53861-57-7,MFCD00011673
Catalog No.:AA00DBUG

53861-57-7 | H-gla-oh

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Purity
Availability
Price(USD)
Quantity
  
10mg
≥ 99% (TLC)
in stock  
$450.00   $315.00
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  • Properties
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Technical Information
Catalog Number:
AA00DBUG
Chemical Name:
H-gla-oh
CAS Number:
53861-57-7
Molecular Formula:
C6H9NO6
Molecular Weight:
191.1388
MDL Number:
MFCD00011673
SMILES:
OC(=O)[C@H](CC(C(=O)O)C(=O)O)N
Properties
Computed Properties
 
Complexity:
223  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-3.7  

Literature

Title: Computational prediction and analysis of protein γ-carboxylation sites based on a random forest method.

Journal: Molecular bioSystems 20121101

Title: Patterns of periodic holes created by increased cell motility.

Journal: Interface focus 20120806

Title: Decreased sensory responses in osteocalcin null mutant mice imply neuropeptide function.

Journal: Cellular and molecular neurobiology 20120701

Title: Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors.

Journal: The Journal of biological chemistry 20120608

Title: Effect of anticoagulation with citrate versus heparin on the adsorption of coagulation factors to blood purification resins with different charge.

Journal: Biomacromolecules 20120213

Title: Evidence of associations between feto-maternal vitamin D status, cord parathyroid hormone and bone-specific alkaline phosphatase, and newborn whole body bone mineral content.

Journal: Nutrients 20120201

Title: Correlation between posttranslational modification and intrinsic disorder in protein.

Journal: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20120101

Title: Regulatory mechanisms in bone following mechanical loading.

Journal: Gene regulation and systems biology 20120101

Title: Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats.

Journal: Nutrition & metabolism 20120101

Title: Antioxidant properties of polysaccharide from the brown seaweed Sargassum graminifolium (Turn.), and its effects on calcium oxalate crystallization.

Journal: Marine drugs 20120101

Title: Enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs.

Journal: International journal of molecular sciences 20120101

Title: Vitamin K: the effect on health beyond coagulation - an overview.

Journal: Food & nutrition research 20120101

Title: Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

Journal: PloS one 20120101

Title: The end-organ impairment in liver cirrhosis: appointments for critical care.

Journal: Critical care research and practice 20120101

Title: Carboxylator: incorporating solvent-accessible surface area for identifying protein carboxylation sites.

Journal: Journal of computer-aided molecular design 20111001

Title: Molecular modulation of osteocalcin and its relevance in diabetes (Review).

Journal: International journal of molecular medicine 20110901

Title: Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate γ-carboxylation.

Journal: Matrix biology : journal of the International Society for Matrix Biology 20110901

Title: Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.

Journal: Growth factors (Chur, Switzerland) 20110801

Title: Osteocalcin is a stress-responsive neuropeptide.

Journal: Endocrine regulations 20110401

Title: Association between atherosclerosis and osteoporosis, the role of vitamin D.

Journal: Archives of medical science : AMS 20110401

Title: Vitamin K, osteoporosis and degenerative diseases of ageing.

Journal: Menopause international 20110301

Title: Extraskeletal osteosarcoma with pulmonary metastasis in a female f344 rat.

Journal: Journal of toxicologic pathology 20110301

Title: The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

Journal: The Journal of biological chemistry 20110218

Title: Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change.

Journal: Molecular and cellular biochemistry 20110201

Title: Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues.

Journal: Journal of inorganic biochemistry 20110101

Title: Approaching biomarkers of membranous nephropathy from a murine model to human disease.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Osteogenic predifferentiation of human bone marrow-derived stem cells by short-term mechanical stimulation.

Journal: The open orthopaedics journal 20110101

Title: Effect of long-term oral anticoagulant therapy on bone mineral density and bone turnover markers: a prospective 12 month study.

Journal: Bratislavske lekarske listy 20110101

Title: STAT6 expression in glioblastoma promotes invasive growth.

Journal: BMC cancer 20110101

Title: Protein C mutation (A267T) results in ER retention and unfolded protein response activation.

Journal: PloS one 20110101

Title: Expression of recombinant human coagulation factor VII by the Lizard Leishmania expression system.

Journal: Journal of biomedicine & biotechnology 20110101

Title: A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy.

Journal: Molecular vision 20110101

Title: Gene-drug interaction in stroke.

Journal: Stroke research and treatment 20110101

Title: Characterization of γ-carboxylated tryptic peptides by collision-induced dissociation and electron transfer dissociation mass spectrometry.

Journal: European journal of mass spectrometry (Chichester, England) 20110101

Title: Investigation and identification of protein γ-glutamyl carboxylation sites.

Journal: BMC bioinformatics 20110101

Title: Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation.

Journal: The Journal of nutritional biochemistry 20101101

Title: Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.

Journal: Calcified tissue international 20101001

Title: Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20101001

Title: Vitamin K-dependent gamma-glutamylcarboxylase in Atlantic salmon (Salmo salar L.).

Journal: Fish physiology and biochemistry 20100901

Title: Exploring the role of the phospholipid ligand in endothelial protein C receptor: a molecular dynamics study.

Journal: Proteins 20100901

Title: Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model.

Journal: Thrombosis and haemostasis 20100801

Title: Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes.

Journal: Osteoarthritis and cartilage 20100801

Title: Characterization of conantokin Rl-A: molecular phylogeny as structure/function study.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20100801

Title: The effects of enamel matrix derivative on the proliferation and differentiation of human mesenchymal stem cells.

Journal: Clinical oral implants research 20100701

Title: Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100601

Title: Targeting adenoviruses with factor x-single-chain antibody fusion proteins.

Journal: Human gene therapy 20100601

Title: The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.

Journal: The Journal of clinical investigation 20100601

Title: A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S.

Journal: Thrombosis research 20100501

Title: Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex.

Journal: Thrombosis research 20100401

Title: Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.

Journal: Cardiovascular research 20100301

Title: Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures.

Journal: Calcified tissue international 20100301

Title: An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase.

Journal: The Journal of biological chemistry 20100219

Title: Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein.

Journal: Experimental cell research 20100115

Title: Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension.

Journal: Kidney & blood pressure research 20100101

Title: Critical evaluation of gamma-irradiated serum used as feeder in the culture and demonstration of putative nanobacteria and calcifying nanoparticles.

Journal: PloS one 20100101

Title: Skeletal site-related variation in human trabecular bone transcriptome and signaling.

Journal: PloS one 20100101

Title: Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans.

Journal: Disease markers 20100101

Title: Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.

Journal: BMC cell biology 20100101

Title: Carbonic anhydrase I is recognized by an SOD1 antibody upon biotinylation of human spinal cord extracts.

Journal: International journal of molecular sciences 20100101

Title: VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.

Journal: PloS one 20100101

Title: GAS6 enhances repair following cuprizone-induced demyelination.

Journal: PloS one 20100101

Title: Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms.

Journal: American journal of physiology. Cell physiology 20091201

Title: Use of a bacterially expressed human factor IX light chain to develop polyclonal antibody anti-hFIX.

Journal: Applied biochemistry and biotechnology 20091101

Title: Vitamin K in parenteral nutrition.

Journal: Gastroenterology 20091101

Title: Metal-binding affinity and selectivity of nonstandard natural amino acid residues from DFT/CDM calculations.

Journal: The journal of physical chemistry. B 20090827

Title: Direct analysis reveals an absence of gamma-carboxyglutamic acid in cancer procoagulant from human tissues.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20090701

Title: Phylogenetic analysis of ALAD and MGP genes related to lead toxicity.

Journal: Toxicology and industrial health 20090701

Title: Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex.

Journal: Biochemistry 20090609

Title: From the Gla domain to a novel small-molecule detector of apoptosis.

Journal: Cell research 20090501

Title: Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues.

Journal: Peptides 20090501

Title: The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix.

Journal: Biophysical journal 20090422

Title: Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion.

Journal: Blood 20090416

Title: Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea.

Journal: Peptides 20090301

Title: Polymorphisms in MGP gene and their association with lead toxicity.

Journal: Toxicology mechanisms and methods 20090301

Title: Platelet factor 4 impairs the anticoagulant activity of activated protein C.

Journal: The Journal of biological chemistry 20090227

Title: Vitamin K, an update for the paediatrician.

Journal: European journal of pediatrics 20090201

Title: Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.

Journal: Thrombosis and haemostasis 20090201

Title: Regulation of pituitary gene expression by adrenalectomy.

Journal: Obesity (Silver Spring, Md.) 20090101

Title: Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay.

Journal: Molecular vision 20090101

Title: BMP-13 emerges as a potential inhibitor of bone formation.

Journal: International journal of biological sciences 20090101

Title: Characterization of porcine factor VII, X and comparison with human factor VII, X.

Journal: Blood cells, molecules & diseases 20090101

Title: Characterization of granulations of calcium and apatite in serum as pleomorphic mineralo-protein complexes and as precursors of putative nanobacteria.

Journal: PloS one 20090101

Title: Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis.

Journal: Vascular health and risk management 20090101

Title: Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain.

Journal: Therapeutics and clinical risk management 20090101

Title: Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma.

Journal: BMC cancer 20090101

Title: Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse.

Journal: BMC research notes 20090101

Title: Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies.

Journal: Arthritis research & therapy 20090101

Title: Endothelial cells influence the osteogenic potential of bone marrow stromal cells.

Journal: Biomedical engineering online 20090101

Title: Fetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding concept.

Journal: PloS one 20090101

Title: Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates.

Journal: The Journal of biological chemistry 20081226

Title: The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study.

Journal: Biochemistry 20081216

Title: Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine.

Journal: Biochemical and biophysical research communications 20081107

Title: Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.

Journal: PLoS medicine 20081001

Title: Noninvasive markers of oxidative DNA stress, RNA degradation and protein degradation are differentially correlated with resting metabolic rate and energy intake in children and adolescents.

Journal: Pediatric research 20080901

Title: Conantokin-P, an unusual conantokin with a long disulfide loop.

Journal: Toxicon : official journal of the International Society on Toxinology 20080801

Title: Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z.

Journal: The Journal of biological chemistry 20080718

Title: Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins.

Journal: Toxicon : official journal of the International Society on Toxinology 20080701

Title: Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells.

Journal: The Journal of biological chemistry 20080627

Title: Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.

Journal: Circulation research 20080509

Title: Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4.

Journal: Circulation research 20080509

Title: Vitamin K intake and atherosclerosis.

Journal: Current opinion in lipidology 20080201

Title: Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks.

Journal: Peptides 20080201

Title: Vascular calcification and uremia: what do we know?

Journal: American journal of nephrology 20080101

Title: Molecular characterization of spontaneous mesenchymal stem cell transformation.

Journal: PloS one 20080101

Title: Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.

Journal: Protein and peptide letters 20080101

Title: Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification.

Journal: Thrombosis research 20080101

Title: gamma-Glutamate and beta-hydroxyaspartate in proteins.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: The vitamin K cycle.

Journal: Vitamins and hormones 20080101

Title: Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification.

Journal: Vitamins and hormones 20080101

Title: Vitamin K and bone health in adult humans.

Journal: Vitamins and hormones 20080101

Title: The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.

Journal: Journal of vascular research 20080101

Title: Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women.

Journal: Journal of bone and mineral metabolism 20080101

Title: Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53.

Journal: Proteome science 20080101

Title: Production of metal ion-dependent monoclonal antibodies against peptides in bovine prothrombin fragment 1.

Journal: Human antibodies 20080101

Title: Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism.

Journal: Cytogenetic and genome research 20080101

Title: Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.

Journal: The Journal of biological chemistry 20071221

Title: The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.

Journal: Blood 20071201

Title: Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification.

Journal: Journal of thrombosis and haemostasis : JTH 20071201

Title: Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of (111)in-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney.

Journal: Biological & pharmaceutical bulletin 20071101

Title: [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function].

Journal: Clinical calcium 20071101

Title: Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways.

Journal: Journal of cellular biochemistry 20071001

Title: Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients.

Journal: Laboratory investigation; a journal of technical methods and pathology 20071001

Title: [Gas-6 and protein S: vitamin K-dependent factors and ligands for the TAM tyrosine kinase receptors family].

Journal: Medecine sciences : M/S 20071001

Title: Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

Journal: Journal of thrombosis and haemostasis : JTH 20070901

Title: Quantum chemical study of the mechanism of action of vitamin K carboxylase (VKC). IV. Intermediates and transition states.

Journal: The journal of physical chemistry. A 20070809

Title: Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X.

Journal: The Biochemical journal 20070715

Title: Vitamin K: the coagulation vitamin that became omnipotent.

Journal: Thrombosis and haemostasis 20070701

Title: Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

Journal: Blood 20070615

Title: A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8.

Journal: The Biochemical journal 20070615

Title: Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats.

Journal: Journal of nutritional science and vitaminology 20070601

Title: Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX.

Journal: The Journal of biological chemistry 20070525

Title: Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane.

Journal: Biophysical journal 20070501

Title: Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.

Journal: The Journal of biological chemistry 20070427

Title: Hydroxyapatite surface-induced peptide folding.

Journal: Journal of the American Chemical Society 20070425

Title: Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist.

Journal: Journal of thrombosis and haemostasis : JTH 20070401

Title: Association of warfarin dose with genes involved in its action and metabolism.

Journal: Human genetics 20070301

Title: [Advances in study of structures and functions of conantokins].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

Title: The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif.

Journal: Journal of the American Chemical Society 20070214

Title: Warfarin-induced vasculopathy.

Journal: Journal of thrombosis and thrombolysis 20070201

Title: Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.

Journal: The British journal of nutrition 20070201

Title: Full-length cDNA cloning and protein three-dimensional structure modeling of porcine prothrombin.

Journal: Blood cells, molecules & diseases 20070101

Title: A distinct epigenetic signature at targets of a leukemia protein.

Journal: BMC genomics 20070101

Title: The vascular biology of calcification.

Journal: Seminars in dialysis 20070101

Title: Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection.

Journal: Oligonucleotides 20070101

Title: Growth arrest-specific protein 6 (GAS6) and the protein C pathway.

Journal: Critical care (London, England) 20070101

Title: Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.

Journal: BMC cancer 20070101

Title: Role of vitamin K on biochemical markers, bone mineral density, and fracture risk.

Journal: Journal of endocrinological investigation 20070101

Title: Single nucleotide polymorphisms in bone turnover-related genes in Koreans: ethnic differences in linkage disequilibrium and haplotype.

Journal: BMC medical genetics 20070101

Title: BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.

Journal: Molecular cancer 20070101

Title: The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability?

Journal: Clinical & developmental immunology 20070101

Title: From gamma-carboxy-glutamate to protein C.

Journal: Journal of thrombosis and haemostasis : JTH 20061201

Title: Molecular dynamics calculations of wild type vs. mutant protein C: relationship between binding affinity to endothelial cell protein C receptor and hereditary disease.

Journal: Journal of biomolecular structure & dynamics 20061201

Title: Vascular calcification: pathobiological mechanisms and clinical implications.

Journal: Circulation research 20061110

Title: Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis.

Journal: Rheumatology (Oxford, England) 20061101

Title: A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide.

Journal: Biochemistry 20061024

Title: Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid.

Journal: The Journal of organic chemistry 20060915

Title: [Protective effects of vitamin K against osteoporosis and its pleiotropic actions].

Journal: Clinical calcium 20060901

Title: High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.

Journal: The Journal of biological chemistry 20060825

Title: The first gamma-carboxyglutamate-containing neuropeptide.

Journal: Neurochemistry international 20060801

Title: Isoelectric points and post-translational modifications of connexin26 and connexin32.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060601

Title: Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile.

Journal: The FEBS journal 20060601

Title: Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery.

Journal: Toxicon : official journal of the International Society on Toxinology 20060501

Title: Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat.

Journal: Bioscience, biotechnology, and biochemistry 20060401

Title: Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure.

Journal: BMC genomics 20060101

Title: Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues.

Journal: Urology 20060101

Title: Osteocalcin and bone-specific alkaline phosphatase in sickle cell haemoglobinopathies.

Journal: Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20060101

Title: Sequential coagulation factor VIIa domain binding to tissue factor.

Journal: Biochemical and biophysical research communications 20051202

Title: The role of gamma-carboxylation in the anti-apoptotic function of gas6.

Journal: Journal of thrombosis and haemostasis : JTH 20051201

Title: Protein C Sapporo (protein C Glu 25 --> Lys): a heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor.

Journal: Thrombosis and haemostasis 20051101

Title: Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice.

Journal: Molecules and cells 20051031

Title: Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties.

Journal: Biochemistry 20050920

Title: Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro.

Journal: Journal of periodontology 20050901

Title: Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050801

Title: Vitamin K in the treatment and prevention of osteoporosis and arterial calcification.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050801

Title: Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates.

Journal: The Journal of biological chemistry 20050722

Title: Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation.

Journal: Biochemistry 20050628

Title: Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone.

Journal: Bone 20050601

Title: Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico.

Journal: Human biology 20050601

Title: [Molecular mechanisms of vitamin K action in the bone homeostasis].

Journal: Clinical calcium 20050501

Title: Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system.

Journal: The Journal of biological chemistry 20050318

Title: Rapid fabrication of keratin-hydroxyapatite hybrid sponges toward osteoblast cultivation and differentiation.

Journal: Biomaterials 20050101

Title: The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

Journal: Blood 20050101

Title: Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus.

Journal: The Journal of urology 20050101

Title: Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii.

Journal: Peptides 20050101

Title: Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.

Journal: Cardiovascular diabetology 20050101

Title: Osteo-Promoter Database (OPD) -- promoter analysis in skeletal cells.

Journal: BMC genomics 20050101

Title: Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension.

Journal: Respiratory research 20050101

Title: Structure-function relationships of C-type lectin-related proteins.

Journal: Pathophysiology of haemostasis and thrombosis 20050101

Title: Chemical modification of cysteine residues is a misleading indicator of their status as active site residues in the vitamin K-dependent gamma-glutamyl carboxylation reaction.

Journal: The Journal of biological chemistry 20041224

Title: Conantokins: peptide antagonists of NMDA receptors.

Journal: Current medicinal chemistry 20041201

Title: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is alpha-D-Gal-(1-->3)-alpha-D-GalNAc.

Journal: European journal of biochemistry 20041201

Title: Oral anticoagulant treatment: friend or foe in cardiovascular disease?

Journal: Blood 20041115

Title: Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.

Journal: The Journal of biological chemistry 20041105

Title: A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide.

Journal: Biochemistry 20041019

Title: Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin.

Journal: The Journal of biological chemistry 20041008

Title: [Serum osteoprotegrin and serum bone gamma-carboxyglutamine acid-containing protein are correlated with bone mineral density in normal women].

Journal: Zhonghua yi xue za zhi 20041002

Title: Multiple 6-bromotryptophan residues in a sleep-inducing peptide.

Journal: Biochemistry 20040928

Title: The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.

Journal: The Journal of biological chemistry 20040730

Title: The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M.

Journal: The Journal of biological chemistry 20040730

Title: Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern.

Journal: Biochemical and biophysical research communications 20040709

Title: Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.

Journal: Biochemical and biophysical research communications 20040702

Title: Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin.

Journal: Journal of thrombosis and haemostasis : JTH 20040701

Title: Matrix GLA protein modulates branching morphogenesis in fetal rat lung.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040601

Title: Platelet factor 4 modulation of the thrombomodulin-protein C system.

Journal: Critical care medicine 20040501

Title: Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20040501

Title: Kinetics of factor Xa inhibition by recombinant tick anticoagulant peptide: both active site and exosite interactions are required for a slow- and tight-binding inhibition mechanism.

Journal: Biochemistry 20040330

Title: Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels.

Journal: Bone 20040301

Title: Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product.

Journal: The Journal of biological chemistry 20040220

Title: A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.

Journal: Journal of molecular biology 20040220

Title: [Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis].

Journal: Zhonghua yi xue za zhi 20040217

Title: Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study.

Journal: Thrombosis and haemostasis 20040201

Title: Use of snake venom inhibitors in studies of the function and tertiary structure of coagulation factors.

Journal: International journal of hematology 20040201

Title: Effects of vitamin K2 on osteoporosis.

Journal: Current pharmaceutical design 20040101

Title: The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis.

Journal: Proteins 20031115

Title: Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Journal: The Journal of biological chemistry 20031114

Title: [Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children].

Journal: Wei sheng yan jiu = Journal of hygiene research 20031101

Title: Vitamin K and bone health.

Journal: The Proceedings of the Nutrition Society 20031101

Title: Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

Journal: Biochemical and biophysical research communications 20031017

Title: Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030901

Title: Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.

Journal: Nature structural biology 20030901

Title: The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.

Journal: The Journal of biological chemistry 20030815

Title: The extended interactions and Gla domain of blood coagulation factor Xa.

Journal: Biochemistry 20030708

Title: Intracrystalline proteins and urolithiasis: a synchrotron X-ray diffraction study of calcium oxalate monohydrate.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030701

Title: Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein.

Journal: The Journal of biological chemistry 20030627

Title: Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein.

Journal: British journal of cancer 20030616

Title: Direct binding properties of conantokins to native N-methyl-d-aspartate receptors.

Journal: The journal of peptide research : official journal of the American Peptide Society 20030601

Title: Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains.

Journal: Biochimica et biophysica acta 20030530

Title: Role of the Gla and first epidermal growth factor-like domains of factor X in the prothrombinase and tissue factor-factor VIIa complexes.

Journal: The Journal of biological chemistry 20030321

Title: Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding.

Journal: Blood 20030315

Title: The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa.

Journal: The Journal of biological chemistry 20030307

Title: Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site.

Journal: The Journal of biological chemistry 20030307

Title: Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity.

Journal: Blood 20030215

Title: Cloning and expression of rat coagulation factor VII.

Journal: Thrombosis research 20030215

Title: Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence.

Journal: The Journal of biological chemistry 20030131

Title: Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi.

Journal: Journal of thrombosis and haemostasis : JTH 20030101

Title: Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile.

Journal: European journal of biochemistry 20021201

Title: Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.

Journal: The Journal of biological chemistry 20021108

Title: Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C Gla domain mutation, Arg15Trp.

Journal: Journal of pediatric hematology/oncology 20021101

Title: Gas6 binding to photoreceptor outer segments requires gamma-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro.

Journal: Experimental eye research 20021001

Title: Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020901

Title: High-performance liquid chromatography--mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin. Determination of gamma-carboxyglutamic acid residues.

Journal: Journal of chromatography. A 20020712

Title: Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.

Journal: Blood 20020701

Title: Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats.

Journal: Journal of hypertension 20020701

Title: Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin.

Journal: The Biochemical journal 20020515

Title: gamma-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin.

Journal: Biochimica et biophysica acta 20020424

Title: Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for gamma-carboxyglutamic acid.

Journal: Toxicon : official journal of the International Society on Toxinology 20020401

Title: Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity.

Journal: Clinical science (London, England : 1979) 20020401

Title: Structure and dynamics of zymogen human blood coagulation factor X.

Journal: Biophysical journal 20020301

Title: A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020301

Title: Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats.

Journal: The Journal of biological chemistry 20020208

Title: Localization of phosphatidylserine binding sites to structural domains of factor Xa.

Journal: The Journal of biological chemistry 20020118

Title: Ca2+ binding to proteins containing gamma-carboxyglutamic acid residues.

Journal: Methods in molecular biology (Clifton, N.J.) 20020101

Title: Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the 'mechanostat' theory.

Journal: Journal of bone and mineral metabolism 20020101

Title: Identification of extrinsic blood coagulation pathway inhibitors from the tick Ornithodoros savignyi (Acari: Argasidae).

Journal: Experimental parasitology 20020101

Title: Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain.

Journal: The Biochemical journal 20011201

Title: Fourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcin.

Journal: Calcified tissue international 20011201

Title: A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase.

Journal: Biochemistry 20011002

Title: Matrix gamma-carboxyglutamic acid protein is a key regulator of PTH-mediated inhibition of mineralization in MC3T3-E1 osteoblast-like cells.

Journal: Endocrinology 20011001

Title: Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites.

Journal: Biophysical journal 20011001

Title: An anti-EGF monoclonal antibody that detects intramolecular communication in factor IX.

Journal: Biochemical and biophysical research communications 20010907

Title: Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B.

Journal: Blood 20010901

Title: Structure-function relationships of the NMDA receptor antagonist conantokin peptides.

Journal: Current drug targets 20010901

Title: A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.

Journal: The Journal of biological chemistry 20010831

Title: A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi.

Journal: Clinical science (London, England : 1979) 20010801

Title: Expression and localization of MGP in rat tooth cementum.

Journal: Archives of oral biology 20010701

Title: The omega-loop region of the human prothrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes.

Journal: The Journal of biological chemistry 20010629

Title: Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain.

Journal: The journal of peptide research : official journal of the American Peptide Society 20010601

Title: Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B.

Journal: Thrombosis research 20010515

Title: Synthesis of gamma-carboxylated polypeptides by alpha-cells of the pancreatic islets.

Journal: Biochemical and biophysical research communications 20010504

Title: Amino acid determinants for NMDA receptor inhibition by conantokin-T.

Journal: Journal of neurochemistry 20010501

Title: Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy.

Journal: Obstetrics and gynecology 20010501

Title: Total chemical synthesis of human matrix Gla protein.

Journal: Protein science : a publication of the Protein Society 20010401

Title: On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila.

Journal: The Journal of biological chemistry 20010316

Title: Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.

Journal: The Journal of biological chemistry 20010309

Title: Posttranslational modifications of recombinant myotube-synthesized human factor IX.

Journal: Blood 20010101

Title: Novel vitamin K-dependent pathways regulating cell survival.

Journal: Apoptosis : an international journal on programmed cell death 20010101

Title: 1,25-Dihydroxyvitamin D3 promotes vitamin K2 metabolism in human osteoblasts.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20010101

Title: Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage.

Journal: Arthritis research 20010101

Title: Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.

Journal: Neuropharmacology 19980801

Title: Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19970819

Title: Carboxyl-terminal proteolytic processing of matrix Gla protein.

Journal: The Journal of biological chemistry 19911105

Title: Synthesis of a gamma-carboxyglutamic acid containing heptapeptide corresponding to bovine prothrombin residues 17-23.

Journal: International journal of peptide and protein research 19861201

Title: Gamma-carboxyglutamate in a neuroactive toxin.

Journal: The Journal of biological chemistry 19841210

Title: Vitamin K dependent carboxylation: synthesis and biological properties of tetrazolyl analogues of pentapeptidic substrates.

Journal: Journal of medicinal chemistry 19840901

Title: Vitamin K dependent carboxylation of glutamate residues to gamma-carboxyglutamate in microsomes from spleen and testes: comparison with liver, lung, and kidney.

Journal: Biochemistry 19830301

Title: Vitamin K-dependent carboxylase: synthesis of an inhibitor of the glutamyl binding site.

Journal: FEBS letters 19830207

Title: Mechanism of action of vitamin K: synthesis of gamma-carboxyglutamic acid.

Journal: CRC critical reviews in biochemistry 19800101

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Tags:53861-57-7 Molecular Formula|53861-57-7 MDL|53861-57-7 SMILES|53861-57-7 H-gla-oh
Catalog No.: AA00DBUG
53861-57-7,MFCD00011673
53861-57-7 | H-gla-oh
Pack Size: 10mg
Purity: ≥ 99% (TLC)
in stock
$450.00 $315.00
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Technical Information
Catalog Number: AA00DBUG
Chemical Name: H-gla-oh
CAS Number: 53861-57-7
Molecular Formula: C6H9NO6
Molecular Weight: 191.1388
MDL Number: MFCD00011673
SMILES: OC(=O)[C@H](CC(C(=O)O)C(=O)O)N
Properties
Complexity: 223  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -3.7  
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Journal: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing20120101

Title: Regulatory mechanisms in bone following mechanical loading.

Journal: Gene regulation and systems biology20120101

Title: Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats.

Journal: Nutrition & metabolism20120101

Title: Antioxidant properties of polysaccharide from the brown seaweed Sargassum graminifolium (Turn.), and its effects on calcium oxalate crystallization.

Journal: Marine drugs20120101

Title: Enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs.

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Title: Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

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Journal: Growth factors (Chur, Switzerland)20110801

Title: Osteocalcin is a stress-responsive neuropeptide.

Journal: Endocrine regulations20110401

Title: Association between atherosclerosis and osteoporosis, the role of vitamin D.

Journal: Archives of medical science : AMS20110401

Title: Vitamin K, osteoporosis and degenerative diseases of ageing.

Journal: Menopause international20110301

Title: Extraskeletal osteosarcoma with pulmonary metastasis in a female f344 rat.

Journal: Journal of toxicologic pathology20110301

Title: The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

Journal: The Journal of biological chemistry20110218

Title: Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change.

Journal: Molecular and cellular biochemistry20110201

Title: Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues.

Journal: Journal of inorganic biochemistry20110101

Title: Approaching biomarkers of membranous nephropathy from a murine model to human disease.

Journal: Journal of biomedicine & biotechnology20110101

Title: Osteogenic predifferentiation of human bone marrow-derived stem cells by short-term mechanical stimulation.

Journal: The open orthopaedics journal20110101

Title: Effect of long-term oral anticoagulant therapy on bone mineral density and bone turnover markers: a prospective 12 month study.

Journal: Bratislavske lekarske listy20110101

Title: STAT6 expression in glioblastoma promotes invasive growth.

Journal: BMC cancer20110101

Title: Protein C mutation (A267T) results in ER retention and unfolded protein response activation.

Journal: PloS one20110101

Title: Expression of recombinant human coagulation factor VII by the Lizard Leishmania expression system.

Journal: Journal of biomedicine & biotechnology20110101

Title: A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy.

Journal: Molecular vision20110101

Title: Gene-drug interaction in stroke.

Journal: Stroke research and treatment20110101

Title: Characterization of γ-carboxylated tryptic peptides by collision-induced dissociation and electron transfer dissociation mass spectrometry.

Journal: European journal of mass spectrometry (Chichester, England)20110101

Title: Investigation and identification of protein γ-glutamyl carboxylation sites.

Journal: BMC bioinformatics20110101

Title: Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation.

Journal: The Journal of nutritional biochemistry20101101

Title: Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.

Journal: Calcified tissue international20101001

Title: Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.

Journal: Arteriosclerosis, thrombosis, and vascular biology20101001

Title: Vitamin K-dependent gamma-glutamylcarboxylase in Atlantic salmon (Salmo salar L.).

Journal: Fish physiology and biochemistry20100901

Title: Exploring the role of the phospholipid ligand in endothelial protein C receptor: a molecular dynamics study.

Journal: Proteins20100901

Title: Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model.

Journal: Thrombosis and haemostasis20100801

Title: Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes.

Journal: Osteoarthritis and cartilage20100801

Title: Characterization of conantokin Rl-A: molecular phylogeny as structure/function study.

Journal: Journal of peptide science : an official publication of the European Peptide Society20100801

Title: The effects of enamel matrix derivative on the proliferation and differentiation of human mesenchymal stem cells.

Journal: Clinical oral implants research20100701

Title: Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry20100601

Title: Targeting adenoviruses with factor x-single-chain antibody fusion proteins.

Journal: Human gene therapy20100601

Title: The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.

Journal: The Journal of clinical investigation20100601

Title: A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S.

Journal: Thrombosis research20100501

Title: Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex.

Journal: Thrombosis research20100401

Title: Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.

Journal: Cardiovascular research20100301

Title: Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures.

Journal: Calcified tissue international20100301

Title: An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase.

Journal: The Journal of biological chemistry20100219

Title: Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein.

Journal: Experimental cell research20100115

Title: Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension.

Journal: Kidney & blood pressure research20100101

Title: Critical evaluation of gamma-irradiated serum used as feeder in the culture and demonstration of putative nanobacteria and calcifying nanoparticles.

Journal: PloS one20100101

Title: Skeletal site-related variation in human trabecular bone transcriptome and signaling.

Journal: PloS one20100101

Title: Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans.

Journal: Disease markers20100101

Title: Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.

Journal: BMC cell biology20100101

Title: Carbonic anhydrase I is recognized by an SOD1 antibody upon biotinylation of human spinal cord extracts.

Journal: International journal of molecular sciences20100101

Title: VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.

Journal: PloS one20100101

Title: GAS6 enhances repair following cuprizone-induced demyelination.

Journal: PloS one20100101

Title: Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms.

Journal: American journal of physiology. Cell physiology20091201

Title: Use of a bacterially expressed human factor IX light chain to develop polyclonal antibody anti-hFIX.

Journal: Applied biochemistry and biotechnology20091101

Title: Vitamin K in parenteral nutrition.

Journal: Gastroenterology20091101

Title: Metal-binding affinity and selectivity of nonstandard natural amino acid residues from DFT/CDM calculations.

Journal: The journal of physical chemistry. B20090827

Title: Direct analysis reveals an absence of gamma-carboxyglutamic acid in cancer procoagulant from human tissues.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis20090701

Title: Phylogenetic analysis of ALAD and MGP genes related to lead toxicity.

Journal: Toxicology and industrial health20090701

Title: Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex.

Journal: Biochemistry20090609

Title: From the Gla domain to a novel small-molecule detector of apoptosis.

Journal: Cell research20090501

Title: Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues.

Journal: Peptides20090501

Title: The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix.

Journal: Biophysical journal20090422

Title: Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion.

Journal: Blood20090416

Title: Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea.

Journal: Peptides20090301

Title: Polymorphisms in MGP gene and their association with lead toxicity.

Journal: Toxicology mechanisms and methods20090301

Title: Platelet factor 4 impairs the anticoagulant activity of activated protein C.

Journal: The Journal of biological chemistry20090227

Title: Vitamin K, an update for the paediatrician.

Journal: European journal of pediatrics20090201

Title: Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.

Journal: Thrombosis and haemostasis20090201

Title: Regulation of pituitary gene expression by adrenalectomy.

Journal: Obesity (Silver Spring, Md.)20090101

Title: Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay.

Journal: Molecular vision20090101

Title: BMP-13 emerges as a potential inhibitor of bone formation.

Journal: International journal of biological sciences20090101

Title: Characterization of porcine factor VII, X and comparison with human factor VII, X.

Journal: Blood cells, molecules & diseases20090101

Title: Characterization of granulations of calcium and apatite in serum as pleomorphic mineralo-protein complexes and as precursors of putative nanobacteria.

Journal: PloS one20090101

Title: Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis.

Journal: Vascular health and risk management20090101

Title: Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain.

Journal: Therapeutics and clinical risk management20090101

Title: Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma.

Journal: BMC cancer20090101

Title: Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse.

Journal: BMC research notes20090101

Title: Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies.

Journal: Arthritis research & therapy20090101

Title: Endothelial cells influence the osteogenic potential of bone marrow stromal cells.

Journal: Biomedical engineering online20090101

Title: Fetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding concept.

Journal: PloS one20090101

Title: Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates.

Journal: The Journal of biological chemistry20081226

Title: The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study.

Journal: Biochemistry20081216

Title: Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine.

Journal: Biochemical and biophysical research communications20081107

Title: Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.

Journal: PLoS medicine20081001

Title: Noninvasive markers of oxidative DNA stress, RNA degradation and protein degradation are differentially correlated with resting metabolic rate and energy intake in children and adolescents.

Journal: Pediatric research20080901

Title: Conantokin-P, an unusual conantokin with a long disulfide loop.

Journal: Toxicon : official journal of the International Society on Toxinology20080801

Title: Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z.

Journal: The Journal of biological chemistry20080718

Title: Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins.

Journal: Toxicon : official journal of the International Society on Toxinology20080701

Title: Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells.

Journal: The Journal of biological chemistry20080627

Title: Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.

Journal: Circulation research20080509

Title: Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4.

Journal: Circulation research20080509

Title: Vitamin K intake and atherosclerosis.

Journal: Current opinion in lipidology20080201

Title: Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks.

Journal: Peptides20080201

Title: Vascular calcification and uremia: what do we know?

Journal: American journal of nephrology20080101

Title: Molecular characterization of spontaneous mesenchymal stem cell transformation.

Journal: PloS one20080101

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Journal: Protein and peptide letters20080101

Title: Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification.

Journal: Thrombosis research20080101

Title: gamma-Glutamate and beta-hydroxyaspartate in proteins.

Journal: Methods in molecular biology (Clifton, N.J.)20080101

Title: The vitamin K cycle.

Journal: Vitamins and hormones20080101

Title: Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification.

Journal: Vitamins and hormones20080101

Title: Vitamin K and bone health in adult humans.

Journal: Vitamins and hormones20080101

Title: The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.

Journal: Journal of vascular research20080101

Title: Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women.

Journal: Journal of bone and mineral metabolism20080101

Title: Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53.

Journal: Proteome science20080101

Title: Production of metal ion-dependent monoclonal antibodies against peptides in bovine prothrombin fragment 1.

Journal: Human antibodies20080101

Title: Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism.

Journal: Cytogenetic and genome research20080101

Title: Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.

Journal: The Journal of biological chemistry20071221

Title: The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.

Journal: Blood20071201

Title: Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification.

Journal: Journal of thrombosis and haemostasis : JTH20071201

Title: Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of (111)in-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney.

Journal: Biological & pharmaceutical bulletin20071101

Title: [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function].

Journal: Clinical calcium20071101

Title: Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways.

Journal: Journal of cellular biochemistry20071001

Title: Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients.

Journal: Laboratory investigation; a journal of technical methods and pathology20071001

Title: [Gas-6 and protein S: vitamin K-dependent factors and ligands for the TAM tyrosine kinase receptors family].

Journal: Medecine sciences : M/S20071001

Title: Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

Journal: Journal of thrombosis and haemostasis : JTH20070901

Title: Quantum chemical study of the mechanism of action of vitamin K carboxylase (VKC). IV. Intermediates and transition states.

Journal: The journal of physical chemistry. A20070809

Title: Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X.

Journal: The Biochemical journal20070715

Title: Vitamin K: the coagulation vitamin that became omnipotent.

Journal: Thrombosis and haemostasis20070701

Title: Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

Journal: Blood20070615

Title: A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8.

Journal: The Biochemical journal20070615

Title: Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats.

Journal: Journal of nutritional science and vitaminology20070601

Title: Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX.

Journal: The Journal of biological chemistry20070525

Title: Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane.

Journal: Biophysical journal20070501

Title: Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.

Journal: The Journal of biological chemistry20070427

Title: Hydroxyapatite surface-induced peptide folding.

Journal: Journal of the American Chemical Society20070425

Title: Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist.

Journal: Journal of thrombosis and haemostasis : JTH20070401

Title: Association of warfarin dose with genes involved in its action and metabolism.

Journal: Human genetics20070301

Title: [Advances in study of structures and functions of conantokins].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences20070301

Title: The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif.

Journal: Journal of the American Chemical Society20070214

Title: Warfarin-induced vasculopathy.

Journal: Journal of thrombosis and thrombolysis20070201

Title: Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.

Journal: The British journal of nutrition20070201

Title: Full-length cDNA cloning and protein three-dimensional structure modeling of porcine prothrombin.

Journal: Blood cells, molecules & diseases20070101

Title: A distinct epigenetic signature at targets of a leukemia protein.

Journal: BMC genomics20070101

Title: The vascular biology of calcification.

Journal: Seminars in dialysis20070101

Title: Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection.

Journal: Oligonucleotides20070101

Title: Growth arrest-specific protein 6 (GAS6) and the protein C pathway.

Journal: Critical care (London, England)20070101

Title: Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.

Journal: BMC cancer20070101

Title: Role of vitamin K on biochemical markers, bone mineral density, and fracture risk.

Journal: Journal of endocrinological investigation20070101

Title: Single nucleotide polymorphisms in bone turnover-related genes in Koreans: ethnic differences in linkage disequilibrium and haplotype.

Journal: BMC medical genetics20070101

Title: BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.

Journal: Molecular cancer20070101

Title: The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability?

Journal: Clinical & developmental immunology20070101

Title: From gamma-carboxy-glutamate to protein C.

Journal: Journal of thrombosis and haemostasis : JTH20061201

Title: Molecular dynamics calculations of wild type vs. mutant protein C: relationship between binding affinity to endothelial cell protein C receptor and hereditary disease.

Journal: Journal of biomolecular structure & dynamics20061201

Title: Vascular calcification: pathobiological mechanisms and clinical implications.

Journal: Circulation research20061110

Title: Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis.

Journal: Rheumatology (Oxford, England)20061101

Title: A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide.

Journal: Biochemistry20061024

Title: Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid.

Journal: The Journal of organic chemistry20060915

Title: [Protective effects of vitamin K against osteoporosis and its pleiotropic actions].

Journal: Clinical calcium20060901

Title: High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.

Journal: The Journal of biological chemistry20060825

Title: The first gamma-carboxyglutamate-containing neuropeptide.

Journal: Neurochemistry international20060801

Title: Isoelectric points and post-translational modifications of connexin26 and connexin32.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20060601

Title: Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile.

Journal: The FEBS journal20060601

Title: Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery.

Journal: Toxicon : official journal of the International Society on Toxinology20060501

Title: Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat.

Journal: Bioscience, biotechnology, and biochemistry20060401

Title: Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure.

Journal: BMC genomics20060101

Title: Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues.

Journal: Urology20060101

Title: Osteocalcin and bone-specific alkaline phosphatase in sickle cell haemoglobinopathies.

Journal: Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria20060101

Title: Sequential coagulation factor VIIa domain binding to tissue factor.

Journal: Biochemical and biophysical research communications20051202

Title: The role of gamma-carboxylation in the anti-apoptotic function of gas6.

Journal: Journal of thrombosis and haemostasis : JTH20051201

Title: Protein C Sapporo (protein C Glu 25 --> Lys): a heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor.

Journal: Thrombosis and haemostasis20051101

Title: Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice.

Journal: Molecules and cells20051031

Title: Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties.

Journal: Biochemistry20050920

Title: Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro.

Journal: Journal of periodontology20050901

Title: Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.

Journal: Arteriosclerosis, thrombosis, and vascular biology20050801

Title: Vitamin K in the treatment and prevention of osteoporosis and arterial calcification.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20050801

Title: Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates.

Journal: The Journal of biological chemistry20050722

Title: Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation.

Journal: Biochemistry20050628

Title: Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone.

Journal: Bone20050601

Title: Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico.

Journal: Human biology20050601

Title: [Molecular mechanisms of vitamin K action in the bone homeostasis].

Journal: Clinical calcium20050501

Title: Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system.

Journal: The Journal of biological chemistry20050318

Title: Rapid fabrication of keratin-hydroxyapatite hybrid sponges toward osteoblast cultivation and differentiation.

Journal: Biomaterials20050101

Title: The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

Journal: Blood20050101

Title: Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus.

Journal: The Journal of urology20050101

Title: Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii.

Journal: Peptides20050101

Title: Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.

Journal: Cardiovascular diabetology20050101

Title: Osteo-Promoter Database (OPD) -- promoter analysis in skeletal cells.

Journal: BMC genomics20050101

Title: Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension.

Journal: Respiratory research20050101

Title: Structure-function relationships of C-type lectin-related proteins.

Journal: Pathophysiology of haemostasis and thrombosis20050101

Title: Chemical modification of cysteine residues is a misleading indicator of their status as active site residues in the vitamin K-dependent gamma-glutamyl carboxylation reaction.

Journal: The Journal of biological chemistry20041224

Title: Conantokins: peptide antagonists of NMDA receptors.

Journal: Current medicinal chemistry20041201

Title: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is alpha-D-Gal-(1-->3)-alpha-D-GalNAc.

Journal: European journal of biochemistry20041201

Title: Oral anticoagulant treatment: friend or foe in cardiovascular disease?

Journal: Blood20041115

Title: Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.

Journal: The Journal of biological chemistry20041105

Title: A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide.

Journal: Biochemistry20041019

Title: Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin.

Journal: The Journal of biological chemistry20041008

Title: [Serum osteoprotegrin and serum bone gamma-carboxyglutamine acid-containing protein are correlated with bone mineral density in normal women].

Journal: Zhonghua yi xue za zhi20041002

Title: Multiple 6-bromotryptophan residues in a sleep-inducing peptide.

Journal: Biochemistry20040928

Title: The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.

Journal: The Journal of biological chemistry20040730

Title: The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M.

Journal: The Journal of biological chemistry20040730

Title: Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern.

Journal: Biochemical and biophysical research communications20040709

Title: Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.

Journal: Biochemical and biophysical research communications20040702

Title: Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin.

Journal: Journal of thrombosis and haemostasis : JTH20040701

Title: Matrix GLA protein modulates branching morphogenesis in fetal rat lung.

Journal: American journal of physiology. Lung cellular and molecular physiology20040601

Title: Platelet factor 4 modulation of the thrombomodulin-protein C system.

Journal: Critical care medicine20040501

Title: Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry.

Journal: Journal of mass spectrometry : JMS20040501

Title: Kinetics of factor Xa inhibition by recombinant tick anticoagulant peptide: both active site and exosite interactions are required for a slow- and tight-binding inhibition mechanism.

Journal: Biochemistry20040330

Title: Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels.

Journal: Bone20040301

Title: Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product.

Journal: The Journal of biological chemistry20040220

Title: A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.

Journal: Journal of molecular biology20040220

Title: [Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis].

Journal: Zhonghua yi xue za zhi20040217

Title: Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study.

Journal: Thrombosis and haemostasis20040201

Title: Use of snake venom inhibitors in studies of the function and tertiary structure of coagulation factors.

Journal: International journal of hematology20040201

Title: Effects of vitamin K2 on osteoporosis.

Journal: Current pharmaceutical design20040101

Title: The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis.

Journal: Proteins20031115

Title: Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Journal: The Journal of biological chemistry20031114

Title: [Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children].

Journal: Wei sheng yan jiu = Journal of hygiene research20031101

Title: Vitamin K and bone health.

Journal: The Proceedings of the Nutrition Society20031101

Title: Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

Journal: Biochemical and biophysical research communications20031017

Title: Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung.

Journal: American journal of physiology. Lung cellular and molecular physiology20030901

Title: Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.

Journal: Nature structural biology20030901

Title: The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.

Journal: The Journal of biological chemistry20030815

Title: The extended interactions and Gla domain of blood coagulation factor Xa.

Journal: Biochemistry20030708

Title: Intracrystalline proteins and urolithiasis: a synchrotron X-ray diffraction study of calcium oxalate monohydrate.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research20030701

Title: Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein.

Journal: The Journal of biological chemistry20030627

Title: Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein.

Journal: British journal of cancer20030616

Title: Direct binding properties of conantokins to native N-methyl-d-aspartate receptors.

Journal: The journal of peptide research : official journal of the American Peptide Society20030601

Title: Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains.

Journal: Biochimica et biophysica acta20030530

Title: Role of the Gla and first epidermal growth factor-like domains of factor X in the prothrombinase and tissue factor-factor VIIa complexes.

Journal: The Journal of biological chemistry20030321

Title: Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding.

Journal: Blood20030315

Title: The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa.

Journal: The Journal of biological chemistry20030307

Title: Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site.

Journal: The Journal of biological chemistry20030307

Title: Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity.

Journal: Blood20030215

Title: Cloning and expression of rat coagulation factor VII.

Journal: Thrombosis research20030215

Title: Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence.

Journal: The Journal of biological chemistry20030131

Title: Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi.

Journal: Journal of thrombosis and haemostasis : JTH20030101

Title: Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile.

Journal: European journal of biochemistry20021201

Title: Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.

Journal: The Journal of biological chemistry20021108

Title: Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C Gla domain mutation, Arg15Trp.

Journal: Journal of pediatric hematology/oncology20021101

Title: Gas6 binding to photoreceptor outer segments requires gamma-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro.

Journal: Experimental eye research20021001

Title: Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells.

Journal: Journal of immunology (Baltimore, Md. : 1950)20020901

Title: High-performance liquid chromatography--mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin. Determination of gamma-carboxyglutamic acid residues.

Journal: Journal of chromatography. A20020712

Title: Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.

Journal: Blood20020701

Title: Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats.

Journal: Journal of hypertension20020701

Title: Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin.

Journal: The Biochemical journal20020515

Title: gamma-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin.

Journal: Biochimica et biophysica acta20020424

Title: Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for gamma-carboxyglutamic acid.

Journal: Toxicon : official journal of the International Society on Toxinology20020401

Title: Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity.

Journal: Clinical science (London, England : 1979)20020401

Title: Structure and dynamics of zymogen human blood coagulation factor X.

Journal: Biophysical journal20020301

Title: A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding.

Journal: Arteriosclerosis, thrombosis, and vascular biology20020301

Title: Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats.

Journal: The Journal of biological chemistry20020208

Title: Localization of phosphatidylserine binding sites to structural domains of factor Xa.

Journal: The Journal of biological chemistry20020118

Title: Ca2+ binding to proteins containing gamma-carboxyglutamic acid residues.

Journal: Methods in molecular biology (Clifton, N.J.)20020101

Title: Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the 'mechanostat' theory.

Journal: Journal of bone and mineral metabolism20020101

Title: Identification of extrinsic blood coagulation pathway inhibitors from the tick Ornithodoros savignyi (Acari: Argasidae).

Journal: Experimental parasitology20020101

Title: Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain.

Journal: The Biochemical journal20011201

Title: Fourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcin.

Journal: Calcified tissue international20011201

Title: A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase.

Journal: Biochemistry20011002

Title: Matrix gamma-carboxyglutamic acid protein is a key regulator of PTH-mediated inhibition of mineralization in MC3T3-E1 osteoblast-like cells.

Journal: Endocrinology20011001

Title: Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites.

Journal: Biophysical journal20011001

Title: An anti-EGF monoclonal antibody that detects intramolecular communication in factor IX.

Journal: Biochemical and biophysical research communications20010907

Title: Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B.

Journal: Blood20010901

Title: Structure-function relationships of the NMDA receptor antagonist conantokin peptides.

Journal: Current drug targets20010901

Title: A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.

Journal: The Journal of biological chemistry20010831

Title: A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi.

Journal: Clinical science (London, England : 1979)20010801

Title: Expression and localization of MGP in rat tooth cementum.

Journal: Archives of oral biology20010701

Title: The omega-loop region of the human prothrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes.

Journal: The Journal of biological chemistry20010629

Title: Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain.

Journal: The journal of peptide research : official journal of the American Peptide Society20010601

Title: Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B.

Journal: Thrombosis research20010515

Title: Synthesis of gamma-carboxylated polypeptides by alpha-cells of the pancreatic islets.

Journal: Biochemical and biophysical research communications20010504

Title: Amino acid determinants for NMDA receptor inhibition by conantokin-T.

Journal: Journal of neurochemistry20010501

Title: Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy.

Journal: Obstetrics and gynecology20010501

Title: Total chemical synthesis of human matrix Gla protein.

Journal: Protein science : a publication of the Protein Society20010401

Title: On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila.

Journal: The Journal of biological chemistry20010316

Title: Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.

Journal: The Journal of biological chemistry20010309

Title: Posttranslational modifications of recombinant myotube-synthesized human factor IX.

Journal: Blood20010101

Title: Novel vitamin K-dependent pathways regulating cell survival.

Journal: Apoptosis : an international journal on programmed cell death20010101

Title: 1,25-Dihydroxyvitamin D3 promotes vitamin K2 metabolism in human osteoblasts.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA20010101

Title: Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage.

Journal: Arthritis research20010101

Title: Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.

Journal: Neuropharmacology19980801

Title: Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.

Journal: Proceedings of the National Academy of Sciences of the United States of America19970819

Title: Carboxyl-terminal proteolytic processing of matrix Gla protein.

Journal: The Journal of biological chemistry19911105

Title: Synthesis of a gamma-carboxyglutamic acid containing heptapeptide corresponding to bovine prothrombin residues 17-23.

Journal: International journal of peptide and protein research19861201

Title: Gamma-carboxyglutamate in a neuroactive toxin.

Journal: The Journal of biological chemistry19841210

Title: Vitamin K dependent carboxylation: synthesis and biological properties of tetrazolyl analogues of pentapeptidic substrates.

Journal: Journal of medicinal chemistry19840901

Title: Vitamin K dependent carboxylation of glutamate residues to gamma-carboxyglutamate in microsomes from spleen and testes: comparison with liver, lung, and kidney.

Journal: Biochemistry19830301

Title: Vitamin K-dependent carboxylase: synthesis of an inhibitor of the glutamyl binding site.

Journal: FEBS letters19830207

Title: Mechanism of action of vitamin K: synthesis of gamma-carboxyglutamic acid.

Journal: CRC critical reviews in biochemistry19800101

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