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Title: Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats.
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Title: Enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs.
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Title: Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.
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Title: Osteocalcin is a stress-responsive neuropeptide.
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Title: The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.
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Title: Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change.
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Title: Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation.
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Title: Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model.
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Title: Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes.
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Title: Characterization of conantokin Rl-A: molecular phylogeny as structure/function study.
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Title: Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.
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Title: An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase.
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Title: Carbonic anhydrase I is recognized by an SOD1 antibody upon biotinylation of human spinal cord extracts.
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Title: Use of a bacterially expressed human factor IX light chain to develop polyclonal antibody anti-hFIX.
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Title: Vitamin K in parenteral nutrition.
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Title: Metal-binding affinity and selectivity of nonstandard natural amino acid residues from DFT/CDM calculations.
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Title: Direct analysis reveals an absence of gamma-carboxyglutamic acid in cancer procoagulant from human tissues.
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Title: Phylogenetic analysis of ALAD and MGP genes related to lead toxicity.
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Title: Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex.
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Title: Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues.
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Title: The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix.
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Title: Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion.
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Title: Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea.
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Title: Polymorphisms in MGP gene and their association with lead toxicity.
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Title: Platelet factor 4 impairs the anticoagulant activity of activated protein C.
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Title: Vitamin K, an update for the paediatrician.
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Title: Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.
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Title: Regulation of pituitary gene expression by adrenalectomy.
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Title: Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay.
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Title: BMP-13 emerges as a potential inhibitor of bone formation.
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Title: Characterization of porcine factor VII, X and comparison with human factor VII, X.
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Title: Characterization of granulations of calcium and apatite in serum as pleomorphic mineralo-protein complexes and as precursors of putative nanobacteria.
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Title: Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis.
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Title: Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma.
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Title: Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse.
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Title: Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies.
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Title: Endothelial cells influence the osteogenic potential of bone marrow stromal cells.
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Title: Fetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding concept.
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Title: Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates.
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Title: The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study.
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Title: Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine.
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Title: Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
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Title: Noninvasive markers of oxidative DNA stress, RNA degradation and protein degradation are differentially correlated with resting metabolic rate and energy intake in children and adolescents.
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Title: Conantokin-P, an unusual conantokin with a long disulfide loop.
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Title: Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z.
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Title: Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins.
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Title: Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells.
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Title: Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.
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Title: Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4.
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Title: Vitamin K intake and atherosclerosis.
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Title: Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks.
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Title: Vascular calcification and uremia: what do we know?
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Title: Molecular characterization of spontaneous mesenchymal stem cell transformation.
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Title: Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.
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Title: Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification.
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Title: gamma-Glutamate and beta-hydroxyaspartate in proteins.
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Title: The vitamin K cycle.
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Title: Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification.
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Title: Vitamin K and bone health in adult humans.
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Title: The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.
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Title: Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women.
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Title: Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53.
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Title: Production of metal ion-dependent monoclonal antibodies against peptides in bovine prothrombin fragment 1.
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Title: Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism.
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Title: Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.
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Title: The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.
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Title: Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification.
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Title: Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of (111)in-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney.
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Title: [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function].
Journal: Clinical calcium 20071101
Title: Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways.
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Title: Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients.
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Title: [Gas-6 and protein S: vitamin K-dependent factors and ligands for the TAM tyrosine kinase receptors family].
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Title: Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.
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Title: Quantum chemical study of the mechanism of action of vitamin K carboxylase (VKC). IV. Intermediates and transition states.
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Title: Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X.
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Title: Vitamin K: the coagulation vitamin that became omnipotent.
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Title: Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
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Title: A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8.
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Title: Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats.
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Title: Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX.
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Title: Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane.
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Title: Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.
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Title: Hydroxyapatite surface-induced peptide folding.
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Title: Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist.
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Title: Association of warfarin dose with genes involved in its action and metabolism.
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Title: [Advances in study of structures and functions of conantokins].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301
Title: The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif.
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Title: Warfarin-induced vasculopathy.
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Title: Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.
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Title: Full-length cDNA cloning and protein three-dimensional structure modeling of porcine prothrombin.
Journal: Blood cells, molecules & diseases 20070101
Title: A distinct epigenetic signature at targets of a leukemia protein.
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Title: The vascular biology of calcification.
Journal: Seminars in dialysis 20070101
Title: Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection.
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Title: Growth arrest-specific protein 6 (GAS6) and the protein C pathway.
Journal: Critical care (London, England) 20070101
Title: Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.
Journal: BMC cancer 20070101
Title: Role of vitamin K on biochemical markers, bone mineral density, and fracture risk.
Journal: Journal of endocrinological investigation 20070101
Title: Single nucleotide polymorphisms in bone turnover-related genes in Koreans: ethnic differences in linkage disequilibrium and haplotype.
Journal: BMC medical genetics 20070101
Title: BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Journal: Molecular cancer 20070101
Title: The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability?
Journal: Clinical & developmental immunology 20070101
Title: From gamma-carboxy-glutamate to protein C.
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Title: Molecular dynamics calculations of wild type vs. mutant protein C: relationship between binding affinity to endothelial cell protein C receptor and hereditary disease.
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Title: Vascular calcification: pathobiological mechanisms and clinical implications.
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Title: Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis.
Journal: Rheumatology (Oxford, England) 20061101
Title: A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide.
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Title: Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid.
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Title: [Protective effects of vitamin K against osteoporosis and its pleiotropic actions].
Journal: Clinical calcium 20060901
Title: High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.
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Title: The first gamma-carboxyglutamate-containing neuropeptide.
Journal: Neurochemistry international 20060801
Title: Isoelectric points and post-translational modifications of connexin26 and connexin32.
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Title: Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile.
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Title: Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery.
Journal: Toxicon : official journal of the International Society on Toxinology 20060501
Title: Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat.
Journal: Bioscience, biotechnology, and biochemistry 20060401
Title: Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure.
Journal: BMC genomics 20060101
Title: Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues.
Journal: Urology 20060101
Title: Osteocalcin and bone-specific alkaline phosphatase in sickle cell haemoglobinopathies.
Journal: Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20060101
Title: Sequential coagulation factor VIIa domain binding to tissue factor.
Journal: Biochemical and biophysical research communications 20051202
Title: The role of gamma-carboxylation in the anti-apoptotic function of gas6.
Journal: Journal of thrombosis and haemostasis : JTH 20051201
Title: Protein C Sapporo (protein C Glu 25 --> Lys): a heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor.
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Title: Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice.
Journal: Molecules and cells 20051031
Title: Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties.
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Title: Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro.
Journal: Journal of periodontology 20050901
Title: Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20050801
Title: Vitamin K in the treatment and prevention of osteoporosis and arterial calcification.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050801
Title: Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates.
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Title: Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation.
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Title: Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone.
Journal: Bone 20050601
Title: Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico.
Journal: Human biology 20050601
Title: [Molecular mechanisms of vitamin K action in the bone homeostasis].
Journal: Clinical calcium 20050501
Title: Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system.
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Title: Rapid fabrication of keratin-hydroxyapatite hybrid sponges toward osteoblast cultivation and differentiation.
Journal: Biomaterials 20050101
Title: The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.
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Title: Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus.
Journal: The Journal of urology 20050101
Title: Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii.
Journal: Peptides 20050101
Title: Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.
Journal: Cardiovascular diabetology 20050101
Title: Osteo-Promoter Database (OPD) -- promoter analysis in skeletal cells.
Journal: BMC genomics 20050101
Title: Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension.
Journal: Respiratory research 20050101
Title: Structure-function relationships of C-type lectin-related proteins.
Journal: Pathophysiology of haemostasis and thrombosis 20050101
Title: Chemical modification of cysteine residues is a misleading indicator of their status as active site residues in the vitamin K-dependent gamma-glutamyl carboxylation reaction.
Journal: The Journal of biological chemistry 20041224
Title: Conantokins: peptide antagonists of NMDA receptors.
Journal: Current medicinal chemistry 20041201
Title: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is alpha-D-Gal-(1-->3)-alpha-D-GalNAc.
Journal: European journal of biochemistry 20041201
Title: Oral anticoagulant treatment: friend or foe in cardiovascular disease?
Journal: Blood 20041115
Title: Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.
Journal: The Journal of biological chemistry 20041105
Title: A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide.
Journal: Biochemistry 20041019
Title: Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin.
Journal: The Journal of biological chemistry 20041008
Title: [Serum osteoprotegrin and serum bone gamma-carboxyglutamine acid-containing protein are correlated with bone mineral density in normal women].
Journal: Zhonghua yi xue za zhi 20041002
Title: Multiple 6-bromotryptophan residues in a sleep-inducing peptide.
Journal: Biochemistry 20040928
Title: The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.
Journal: The Journal of biological chemistry 20040730
Title: The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M.
Journal: The Journal of biological chemistry 20040730
Title: Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern.
Journal: Biochemical and biophysical research communications 20040709
Title: Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.
Journal: Biochemical and biophysical research communications 20040702
Title: Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin.
Journal: Journal of thrombosis and haemostasis : JTH 20040701
Title: Matrix GLA protein modulates branching morphogenesis in fetal rat lung.
Journal: American journal of physiology. Lung cellular and molecular physiology 20040601
Title: Platelet factor 4 modulation of the thrombomodulin-protein C system.
Journal: Critical care medicine 20040501
Title: Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry.
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Title: Kinetics of factor Xa inhibition by recombinant tick anticoagulant peptide: both active site and exosite interactions are required for a slow- and tight-binding inhibition mechanism.
Journal: Biochemistry 20040330
Title: Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels.
Journal: Bone 20040301
Title: Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product.
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Title: A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.
Journal: Journal of molecular biology 20040220
Title: [Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis].
Journal: Zhonghua yi xue za zhi 20040217
Title: Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study.
Journal: Thrombosis and haemostasis 20040201
Title: Use of snake venom inhibitors in studies of the function and tertiary structure of coagulation factors.
Journal: International journal of hematology 20040201
Title: Effects of vitamin K2 on osteoporosis.
Journal: Current pharmaceutical design 20040101
Title: The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis.
Journal: Proteins 20031115
Title: Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Journal: The Journal of biological chemistry 20031114
Title: [Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children].
Journal: Wei sheng yan jiu = Journal of hygiene research 20031101
Title: Vitamin K and bone health.
Journal: The Proceedings of the Nutrition Society 20031101
Title: Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
Journal: Biochemical and biophysical research communications 20031017
Title: Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung.
Journal: American journal of physiology. Lung cellular and molecular physiology 20030901
Title: Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Journal: Nature structural biology 20030901
Title: The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.
Journal: The Journal of biological chemistry 20030815
Title: The extended interactions and Gla domain of blood coagulation factor Xa.
Journal: Biochemistry 20030708
Title: Intracrystalline proteins and urolithiasis: a synchrotron X-ray diffraction study of calcium oxalate monohydrate.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030701
Title: Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein.
Journal: The Journal of biological chemistry 20030627
Title: Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein.
Journal: British journal of cancer 20030616
Title: Direct binding properties of conantokins to native N-methyl-d-aspartate receptors.
Journal: The journal of peptide research : official journal of the American Peptide Society 20030601
Title: Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains.
Journal: Biochimica et biophysica acta 20030530
Title: Role of the Gla and first epidermal growth factor-like domains of factor X in the prothrombinase and tissue factor-factor VIIa complexes.
Journal: The Journal of biological chemistry 20030321
Title: Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding.
Journal: Blood 20030315
Title: The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa.
Journal: The Journal of biological chemistry 20030307
Title: Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site.
Journal: The Journal of biological chemistry 20030307
Title: Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity.
Journal: Blood 20030215
Title: Cloning and expression of rat coagulation factor VII.
Journal: Thrombosis research 20030215
Title: Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence.
Journal: The Journal of biological chemistry 20030131
Title: Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi.
Journal: Journal of thrombosis and haemostasis : JTH 20030101
Title: Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile.
Journal: European journal of biochemistry 20021201
Title: Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.
Journal: The Journal of biological chemistry 20021108
Title: Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C Gla domain mutation, Arg15Trp.
Journal: Journal of pediatric hematology/oncology 20021101
Title: Gas6 binding to photoreceptor outer segments requires gamma-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro.
Journal: Experimental eye research 20021001
Title: Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20020901
Title: High-performance liquid chromatography--mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin. Determination of gamma-carboxyglutamic acid residues.
Journal: Journal of chromatography. A 20020712
Title: Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.
Journal: Blood 20020701
Title: Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats.
Journal: Journal of hypertension 20020701
Title: Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin.
Journal: The Biochemical journal 20020515
Title: gamma-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin.
Journal: Biochimica et biophysica acta 20020424
Title: Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for gamma-carboxyglutamic acid.
Journal: Toxicon : official journal of the International Society on Toxinology 20020401
Title: Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity.
Journal: Clinical science (London, England : 1979) 20020401
Title: Structure and dynamics of zymogen human blood coagulation factor X.
Journal: Biophysical journal 20020301
Title: A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20020301
Title: Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats.
Journal: The Journal of biological chemistry 20020208
Title: Localization of phosphatidylserine binding sites to structural domains of factor Xa.
Journal: The Journal of biological chemistry 20020118
Title: Ca2+ binding to proteins containing gamma-carboxyglutamic acid residues.
Journal: Methods in molecular biology (Clifton, N.J.) 20020101
Title: Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the 'mechanostat' theory.
Journal: Journal of bone and mineral metabolism 20020101
Title: Identification of extrinsic blood coagulation pathway inhibitors from the tick Ornithodoros savignyi (Acari: Argasidae).
Journal: Experimental parasitology 20020101
Title: Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain.
Journal: The Biochemical journal 20011201
Title: Fourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcin.
Journal: Calcified tissue international 20011201
Title: A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase.
Journal: Biochemistry 20011002
Title: Matrix gamma-carboxyglutamic acid protein is a key regulator of PTH-mediated inhibition of mineralization in MC3T3-E1 osteoblast-like cells.
Journal: Endocrinology 20011001
Title: Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites.
Journal: Biophysical journal 20011001
Title: An anti-EGF monoclonal antibody that detects intramolecular communication in factor IX.
Journal: Biochemical and biophysical research communications 20010907
Title: Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B.
Journal: Blood 20010901
Title: Structure-function relationships of the NMDA receptor antagonist conantokin peptides.
Journal: Current drug targets 20010901
Title: A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.
Journal: The Journal of biological chemistry 20010831
Title: A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi.
Journal: Clinical science (London, England : 1979) 20010801
Title: Expression and localization of MGP in rat tooth cementum.
Journal: Archives of oral biology 20010701
Title: The omega-loop region of the human prothrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes.
Journal: The Journal of biological chemistry 20010629
Title: Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain.
Journal: The journal of peptide research : official journal of the American Peptide Society 20010601
Title: Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B.
Journal: Thrombosis research 20010515
Title: Synthesis of gamma-carboxylated polypeptides by alpha-cells of the pancreatic islets.
Journal: Biochemical and biophysical research communications 20010504
Title: Amino acid determinants for NMDA receptor inhibition by conantokin-T.
Journal: Journal of neurochemistry 20010501
Title: Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy.
Journal: Obstetrics and gynecology 20010501
Title: Total chemical synthesis of human matrix Gla protein.
Journal: Protein science : a publication of the Protein Society 20010401
Title: On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila.
Journal: The Journal of biological chemistry 20010316
Title: Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.
Journal: The Journal of biological chemistry 20010309
Title: Posttranslational modifications of recombinant myotube-synthesized human factor IX.
Journal: Blood 20010101
Title: Novel vitamin K-dependent pathways regulating cell survival.
Journal: Apoptosis : an international journal on programmed cell death 20010101
Title: 1,25-Dihydroxyvitamin D3 promotes vitamin K2 metabolism in human osteoblasts.
Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20010101
Title: Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage.
Journal: Arthritis research 20010101
Title: Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Journal: Neuropharmacology 19980801
Title: Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19970819
Title: Carboxyl-terminal proteolytic processing of matrix Gla protein.
Journal: The Journal of biological chemistry 19911105
Title: Synthesis of a gamma-carboxyglutamic acid containing heptapeptide corresponding to bovine prothrombin residues 17-23.
Journal: International journal of peptide and protein research 19861201
Title: Gamma-carboxyglutamate in a neuroactive toxin.
Journal: The Journal of biological chemistry 19841210
Title: Vitamin K dependent carboxylation: synthesis and biological properties of tetrazolyl analogues of pentapeptidic substrates.
Journal: Journal of medicinal chemistry 19840901
Title: Vitamin K dependent carboxylation of glutamate residues to gamma-carboxyglutamate in microsomes from spleen and testes: comparison with liver, lung, and kidney.
Journal: Biochemistry 19830301
Title: Vitamin K-dependent carboxylase: synthesis of an inhibitor of the glutamyl binding site.
Journal: FEBS letters 19830207
Title: Mechanism of action of vitamin K: synthesis of gamma-carboxyglutamic acid.
Journal: CRC critical reviews in biochemistry 19800101