51529-01-2,MFCD00069278
Catalog No.:AA00DDPM

51529-01-2 | Flupenthixol dihydrochloride

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5mg
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10mg
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$180.00   $126.00
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25mg
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50mg
≥95%
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100mg
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  • Technical Information
  • Properties
  • Literature
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Technical Information
Catalog Number:
AA00DDPM
Chemical Name:
Flupenthixol dihydrochloride
CAS Number:
51529-01-2
Molecular Formula:
C23H26ClF3N2OS
Molecular Weight:
470.9785
MDL Number:
MFCD00069278
SMILES:
OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F.Cl
Properties
Properties
 
BP:
554.7°C at 760 mmHg  
Form:
Solid  
MP:
>218°C (dec.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
592  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20121101

Title: Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats.

Journal: European journal of pharmacology 20121015

Title: Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys.

Journal: Neurobiology of disease 20121001

Title: Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20121001

Title: Acute stress induces selective alterations in cost/benefit decision-making.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120901

Title: The role of dopamine in the accumbens core in the expression of Pavlovian-conditioned responses.

Journal: The European journal of neuroscience 20120801

Title: Testing the contributions of striatal dopamine loss to the genesis of parkinsonian signs.

Journal: Neurobiology of disease 20120701

Title: Evidence of significant synergism between antibiotics and the antipsychotic, antimicrobial drug flupenthixol.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120601

Title: Comment on Administration of the combination clonazepam-Deanxit as treatment for tinnitus.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20120601

Title: Flupentixol: relevance of stereoselective therapeutic drug monitoring.

Journal: Psychopharmacology 20120601

Title: Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein.

Journal: Biochemistry 20120403

Title: Seeking-taking chain schedules of cocaine and sucrose self-administration: effects of reward size, reward omission, and α-flupenthixol.

Journal: Psychopharmacology 20120401

Title: Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20120301

Title: Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120101

Title: Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120101

Title: Tardive syndrome and Parkinson's disease responsive to concomitant tetrabenazine and levodopa therapy.

Journal: Parkinsonism & related disorders 20111201

Title: RE: PBS delisting.

Journal: The Australian and New Zealand journal of psychiatry 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20111001

Title: Effectiveness and costs of flupentixol compared to other first- and second-generation antipsychotics in the treatment of schizophrenia.

Journal: Psychopharmacology 20110801

Title: Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20110701

Title: Administration of the combination clonazepam-Deanxit as treatment for tinnitus.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20110601

Title: PBS delisting.

Journal: The Australian and New Zealand journal of psychiatry 20110601

Title: Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110420

Title: Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine.

Journal: Psychopharmacology 20110401

Title: The curious case of a catatonic patient.

Journal: Schizophrenia bulletin 20110301

Title: A selective role for dopamine in stimulus-reward learning.

Journal: Nature 20110106

Title: [Antipsychotic agents in the treatment of somatoform disorders; a review].

Journal: Tijdschrift voor psychiatrie 20110101

Title: Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship.

Journal: PloS one 20110101

Title: Dopamine transmission in the amygdala modulates surprise in an aversive blocking paradigm.

Journal: Behavioral neuroscience 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Comparative study on abdominal acupuncture and western medicine for treatment of menopause depressive disorder].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20101101

Title: External incentives and internal states guide goal-directed behavior via the differential recruitment of the nucleus accumbens and the medial prefrontal cortex.

Journal: Neuroscience 20101013

Title: Dopamine enhances locomotor activity for mating in male honeybees (Apis mellifera L.).

Journal: Journal of insect physiology 20100901

Title: Differential effects of dopaminergic manipulations on risky choice.

Journal: Psychopharmacology 20100801

Title: [Study on catgut implantation therapy compared with Deanxit for treatment of depression].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20100801

Title: Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects.

Journal: The European journal of neuroscience 20100701

Title: The effects of single dose anxiolytic medication on the CO2 models of anxiety: differentiation of subjective and objective measures.

Journal: Journal of psychopharmacology (Oxford, England) 20100501

Title: The role of solvents in the signal separation for quantitative (1)H NMR spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20100501

Title: Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100301

Title: Effects of disconnection of amygdala dopamine and nucleus accumbens N-methyl-d-aspartate receptors on ethanol-seeking behavior in mice.

Journal: The European journal of neuroscience 20100101

Title: A case of schizophrenia with dysphagia successfully treated by a multidimensional approach.

Journal: General hospital psychiatry 20100101

Title: Flupenthixol-induced tardive dystonia presenting as severe dysphagia.

Journal: Neurology India 20100101

Title: Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

Journal: Behavioral neuroscience 20091001

Title: Long-term treatment with flupentixol results of a post-marketing surveillance study.

Journal: Journal of psychopharmacology (Oxford, England) 20090901

Title: Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.

Journal: Science (New York, N.Y.) 20090626

Title: Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090601

Title: Contribution of dopamine receptors to periaqueductal gray-mediated antinociception.

Journal: Psychopharmacology 20090601

Title: A role for medial prefrontal dopaminergic innervation in instrumental conditioning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090520

Title: Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090501

Title: Functional interaction between the basolateral amygdala and the nucleus accumbens underlies incentive motivation for food reward on a fixed ratio schedule.

Journal: Neuroscience 20090410

Title: Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state, and behavioral paradigms.

Journal: Psychopharmacology 20090401

Title: Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090301

Title: Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects.

Journal: Neuropharmacology 20090301

Title: Involvement of Basal Ganglia network in motor disabilities induced by typical antipsychotics.

Journal: PloS one 20090101

Title: Behavioral responses of dopamine beta-hydroxylase knockout mice to modafinil suggest a dual noradrenergic-dopaminergic mechanism of action.

Journal: Pharmacology, biochemistry, and behavior 20081201

Title: Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity.

Journal: Psychopharmacology 20081201

Title: Distinct contributions of dopamine receptors in the nucleus accumbens core or shell to established cocaine reinforcement under a second-order schedule.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081201

Title: Dopaminergic and glutamatergic regulation of effort- and delay-based decision making.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080701

Title: Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia.

Journal: Alimentary pharmacology & therapeutics 20080601

Title: Bidirectional cannabinoid modulation of social behavior in adolescent rats.

Journal: Psychopharmacology 20080401

Title: Neurochemical basis of conditioned partner preference in the female rat: II. Disruption by flupenthixol.

Journal: Behavioral neuroscience 20080401

Title: Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine.

Journal: Psychopharmacology 20080301

Title: [Efficacy and safety of Deanxit combined with Wuling Capsule in treating post-stroke depression: a randomized controlled trial].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080301

Title: Dopaminergic modulation of reproductive behavior and activity in male zebra finches.

Journal: Behavioural brain research 20080211

Title: Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum.

Journal: Neuron 20080207

Title: Purpura and ecchymosis under carbamazepine, chloral hydrate and melitracen-flupentixol.

Journal: European journal of dermatology : EJD 20080101

Title: Applying long-acting injectable antipsychotics in first-episode schizophrenia to achieve first remission.

Journal: CNS drugs 20080101

Title: Antipsychotic polypharmacy in the emergency treatment of highly aggressive schizophrenic prisoners - a retrospective study.

Journal: International journal of prisoner health 20080101

Title: [Development of a method for determining antidepressant drugs in nails and its usefulness in forensic toxicology].

Journal: Archiwum medycyny sadowej i kryminologii 20080101

Title: Validation of a sensitive LC/MS/MS method for simultaneous quantitation of flupentixol and melitracene in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20071221

Title: [Intervals between hospitalisations in schizophrenia patients under antipsychotics in depot-form versus oral second generation antipsychotics].

Journal: Psychiatrische Praxis 20070901

Title: Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070630

Title: Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.

Journal: Psychopharmacology 20070601

Title: Medial prefrontal cortex infusion of alpha-flupenthixol attenuates systemic d-amphetamine-induced disruption of conditional discrimination performance in rats.

Journal: Psychopharmacology 20070601

Title: Clozapine, SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance.

Journal: Psychopharmacology 20070301

Title: Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol.

Journal: Psychopharmacology 20070201

Title: Is the superior efficacy of new generation antipsychotics an artifact of LOCF?

Journal: Schizophrenia bulletin 20070101

Title: The impact of self-help group attendance on relapse rates after alcohol detoxification in a controlled study.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20070101

Title: Fecal bulking in a frequently mated female rat. Colonic obstruction due to severe vaginal distension.

Journal: Lab animal 20061101

Title: Self-cannibalism: an unusual case of self-mutilation.

Journal: The Australian and New Zealand journal of psychiatry 20061001

Title: Characterization of dopamine-dependent rewarding and locomotor stimulant effects of intravenously-administered methylphenidate in rats.

Journal: Neuroscience 20060901

Title: Clinical investigation on hypotensive patients with vertigo.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20060901

Title: Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1).

Journal: Biochemical pharmacology 20060714

Title: Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060701

Title: Flupentixol.

Journal: Nursing times 20060701

Title: Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket.

Journal: The Biochemical journal 20060615

Title: Post-training intra-striatal scopolamine or flupenthixol impairs radial maze learning in rats.

Journal: Behavioural brain research 20060603

Title: Allosteric modulation of the human P-glycoprotein involves conformational changes mimicking catalytic transition intermediates.

Journal: Archives of biochemistry and biophysics 20060601

Title: Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein.

Journal: The Journal of biological chemistry 20060421

Title: Modulator-induced interference in functional cross talk between the substrate and the ATP sites of human P-glycoprotein.

Journal: Biochemistry 20060227

Title: Antimicrobial potentiality of the thioxanthene flupenthixol through extensive in vitro and in vivo experiments.

Journal: International journal of antimicrobial agents 20060101

Title: An aplysia dopamine1-like receptor: molecular and functional characterization.

Journal: Journal of neurochemistry 20060101

Title: Alcohol-induced impulsivity in rats: an effect of cue salience?

Journal: Psychopharmacology 20060101

Title: Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20050901

Title: The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer.

Journal: Cancer research 20050801

Title: Deliberate self harm (and attempted suicide).

Journal: Clinical evidence 20050601

Title: Modulation of memory consolidation by the basolateral amygdala or nucleus accumbens shell requires concurrent dopamine receptor activation in both brain regions.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20050501

Title: [Prescription of psychotropic drugs for schizophrenic outpatients in Hungary].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20050301

Title: Attenuation of d-amphetamine-induced disruption of conditional discrimination performance by alpha-flupenthixol.

Journal: Psychopharmacology 20050101

Title: Brief alteration in dopaminergic function during development causes deficits in adult reproductive behavior.

Journal: Journal of neurobiology 20041201

Title: Deliberate self harm.

Journal: Clinical evidence 20041201

Title: Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041101

Title: Olanzapine versus flupenthixol in the treatment of inpatients with schizophrenia: a randomized double-blind trial.

Journal: Pharmacopsychiatry 20041101

Title: [Alterations of gait parameters under external cueing in schizophrenic patients: a switch study].

Journal: Psychiatrische Praxis 20041101

Title: [Incidence of rigor during treatment with flupentixol decanoate in comparison to risperidone].

Journal: Psychiatrische Praxis 20041101

Title: Flupenthixol and cefotiam: effects on vitamin A metabolism in rats.

Journal: The British journal of nutrition 20041001

Title: The effects of dopamine receptor agonists and antagonists on the secretory rate of cockroach (Periplaneta americana) salivary glands.

Journal: Journal of insect physiology 20040901

Title: Chronic antidopaminergic medication might affect amygdala structure in patients with schizophrenia.

Journal: Pharmacopsychiatry 20040901

Title: Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by rats.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040811

Title: Long-acting injectable risperidone: safety and efficacy in stable patients switched from conventional depot antipsychotics.

Journal: International clinical psychopharmacology 20040701

Title: [Quality of life and therapeutic result in outpatients with schizophrenia under flupenthixol treatment].

Journal: Fortschritte der Neurologie-Psychiatrie 20040701

Title: Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake.

Journal: Psychopharmacology 20040401

Title: Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040401

Title: Dopamine antagonists do not block conditioned place preference induced by paced mating behavior in female rats.

Journal: Behavioral neuroscience 20040401

Title: The impact of antipsychotics on psychomotor performance with regards to car driving skills.

Journal: Journal of clinical psychopharmacology 20040401

Title: Sexual-incentive motivation and paced sexual behavior in female rats after treatment with drugs modifying dopaminergic neurotransmission.

Journal: Pharmacology, biochemistry, and behavior 20040301

Title: Flow and injection characteristics of pharmaceutical parenteral formulations using a micro-capillary rheometer.

Journal: International journal of pharmaceutics 20040211

Title: Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040201

Title: Modulation of the discriminative stimulus effects of mu opioid agonists in rats: I. Effects of dopamine D2/3 antagonists.

Journal: Behavioural pharmacology 20040201

Title: Flupentixol and trifluperidol reduce interleukin-1 beta and interleukin-2 release by rat mixed glial and microglial cell cultures.

Journal: Polish journal of pharmacology 20040101

Title: A selective 19F nuclear magnetic resonance spectroscopic method for the assay of the neuroleptic drug cis(Z)-flupentixol in human serum.

Journal: Analytical biochemistry 20031215

Title: Deliberate self harm.

Journal: Clinical evidence 20031201

Title: Gender-related differences in pharmacological relapse prevention with flupenthixol decanoate in detoxified alcoholics.

Journal: Archives of women's mental health 20031101

Title: Acute and maintenance ECT with flupenthixol in refractory schizophrenia: sustained improvements in psychopathology, quality of life, and social outcomes.

Journal: Schizophrenia research 20030901

Title: Flupentixol and trifluperidol reduce secretion of tumor necrosis factor-alpha and nitric oxide by rat microglial cells.

Journal: Neurochemistry international 20030701

Title: Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats.

Journal: Psychopharmacology 20030601

Title: Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation.

Journal: The Journal of biological chemistry 20030516

Title: Analysis of two D1-like dopamine receptors from the honey bee Apis mellifera reveals agonist-independent activity.

Journal: Brain research. Molecular brain research 20030512

Title: Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030501

Title: [Comparative effectiveness of flupenthixol and risperidone on negative symptoms of schizophrenia].

Journal: Psychiatrische Praxis 20030501

Title: Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study.

Journal: European addiction research 20030401

Title: SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain.

Journal: Journal of neurochemistry 20030401

Title: Local-global processing in early-onset schizophrenia: evidence for an impairment in shifting the spatial scale of attention.

Journal: Brain and cognition 20030201

Title: Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area.

Journal: Molecular psychiatry 20030101

Title: Role of AMPA and NMDA receptors in the nucleus accumbens shell in turning behaviour of rats: interaction with dopamine receptors.

Journal: Neuropharmacology 20030101

Title: Flupenthixol versus risperidone: subjective quality of life as an important factor for compliance in chronic schizophrenic patients.

Journal: Neuropsychobiology 20030101

Title: [Use of fluanxol in borderline mental disorders].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: [Psychotropic drugs used in a psychiatric hospital (pharmaco-epidemiologic aspects)].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: Dopamine receptor blockade in the rat medial prefrontal cortex reduces spontaneous and amphetamine-induced activity and does not affect prepulse inhibition.

Journal: Behavioural pharmacology 20021201

Title: [The risk of rehospitalisation during therapy with atypical and typical neuroleptics--a contribution to differential indication].

Journal: Psychiatrische Praxis 20021001

Title: Association between flupenthixol treatment and emergence of manic symptoms.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20021001

Title: Differential effects of high-dose amisulpride versus flupentixol on latent dimensions of depressive and negative symptomatology in acute schizophrenia: an evaluation using confirmatory factor analysis.

Journal: International clinical psychopharmacology 20020901

Title: Flupenthixol decanoate and injection site abscesses in an obese patient.

Journal: The Australian and New Zealand journal of psychiatry 20020801

Title: Are monoaminergic systems involved in the lethargy induced by a parasitoid wasp in the cockroach prey?

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20020501

Title: Full remission of tardive dyskinesia following general anaesthesia.

Journal: Journal of neurology 20020501

Title: Switching to amisulpride due to hepatic complications.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20020501

Title: Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases.

Journal: Journal of chromatography. A 20020301

Title: Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes.

Journal: Behavioural brain research 20020201

Title: Depot injections and nut allergy.

Journal: The British journal of psychiatry : the journal of mental science 20020201

Title: Intolerance to neuroleptics and susceptibility for malignant hyperthermia in a patient with proximal myotonic myopathy (PROMM) and schizophrenia.

Journal: Neuromuscular disorders : NMD 20020101

Title: Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels.

Journal: Neuropsychobiology 20020101

Title: Combined ECT and neuroleptic therapy in treatment-refractory schizophrenia: prediction of outcome.

Journal: Psychiatry research 20011215

Title: Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201

Title: HPLC-ESI-MS/MS determination of zuclopenthixol in a fatal intoxication during psychiatric therapy.

Journal: Forensic science international 20011201

Title: Effect of flupenthixol on subjective and cardiovascular responses to intravenous cocaine in humans.

Journal: Drug and alcohol dependence 20011101

Title: Flow-injection chemiluminometric determination of some thioxanthene derivatives in pharmaceutical formulations and biological fluids using the [Ru(dipy)3(2+)]-Ce(IV) system.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20011101

Title: Gene expression in schizophrenia.

Journal: The American journal of psychiatry 20011001

Title: A falling HbA1c is not necessarily an indicator of improving diabetes control.

Journal: Annals of clinical biochemistry 20010701

Title: Leptin reverses sucrose-conditioned place preference in food-restricted rats.

Journal: Physiology & behavior 20010501

Title: Studies on the involvement of the dopaminergic system in the 5-HT2 agonist (DOI)-induced premature responding in a five-choice serial reaction time task.

Journal: Brain research bulletin 20010101

Title: Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20010101

Title: The dopamine antagonist, alpha-flupenthixol, interferes with naloxone-induced place aversion learning, but not with acute opiate dependence in rats.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: Remission of tardive dyskinesia after changing from flupenthixol to olanzapine.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20000801

Title: Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.

Journal: International journal of antimicrobial agents 20000401

Title: Effects of flupenthixol and quadazocine on self-administration of speedball combinations of cocaine and heroin by rhesus monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19991001

Title: U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking.

Journal: Psychopharmacology 19990601

Title: Flupenthixol treatment for cocaine abusers with schizophrenia: a pilot study.

Journal: The American journal of drug and alcohol abuse 19980801

Title: Iatrogenic complications of depot antipsychotics given to unfamiliar patients.

Journal: Journal of the Royal Society of Medicine 19980101

Title: Tolerability of low dose neuroleptics: a case control study of flupenthixol.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 19971101

Title: High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.

Journal: The Journal of biological chemistry 19941111

Title: Convulsions after enflurane in a schizophrenic patient receiving neuroleptics.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 19940501

Title: Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists.

Journal: Cancer research 19940201

Title: Depot flupenthixol-induced mania.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19930601

Title: [Pharmacotoxic psychosis and extrapyramidal motor syndrome. A case of acute adverse effect of fluoxetine and flupenthixol].

Journal: Der Nervenarzt 19920901

Title: [D-TRP11]-neurotensin, unlike alpha-flupenthixol, may not block amphetamine-induced hyperactivity in rats.

Journal: Neuropharmacology 19890301

Title: Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.

Journal: European journal of pharmacology 19840713

Title: Neuroleptic malignant syndrome.

Journal: British medical journal (Clinical research ed.) 19840623

Title: Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate.

Journal: Neuropsychobiology 19830101

Title: Flupenthixol versus haloperidol in acute psychosis.

Journal: Pharmatherapeutica 19830101

Title: Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice.

Journal: Journal of neural transmission 19820101

Title: Persistent involuntary movements after treatment with flupenthixol.

Journal: British medical journal (Clinical research ed.) 19810530

Title: Depressive and extrapyramidal symptoms and clinical effects: a trial of fluphenazine versus flupenthixol in maintenance of schizophrenic out-patients.

Journal: The British journal of psychiatry : the journal of mental science 19791201

Title: Depot injections and tardive dyskinesia.

Journal: The British journal of psychiatry : the journal of mental science 19781001

Title: Comparison of antipsychotic depot injections in the maintenance treatment of schizophrenia.

Journal: The British journal of psychiatry : the journal of mental science 19761101

Title: A controlled comparison of flupenthixol and amitriptyline in depressed outpatients.

Journal: British medical journal 19760508

Title: [Allergotoxic brain reaction to flupentixol-depot].

Journal: Psychiatria polska 19760101

Title: Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions.

Journal: Scottish medical journal 19750101

Title: Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6.

Title: Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.

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Related Products of 51529-01-2
Tags:51529-01-2 Molecular Formula|51529-01-2 MDL|51529-01-2 SMILES|51529-01-2 Flupenthixol dihydrochloride
Catalog No.: AA00DDPM
51529-01-2,MFCD00069278
51529-01-2 | Flupenthixol dihydrochloride
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Technical Information
Catalog Number: AA00DDPM
Chemical Name: Flupenthixol dihydrochloride
CAS Number: 51529-01-2
Molecular Formula: C23H26ClF3N2OS
Molecular Weight: 470.9785
MDL Number: MFCD00069278
SMILES: OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F.Cl
Properties
BP: 554.7°C at 760 mmHg  
Form: Solid  
MP: >218°C (dec.)  
Storage: Inert atmosphere;-20 ℃;  
Complexity: 592  
Covalently-Bonded Unit Count: 3  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20121101

Title: Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats.

Journal: European journal of pharmacology20121015

Title: Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys.

Journal: Neurobiology of disease20121001

Title: Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20121001

Title: Acute stress induces selective alterations in cost/benefit decision-making.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20120901

Title: The role of dopamine in the accumbens core in the expression of Pavlovian-conditioned responses.

Journal: The European journal of neuroscience20120801

Title: Testing the contributions of striatal dopamine loss to the genesis of parkinsonian signs.

Journal: Neurobiology of disease20120701

Title: Evidence of significant synergism between antibiotics and the antipsychotic, antimicrobial drug flupenthixol.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology20120601

Title: Comment on Administration of the combination clonazepam-Deanxit as treatment for tinnitus.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology20120601

Title: Flupentixol: relevance of stereoselective therapeutic drug monitoring.

Journal: Psychopharmacology20120601

Title: Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein.

Journal: Biochemistry20120403

Title: Seeking-taking chain schedules of cocaine and sucrose self-administration: effects of reward size, reward omission, and α-flupenthixol.

Journal: Psychopharmacology20120401

Title: Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.

Journal: The Journal of pharmacology and experimental therapeutics20120301

Title: Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20120101

Title: Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20120101

Title: Tardive syndrome and Parkinson's disease responsive to concomitant tetrabenazine and levodopa therapy.

Journal: Parkinsonism & related disorders20111201

Title: RE: PBS delisting.

Journal: The Australian and New Zealand journal of psychiatry20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie20111001

Title: Effectiveness and costs of flupentixol compared to other first- and second-generation antipsychotics in the treatment of schizophrenia.

Journal: Psychopharmacology20110801

Title: Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20110701

Title: Administration of the combination clonazepam-Deanxit as treatment for tinnitus.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology20110601

Title: PBS delisting.

Journal: The Australian and New Zealand journal of psychiatry20110601

Title: Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110420

Title: Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine.

Journal: Psychopharmacology20110401

Title: The curious case of a catatonic patient.

Journal: Schizophrenia bulletin20110301

Title: A selective role for dopamine in stimulus-reward learning.

Journal: Nature20110106

Title: [Antipsychotic agents in the treatment of somatoform disorders; a review].

Journal: Tijdschrift voor psychiatrie20110101

Title: Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship.

Journal: PloS one20110101

Title: Dopamine transmission in the amygdala modulates surprise in an aversive blocking paradigm.

Journal: Behavioral neuroscience20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: [Comparative study on abdominal acupuncture and western medicine for treatment of menopause depressive disorder].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion20101101

Title: External incentives and internal states guide goal-directed behavior via the differential recruitment of the nucleus accumbens and the medial prefrontal cortex.

Journal: Neuroscience20101013

Title: Dopamine enhances locomotor activity for mating in male honeybees (Apis mellifera L.).

Journal: Journal of insect physiology20100901

Title: Differential effects of dopaminergic manipulations on risky choice.

Journal: Psychopharmacology20100801

Title: [Study on catgut implantation therapy compared with Deanxit for treatment of depression].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion20100801

Title: Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects.

Journal: The European journal of neuroscience20100701

Title: The effects of single dose anxiolytic medication on the CO2 models of anxiety: differentiation of subjective and objective measures.

Journal: Journal of psychopharmacology (Oxford, England)20100501

Title: The role of solvents in the signal separation for quantitative (1)H NMR spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis20100501

Title: Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20100301

Title: Effects of disconnection of amygdala dopamine and nucleus accumbens N-methyl-d-aspartate receptors on ethanol-seeking behavior in mice.

Journal: The European journal of neuroscience20100101

Title: A case of schizophrenia with dysphagia successfully treated by a multidimensional approach.

Journal: General hospital psychiatry20100101

Title: Flupenthixol-induced tardive dystonia presenting as severe dysphagia.

Journal: Neurology India20100101

Title: Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

Journal: Behavioral neuroscience20091001

Title: Long-term treatment with flupentixol results of a post-marketing surveillance study.

Journal: Journal of psychopharmacology (Oxford, England)20090901

Title: Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.

Journal: Science (New York, N.Y.)20090626

Title: Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20090601

Title: Contribution of dopamine receptors to periaqueductal gray-mediated antinociception.

Journal: Psychopharmacology20090601

Title: A role for medial prefrontal dopaminergic innervation in instrumental conditioning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20090520

Title: Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20090501

Title: Functional interaction between the basolateral amygdala and the nucleus accumbens underlies incentive motivation for food reward on a fixed ratio schedule.

Journal: Neuroscience20090410

Title: Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state, and behavioral paradigms.

Journal: Psychopharmacology20090401

Title: Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20090301

Title: Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects.

Journal: Neuropharmacology20090301

Title: Involvement of Basal Ganglia network in motor disabilities induced by typical antipsychotics.

Journal: PloS one20090101

Title: Behavioral responses of dopamine beta-hydroxylase knockout mice to modafinil suggest a dual noradrenergic-dopaminergic mechanism of action.

Journal: Pharmacology, biochemistry, and behavior20081201

Title: Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity.

Journal: Psychopharmacology20081201

Title: Distinct contributions of dopamine receptors in the nucleus accumbens core or shell to established cocaine reinforcement under a second-order schedule.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20081201

Title: Dopaminergic and glutamatergic regulation of effort- and delay-based decision making.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20080701

Title: Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia.

Journal: Alimentary pharmacology & therapeutics20080601

Title: Bidirectional cannabinoid modulation of social behavior in adolescent rats.

Journal: Psychopharmacology20080401

Title: Neurochemical basis of conditioned partner preference in the female rat: II. Disruption by flupenthixol.

Journal: Behavioral neuroscience20080401

Title: Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine.

Journal: Psychopharmacology20080301

Title: [Efficacy and safety of Deanxit combined with Wuling Capsule in treating post-stroke depression: a randomized controlled trial].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine20080301

Title: Dopaminergic modulation of reproductive behavior and activity in male zebra finches.

Journal: Behavioural brain research20080211

Title: Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum.

Journal: Neuron20080207

Title: Purpura and ecchymosis under carbamazepine, chloral hydrate and melitracen-flupentixol.

Journal: European journal of dermatology : EJD20080101

Title: Applying long-acting injectable antipsychotics in first-episode schizophrenia to achieve first remission.

Journal: CNS drugs20080101

Title: Antipsychotic polypharmacy in the emergency treatment of highly aggressive schizophrenic prisoners - a retrospective study.

Journal: International journal of prisoner health20080101

Title: [Development of a method for determining antidepressant drugs in nails and its usefulness in forensic toxicology].

Journal: Archiwum medycyny sadowej i kryminologii20080101

Title: Validation of a sensitive LC/MS/MS method for simultaneous quantitation of flupentixol and melitracene in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis20071221

Title: [Intervals between hospitalisations in schizophrenia patients under antipsychotics in depot-form versus oral second generation antipsychotics].

Journal: Psychiatrische Praxis20070901

Title: Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics20070801

Title: Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20070630

Title: Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.

Journal: Psychopharmacology20070601

Title: Medial prefrontal cortex infusion of alpha-flupenthixol attenuates systemic d-amphetamine-induced disruption of conditional discrimination performance in rats.

Journal: Psychopharmacology20070601

Title: Clozapine, SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance.

Journal: Psychopharmacology20070301

Title: Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol.

Journal: Psychopharmacology20070201

Title: Is the superior efficacy of new generation antipsychotics an artifact of LOCF?

Journal: Schizophrenia bulletin20070101

Title: The impact of self-help group attendance on relapse rates after alcohol detoxification in a controlled study.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire)20070101

Title: Fecal bulking in a frequently mated female rat. Colonic obstruction due to severe vaginal distension.

Journal: Lab animal20061101

Title: Self-cannibalism: an unusual case of self-mutilation.

Journal: The Australian and New Zealand journal of psychiatry20061001

Title: Characterization of dopamine-dependent rewarding and locomotor stimulant effects of intravenously-administered methylphenidate in rats.

Journal: Neuroscience20060901

Title: Clinical investigation on hypotensive patients with vertigo.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery20060901

Title: Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1).

Journal: Biochemical pharmacology20060714

Title: Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20060701

Title: Flupentixol.

Journal: Nursing times20060701

Title: Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket.

Journal: The Biochemical journal20060615

Title: Post-training intra-striatal scopolamine or flupenthixol impairs radial maze learning in rats.

Journal: Behavioural brain research20060603

Title: Allosteric modulation of the human P-glycoprotein involves conformational changes mimicking catalytic transition intermediates.

Journal: Archives of biochemistry and biophysics20060601

Title: Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein.

Journal: The Journal of biological chemistry20060421

Title: Modulator-induced interference in functional cross talk between the substrate and the ATP sites of human P-glycoprotein.

Journal: Biochemistry20060227

Title: Antimicrobial potentiality of the thioxanthene flupenthixol through extensive in vitro and in vivo experiments.

Journal: International journal of antimicrobial agents20060101

Title: An aplysia dopamine1-like receptor: molecular and functional characterization.

Journal: Journal of neurochemistry20060101

Title: Alcohol-induced impulsivity in rats: an effect of cue salience?

Journal: Psychopharmacology20060101

Title: Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20050901

Title: The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer.

Journal: Cancer research20050801

Title: Deliberate self harm (and attempted suicide).

Journal: Clinical evidence20050601

Title: Modulation of memory consolidation by the basolateral amygdala or nucleus accumbens shell requires concurrent dopamine receptor activation in both brain regions.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20050501

Title: [Prescription of psychotropic drugs for schizophrenic outpatients in Hungary].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology20050301

Title: Attenuation of d-amphetamine-induced disruption of conditional discrimination performance by alpha-flupenthixol.

Journal: Psychopharmacology20050101

Title: Brief alteration in dopaminergic function during development causes deficits in adult reproductive behavior.

Journal: Journal of neurobiology20041201

Title: Deliberate self harm.

Journal: Clinical evidence20041201

Title: Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20041101

Title: Olanzapine versus flupenthixol in the treatment of inpatients with schizophrenia: a randomized double-blind trial.

Journal: Pharmacopsychiatry20041101

Title: [Alterations of gait parameters under external cueing in schizophrenic patients: a switch study].

Journal: Psychiatrische Praxis20041101

Title: [Incidence of rigor during treatment with flupentixol decanoate in comparison to risperidone].

Journal: Psychiatrische Praxis20041101

Title: Flupenthixol and cefotiam: effects on vitamin A metabolism in rats.

Journal: The British journal of nutrition20041001

Title: The effects of dopamine receptor agonists and antagonists on the secretory rate of cockroach (Periplaneta americana) salivary glands.

Journal: Journal of insect physiology20040901

Title: Chronic antidopaminergic medication might affect amygdala structure in patients with schizophrenia.

Journal: Pharmacopsychiatry20040901

Title: Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by rats.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20040811

Title: Long-acting injectable risperidone: safety and efficacy in stable patients switched from conventional depot antipsychotics.

Journal: International clinical psychopharmacology20040701

Title: [Quality of life and therapeutic result in outpatients with schizophrenia under flupenthixol treatment].

Journal: Fortschritte der Neurologie-Psychiatrie20040701

Title: Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake.

Journal: Psychopharmacology20040401

Title: Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20040401

Title: Dopamine antagonists do not block conditioned place preference induced by paced mating behavior in female rats.

Journal: Behavioral neuroscience20040401

Title: The impact of antipsychotics on psychomotor performance with regards to car driving skills.

Journal: Journal of clinical psychopharmacology20040401

Title: Sexual-incentive motivation and paced sexual behavior in female rats after treatment with drugs modifying dopaminergic neurotransmission.

Journal: Pharmacology, biochemistry, and behavior20040301

Title: Flow and injection characteristics of pharmaceutical parenteral formulations using a micro-capillary rheometer.

Journal: International journal of pharmaceutics20040211

Title: Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20040201

Title: Modulation of the discriminative stimulus effects of mu opioid agonists in rats: I. Effects of dopamine D2/3 antagonists.

Journal: Behavioural pharmacology20040201

Title: Flupentixol and trifluperidol reduce interleukin-1 beta and interleukin-2 release by rat mixed glial and microglial cell cultures.

Journal: Polish journal of pharmacology20040101

Title: A selective 19F nuclear magnetic resonance spectroscopic method for the assay of the neuroleptic drug cis(Z)-flupentixol in human serum.

Journal: Analytical biochemistry20031215

Title: Deliberate self harm.

Journal: Clinical evidence20031201

Title: Gender-related differences in pharmacological relapse prevention with flupenthixol decanoate in detoxified alcoholics.

Journal: Archives of women's mental health20031101

Title: Acute and maintenance ECT with flupenthixol in refractory schizophrenia: sustained improvements in psychopathology, quality of life, and social outcomes.

Journal: Schizophrenia research20030901

Title: Flupentixol and trifluperidol reduce secretion of tumor necrosis factor-alpha and nitric oxide by rat microglial cells.

Journal: Neurochemistry international20030701

Title: Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats.

Journal: Psychopharmacology20030601

Title: Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation.

Journal: The Journal of biological chemistry20030516

Title: Analysis of two D1-like dopamine receptors from the honey bee Apis mellifera reveals agonist-independent activity.

Journal: Brain research. Molecular brain research20030512

Title: Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20030501

Title: [Comparative effectiveness of flupenthixol and risperidone on negative symptoms of schizophrenia].

Journal: Psychiatrische Praxis20030501

Title: Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study.

Journal: European addiction research20030401

Title: SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain.

Journal: Journal of neurochemistry20030401

Title: Local-global processing in early-onset schizophrenia: evidence for an impairment in shifting the spatial scale of attention.

Journal: Brain and cognition20030201

Title: Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area.

Journal: Molecular psychiatry20030101

Title: Role of AMPA and NMDA receptors in the nucleus accumbens shell in turning behaviour of rats: interaction with dopamine receptors.

Journal: Neuropharmacology20030101

Title: Flupenthixol versus risperidone: subjective quality of life as an important factor for compliance in chronic schizophrenic patients.

Journal: Neuropsychobiology20030101

Title: [Use of fluanxol in borderline mental disorders].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20030101

Title: [Psychotropic drugs used in a psychiatric hospital (pharmaco-epidemiologic aspects)].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20030101

Title: Dopamine receptor blockade in the rat medial prefrontal cortex reduces spontaneous and amphetamine-induced activity and does not affect prepulse inhibition.

Journal: Behavioural pharmacology20021201

Title: [The risk of rehospitalisation during therapy with atypical and typical neuroleptics--a contribution to differential indication].

Journal: Psychiatrische Praxis20021001

Title: Association between flupenthixol treatment and emergence of manic symptoms.

Journal: European psychiatry : the journal of the Association of European Psychiatrists20021001

Title: Differential effects of high-dose amisulpride versus flupentixol on latent dimensions of depressive and negative symptomatology in acute schizophrenia: an evaluation using confirmatory factor analysis.

Journal: International clinical psychopharmacology20020901

Title: Flupenthixol decanoate and injection site abscesses in an obese patient.

Journal: The Australian and New Zealand journal of psychiatry20020801

Title: Are monoaminergic systems involved in the lethargy induced by a parasitoid wasp in the cockroach prey?

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology20020501

Title: Full remission of tardive dyskinesia following general anaesthesia.

Journal: Journal of neurology20020501

Title: Switching to amisulpride due to hepatic complications.

Journal: European psychiatry : the journal of the Association of European Psychiatrists20020501

Title: Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases.

Journal: Journal of chromatography. A20020301

Title: Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes.

Journal: Behavioural brain research20020201

Title: Depot injections and nut allergy.

Journal: The British journal of psychiatry : the journal of mental science20020201

Title: Intolerance to neuroleptics and susceptibility for malignant hyperthermia in a patient with proximal myotonic myopathy (PROMM) and schizophrenia.

Journal: Neuromuscular disorders : NMD20020101

Title: Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels.

Journal: Neuropsychobiology20020101

Title: Combined ECT and neuroleptic therapy in treatment-refractory schizophrenia: prediction of outcome.

Journal: Psychiatry research20011215

Title: Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20011201

Title: HPLC-ESI-MS/MS determination of zuclopenthixol in a fatal intoxication during psychiatric therapy.

Journal: Forensic science international20011201

Title: Effect of flupenthixol on subjective and cardiovascular responses to intravenous cocaine in humans.

Journal: Drug and alcohol dependence20011101

Title: Flow-injection chemiluminometric determination of some thioxanthene derivatives in pharmaceutical formulations and biological fluids using the [Ru(dipy)3(2+)]-Ce(IV) system.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry20011101

Title: Gene expression in schizophrenia.

Journal: The American journal of psychiatry20011001

Title: A falling HbA1c is not necessarily an indicator of improving diabetes control.

Journal: Annals of clinical biochemistry20010701

Title: Leptin reverses sucrose-conditioned place preference in food-restricted rats.

Journal: Physiology & behavior20010501

Title: Studies on the involvement of the dopaminergic system in the 5-HT2 agonist (DOI)-induced premature responding in a five-choice serial reaction time task.

Journal: Brain research bulletin20010101

Title: Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire)20010101

Title: The dopamine antagonist, alpha-flupenthixol, interferes with naloxone-induced place aversion learning, but not with acute opiate dependence in rats.

Journal: Pharmacology, biochemistry, and behavior20010101

Title: Remission of tardive dyskinesia after changing from flupenthixol to olanzapine.

Journal: European psychiatry : the journal of the Association of European Psychiatrists20000801

Title: Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.

Journal: International journal of antimicrobial agents20000401

Title: Effects of flupenthixol and quadazocine on self-administration of speedball combinations of cocaine and heroin by rhesus monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology19991001

Title: U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking.

Journal: Psychopharmacology19990601

Title: Flupenthixol treatment for cocaine abusers with schizophrenia: a pilot study.

Journal: The American journal of drug and alcohol abuse19980801

Title: Iatrogenic complications of depot antipsychotics given to unfamiliar patients.

Journal: Journal of the Royal Society of Medicine19980101

Title: Tolerability of low dose neuroleptics: a case control study of flupenthixol.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology19971101

Title: High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.

Journal: The Journal of biological chemistry19941111

Title: Convulsions after enflurane in a schizophrenic patient receiving neuroleptics.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie19940501

Title: Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists.

Journal: Cancer research19940201

Title: Depot flupenthixol-induced mania.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde19930601

Title: [Pharmacotoxic psychosis and extrapyramidal motor syndrome. A case of acute adverse effect of fluoxetine and flupenthixol].

Journal: Der Nervenarzt19920901

Title: [D-TRP11]-neurotensin, unlike alpha-flupenthixol, may not block amphetamine-induced hyperactivity in rats.

Journal: Neuropharmacology19890301

Title: Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.

Journal: European journal of pharmacology19840713

Title: Neuroleptic malignant syndrome.

Journal: British medical journal (Clinical research ed.)19840623

Title: Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate.

Journal: Neuropsychobiology19830101

Title: Flupenthixol versus haloperidol in acute psychosis.

Journal: Pharmatherapeutica19830101

Title: Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice.

Journal: Journal of neural transmission19820101

Title: Persistent involuntary movements after treatment with flupenthixol.

Journal: British medical journal (Clinical research ed.)19810530

Title: Depressive and extrapyramidal symptoms and clinical effects: a trial of fluphenazine versus flupenthixol in maintenance of schizophrenic out-patients.

Journal: The British journal of psychiatry : the journal of mental science19791201

Title: Depot injections and tardive dyskinesia.

Journal: The British journal of psychiatry : the journal of mental science19781001

Title: Comparison of antipsychotic depot injections in the maintenance treatment of schizophrenia.

Journal: The British journal of psychiatry : the journal of mental science19761101

Title: A controlled comparison of flupenthixol and amitriptyline in depressed outpatients.

Journal: British medical journal19760508

Title: [Allergotoxic brain reaction to flupentixol-depot].

Journal: Psychiatria polska19760101

Title: Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions.

Journal: Scottish medical journal19750101

Title: Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6.

Title: Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.

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