging study comparing adult to neonatal cardiomyocytes.

Journal: Journal of toxicology and environmental health. Part A 20070315

Title: Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity.

Journal: Molecular immunology 20070301

Title: Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases.

Journal: Apoptosis : an international journal on programmed cell death 20070201

Title: Topical administration of oleandrin could protect against gentamicin ototoxicity via inhibition of activator protein-1 and c-Jun N-terminal kinase.

Journal: Medical hypotheses 20070101

Title: Nerium oleander (Oleandrin).

Journal: Journal of the Society for Integrative Oncology 20070101

Title: Naturally occurring NF-kappaB inhibitors.

Journal: Mini reviews in medicinal chemistry 20060801

Title: Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells.

Journal: Journal of clinical immunology 20060701

Title: Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5.

Journal: Cancer research 20060601

Title: Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity.

Journal: Journal of cellular physiology 20060401

Title: The new enzyme-linked immunosorbent digoxin assay on the ADVIA Integrated Modular System is virtually free from oleander interference.

Journal: Therapeutic drug monitoring 20060401

Title: Oleandrin-mediated oxidative stress in human melanoma cells.

Journal: Journal of experimental therapeutics & oncology 20060101

Title: Unexpectedly dangerous escargot stew: oleandrin poisoning through the alimentary chain.

Journal: Journal of analytical toxicology 20060101

Title: Cytotoxic effects of leaf, stem and root extracts of Nerium oleander on leukemia cell lines and role of the p-glycoprotein in this effect.

Journal: Journal of experimental therapeutics & oncology 20060101

Title: A non-fatal oleander poisoning.

Journal: International journal of legal medicine 20050701

Title: Determination of oleandrin in tissues and biological fluids by liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of agricultural and food chemistry 20050601

Title: Chemosensitization and radiosensitization of tumors by plant polyphenols.

Journal: Antioxidants & redox signaling 20050101

Title: Rapid detection of oleander poisoning using digoxin immunoassays: comparison of five assays.

Journal: Therapeutic drug monitoring 20041201

Title: A rare cause of complete heart block after transdermal botanical treatment for psoriasis.

Journal: Pacing and clinical electrophysiology : PACE 20041201

Title: Toxic and sub-lethal effects of oleandrin on biochemical parameters of fresh water air breathing murrel, Channa punctatus (Bloch.).

Journal: Indian journal of experimental biology 20040401

Title: Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin.

Journal: Toxicology and applied pharmacology 20040315

Title: Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide.

Journal: Biochemical pharmacology 20031201

Title: A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20030821

Title: Toxic potential of oleander derived compost and vegetables grown with oleander soil amendments.

Journal: Veterinary and human toxicology 20030801

Title: Activated charcoal is effective but equilibrium dialysis is ineffective in removing oleander leaf extract and oleandrin from human serum: monitoring the effect by measuring apparent digoxin concentration.

Journal: Therapeutic drug monitoring 20030601

Title: Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.

Journal: Cancer letters 20021128

Title: Determination of bovine blood oleandrin by high-performance liquid chromatography and postcolumn derivatization.

Journal: Journal of chromatographic science 20021001

Title: Simultaneous determination of cardenolides by sonic spray ionization liquid chromatography-ion trap mass spectrometry--a fatal case of oleander poisoning.

Journal: Journal of analytical toxicology 20020101

Title: Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.

Journal: Journal of experimental therapeutics & oncology 20020101

Title: Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.

Journal: Biochemical pharmacology 20010815

Title: Jortani SA, et al. Inhibition of Na,K-ATPase by oleandrin and oleandrigenin, and their detection by digoxin immunoassays. Clin Chem. 1996 Oct;42(10):1654-8.

Title: Yang P, et al. Cellular location and expression of Na+, K+-ATPase α subunits affect the anti-proliferative activity of oleandrin. Mol Carcinog. 2014 Apr;53(4):253-63.

Title: Garofalo S, et al. The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells. J Neurosci. 2017 Apr 5;37(14):3926-3939.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:465-16-7 Molecular Formula|465-16-7 MDL|465-16-7 SMILES|465-16-7 OLEANDRIN