528-48-3,MFCD00006829
Catalog No.:AA00DE52

528-48-3 | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one

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Purity
Availability
Price(USD)
Quantity
  
100mg
>96.0%(HPLC)
in stock  
$37.00   $26.00
- +
1g
>97%(HPLC)powder
in stock  
$107.00   $75.00
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Technical Information
Catalog Number:
AA00DE52
Chemical Name:
2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
CAS Number:
528-48-3
Molecular Formula:
C15H10O6
Molecular Weight:
286.2363
MDL Number:
MFCD00006829
SMILES:
Oc1ccc2c(c1)oc(c(c2=O)O)c1ccc(c(c1)O)O
Properties
Properties
 
BP:
599.4°C at 760 mmHg  
Form:
Solid  
MP:
330 °C  
Refractive Index:
1.4413 (estimate)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
459  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2  

Literature

Title: Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20181001

Title: Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20181001

Title: Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180701

Title: Fisetin-induced apoptosis of human oral cancer SCC-4 cells through reactive oxygen species production, endoplasmic reticulum stress, caspase-, and mitochondria-dependent signaling pathways.

Journal: Environmental toxicology 20170601

Title: Potentiation of luteolin cytotoxicity by flavonols fisetin and quercetin in human chronic lymphocytic leukemia cell lines.

Journal: Food & function 20160914

Title: Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells.

Journal: Cancer cell international 20160101

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells.

Journal: Food & function 20150101

Title: Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

Journal: Fitoterapia 20140401

Title: Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-κB activation and antioxidant defence.

Journal: PloS one 20140101

Title: Hypocholesterolemic effect of daily fisetin supplementation in high fat fed Sprague-Dawley rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130701

Title: Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.

Journal: Chemical research in toxicology 20121119

Title: Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management.

Journal: Biochemical pharmacology 20121115

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Mechanisms of toxicity of amorphous silica nanoparticles on human lung submucosal cells in vitro: protective effects of fisetin.

Journal: Chemical research in toxicology 20121015

Title: Induced chirality in fisetin upon binding to serum albumin: experimental circular dichroism and TDDFT calculations.

Journal: Journal of molecular modeling 20120901

Title: Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.

Journal: Biochemistry 20120807

Title: Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells.

Journal: Immunopharmacology and immunotoxicology 20120801

Title: Synthesis of flavonol 3-O-glycoside by UGT78D1.

Journal: Glycoconjugate journal 20120801

Title: Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

Journal: European journal of medicinal chemistry 20120801

Title: A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson's disease.

Journal: Journal of medicinal food 20120801

Title: A fluorimetric assay for human reticulocyte 15-lipoxygenase-1 activity.

Journal: Analytical biochemistry 20120701

Title: Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells.

Journal: Cancer letters 20120628

Title: Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

Journal: European journal of medicinal chemistry 20120601

Title: Fisetin and rutin as 3C protease inhibitors of enterovirus A71.

Journal: Journal of virological methods 20120601

Title: Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

Title: Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation.

Journal: The Journal of biological chemistry 20120601

Title: Study of the interaction between fisetin and human serum albumin: a biophysical approach.

Journal: Protein and peptide letters 20120601

Title: Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice.

Journal: International journal of pharmaceutics 20120510

Title: Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.

Journal: Molecules (Basel, Switzerland) 20120507

Title: The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501

Title: Discovery and development of spleen tyrosine kinase (SYK) inhibitors.

Journal: Journal of medicinal chemistry 20120426

Title: Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.

Journal: International journal of cancer 20120401

Title: Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro.

Journal: Journal of microbiology (Seoul, Korea) 20120401

Title: 3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20120401

Title: 3,3',4',5,5'-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation.

Journal: Neuroscience letters 20120328

Title: The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system.

Journal: Behavioural brain research 20120317

Title: Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.

Journal: European journal of pharmacology 20120315

Title: Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Drosophila models of proteinopathies: the little fly that could.

Journal: Current pharmaceutical design 20120301

Title: Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.

Journal: Bioorganic & medicinal chemistry letters 20120301

Title: Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol.

Journal: Aging 20120301

Title: Autophagy and cancer.

Journal: Experimental & molecular medicine 20120227

Title: Development of a liposomal formulation of the natural flavonoid fisetin.

Journal: International journal of pharmaceutics 20120214

Title: Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy.

Journal: International journal of oncology 20120201

Title: Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway.

Journal: Archives of toxicology 20120201

Title: Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention.

Journal: Carcinogenesis 20120201

Title: Metabolic effects of silibinin in the rat liver.

Journal: Chemico-biological interactions 20120125

Title: Molecular dynamic behavior and binding affinity of flavonoid analogues to the cyclin dependent kinase 6/cyclin D complex.

Journal: Journal of chemical information and modeling 20120123

Title: Spectroscopic exploration of mode of binding of ctDNA with 3-hydroxyflavone: a contrast to the mode of binding with flavonoids having additional hydroxyl groups.

Journal: The journal of physical chemistry. B 20120112

Title: Chemical modification of the multitarget neuroprotective compound fisetin.

Journal: Journal of medicinal chemistry 20120112

Title: Targeting the wingless signaling pathway with natural compounds as chemopreventive or chemotherapeutic agents.

Journal: Current pharmaceutical biotechnology 20120101

Title: MAP Kinases and Prostate Cancer.

Journal: Journal of signal transduction 20120101

Title: Rhus verniciflua stokes against advanced cancer: a perspective from the Korean Integrative Cancer Center.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells.

Journal: International journal of biological sciences 20120101

Title: C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.

Journal: PloS one 20120101

Title: Isolation and characterization of activators of ERK/MAPK from citrus plants.

Journal: International journal of molecular sciences 20120101

Title: Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system.

Journal: Surgical neurology international 20120101

Title: Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans.

Journal: PloS one 20120101

Title: Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans.

Journal: Frontiers in genetics 20120101

Title: Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells.

Journal: PloS one 20120101

Title: A review: inflammatory process in Alzheimer's disease, role of cytokines.

Journal: TheScientificWorldJournal 20120101

Title: A series of novel neuroprotective blood brain barrier penetrating flavonoid drugs to treat acute ischemic stroke.

Journal: Current pharmaceutical design 20120101

Title: Flavonoids inhibit the respiratory burst of neutrophils in mammals.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

Journal: PloS one 20120101

Title: Microbial transformations of 7-hydroxyflavanone.

Journal: TheScientificWorldJournal 20120101

Title: Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple.

Journal: Acta biochimica Polonica 20120101

Title: Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo.

Journal: Oxidative medicine and cellular longevity 20120101

Title: A comparative study of phytoestrogen action in mitigating apoptosis induced by oxidative stress.

Journal: In vivo (Athens, Greece) 20120101

Title: Fisetin Inhibits Osteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 Signaling Pathways.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite.

Journal: Biochemical pharmacology 20111201

Title: Application of comparative vibrational spectroscopic and mechanistic studies in analysis of fisetin structure.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111201

Title: Fluorescence light-up recognition of DNA nucleotide based on selective abasic site binding of an excited-state intramolecular proton transfer probe.

Journal: The Analyst 20111107

Title: Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders.

Journal: Experimental neurology 20111101

Title: Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats.

Journal: European journal of pharmacology 20111015

Title: Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity.

Journal: Journal of agricultural and food chemistry 20111012

Title: Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.

Journal: Aging cell 20111001

Title: The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells.

Journal: International journal of oncology 20111001

Title: Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters.

Journal: Free radical biology & medicine 20111001

Title: Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin.

Journal: International immunopharmacology 20110901

Title: Fisetin induces Nrf2-mediated HO-1 expression through PKC-δ and p38 in human umbilical vein endothelial cells.

Journal: Journal of cellular biochemistry 20110901

Title: The lipogenesis pathway as a cancer target.

Journal: Journal of medicinal chemistry 20110825

Title: Photophysical behavior of fisetin in dimyristoylphosphatidylcholine liposome membrane.

Journal: The journal of physical chemistry. B 20110825

Title: Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice.

Journal: Cancer chemotherapy and pharmacology 20110801

Title: Longevity and stress in Caenorhabditis elegans.

Journal: Aging 20110801

Title: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells.

Journal: Toxicology letters 20110624

Title: Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.

Journal: Chemistry & biology 20110624

Title: Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.

Journal: Human molecular genetics 20110615

Title: The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.

Journal: Journal of molecular biology 20110603

Title: Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.

Journal: The Journal of investigative dermatology 20110601

Title: Fisetin: a natural fist against melanoma?

Journal: The Journal of investigative dermatology 20110601

Title: Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.

Journal: Interdisciplinary toxicology 20110601

Title: Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid.

Journal: International journal of environmental research and public health 20110601

Title: Comparative spectroscopic and mechanistic study of chelation properties of fisetin with iron in aqueous buffered solutions. Implications on in vitro antioxidant activity.

Journal: Dalton transactions (Cambridge, England : 2003) 20110507

Title: Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110501

Title: Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.

Journal: Bioorganic & medicinal chemistry 20110501

Title: Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20110428

Title: HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos.

Journal: Analytical and bioanalytical chemistry 20110301

Title: Directly suspended droplet microextraction with in injection-port derivatization coupled to gas chromatography-mass spectrometry for the analysis of polyphenols in herbal infusions, fruits and functional foods.

Journal: Journal of chromatography. A 20110204

Title: Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells.

Journal: Basic & clinical pharmacology & toxicology 20110201

Title: Anticancer activity of a combination of cisplatin and fisetin in embryonal carcinoma cells and xenograft tumors.

Journal: Molecular cancer therapeutics 20110201

Title: New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals.

Journal: Anti-cancer drugs 20110201

Title: Probing the interactions of hemoglobin with antioxidant flavonoids via fluorescence spectroscopy and molecular modeling studies.

Journal: Biophysical chemistry 20110201

Title: ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.

Journal: Human molecular genetics 20110115

Title: Prooxidant activity of fisetin: effects on energy metabolism in the rat liver.

Journal: Journal of biochemical and molecular toxicology 20110101

Title: Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis.

Journal: Cancer letters 20110101

Title: Multiple prototropism of fisetin in sodium cholate and related bile salt media.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101

Title: Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences 20110101

Title: Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?

Journal: PloS one 20110101

Title: Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells.

Journal: Drug design, development and therapy 20110101

Title: Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression.

Journal: PloS one 20110101

Title: Genotoxic potential of Cotinus coggygria Scop. (Anacardiaceae) stem extract in vivo.

Journal: Genetics and molecular biology 20110101

Title: Resveratrol inhibits Cdk5 activity through regulation of p35 expression.

Journal: Molecular pain 20110101

Title: Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes.

Journal: PloS one 20110101

Title: Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation.

Journal: PloS one 20110101

Title: Quercetin and cancer chemoprevention.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Assessment and histological analysis of the IPRL technique for sequential in situ liver biopsy.

Journal: Comparative hepatology 20110101

Title: Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma cells.

Journal: PloS one 20110101

Title: ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells.

Journal: PloS one 20110101

Title: Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells.

Journal: PloS one 20110101

Title: Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells.

Journal: Neoplasma 20110101

Title: In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines.

Journal: BMC complementary and alternative medicine 20110101

Title: A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

Journal: PloS one 20110101

Title: Quercetin inhibits IL-1β-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves' orbitopathy.

Journal: PloS one 20110101

Title: Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Journal: Molecular neurodegeneration 20110101

Title: Flavonoids: A versatile source of anticancer drugs.

Journal: Pharmacognosy reviews 20110101

Title: Tasco(®), a product of Ascophyllum nodosum, imparts thermal stress tolerance in Caenorhabditis elegans.

Journal: Marine drugs 20110101

Title: Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia.

Journal: International journal of molecular sciences 20110101

Title: Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives.

Journal: Oxidative medicine and cellular longevity 20110101

Title: A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.

Journal: PloS one 20110101

Title: Antiviral activity of four types of bioflavonoid against dengue virus type-2.

Journal: Virology journal 20110101

Title: Elevated carbon dioxide increases contents of flavonoids and phenolic compounds, and antioxidant activities in Malaysian young ginger (Zingiber officinale Roscoe.) varieties.

Journal: Molecules (Basel, Switzerland) 20101103

Title: Polyphenols and human health: prevention of disease and mechanisms of action.

Journal: Nutrients 20101101

Title: Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents.

Journal: Planta medica 20101001

Title: Flavonols attenuate the immediate and late-phase asthmatic responses to aerosolized-ovalbumin exposure in the conscious guinea pig.

Journal: Fitoterapia 20101001

Title: Relationships between structures of hydroxyflavones and their antioxidative effects.

Journal: Bioorganic & medicinal chemistry letters 20100915

Title: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.

Journal: Cancer metastasis reviews 20100901

Title: Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.

Journal: Carcinogenesis 20100801

Title: Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin.

Journal: International journal of radiation oncology, biology, physics 20100801

Title: Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.

Journal: Aging 20100801

Title: Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

Journal: Biochemical pharmacology 20100601

Title: Chemoinformatics-assisted development of new anti-biofilm compounds.

Journal: Applied microbiology and biotechnology 20100601

Title: [Studies on the flavonoids from Lignum Dalbergiae Odoriferae (II)].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

Title: Overcoming multidrug resistance in human cancer cells by natural compounds.

Journal: Toxins 20100601

Title: Rapid effects of phytoestrogens on human colonic smooth muscle are mediated by oestrogen receptor beta.

Journal: Molecular and cellular endocrinology 20100514

Title: Sensor for fisetin based on gold nanoparticles in ionic liquid and binuclear nickel complex immobilized in silica.

Journal: The Analyst 20100501

Title: Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity.

Journal: Journal of neurochemistry 20100401

Title: On-line HPLC method for screening of antioxidants against superoxide anion radical from complex mixtures.

Journal: Journal of separation science 20100401

Title: Apoptosis by dietary agents for prevention and treatment of prostate cancer.

Journal: Endocrine-related cancer 20100301

Title: The actions of fisetin on glucose metabolism in the rat liver.

Journal: Cell biochemistry and function 20100301

Title: An in vitro micronucleus assay with size-classified micronucleus counting to discriminate aneugens from clastogens.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100201

Title: The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells.

Journal: Mutation research 20100201

Title: Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Journal: Journal of medicinal chemistry 20100114

Title: Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells.

Journal: Molecular and cellular biochemistry 20100101

Title: Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.

Journal: European journal of medicinal chemistry 20100101

Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Journal: Bioorganic & medicinal chemistry 20100101

Title: Protection of burn-induced skin injuries by the flavonoid kaempferol.

Journal: BMB reports 20100101

Title: The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

Journal: International journal of cell biology 20100101

Title: Excess production of Bacillus subtilis quercetin 2,3-dioxygenase affects cell viability in the presence of quercetin.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy.

Journal: Journal of biological regulators and homeostatic agents 20100101

Title: Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

Title: Apoptotic effects of chrysin in human cancer cell lines.

Journal: International journal of molecular sciences 20100101

Title: Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells.

Journal: Nutrition and cancer 20100101

Title: A novel dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II.

Journal: PloS one 20100101

Title: Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.

Journal: Pharmacognosy reviews 20100101

Title: Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: implications on in vitro antioxidant activity.

Journal: The journal of physical chemistry. A 20091224

Title: Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin.

Journal: Genes & nutrition 20091201

Title: Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography.

Journal: Analytical and bioanalytical chemistry 20091201

Title: Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling.

Journal: Immune network 20091201

Title: Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB.

Journal: International journal of cancer 20091115

Title: Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549.

Journal: Journal of agricultural and food chemistry 20091014

Title: Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha.

Journal: The Journal of biological chemistry 20091002

Title: The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes.

Journal: British journal of pharmacology 20091001

Title: Structure and antioxidant activity of brominated flavonols and flavanones.

Journal: Journal of mass spectrometry : JMS 20091001

Title: Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.

Journal: Current genomics 20090801

Title: Potential neuroprotective drugs in cerebral ischemia: new saturated and polyunsaturated lipids coupled to hydrophilic moieties: synthesis and biological activity.

Journal: Journal of medicinal chemistry 20090723

Title: Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles.

Journal: Analytical and bioanalytical chemistry 20090601

Title: Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.

Journal: Carcinogenesis 20090601

Title: Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells.

Journal: BMB reports 20090531

Title: Inhibition of LPS-induced pulmonary inflammation by specific flavonoids.

Journal: Biochemical and biophysical research communications 20090508

Title: Study on fisetin-aluminium(III) interaction in aqueous buffered solutions by spectroscopy and molecular modeling.

Journal: Journal of inorganic biochemistry 20090501

Title: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090501

Title: Distribution and major sources of flavonoid intakes in the middle-aged Japanese women.

Journal: Journal of clinical biochemistry and nutrition 20090501

Title: In vitro antiproliferative characteristics of flavonoids and diazepam on SNU-C4 colorectal adenocarcinoma cells.

Journal: Journal of natural medicines 20090401

Title: Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (Seprafilm) for the prevention of postoperative intra-abdominal adhesions.

Journal: Clinics (Sao Paulo, Brazil) 20090401

Title: Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

Journal: Molecular and cellular endocrinology 20090325

Title: Mechanism of CYP2C9 inhibition by flavones and flavonols.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090301

Title: Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models.

Journal: International immunopharmacology 20090301

Title: Development of an in vitro test system measuring transcriptional downregulatory activities on IL-13.

Journal: Journal of microbiology and biotechnology 20090301

Title: MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites.

Journal: The Plant journal : for cell and molecular biology 20090201

Title: A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.

Journal: Carcinogenesis 20090201

Title: Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.

Journal: Journal of agricultural and food chemistry 20090114

Title: Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization.

Journal: Nutrition and cancer 20090101

Title: Synergetic effects of granulocyte-colony stimulating factor and cognitive training on spatial learning and survival of newborn hippocampal neurons.

Journal: PloS one 20090101

Title: Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes.

Journal: The American journal of Chinese medicine 20090101

Title: Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.

Journal: Microbial cell factories 20090101

Title: Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.

Journal: Journal of biomedicine & biotechnology 20090101

Title: Directed therapy for exfoliation syndrome.

Journal: The open ophthalmology journal 20090101

Title: Directed Therapy: An Approach to the Improved Treatment of Exfoliation syndrome.

Journal: Middle East African journal of ophthalmology 20090101

Title: MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals.

Journal: Genetics and molecular biology 20090101

Title: Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.

Journal: Journal of agricultural and food chemistry 20081224

Title: Ultrasound extracted flavonoids from four varieties of Portuguese red grape skins determined by reverse-phase high-performance liquid chromatography with electrochemical detection.

Journal: Analytica chimica acta 20081223

Title: Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green.

Journal: Journal of cellular biochemistry 20081215

Title: Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.

Journal: British journal of cancer 20081209

Title: Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein.

Journal: Neuroscience letters 20081031

Title: A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.

Journal: Cancer research 20081015

Title: Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages.

Journal: Biochimica et biophysica acta 20081001

Title: Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells.

Journal: Archives of pharmacal research 20081001

Title: Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.

Journal: Carcinogenesis 20080901

Title: Protective effects of epigallocatechin gallate after UV irradiation of cultured human lens epithelial cells.

Journal: Korean journal of ophthalmology : KJO 20080901

Title: The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity.

Journal: Archives of biochemistry and biophysics 20080815

Title: Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells.

Journal: Cancer letters 20080708

Title: Dietary agents for chemoprevention of prostate cancer.

Journal: Cancer letters 20080708

Title: Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.

Journal: Biological & pharmaceutical bulletin 20080701

Title: Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.

Journal: Carcinogenesis 20080501

Title: Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.

Journal: International immunopharmacology 20080301

Title: The effect of flavonoid derivatives on doxorubicin transport and metabolism.

Journal: Bioorganic & medicinal chemistry 20080215

Title: Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.

Journal: Free radical biology & medicine 20080215

Title: Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells.

Journal: Biological & pharmaceutical bulletin 20080201

Title: Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons.

Journal: Brain research 20080116

Title: Potentiometric determination of aqueous dissociation constants of flavonols sparingly soluble in water.

Journal: Talanta 20080115

Title: Flavonoids with DNA strand-scission activity from Rhus javanica var. roxburghiana.

Journal: Fitoterapia 20080101

Title: [Spectroscopic characterization of binding between human serum albumin and 3,3', 4',7-tetrahydroxyflavone].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20080101

Title: The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells.

Journal: Molecular vision 20080101

Title: Inflammaging as a prodrome to Alzheimer's disease.

Journal: Journal of neuroinflammation 20080101

Title: Cupric ion reducing antioxidant capacity assay for food antioxidants: vitamins, polyphenolics, and flavonoids in food extracts.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans.

Journal: PloS one 20080101

Title: Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans.

Journal: Archives of toxicology 20071201

Title: Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Journal: Bioorganic & medicinal chemistry 20071201

Title: Protective effects of epigallocatechin gallate after UV irradiation in cultured human retinal pigment epithelial cells.

Journal: Korean journal of ophthalmology : KJO 20071201

Title: [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20071201

Title: A novel approach to screening for new neuroprotective compounds for the treatment of stroke.

Journal: Brain research 20071010

Title: Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001

Title: Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.

Journal: Bioorganic & medicinal chemistry 20071001

Title: Determination of flavonoid aglycones in several food samples by mixed micellar electrokinetic chromatography.

Journal: Journal of separation science 20071001

Title: Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.

Journal: The Journal of nutrition 20071001

Title: Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

Journal: Microbiology (Reading, England) 20071001

Title: Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin.

Journal: Journal of enzyme inhibition and medicinal chemistry 20070801

Title: Inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.

Journal: Journal of enzyme inhibition and medicinal chemistry 20070801

Title: Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 Cl 41 cells.

Journal: Molecular carcinogenesis 20070601

Title: Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects.

Journal: International journal of biological macromolecules 20070601

Title: Flavonoids and related compounds as anti-allergic substances.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20070601

Title: Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.

Journal: Molecular pharmacology 20070601

Title: Interaction of flavonoids and intestinal facilitated glucose transporters.

Journal: Planta medica 20070401

Title: 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.

Journal: Diabetes 20070301

Title: Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070201

Title: Design and synthesis of compounds that extend yeast replicative lifespan.

Journal: Aging cell 20070201

Title: Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201

Title: Anti-inflammatory activity of fisetin in human mast cells (HMC-1).

Journal: Pharmacological research 20070101

Title: Comparative study of the photophysical behavior of fisetin in homogeneous media and in anionic and cationic reverse micelles media.

Journal: Photochemistry and photobiology 20070101

Title: Distinctive antioxidant and antiinflammatory effects of flavonols.

Journal: Journal of agricultural and food chemistry 20061227

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives.

Journal: Free radical research 20061001

Title: Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway.

Journal: The European journal of neuroscience 20061001

Title: Study of the complexation of fisetin with cyclodextrins.

Journal: The journal of physical chemistry. A 20060914

Title: Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment.

Journal: Oncology reports 20060801

Title: Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death.

Journal: Investigative ophthalmology & visual science 20060701

Title: Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes.

Journal: Journal of ethnopharmacology 20060615

Title: Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

Journal: Journal of medicinal chemistry 20060601

Title: Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.

Journal: Life sciences 20060515

Title: Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20060301

Title: Antioxidants from Rabdosia japonica.

Journal: Phytotherapy research : PTR 20060301

Title: Effect of different flavonoids on collagen synthesis in human fibroblasts.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20060301

Title: Luteolin, a flavonoid, inhibits AP-1 activation by basophils.

Journal: Biochemical and biophysical research communications 20060203

Title: Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions.

Journal: Transplantation 20060127

Title: Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines.

Journal: Prostate cancer and prostatic diseases 20060101

Title: A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.

Journal: Journal of natural products 20060101

Title: Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils.

Journal: International archives of allergy and immunology 20060101

Title: Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.

Journal: Journal of medicinal chemistry 20051201

Title: Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells.

Journal: Biological & pharmaceutical bulletin 20051201

Title: Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells.

Journal: Biochimica et biophysica acta 20051130

Title: Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.

Journal: Journal of agricultural and food chemistry 20051102

Title: Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.

Journal: Archives of pharmacal research 20051101

Title: Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.

Journal: Molecular pharmacology 20051001

Title: Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease.

Journal: Free radical research 20051001

Title: Properties of normal and glycated human hemoglobin in presence and absence of antioxidant.

Journal: Biochemical and biophysical research communications 20050902

Title: Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity.

Journal: The British journal of nutrition 20050901

Title: Interactions of the plant flavonoid fisetin with macromolecular targets: insights from fluorescence spectroscopic studies.

Journal: Journal of photochemistry and photobiology. B, Biology 20050801

Title: Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.

Journal: Biochemical pharmacology 20050715

Title: Inhibition of P-glycoprotein by natural products in human breast cancer cells.

Journal: Archives of pharmacal research 20050701

Title: Determination of dissociation constants of flavonoids by capillary electrophoresis.

Journal: Electrophoresis 20050501

Title: Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids.

Journal: Archives of pharmacal research 20050501

Title: Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin.

Journal: Mutation research 20050404

Title: A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase.

Journal: Nitric oxide : biology and chemistry 20050301

Title: Synergistic effects of flavonoids and ascorbate on enhancement in DNA degradation induced by a bleomycin-Fe complex.

Journal: Free radical research 20050301

Title: Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

Journal: Journal of medicinal chemistry 20050210

Title: Evaluation of the antioxidant activity of flavonoids by 'ferric reducing antioxidant power' assay and cyclic voltammetry.

Journal: Biochimica et biophysica acta 20050118

Title: Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method.

Journal: Journal of agricultural and food chemistry 20041229

Title: Vascular and anti-oxidant actions of flavonols and flavones.

Journal: Clinical and experimental pharmacology & physiology 20041101

Title: Oxidation products of quercetin catalyzed by mushroom tyrosinase.

Journal: Bioorganic & medicinal chemistry 20041015

Title: Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040901

Title: Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation.

Journal: Journal of neurochemistry 20040901

Title: Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Journal: Nature 20040805

Title: Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes.

Journal: FEBS letters 20040716

Title: Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils.

Journal: International archives of allergy and immunology 20040601

Title: Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601

Title: Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601

Title: Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501

Title: Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.

Journal: Molecular pharmacology 20040501

Title: Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

Journal: The Journal of biological chemistry 20040109

Title: Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua.

Journal: Journal of ethnopharmacology 20040101

Title: Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways.

Journal: Nutrition and cancer 20040101

Title: Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship.

Journal: Neurotoxicity research 20040101

Title: Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

Title: Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta.

Journal: Life sciences 20031219

Title: Neuroprotection by flavonoids.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20031201

Title: Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.

Journal: Phytotherapy research : PTR 20031201

Title: Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids.

Journal: Indian journal of biochemistry & biophysics 20031201

Title: Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate.

Journal: Journal of agricultural and food chemistry 20031119

Title: Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-, Fe-ascorbate- and Fe-microsomal systems.

Journal: Biochemical pharmacology 20031001

Title: Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102.

Journal: Mutation research 20030909

Title: Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030901

Title: Anti-allergic substances contained in the pollen of Cryptomeria japonica possess diverse effects on the degranulation of RBL-2H3 cells.

Journal: Journal of pharmacological sciences 20030701

Title: Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils.

Journal: The Journal of allergy and clinical immunology 20030601

Title: HTS compatible assay for antioxidative agents using primary cultured hepatocytes.

Journal: Assay and drug development technologies 20030601

Title: Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells.

Journal: Journal of cellular physiology 20030501

Title: Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase.

Journal: Biochemistry. Biokhimiia 20030401

Title: Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.

Journal: Journal of agricultural and food chemistry 20030312

Title: Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by beta-glucosidase in the presence of amino acids.

Journal: Biological & pharmaceutical bulletin 20030301

Title: Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action.

Journal: Biochemical pharmacology 20030301

Title: Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study.

Journal: Biochemical pharmacology 20030301

Title: Effect of flavonoids on MRP1-mediated transport in Panc-1 cells.

Journal: Journal of pharmaceutical sciences 20030201

Title: Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions.

Journal: Kidney international 20030201

Title: Cell culture protection and in vivo neuroprotective capacity of flavonoids.

Journal: Neurotoxicity research 20030101

Title: Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

Journal: Journal of natural products 20021201

Title: Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features.

Journal: Journal of cardiovascular pharmacology 20021101

Title: Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.

Journal: Bioorganic & medicinal chemistry 20021001

Title: Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

Journal: Archives of toxicology 20020601

Title: Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver.

Journal: International journal of clinical pharmacology and therapeutics 20020501

Title: Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis.

Journal: Bioscience, biotechnology, and biochemistry 20020501

Title: Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols.

Journal: Biochemical pharmacology 20020315

Title: The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent.

Journal: Chemical research in toxicology 20020301

Title: Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

Journal: Biochemical pharmacology 20020115

Title: Toward the rational design of protein kinase casein kinase-2 inhibitors.

Journal: Pharmacology & therapeutics 20020101

Title: Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells.

Journal: Environmental and molecular mutagenesis 20020101

Title: Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation.

Journal: International journal of oncology 20010601

Title: Structure-activity study on the quinone/quinone methide chemistry of flavonoids.

Journal: Chemical research in toxicology 20010401

Title: Hydroxylations and methylations of quercetin, fisetin, and catechin by Streptomyces griseus.

Journal: Journal of natural products 20010401

Title: Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides.

Journal: Advances in experimental medicine and biology 20010101

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

Title: Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.

Journal: Anticancer research 20000101

Title: Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.

Journal: Pharmaceutical research 19961201

Title: Inhibition of HIV activation in latently infected cells by flavonoid compounds.

Journal: AIDS research and human retroviruses 19960101

Title: Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.

Journal: Biochemical pharmacology 19940803

Title: Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

Journal: Journal of natural products 19940101

Title: Flavones are inhibitors of HIV-1 proteinase.

Journal: Biochemical and biophysical research communications 19921030

Title: Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana.

Journal: Journal of ethnopharmacology 19920401

Title: Inhibition of reverse transcriptases by flavonoids.

Journal: Antiviral research 19890901

Title: Kim SC, et al. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44.

Title: Mukhtar E, et al. Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells. Cancer Lett. 2015 Oct 28;367(2):173-83.

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SDS
Tags:528-48-3 Molecular Formula|528-48-3 MDL|528-48-3 SMILES|528-48-3 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
Catalog No.: AA00DE52
528-48-3,MFCD00006829
528-48-3 | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
Pack Size: 100mg
Purity: >96.0%(HPLC)
in stock
$37.00 $26.00
Pack Size: 1g
Purity: >97%(HPLC)powder
in stock
$107.00 $75.00
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Technical Information
Catalog Number: AA00DE52
Chemical Name: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
CAS Number: 528-48-3
Molecular Formula: C15H10O6
Molecular Weight: 286.2363
MDL Number: MFCD00006829
SMILES: Oc1ccc2c(c1)oc(c(c2=O)O)c1ccc(c(c1)O)O
Properties
BP: 599.4°C at 760 mmHg  
Form: Solid  
MP: 330 °C  
Refractive Index: 1.4413 (estimate)  
Storage: Keep in dry area;-20 ℃;  
Complexity: 459  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 21  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2  
Literature fold

Title: Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20181001

Title: Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20181001

Title: Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20180701

Title: Fisetin-induced apoptosis of human oral cancer SCC-4 cells through reactive oxygen species production, endoplasmic reticulum stress, caspase-, and mitochondria-dependent signaling pathways.

Journal: Environmental toxicology20170601

Title: Potentiation of luteolin cytotoxicity by flavonols fisetin and quercetin in human chronic lymphocytic leukemia cell lines.

Journal: Food & function20160914

Title: Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells.

Journal: Cancer cell international20160101

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20150201

Title: Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells.

Journal: Food & function20150101

Title: Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

Journal: Fitoterapia20140401

Title: Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-κB activation and antioxidant defence.

Journal: PloS one20140101

Title: Hypocholesterolemic effect of daily fisetin supplementation in high fat fed Sprague-Dawley rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20130701

Title: Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.

Journal: Chemical research in toxicology20121119

Title: Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management.

Journal: Biochemical pharmacology20121115

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: Mechanisms of toxicity of amorphous silica nanoparticles on human lung submucosal cells in vitro: protective effects of fisetin.

Journal: Chemical research in toxicology20121015

Title: Induced chirality in fisetin upon binding to serum albumin: experimental circular dichroism and TDDFT calculations.

Journal: Journal of molecular modeling20120901

Title: Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.

Journal: Biochemistry20120807

Title: Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells.

Journal: Immunopharmacology and immunotoxicology20120801

Title: Synthesis of flavonol 3-O-glycoside by UGT78D1.

Journal: Glycoconjugate journal20120801

Title: Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

Journal: European journal of medicinal chemistry20120801

Title: A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson's disease.

Journal: Journal of medicinal food20120801

Title: A fluorimetric assay for human reticulocyte 15-lipoxygenase-1 activity.

Journal: Analytical biochemistry20120701

Title: Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells.

Journal: Cancer letters20120628

Title: Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

Journal: European journal of medicinal chemistry20120601

Title: Fisetin and rutin as 3C protease inhibitors of enterovirus A71.

Journal: Journal of virological methods20120601

Title: Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120601

Title: Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation.

Journal: The Journal of biological chemistry20120601

Title: Study of the interaction between fisetin and human serum albumin: a biophysical approach.

Journal: Protein and peptide letters20120601

Title: Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice.

Journal: International journal of pharmaceutics20120510

Title: Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.

Journal: Molecules (Basel, Switzerland)20120507

Title: The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20120501

Title: Discovery and development of spleen tyrosine kinase (SYK) inhibitors.

Journal: Journal of medicinal chemistry20120426

Title: Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.

Journal: International journal of cancer20120401

Title: Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro.

Journal: Journal of microbiology (Seoul, Korea)20120401

Title: 3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology20120401

Title: 3,3',4',5,5'-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation.

Journal: Neuroscience letters20120328

Title: The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system.

Journal: Behavioural brain research20120317

Title: Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.

Journal: European journal of pharmacology20120315

Title: Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120301

Title: Drosophila models of proteinopathies: the little fly that could.

Journal: Current pharmaceutical design20120301

Title: Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.

Journal: Bioorganic & medicinal chemistry letters20120301

Title: Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol.

Journal: Aging20120301

Title: Autophagy and cancer.

Journal: Experimental & molecular medicine20120227

Title: Development of a liposomal formulation of the natural flavonoid fisetin.

Journal: International journal of pharmaceutics20120214

Title: Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy.

Journal: International journal of oncology20120201

Title: Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway.

Journal: Archives of toxicology20120201

Title: Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention.

Journal: Carcinogenesis20120201

Title: Metabolic effects of silibinin in the rat liver.

Journal: Chemico-biological interactions20120125

Title: Molecular dynamic behavior and binding affinity of flavonoid analogues to the cyclin dependent kinase 6/cyclin D complex.

Journal: Journal of chemical information and modeling20120123

Title: Spectroscopic exploration of mode of binding of ctDNA with 3-hydroxyflavone: a contrast to the mode of binding with flavonoids having additional hydroxyl groups.

Journal: The journal of physical chemistry. B20120112

Title: Chemical modification of the multitarget neuroprotective compound fisetin.

Journal: Journal of medicinal chemistry20120112

Title: Targeting the wingless signaling pathway with natural compounds as chemopreventive or chemotherapeutic agents.

Journal: Current pharmaceutical biotechnology20120101

Title: MAP Kinases and Prostate Cancer.

Journal: Journal of signal transduction20120101

Title: Rhus verniciflua stokes against advanced cancer: a perspective from the Korean Integrative Cancer Center.

Journal: Journal of biomedicine & biotechnology20120101

Title: Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells.

Journal: International journal of biological sciences20120101

Title: C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.

Journal: PloS one20120101

Title: Isolation and characterization of activators of ERK/MAPK from citrus plants.

Journal: International journal of molecular sciences20120101

Title: Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system.

Journal: Surgical neurology international20120101

Title: Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography.

Journal: Biological & pharmaceutical bulletin20120101

Title: Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans.

Journal: PloS one20120101

Title: Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans.

Journal: Frontiers in genetics20120101

Title: Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells.

Journal: PloS one20120101

Title: A review: inflammatory process in Alzheimer's disease, role of cytokines.

Journal: TheScientificWorldJournal20120101

Title: A series of novel neuroprotective blood brain barrier penetrating flavonoid drugs to treat acute ischemic stroke.

Journal: Current pharmaceutical design20120101

Title: Flavonoids inhibit the respiratory burst of neutrophils in mammals.

Journal: Oxidative medicine and cellular longevity20120101

Title: Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

Journal: PloS one20120101

Title: Microbial transformations of 7-hydroxyflavanone.

Journal: TheScientificWorldJournal20120101

Title: Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple.

Journal: Acta biochimica Polonica20120101

Title: Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.

Journal: Oxidative medicine and cellular longevity20120101

Title: Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo.

Journal: Oxidative medicine and cellular longevity20120101

Title: A comparative study of phytoestrogen action in mitigating apoptosis induced by oxidative stress.

Journal: In vivo (Athens, Greece)20120101

Title: Fisetin Inhibits Osteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 Signaling Pathways.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite.

Journal: Biochemical pharmacology20111201

Title: Application of comparative vibrational spectroscopic and mechanistic studies in analysis of fisetin structure.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20111201

Title: Fluorescence light-up recognition of DNA nucleotide based on selective abasic site binding of an excited-state intramolecular proton transfer probe.

Journal: The Analyst20111107

Title: Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders.

Journal: Experimental neurology20111101

Title: Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats.

Journal: European journal of pharmacology20111015

Title: Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity.

Journal: Journal of agricultural and food chemistry20111012

Title: Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.

Journal: Aging cell20111001

Title: The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells.

Journal: International journal of oncology20111001

Title: Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters.

Journal: Free radical biology & medicine20111001

Title: Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin.

Journal: International immunopharmacology20110901

Title: Fisetin induces Nrf2-mediated HO-1 expression through PKC-δ and p38 in human umbilical vein endothelial cells.

Journal: Journal of cellular biochemistry20110901

Title: The lipogenesis pathway as a cancer target.

Journal: Journal of medicinal chemistry20110825

Title: Photophysical behavior of fisetin in dimyristoylphosphatidylcholine liposome membrane.

Journal: The journal of physical chemistry. B20110825

Title: Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice.

Journal: Cancer chemotherapy and pharmacology20110801

Title: Longevity and stress in Caenorhabditis elegans.

Journal: Aging20110801

Title: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells.

Journal: Toxicology letters20110624

Title: Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.

Journal: Chemistry & biology20110624

Title: Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.

Journal: Human molecular genetics20110615

Title: The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.

Journal: Journal of molecular biology20110603

Title: Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.

Journal: The Journal of investigative dermatology20110601

Title: Fisetin: a natural fist against melanoma?

Journal: The Journal of investigative dermatology20110601

Title: Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.

Journal: Interdisciplinary toxicology20110601

Title: Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid.

Journal: International journal of environmental research and public health20110601

Title: Comparative spectroscopic and mechanistic study of chelation properties of fisetin with iron in aqueous buffered solutions. Implications on in vitro antioxidant activity.

Journal: Dalton transactions (Cambridge, England : 2003)20110507

Title: Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20110501

Title: Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.

Journal: Bioorganic & medicinal chemistry20110501

Title: Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20110428

Title: HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos.

Journal: Analytical and bioanalytical chemistry20110301

Title: Directly suspended droplet microextraction with in injection-port derivatization coupled to gas chromatography-mass spectrometry for the analysis of polyphenols in herbal infusions, fruits and functional foods.

Journal: Journal of chromatography. A20110204

Title: Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells.

Journal: Basic & clinical pharmacology & toxicology20110201

Title: Anticancer activity of a combination of cisplatin and fisetin in embryonal carcinoma cells and xenograft tumors.

Journal: Molecular cancer therapeutics20110201

Title: New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals.

Journal: Anti-cancer drugs20110201

Title: Probing the interactions of hemoglobin with antioxidant flavonoids via fluorescence spectroscopy and molecular modeling studies.

Journal: Biophysical chemistry20110201

Title: ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.

Journal: Human molecular genetics20110115

Title: Prooxidant activity of fisetin: effects on energy metabolism in the rat liver.

Journal: Journal of biochemical and molecular toxicology20110101

Title: Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis.

Journal: Cancer letters20110101

Title: Multiple prototropism of fisetin in sodium cholate and related bile salt media.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology20110101

Title: Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences20110101

Title: Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?

Journal: PloS one20110101

Title: Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells.

Journal: Drug design, development and therapy20110101

Title: Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression.

Journal: PloS one20110101

Title: Genotoxic potential of Cotinus coggygria Scop. (Anacardiaceae) stem extract in vivo.

Journal: Genetics and molecular biology20110101

Title: Resveratrol inhibits Cdk5 activity through regulation of p35 expression.

Journal: Molecular pain20110101

Title: Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes.

Journal: PloS one20110101

Title: Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation.

Journal: PloS one20110101

Title: Quercetin and cancer chemoprevention.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Assessment and histological analysis of the IPRL technique for sequential in situ liver biopsy.

Journal: Comparative hepatology20110101

Title: Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma cells.

Journal: PloS one20110101

Title: ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells.

Journal: PloS one20110101

Title: Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells.

Journal: PloS one20110101

Title: Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells.

Journal: Neoplasma20110101

Title: In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines.

Journal: BMC complementary and alternative medicine20110101

Title: A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

Journal: PloS one20110101

Title: Quercetin inhibits IL-1β-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves' orbitopathy.

Journal: PloS one20110101

Title: Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Journal: Molecular neurodegeneration20110101

Title: Flavonoids: A versatile source of anticancer drugs.

Journal: Pharmacognosy reviews20110101

Title: Tasco(®), a product of Ascophyllum nodosum, imparts thermal stress tolerance in Caenorhabditis elegans.

Journal: Marine drugs20110101

Title: Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia.

Journal: International journal of molecular sciences20110101

Title: Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives.

Journal: Oxidative medicine and cellular longevity20110101

Title: A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.

Journal: PloS one20110101

Title: Antiviral activity of four types of bioflavonoid against dengue virus type-2.

Journal: Virology journal20110101

Title: Elevated carbon dioxide increases contents of flavonoids and phenolic compounds, and antioxidant activities in Malaysian young ginger (Zingiber officinale Roscoe.) varieties.

Journal: Molecules (Basel, Switzerland)20101103

Title: Polyphenols and human health: prevention of disease and mechanisms of action.

Journal: Nutrients20101101

Title: Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents.

Journal: Planta medica20101001

Title: Flavonols attenuate the immediate and late-phase asthmatic responses to aerosolized-ovalbumin exposure in the conscious guinea pig.

Journal: Fitoterapia20101001

Title: Relationships between structures of hydroxyflavones and their antioxidative effects.

Journal: Bioorganic & medicinal chemistry letters20100915

Title: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.

Journal: Cancer metastasis reviews20100901

Title: Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.

Journal: Bioorganic & medicinal chemistry letters20100815

Title: Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.

Journal: Carcinogenesis20100801

Title: Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin.

Journal: International journal of radiation oncology, biology, physics20100801

Title: Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.

Journal: Aging20100801

Title: Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

Journal: Biochemical pharmacology20100601

Title: Chemoinformatics-assisted development of new anti-biofilm compounds.

Journal: Applied microbiology and biotechnology20100601

Title: [Studies on the flavonoids from Lignum Dalbergiae Odoriferae (II)].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20100601

Title: Overcoming multidrug resistance in human cancer cells by natural compounds.

Journal: Toxins20100601

Title: Rapid effects of phytoestrogens on human colonic smooth muscle are mediated by oestrogen receptor beta.

Journal: Molecular and cellular endocrinology20100514

Title: Sensor for fisetin based on gold nanoparticles in ionic liquid and binuclear nickel complex immobilized in silica.

Journal: The Analyst20100501

Title: Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity.

Journal: Journal of neurochemistry20100401

Title: On-line HPLC method for screening of antioxidants against superoxide anion radical from complex mixtures.

Journal: Journal of separation science20100401

Title: Apoptosis by dietary agents for prevention and treatment of prostate cancer.

Journal: Endocrine-related cancer20100301

Title: The actions of fisetin on glucose metabolism in the rat liver.

Journal: Cell biochemistry and function20100301

Title: An in vitro micronucleus assay with size-classified micronucleus counting to discriminate aneugens from clastogens.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20100201

Title: The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells.

Journal: Mutation research20100201

Title: Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Journal: Journal of medicinal chemistry20100114

Title: Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells.

Journal: Molecular and cellular biochemistry20100101

Title: Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.

Journal: European journal of medicinal chemistry20100101

Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Journal: Bioorganic & medicinal chemistry20100101

Title: Protection of burn-induced skin injuries by the flavonoid kaempferol.

Journal: BMB reports20100101

Title: The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

Journal: International journal of cell biology20100101

Title: Excess production of Bacillus subtilis quercetin 2,3-dioxygenase affects cell viability in the presence of quercetin.

Journal: Bioscience, biotechnology, and biochemistry20100101

Title: Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy.

Journal: Journal of biological regulators and homeostatic agents20100101

Title: Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20100101

Title: Apoptotic effects of chrysin in human cancer cell lines.

Journal: International journal of molecular sciences20100101

Title: Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells.

Journal: Nutrition and cancer20100101

Title: A novel dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes.

Journal: Oxidative medicine and cellular longevity20100101

Title: Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II.

Journal: PloS one20100101

Title: Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.

Journal: Pharmacognosy reviews20100101

Title: Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: implications on in vitro antioxidant activity.

Journal: The journal of physical chemistry. A20091224

Title: Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin.

Journal: Genes & nutrition20091201

Title: Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography.

Journal: Analytical and bioanalytical chemistry20091201

Title: Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling.

Journal: Immune network20091201

Title: Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB.

Journal: International journal of cancer20091115

Title: Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549.

Journal: Journal of agricultural and food chemistry20091014

Title: Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha.

Journal: The Journal of biological chemistry20091002

Title: The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes.

Journal: British journal of pharmacology20091001

Title: Structure and antioxidant activity of brominated flavonols and flavanones.

Journal: Journal of mass spectrometry : JMS20091001

Title: Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

Journal: Bioorganic & medicinal chemistry letters20090815

Title: Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.

Journal: Current genomics20090801

Title: Potential neuroprotective drugs in cerebral ischemia: new saturated and polyunsaturated lipids coupled to hydrophilic moieties: synthesis and biological activity.

Journal: Journal of medicinal chemistry20090723

Title: Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles.

Journal: Analytical and bioanalytical chemistry20090601

Title: Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.

Journal: Carcinogenesis20090601

Title: Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells.

Journal: BMB reports20090531

Title: Inhibition of LPS-induced pulmonary inflammation by specific flavonoids.

Journal: Biochemical and biophysical research communications20090508

Title: Study on fisetin-aluminium(III) interaction in aqueous buffered solutions by spectroscopy and molecular modeling.

Journal: Journal of inorganic biochemistry20090501

Title: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin.

Journal: American journal of physiology. Gastrointestinal and liver physiology20090501

Title: Distribution and major sources of flavonoid intakes in the middle-aged Japanese women.

Journal: Journal of clinical biochemistry and nutrition20090501

Title: In vitro antiproliferative characteristics of flavonoids and diazepam on SNU-C4 colorectal adenocarcinoma cells.

Journal: Journal of natural medicines20090401

Title: Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (Seprafilm) for the prevention of postoperative intra-abdominal adhesions.

Journal: Clinics (Sao Paulo, Brazil)20090401

Title: Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

Journal: Molecular and cellular endocrinology20090325

Title: Mechanism of CYP2C9 inhibition by flavones and flavonols.

Journal: Drug metabolism and disposition: the biological fate of chemicals20090301

Title: Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models.

Journal: International immunopharmacology20090301

Title: Development of an in vitro test system measuring transcriptional downregulatory activities on IL-13.

Journal: Journal of microbiology and biotechnology20090301

Title: MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites.

Journal: The Plant journal : for cell and molecular biology20090201

Title: A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.

Journal: Carcinogenesis20090201

Title: Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.

Journal: Journal of agricultural and food chemistry20090114

Title: Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization.

Journal: Nutrition and cancer20090101

Title: Synergetic effects of granulocyte-colony stimulating factor and cognitive training on spatial learning and survival of newborn hippocampal neurons.

Journal: PloS one20090101

Title: Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes.

Journal: The American journal of Chinese medicine20090101

Title: Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.

Journal: Microbial cell factories20090101

Title: Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.

Journal: Journal of biomedicine & biotechnology20090101

Title: Directed therapy for exfoliation syndrome.

Journal: The open ophthalmology journal20090101

Title: Directed Therapy: An Approach to the Improved Treatment of Exfoliation syndrome.

Journal: Middle East African journal of ophthalmology20090101

Title: MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals.

Journal: Genetics and molecular biology20090101

Title: Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.

Journal: Journal of agricultural and food chemistry20081224

Title: Ultrasound extracted flavonoids from four varieties of Portuguese red grape skins determined by reverse-phase high-performance liquid chromatography with electrochemical detection.

Journal: Analytica chimica acta20081223

Title: Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green.

Journal: Journal of cellular biochemistry20081215

Title: Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.

Journal: British journal of cancer20081209

Title: Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein.

Journal: Neuroscience letters20081031

Title: A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.

Journal: Cancer research20081015

Title: Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages.

Journal: Biochimica et biophysica acta20081001

Title: Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells.

Journal: Archives of pharmacal research20081001

Title: Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.

Journal: Carcinogenesis20080901

Title: Protective effects of epigallocatechin gallate after UV irradiation of cultured human lens epithelial cells.

Journal: Korean journal of ophthalmology : KJO20080901

Title: The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity.

Journal: Archives of biochemistry and biophysics20080815

Title: Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells.

Journal: Cancer letters20080708

Title: Dietary agents for chemoprevention of prostate cancer.

Journal: Cancer letters20080708

Title: Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.

Journal: Biological & pharmaceutical bulletin20080701

Title: Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.

Journal: Carcinogenesis20080501

Title: Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.

Journal: International immunopharmacology20080301

Title: The effect of flavonoid derivatives on doxorubicin transport and metabolism.

Journal: Bioorganic & medicinal chemistry20080215

Title: Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.

Journal: Free radical biology & medicine20080215

Title: Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells.

Journal: Biological & pharmaceutical bulletin20080201

Title: Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons.

Journal: Brain research20080116

Title: Potentiometric determination of aqueous dissociation constants of flavonols sparingly soluble in water.

Journal: Talanta20080115

Title: Flavonoids with DNA strand-scission activity from Rhus javanica var. roxburghiana.

Journal: Fitoterapia20080101

Title: [Spectroscopic characterization of binding between human serum albumin and 3,3', 4',7-tetrahydroxyflavone].

Journal: Guang pu xue yu guang pu fen xi = Guang pu20080101

Title: The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells.

Journal: Molecular vision20080101

Title: Inflammaging as a prodrome to Alzheimer's disease.

Journal: Journal of neuroinflammation20080101

Title: Cupric ion reducing antioxidant capacity assay for food antioxidants: vitamins, polyphenolics, and flavonoids in food extracts.

Journal: Methods in molecular biology (Clifton, N.J.)20080101

Title: Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans.

Journal: PloS one20080101

Title: Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans.

Journal: Archives of toxicology20071201

Title: Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Journal: Bioorganic & medicinal chemistry20071201

Title: Protective effects of epigallocatechin gallate after UV irradiation in cultured human retinal pigment epithelial cells.

Journal: Korean journal of ophthalmology : KJO20071201

Title: [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

Journal: Ai zheng = Aizheng = Chinese journal of cancer20071201

Title: A novel approach to screening for new neuroprotective compounds for the treatment of stroke.

Journal: Brain research20071010

Title: Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20071001

Title: Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.

Journal: Bioorganic & medicinal chemistry20071001

Title: Determination of flavonoid aglycones in several food samples by mixed micellar electrokinetic chromatography.

Journal: Journal of separation science20071001

Title: Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.

Journal: The Journal of nutrition20071001

Title: Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

Journal: Microbiology (Reading, England)20071001

Title: Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin.

Journal: Journal of enzyme inhibition and medicinal chemistry20070801

Title: Inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.

Journal: Journal of enzyme inhibition and medicinal chemistry20070801

Title: Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 Cl 41 cells.

Journal: Molecular carcinogenesis20070601

Title: Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects.

Journal: International journal of biological macromolecules20070601

Title: Flavonoids and related compounds as anti-allergic substances.

Journal: Allergology international : official journal of the Japanese Society of Allergology20070601

Title: Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.

Journal: Molecular pharmacology20070601

Title: Interaction of flavonoids and intestinal facilitated glucose transporters.

Journal: Planta medica20070401

Title: 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry letters20070301

Title: The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.

Journal: Diabetes20070301

Title: Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

Journal: Drug metabolism and disposition: the biological fate of chemicals20070201

Title: Design and synthesis of compounds that extend yeast replicative lifespan.

Journal: Aging cell20070201

Title: Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20070201

Title: Anti-inflammatory activity of fisetin in human mast cells (HMC-1).

Journal: Pharmacological research20070101

Title: Comparative study of the photophysical behavior of fisetin in homogeneous media and in anionic and cationic reverse micelles media.

Journal: Photochemistry and photobiology20070101

Title: Distinctive antioxidant and antiinflammatory effects of flavonols.

Journal: Journal of agricultural and food chemistry20061227

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling20061101

Title: A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives.

Journal: Free radical research20061001

Title: Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway.

Journal: The European journal of neuroscience20061001

Title: Study of the complexation of fisetin with cyclodextrins.

Journal: The journal of physical chemistry. A20060914

Title: Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment.

Journal: Oncology reports20060801

Title: Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death.

Journal: Investigative ophthalmology & visual science20060701

Title: Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes.

Journal: Journal of ethnopharmacology20060615

Title: Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

Journal: Journal of medicinal chemistry20060601

Title: Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.

Journal: Life sciences20060515

Title: Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20060301

Title: Antioxidants from Rabdosia japonica.

Journal: Phytotherapy research : PTR20060301

Title: Effect of different flavonoids on collagen synthesis in human fibroblasts.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands)20060301

Title: Luteolin, a flavonoid, inhibits AP-1 activation by basophils.

Journal: Biochemical and biophysical research communications20060203

Title: Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions.

Journal: Transplantation20060127

Title: Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines.

Journal: Prostate cancer and prostatic diseases20060101

Title: A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.

Journal: Journal of natural products20060101

Title: Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils.

Journal: International archives of allergy and immunology20060101

Title: Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.

Journal: Journal of medicinal chemistry20051201

Title: Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells.

Journal: Biological & pharmaceutical bulletin20051201

Title: Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells.

Journal: Biochimica et biophysica acta20051130

Title: Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.

Journal: Journal of agricultural and food chemistry20051102

Title: Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.

Journal: Archives of pharmacal research20051101

Title: Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.

Journal: Molecular pharmacology20051001

Title: Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease.

Journal: Free radical research20051001

Title: Properties of normal and glycated human hemoglobin in presence and absence of antioxidant.

Journal: Biochemical and biophysical research communications20050902

Title: Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity.

Journal: The British journal of nutrition20050901

Title: Interactions of the plant flavonoid fisetin with macromolecular targets: insights from fluorescence spectroscopic studies.

Journal: Journal of photochemistry and photobiology. B, Biology20050801

Title: Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.

Journal: Biochemical pharmacology20050715

Title: Inhibition of P-glycoprotein by natural products in human breast cancer cells.

Journal: Archives of pharmacal research20050701

Title: Determination of dissociation constants of flavonoids by capillary electrophoresis.

Journal: Electrophoresis20050501

Title: Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids.

Journal: Archives of pharmacal research20050501

Title: Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin.

Journal: Mutation research20050404

Title: A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase.

Journal: Nitric oxide : biology and chemistry20050301

Title: Synergistic effects of flavonoids and ascorbate on enhancement in DNA degradation induced by a bleomycin-Fe complex.

Journal: Free radical research20050301

Title: Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

Journal: Journal of medicinal chemistry20050210

Title: Evaluation of the antioxidant activity of flavonoids by 'ferric reducing antioxidant power' assay and cyclic voltammetry.

Journal: Biochimica et biophysica acta20050118

Title: Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method.

Journal: Journal of agricultural and food chemistry20041229

Title: Vascular and anti-oxidant actions of flavonols and flavones.

Journal: Clinical and experimental pharmacology & physiology20041101

Title: Oxidation products of quercetin catalyzed by mushroom tyrosinase.

Journal: Bioorganic & medicinal chemistry20041015

Title: Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20040901

Title: Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation.

Journal: Journal of neurochemistry20040901

Title: Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Journal: Nature20040805

Title: Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes.

Journal: FEBS letters20040716

Title: Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils.

Journal: International archives of allergy and immunology20040601

Title: Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.

Journal: Drug metabolism and disposition: the biological fate of chemicals20040601

Title: Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20040601

Title: Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase.

Journal: Drug metabolism and disposition: the biological fate of chemicals20040501

Title: Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.

Journal: Molecular pharmacology20040501

Title: Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

Journal: The Journal of biological chemistry20040109

Title: Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua.

Journal: Journal of ethnopharmacology20040101

Title: Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways.

Journal: Nutrition and cancer20040101

Title: Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship.

Journal: Neurotoxicity research20040101

Title: Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20040101

Title: Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta.

Journal: Life sciences20031219

Title: Neuroprotection by flavonoids.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas20031201

Title: Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.

Journal: Phytotherapy research : PTR20031201

Title: Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids.

Journal: Indian journal of biochemistry & biophysics20031201

Title: Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate.

Journal: Journal of agricultural and food chemistry20031119

Title: Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-, Fe-ascorbate- and Fe-microsomal systems.

Journal: Biochemical pharmacology20031001

Title: Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102.

Journal: Mutation research20030909

Title: Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20030901

Title: Anti-allergic substances contained in the pollen of Cryptomeria japonica possess diverse effects on the degranulation of RBL-2H3 cells.

Journal: Journal of pharmacological sciences20030701

Title: Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils.

Journal: The Journal of allergy and clinical immunology20030601

Title: HTS compatible assay for antioxidative agents using primary cultured hepatocytes.

Journal: Assay and drug development technologies20030601

Title: Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells.

Journal: Journal of cellular physiology20030501

Title: Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase.

Journal: Biochemistry. Biokhimiia20030401

Title: Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.

Journal: Journal of agricultural and food chemistry20030312

Title: Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by beta-glucosidase in the presence of amino acids.

Journal: Biological & pharmaceutical bulletin20030301

Title: Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action.

Journal: Biochemical pharmacology20030301

Title: Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study.

Journal: Biochemical pharmacology20030301

Title: Effect of flavonoids on MRP1-mediated transport in Panc-1 cells.

Journal: Journal of pharmaceutical sciences20030201

Title: Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions.

Journal: Kidney international20030201

Title: Cell culture protection and in vivo neuroprotective capacity of flavonoids.

Journal: Neurotoxicity research20030101

Title: Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

Journal: Journal of natural products20021201

Title: Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features.

Journal: Journal of cardiovascular pharmacology20021101

Title: Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.

Journal: Bioorganic & medicinal chemistry20021001

Title: Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

Journal: Archives of toxicology20020601

Title: Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver.

Journal: International journal of clinical pharmacology and therapeutics20020501

Title: Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis.

Journal: Bioscience, biotechnology, and biochemistry20020501

Title: Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols.

Journal: Biochemical pharmacology20020315

Title: The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent.

Journal: Chemical research in toxicology20020301

Title: Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

Journal: Biochemical pharmacology20020115

Title: Toward the rational design of protein kinase casein kinase-2 inhibitors.

Journal: Pharmacology & therapeutics20020101

Title: Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells.

Journal: Environmental and molecular mutagenesis20020101

Title: Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation.

Journal: International journal of oncology20010601

Title: Structure-activity study on the quinone/quinone methide chemistry of flavonoids.

Journal: Chemical research in toxicology20010401

Title: Hydroxylations and methylations of quercetin, fisetin, and catechin by Streptomyces griseus.

Journal: Journal of natural products20010401

Title: Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides.

Journal: Advances in experimental medicine and biology20010101

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment20000701

Title: Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.

Journal: Anticancer research20000101

Title: Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.

Journal: Pharmaceutical research19961201

Title: Inhibition of HIV activation in latently infected cells by flavonoid compounds.

Journal: AIDS research and human retroviruses19960101

Title: Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.

Journal: Biochemical pharmacology19940803

Title: Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

Journal: Journal of natural products19940101

Title: Flavones are inhibitors of HIV-1 proteinase.

Journal: Biochemical and biophysical research communications19921030

Title: Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana.

Journal: Journal of ethnopharmacology19920401

Title: Inhibition of reverse transcriptases by flavonoids.

Journal: Antiviral research19890901

Title: Kim SC, et al. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44.

Title: Mukhtar E, et al. Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells. Cancer Lett. 2015 Oct 28;367(2):173-83.

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