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52278-77-0,MFCD01937860
Catalog No.:AA00DE6Z

52278-77-0 | 5-HYDROXY-2'-DEOXYCYTIDINE

Pack Size
Purity
Availability
Price(USD)
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2mg
2 weeks  
$143.00   $100.00
- +
5mg
2 weeks  
$233.00   $163.00
- +
10mg
2 weeks  
$340.00   $238.00
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25mg
2 weeks  
$652.00   $457.00
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50mg
2 weeks  
$1,099.00   $769.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DE6Z
Chemical Name:
5-HYDROXY-2'-DEOXYCYTIDINE
CAS Number:
52278-77-0
Molecular Formula:
C9H13N3O5
Molecular Weight:
243.2166
MDL Number:
MFCD01937860
SMILES:
C1C(C(OC1N2C=C(C(=NC2=O)N)O)CO)O
Properties
Properties
 
Form:
Solid  
MP:
109-110°C  
Storage:
-20 ℃;Keep in dry area;  

Computed Properties
 
Complexity:
394  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
-1.9  

Literature

Title: In vivo treatment with aflatoxin B1 increases DNA oxidation, base excision repair activity and 8-oxoguanine DNA glycosylase 1 levels in mouse lung.

Journal: Toxicology 20140703

Title: Mutagen-mediated enhancement of HIV-1 replication in persistently infected cells.

Journal: Virology 20120315

Title: Thermodynamic signature of DNA damage: characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine base pair.

Journal: Biochemistry 20120306

Title: Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461.

Journal: PloS one 20110101

Title: Defective repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III.

Journal: Free radical biology & medicine 20100301

Title: Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides.

Journal: Drugs 20090101

Title: Reaction of 2'-deoxycytidine with peroxynitrite in the presence of ammonium bromide.

Journal: Bioorganic & medicinal chemistry 20080501

Title: Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway.

Journal: DNA repair 20070104

Title: Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.

Journal: Journal of medicinal chemistry 20061019

Title: Ascorbate and H2O2 induced oxidative DNA damage in Jurkat cells.

Journal: Free radical biology & medicine 20060615

Title: Oxidation of 5-hydroxypyrimidine nucleosides to 5-hydroxyhydantoin and its alpha-hydroxy-ketone isomer.

Journal: Chemical research in toxicology 20050801

Title: Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection.

Journal: Virology 20050720

Title: Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.

Journal: Bioorganic & medicinal chemistry 20010301

Title: The role of duck hepatitis B virus and aflatoxin B1 in the induction of oxidative stress in the liver.

Journal: Cancer detection and prevention 20010101

Title: Lethal mutagenesis of HIV with mutagenic nucleoside analogs.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19990216

Title: New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

Journal: The Journal of biological chemistry 19940722

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