Title: Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Journal: Antimicrobial agents and chemotherapy 20140401
Title: 2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.
Journal: Journal of medicinal chemistry 20101125
Title: PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Journal: Antimicrobial agents and chemotherapy 20100801
Title: Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication.
Journal: Bioorganic & medicinal chemistry 20100715
Title: Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication.
Journal: Journal of medicinal chemistry 20100422
Title: Chemical stability of 4'-azidocytidine and its prodrug balapiravir.
Journal: Drug development and industrial pharmacy 20100401
Title: The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
Journal: Bioorganic & medicinal chemistry letters 20090801
Title: The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
Journal: Journal of medicinal chemistry 20090514
Title: Substituted imidazopyridines as potent inhibitors of HCV replication.
Journal: Journal of hepatology 20090501
Title: Amidinoanthracyclines - a new group of potential anti-hepatitis C virus compounds.
Journal: Biological chemistry 20090401
Title: The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
Journal: Journal of medicinal chemistry 20090108
Title: 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
Journal: Antimicrobial agents and chemotherapy 20081201
Title: New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection.
Journal: Bioorganic & medicinal chemistry 20081001
Title: Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C.
Journal: Hepatology (Baltimore, Md.) 20080801
Title: R1626 plus peginterferon Alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin.
Journal: Hepatology (Baltimore, Md.) 20080801
Title: Physicochemical properties of the nucleoside prodrug R1626 leading to high oral bioavailability.
Journal: Drug development and industrial pharmacy 20080701
Title: Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients.
Journal: The Journal of antimicrobial chemotherapy 20080601
Title: The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors.
Journal: Antimicrobial agents and chemotherapy 20080501
Title: 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.
Journal: The Journal of biological chemistry 20080125
Title: Future treatment options for HCV: double, triple, what is the optimal combination?
Journal: Best practice & research. Clinical gastroenterology 20080101
Title: Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
Journal: Bioorganic & medicinal chemistry letters 20070501
Title: Specific targeted antiviral therapy for hepatitis C.
Journal: Current gastroenterology reports 20070301
Title: In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance.
Journal: Virology 20060801
Title: The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.
Journal: The Journal of biological chemistry 20060217
Title: Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides.
Journal: Journal of medicinal chemistry 19920417
Title: Klumpp K, et al. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9.
Title: Smith DB, et al. Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6.
Title: Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207(9):1442-1450.
