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515-13-9,MFCD00468041
Catalog No.:AA00DBZ0

515-13-9 | BETA-ELEMENE

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10mg
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$62.00   $43.00
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25mg
≥95%
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$136.00   $95.00
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50mg
≥95%
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$239.00   $167.00
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250mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DBZ0
Chemical Name:
BETA-ELEMENE
CAS Number:
515-13-9
Molecular Formula:
C15H24
Molecular Weight:
204.3511
MDL Number:
MFCD00468041
SMILES:
C=C[C@]1(C)CC[C@H](C[C@H]1C(=C)C)C(=C)C
Properties
Computed Properties
 
Complexity:
284  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
15  
Rotatable Bond Count:
3  
XLogP3:
6.1  

Downstream Synthesis Route
14814-09-6    515-13-9   
C42H90O9S3Si3 

[1]Patent:JP2016/65017,2016,A.Locationinpatent:Paragraph0057;0058

Literature

Title: Systematic review of β-elemene injection as adjunctive treatment for lung cancer.

Journal: Chinese journal of integrative medicine 20121101

Title: β-elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cells.

Journal: Anticancer research 20120801

Title: Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils.

Journal: Journal of food science 20120801

Title: Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line.

Journal: Molecular medicine reports 20120701

Title: Β-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.

Journal: Journal of neuro-oncology 20120401

Title: Down-regulation of survivin and hypoxia-inducible factor-1 α by β-elemene enhances the radiosensitivity of lung adenocarcinoma xenograft.

Journal: Cancer biotherapy & radiopharmaceuticals 20120201

Title: β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells.

Journal: The Journal of pharmacy and pharmacology 20120101

Title: Reversion of multidrug resistance in a chemoresistant human breast cancer cell line by β-elemene.

Journal: Pharmacology 20120101

Title: β-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways.

Journal: Asian Pacific journal of cancer prevention : APJCP 20120101

Title: β-elemene inhibits proliferation of human glioblastoma cells through the activation of glia maturation factor β and induces sensitization to cisplatin.

Journal: Oncology reports 20110801

Title: Preparation and characterization of β-elemene-loaded microemulsion.

Journal: Drug development and industrial pharmacy 20110701

Title: β-Elemene radiosensitizes lung cancer A549 cells by enhancing DNA damage and inhibiting DNA repair.

Journal: Phytotherapy research : PTR 20110701

Title: Protection of endothelial cells, inhibition of neointimal hyperplasia by β-elemene in an injured artery.

Journal: Cardiovascular drugs and therapy 20110601

Title: [Analysis of content changes of volatile oil and beta-elemene in oil in Sarcandrae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

Title: Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance.

Journal: Journal of molecular neuroscience : MN 20110501

Title: Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis.

Journal: Cancer chemotherapy and pharmacology 20110401

Title: Composition of the essential oil of Bidens tripartita L. roots and its antibacterial and antifungal activities.

Journal: Journal of medicinal food 20110401

Title: [GC-MS analysis of volatile oil of olibanum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401

Title: Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis.

Journal: Frontiers of medicine 20110301

Title: Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone.

Journal: Organic & biomolecular chemistry 20110221

Title: ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6.

Journal: International journal of oncology 20110201

Title: Chemical composition and antimicrobial activity of the essential oils of Anthospermum emirnense and Anthospermum perrieri (Rubiaceae).

Journal: Chemistry & biodiversity 20110101

Title: β-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS.

Journal: PloS one 20110101

Title: Essential oil composition of Vismia macrophylla leaves (Guttiferae).

Journal: Natural product communications 20110101

Title: β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis.

Journal: BMC cancer 20110101

Title: Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells.

Journal: Molecular medicine reports 20110101

Title: Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells.

Journal: Molecular medicine reports 20110101

Title: Applications of nanoparticles in herbal medicine: zedoary turmeric oil and its active compound β-elemene.

Journal: The American journal of Chinese medicine 20110101

Title: [Comparison of content of curdione, curcumol, germacrone and beta-elemene in different varieties of vinegar backed Rhizoma Curcuma].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

Title: Evaluation of cisplatin in combination with β-elemene as a regimen for prostate cancer chemotherapy.

Journal: Basic & clinical pharmacology & toxicology 20101101

Title: Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells.

Journal: The Journal of pharmacy and pharmacology 20100801

Title: Downregulation of IL-17 and IFN-gamma in the optic nerve by beta-elemene in experimental autoimmune encephalomyelitis.

Journal: International immunopharmacology 20100701

Title: [Mechanism study of beta-elemene derivative (ET) in NB4 cell on apoptosis induction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100501

Title: [Effects of beta-elemene on proliferation and apoptosis of human multiple myeloma cell RPMI-8226].

Journal: Zhongguo shi yan xue ye xue za zhi 20100401

Title: Radioactive synthesis and biodistribution study of beta-elemene-99mTc(CO)3 conjugates.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090801

Title: beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis.

Journal: Oncology reports 20090701

Title: ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090401

Title: Validation of a sensitive gas chromatographic-mass spectrometric method for the simultaneous determination of beta-elemene and beta-elemenal in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090201

Title: Synthesis and in vitro anti-proliferative activity of beta-elemene monosubstituted derivatives in HeLa cells mediated through arrest of cell cycle at the G1 phase.

Journal: Bioorganic & medicinal chemistry 20090201

Title: Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds.

Journal: The Journal of pharmacy and pharmacology 20090201

Title: [Beta-elemene inhibits expression of ANG II and RhoA/ROCK signaling in hepatic stellate cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

Title: Anti-cancer properties of Nigella spp. essential oils and their major constituents, thymoquinone and beta-elemene.

Journal: Current clinical pharmacology 20090101

Title: [Effect of beta-elemene on the proliferation, migration and RhoA expression of hepatic stellate cells induced by angiotensin II].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20081001

Title: N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway.

Journal: Cancer letters 20080928

Title: Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation.

Journal: Cancer letters 20080608

Title: Ab initio analysis of the Cope rearrangement of germacrane sesquiterpenoids.

Journal: Journal of molecular modeling 20080501

Title: [Effect of traditional Chinese medicine on quality of life and survival period in patients with progressive gastric cancer].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080201

Title: Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme.

Journal: Nature chemical biology 20071101

Title: In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma.

Journal: International journal of oncology 20070801

Title: [Extraction and identification of volatile constituents in the flowers of Aglaia odorata Lour].

Journal: Se pu = Chinese journal of chromatography 20070501

Title: [GC-MS analysis of essential oil from anthodiums of Chrysanthemum morifolium processed by microwave-airflow and steam calefaction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070201

Title: Analysis of volatile components of Curcuma sichuanensis X. X. Chen by gas chromatography-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20070117

Title: Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line.

Journal: Zhongguo shi yan xue ye xue za zhi 20061201

Title: [Research of beta-elemene interventional treatment on VX2 carcinoma transplanted on kidney in rabbits].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20061101

Title: [Immunotherapeutic effects of beta-elemene combined with interleukin-23 gene-modified dendritic cells on murine pancreatic carcinoma].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20060901

Title: The synthesis and anti-proliferative effects of beta-elemene derivatives with mTOR inhibition activity.

Journal: Bioorganic & medicinal chemistry 20060801

Title: [Radiosensitization of beta-elemene on VX2 carcinoma transplanted on kidney in rabbits in vivo].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060701

Title: Assessing the quality of RCTs on the effect of beta-elemene, one ingredient of a Chinese herb, against malignant tumors.

Journal: Contemporary clinical trials 20060201

Title: [Study on pharmacokinetics of PVP coated beta-elemene liposome in rats].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060201

Title: The pharmacokinetics of a novel anti-tumor agent, beta-elemene, in Sprague-Dawley rats.

Journal: Biopharmaceutics & drug disposition 20051001

Title: Characterization and body distribution of beta-elemene solid lipid nanoparticles (SLN).

Journal: Drug development and industrial pharmacy 20050901

Title: Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death.

Journal: Cellular and molecular life sciences : CMLS 20050401

Title: Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase.

Journal: Cellular and molecular life sciences : CMLS 20050401

Title: [Excretion of beta-elemene from rat respiratory tracts].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050101

Title: [Effects of arsenic trioxide, ginseng saponin and beta-elemene on telomere-telomerase system in K562 cell line].

Journal: Zhongguo shi yan xue ye xue za zhi 20040601

Title: [Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by beta-elemene].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040501

Title: Effect of the essential oil from the flowers of Magnolia sieboldii on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 by rat peritoneal macrophages.

Journal: Planta medica 20020501

Title: [Constituents analysis on volatile oil of Pogostemon cablin from different collection time cultivated in Hainan].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101

Title: [beta-elemene induces apoptosis of K562 leukemia cells].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20010501

Title: [Quantum chemistry Ab initio calculation of vibration spectrum of beta-elemene].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20010401

Title: [Supercritical fluid extraction of beta-elemene under lower pressure].

Journal: Se pu = Chinese journal of chromatography 20010301

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