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495-31-8,MFCD09953919
Catalog No.:AA00DBS5

495-31-8 | Nodakenin

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Purity
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1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
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10mg
≥98%
in stock  
$306.00   $214.00
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25mg
≥98%
in stock  
$706.00   $494.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DBS5
Chemical Name:
Nodakenin
CAS Number:
495-31-8
Molecular Formula:
C20H24O9
Molecular Weight:
408.3992
MDL Number:
MFCD09953919
SMILES:
OC[C@H]1O[C@@H](OC([C@@H]2Oc3c(C2)cc2c(c3)oc(=O)cc2)(C)C)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
650  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
0.3  

Literature

Title: Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shock.

Journal: The Journal of pharmacology and experimental therapeutics 20120901

Title: [Chemical constituents contained in seeds of Notopterygium franchetii].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401

Title: Determination of 5-hydroxymethyl-2-furfural, albiflorin, paeoniflorin, liquiritin, ferulic acid, nodakenin, and glycyrrhizin by HPLC-PDA, and evaluation of the cytotoxicity of Palmul-tang, a traditional Korean herbal medicine.

Journal: Archives of pharmacal research 20120101

Title: Development and validation of a reliable high-performance liquid chromatographic method for determination of nodakenin in rat plasma and its application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20111001

Title: Biotransformation of nodakenin and simultaneous quantification of nodakenin and its aglycone in incubated system of human intestinal bacteria by HPLC method.

Journal: Journal of Asian natural products research 20090101

Title: Determination and pharmacokinetic study of nodakenin in rat plasma by RP-HPLC method.

Journal: Biomedical chromatography : BMC 20080701

Title: Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice.

Journal: Life sciences 20070501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.

Journal: Archives of pharmacal research 20030901

Title: [Determination of content of nodakenin in Notopterygium incisum ting from different source by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011101

Title: Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.

Journal: Journal of natural products 20010501

Title: Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.

Journal: Bioorganic & medicinal chemistry 19941001

Title: Kim DH, et al. Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Life Sci. 2007 May 1;80(21):1944-50.

Title: Xiong Y, et al. The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma. Immunopharmacol Immunotoxicol. 2014 Oct;36(5):341-8.

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