Home Other Building Blocks 53109-32-3
53109-32-3,MFCD00133207
Catalog No.:AA00DC7N

53109-32-3 | CYCLO(-HIS-PRO)

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Purity
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10mg
≥95%
in stock  
$116.00   $81.00
- +
25mg
≥ 98% (HPLC)
in stock  
$192.00   $134.00
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100mg
≥ 98% (HPLC)
in stock  
$369.00   $259.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DC7N
Chemical Name:
CYCLO(-HIS-PRO)
CAS Number:
53109-32-3
Molecular Formula:
C11H14N4O2
Molecular Weight:
234.2545
MDL Number:
MFCD00133207
SMILES:
O=C1N[C@@H](Cc2cnc[nH]2)C(=O)N2[C@H]1CCC2
Properties
Properties
 
BP:
659.3±48.0 °C(Predicted)  
Form:
Solid  
MP:
162-164 °C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
346  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
-0.4  

Downstream Synthesis Route

[1]Arena,Giuseppe;Impellizzeri,Giuseppe;Maccarrone,Giuseppe;Pappalardo,Giuseppe;Sciotto,Domenico;Rizzarelli,Enrico[JournaloftheChemicalSociety.PerkintransactionsII,1992,#3,p.371-376]

[1]RSCAdvances,2014,vol.4,p.37371-37374

Literature

Title: Protective effect of cyclo(his-pro) on streptozotocin-induced cytotoxicity and apoptosis in vitro.

Journal: Journal of microbiology and biotechnology 20110201

Title: Structural analysis and the effect of cyclo(His-Pro) dipeptide on neurotoxins--a dynamics and density functional theory study.

Journal: Journal of molecular modeling 20100201

Title: Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling.

Journal: Journal of neurochemistry 20091101

Title: Body weight reduction in rats by oral treatment with zinc plus cyclo-(His-Pro).

Journal: British journal of pharmacology 20090901

Title: Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence.

Journal: Journal of cellular and molecular medicine 20090601

Title: Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

Journal: PloS one 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Raw vegetable food containing high cyclo (his-pro) improved insulin sensitivity and body weight control.

Journal: Metabolism: clinical and experimental 20051101

Title: Structure-based exploration of cyclic dipeptide chitinase inhibitors.

Journal: Journal of medicinal chemistry 20041104

Title: Anti-hyperglycemic activity of zinc plus cyclo (his-pro) in genetically diabetic Goto-Kakizaki and aged rats.

Journal: Experimental biology and medicine (Maywood, N.J.) 20031201

Title: Mice lacking the thyrotropin-releasing hormone gene: what do they tell us?

Journal: Thyroid : official journal of the American Thyroid Association 20031201

Title: Effects of cyclo (his-pro) plus zinc on glucose metabolism in genetically diabetic obese mice.

Journal: Diabetes, obesity & metabolism 20030901

Title: Cyclo (His-Pro) potentiates GABA/ethanol-mediated chloride uptake by neurosynaptosomes.

Journal: Peptides 20030301

Title: Synthesis and biological activity of novel neuroprotective diketopiperazines.

Journal: Bioorganic & medicinal chemistry 20020901

Title: Effects of arachidonic acid and cyclo (his-pro) on zinc transport across small intestine and muscle tissues.

Journal: Life sciences 20011207

Title: Role of endogenous cyclo(His-Pro) in voluntary alcohol consumption by alcohol-preferring C57BL mice.

Journal: Peptides 20011201

Title: Synergistic antidiabetic activities of zinc, cyclo (his-pro), and arachidonic acid.

Journal: Metabolism: clinical and experimental 20010101

Title: Relationship between plasma cyclo (His-Pro), a neuropeptide common to processed protein-rich food, and C-peptide/insulin molar ratio in obese women.

Journal: Nutritional neuroscience 20010101

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