520-33-2,MFCD00075646
Catalog No.:AA00DED8

520-33-2 | (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

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Purity
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1g
97%
in stock  
$7.00   $5.00
- +
5g
97%
in stock  
$11.00   $8.00
- +
10g
97%
in stock  
$13.00   $9.00
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25g
≥98%
in stock  
$28.00   $19.00
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500g
97%
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$393.00 $275.00
  • Technical Information
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Technical Information
Catalog Number:
AA00DED8
Chemical Name:
(S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
CAS Number:
520-33-2
Molecular Formula:
C16H14O6
Molecular Weight:
302.2788
MDL Number:
MFCD00075646
SMILES:
COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O
FEMA Number:
4313
Properties
Computed Properties
 
Complexity:
413  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.4  

Literature

Title: Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.

Journal: Toxicology letters 20180915

Title: Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl(4)-induced acute liver injury and LPS-treated RAW264.7 cells.

Journal: Toxicology letters 20170515

Title: Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway.

Journal: Toxicology 20170415

Title: Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.

Journal: Chemico-biological interactions 20151205

Title: Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.

Journal: Journal of biochemical and molecular toxicology 20150301

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters 20150105

Title: Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity.

Journal: Pharmacology, biochemistry, and behavior 20140901

Title: Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.

Journal: Mediators of inflammation 20140101

Title: Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

Journal: Journal of pharmaceutical sciences 20130901

Title: Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.

Journal: Food chemistry 20121215

Title: Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori.

Journal: Food chemistry 20121215

Title: Iron reduction potentiates hydroxyl radical formation only in flavonols.

Journal: Food chemistry 20121215

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.

Journal: Journal of molecular recognition : JMR 20121101

Title: The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

Journal: The Journal of nutritional biochemistry 20121001

Title: Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells.

Journal: Food & function 20121001

Title: Evaluation of matrix effect in determination of some bioflavonoids in food samples by LC-MS/MS method.

Journal: Talanta 20120915

Title: Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins.

Journal: Food chemistry 20120915

Title: Composition of native Australian herbs polyphenolic-rich fractions and in vitro inhibitory activities against key enzymes relevant to metabolic syndrome.

Journal: Food chemistry 20120915

Title: Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Rapid assessment of endpoint antioxidant capacity of red wines through microchemical methods using a kinetic matching approach.

Journal: Talanta 20120815

Title: Evaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography.

Journal: Analytica chimica acta 20120813

Title: Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701

Title: Synergy of flavone with vancomycin and oxacillin against vancomycin-intermediate Staphyloccus aureus.

Journal: Pakistan journal of pharmaceutical sciences 20120701

Title: Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

Journal: Toxicology mechanisms and methods 20120601

Title: A prenylated flavanone from Dalea elegans inhibits rhodamine 6 G efflux and reverses fluconazole-resistance in Candida albicans.

Journal: Planta medica 20120601

Title: In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.

Journal: Molecular nutrition & food research 20120601

Title: Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells.

Journal: Journal of agricultural and food chemistry 20120509

Title: In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8).

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120501

Title: An investigation on the interaction of DNA with hesperetin/apigenin in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical application.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120501

Title: Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.

Journal: Journal of natural products 20120427

Title: Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.

Journal: Bioorganic & medicinal chemistry 20120415

Title: Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.

Journal: Journal of pharmaceutical and biomedical analysis 20120407

Title: Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: effect of dose and physicochemical properties.

Journal: Journal of pharmaceutical sciences 20120401

Title: Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.

Journal: Food & function 20120401

Title: Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.

Journal: Molecular nutrition & food research 20120401

Title: Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Autophagy and cancer.

Journal: Experimental & molecular medicine 20120227

Title: Interference of selected flavonoid aglycons in platelet aggregation assays.

Journal: Clinical chemistry and laboratory medicine 20120227

Title: Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations.

Journal: Biochemical and biophysical research communications 20120217

Title: Neuroprotective effects of citrus flavonoids.

Journal: Journal of agricultural and food chemistry 20120201

Title: Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption.

Journal: Journal of the Academy of Nutrition and Dietetics 20120201

Title: Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20120125

Title: Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach.

Journal: Journal of agricultural and food chemistry 20120111

Title: UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis 20120105

Title: Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.

Journal: International journal of biological macromolecules 20120101

Title: Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes.

Journal: The Journal of pharmacy and pharmacology 20120101

Title: Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Study of lipid profile and parieto-temporal lipid peroxidation in AlCl₃ mediated neurotoxicity. Modulatory effect of fenugreek seeds.

Journal: Lipids in health and disease 20120101

Title: Multiple functions of microsomal triglyceride transfer protein.

Journal: Nutrition & metabolism 20120101

Title: Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.

Journal: BMC complementary and alternative medicine 20120101

Title: Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus.

Journal: Bioinformation 20120101

Title: Does dietary inulin affect biological activity of a grapefruit flavonoid-rich extract?

Journal: Nutrition & metabolism 20120101

Title: Characterisation of flavonoid aglycones by negative ion chip-based nanospray tandem mass spectrometry.

Journal: International journal of analytical chemistry 20120101

Title: Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents.

Journal: Asian Pacific journal of cancer prevention : APJCP 20120101

Title: Antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of Punica granatum in alloxan-induced non-insulin-dependent diabetes mellitus albino rats.

Journal: Indian journal of pharmacology 20120101

Title: Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Journal: Frontiers in microbiology 20120101

Title: Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.

Journal: Mediators of inflammation 20120101

Title: Computational prediction of protein-protein interactions of human tyrosinase.

Journal: Enzyme research 20120101

Title: The effects of jiang-zhi-ning and its main components on cholesterol metabolism.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: The chemotherapeutic potential of Terminalia ferdinandiana: Phytochemistry and bioactivity.

Journal: Pharmacognosy reviews 20120101

Title: Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation.

Journal: PPAR research 20120101

Title: Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.

Journal: Oxidative medicine and cellular longevity 20120101

Title: [Study on chemical constituents of Artemisia sphaerocephala].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

Title: Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats.

Journal: Vascular pharmacology 20120101

Title: Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.

Journal: Biopharmaceutics & drug disposition 20111201

Title: Toxicological aspects of the use of phenolic compounds in disease prevention.

Journal: Interdisciplinary toxicology 20111201

Title: Study on the interference of rat feed to pharmacokinetics of flavonoids.

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111201

Title: Analysis of flavonoids by capillary zone electrophoresis with electrokinetic supercharging.

Journal: The Analyst 20111107

Title: Evaluation of binding and thermodynamic characteristics of interactions between a citrus flavonoid hesperitin with protein and effects of metal ions on binding.

Journal: Molecular biology reports 20111101

Title: Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats.

Journal: Ecotoxicology and environmental safety 20111001

Title: Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.

Journal: Cell biology and toxicology 20111001

Title: Microbial metabolism. Part 13. Metabolites of hesperetin.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: Binding of citrus flavanones and their glucuronides and chalcones to human serum albumin.

Journal: Food & function 20111001

Title: Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7.

Journal: Molecular and cellular endocrinology 20110915

Title: Hesperidin promotes cyclobutane pyrimidine dimer repair in UVB-exposed mice epidermis.

Journal: Irish journal of medical science 20110901

Title: Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.

Journal: Cardiovascular toxicology 20110901

Title: Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents.

Journal: Pharmacology, biochemistry, and behavior 20110901

Title: Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study.

Journal: European review for medical and pharmacological sciences 20110901

Title: Flavonoids in prevention of diseases with respect to modulation of Ca-pump function.

Journal: Interdisciplinary toxicology 20110901

Title: Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.

Journal: European journal of medicinal chemistry 20110801

Title: Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey.

Journal: Molecules (Basel, Switzerland) 20110727

Title: Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20110601

Title: Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.

Journal: Journal of agricultural and food chemistry 20110525

Title: Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion.

Journal: Journal of agricultural and food chemistry 20110511

Title: Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.

Journal: The Journal of clinical endocrinology and metabolism 20110501

Title: Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.

Journal: Diabetes 20110501

Title: Intrinsic and extrinsic regulation of innate immune receptors.

Journal: Yonsei medical journal 20110501

Title: Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFκB, p38 and caspase-3.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110401

Title: Analysis of isoflavones and flavonoids in human urine by UHPLC.

Journal: Analytical and bioanalytical chemistry 20110301

Title: Hesperetin, a potential therapy for carcinoid cancer.

Journal: American journal of surgery 20110301

Title: Assessment of Antioxidant and Phenolic Compound Concentrations as well as Xanthine Oxidase and Tyrosinase Inhibitory Properties of Different Extracts of Pleurotus citrinopileatus Fruiting Bodies.

Journal: Mycobiology 20110301

Title: Prenylated flavanones with anti-tyrosinase activity from Dalea boliviana.

Journal: Journal of natural products 20110225

Title: Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals.

Journal: Oncology reports 20110201

Title: Stereoisomeric separation of some flavanones using highly succinate-substituted α-cyclosophoro-octadecaoses as chiral additives in capillary electrophoresis.

Journal: Carbohydrate research 20110103

Title: Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of piper sarmentosum on experimental rabbits fed with cholesterol diet.

Journal: Lipids in health and disease 20110101

Title: Identification of chemical constituents in extracts and rat plasma from Fructus Aurantii by UPLC-PDA-Q-TOF/MS.

Journal: Phytochemical analysis : PCA 20110101

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences 20110101

Title: Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.

Journal: Lipids in health and disease 20110101

Title: [Aromatic constituents of Heteroplexis micocephal and their bioactivities].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101

Title: Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin. [corrected].

Journal: PloS one 20110101

Title: Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.

Journal: International journal of medical sciences 20110101

Title: C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent.

Journal: PloS one 20110101

Title: Inhibitory effect of phthalic Acid on tyrosinase: the mixed-type inhibition and docking simulations.

Journal: Enzyme research 20110101

Title: Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Towards Al-induced manganese-containing superoxide dismutase inactivation and conformational changes: an integrating study with docking simulations.

Journal: Enzyme research 20110101

Title: Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice.

Journal: Genetics and molecular biology 20110101

Title: Evaluation of antiaggregatory activity of flavonoid aglycone series.

Journal: Nutrition journal 20110101

Title: Diet-induced metabolic hamster model of nonalcoholic fatty liver disease.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20110101

Title: To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial.

Journal: BMC gastroenterology 20110101

Title: Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma.

Journal: Mediators of inflammation 20110101

Title: Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Development and validation of a UHPLC method for the determination of flavonoids in red wine.

Journal: Journal of AOAC International 20110101

Title: Tissue distribution of hesperetin in rats after a dietary intake.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis.

Journal: BMC complementary and alternative medicine 20110101

Title: Role of phenolic compounds in peptic ulcer: An overview.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Adaptation of Rhizobium leguminosarum to pea, alfalfa and sugar beet rhizospheres investigated by comparative transcriptomics.

Journal: Genome biology 20110101

Title: Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice.

Journal: Pharmacognosy research 20110101

Title: Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.

Journal: PloS one 20110101

Title: Antioxidant Activities of Plumbagin and Its Cu (II) Complex.

Journal: Bioinorganic chemistry and applications 20110101

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science 20110101

Title: Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease.

Journal: Journal of inflammation (London, England) 20110101

Title: Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study.

Journal: PloS one 20110101

Title: Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia.

Journal: International journal of molecular sciences 20110101

Title: Antiviral activity of four types of bioflavonoid against dengue virus type-2.

Journal: Virology journal 20110101

Title: Potential of herbs in skin protection from ultraviolet radiation.

Journal: Pharmacognosy reviews 20110101

Title: 7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation.

Journal: Phytotherapy research : PTR 20101201

Title: Carboxymethylated cyclosophoraose as a novel chiral additive for the stereoisomeric separation of some flavonoids by capillary electrophoresis.

Journal: Carbohydrate research 20101102

Title: Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.

Journal: Acta tropica 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Polyphenols and human health: prevention of disease and mechanisms of action.

Journal: Nutrients 20101101

Title: Free fruit at workplace intervention increases total fruit intake: a validation study using 24 h dietary recall and urinary flavonoid excretion.

Journal: European journal of clinical nutrition 20101001

Title: Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.

Journal: European journal of medicinal chemistry 20101001

Title: Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.

Journal: Journal of separation science 20101001

Title: Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media.

Journal: Archives of biochemistry and biophysics 20100901

Title: Selective inhibition of methoxyflavonoids on human CYP1B1 activity.

Journal: Bioorganic & medicinal chemistry 20100901

Title: Micronutrient synergy--a new tool in effective control of metastasis and other key mechanisms of cancer.

Journal: Cancer metastasis reviews 20100901

Title: Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity.

Journal: Nutrition research (New York, N.Y.) 20100901

Title: Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis.

Journal: Journal of food science 20100901

Title: Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters.

Journal: Journal of medicinal food 20100801

Title: Chemical synthesis of citrus flavanone glucuronides.

Journal: Journal of agricultural and food chemistry 20100728

Title: Passive asymmetric transport of hesperetin across isolated rabbit cornea.

Journal: International journal of pharmaceutics 20100715

Title: Hesperidin and hesperetin membrane interaction: understanding the role of 7-O-glycoside moiety in flavonoids.

Journal: Archives of biochemistry and biophysics 20100701

Title: Protective effects of silybin and analogues against X-ray radiation-induced damage.

Journal: Acta biochimica et biophysica Sinica 20100701

Title: Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.

Journal: The British journal of nutrition 20100601

Title: The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.

Journal: Molecular nutrition & food research 20100601

Title: Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.

Journal: Journal of agricultural and food chemistry 20100526

Title: Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.

Journal: Journal of agricultural and food chemistry 20100526

Title: Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway.

Journal: The Journal of nutritional biochemistry 20100501

Title: Extracellular monoenzyme deglycosylation system of 7-O-linked flavonoid beta-rutinosides and its disaccharide transglycosylation activity from Stilbella fimetaria.

Journal: Archives of microbiology 20100501

Title: The effect of component of cream for topical delivery of hesperetin.

Journal: Chemical & pharmaceutical bulletin 20100501

Title: Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.

Journal: Natural product communications 20100501

Title: Cytotoxic activities of several geranyl-substituted flavanones.

Journal: Journal of natural products 20100423

Title: Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.

Journal: Journal of ethnopharmacology 20100421

Title: The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.

Journal: Biochemical and biophysical research communications 20100409

Title: Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100401

Title: Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.

Journal: European journal of clinical nutrition 20100401

Title: In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system.

Journal: International journal of pharmaceutics 20100330

Title: Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions.

Journal: Drug development and industrial pharmacy 20100301

Title: Influence of oryzanol and ferulic Acid on the lipid metabolism and antioxidative status in high fat-fed mice.

Journal: Journal of clinical biochemistry and nutrition 20100301

Title: Enzyme technology for precision functional food ingredient processes.

Journal: Annals of the New York Academy of Sciences 20100301

Title: Optical isomer separation of flavanones and flavanone glycosides by nano-liquid chromatography using a phenyl-carbamate-propyl-beta-cyclodextrin chiral stationary phase.

Journal: Journal of chromatography. A 20100212

Title: Identification of bisprenylated benzoic acid derivatives from yerba santa (Eriodictyon ssp.) using sensory-guided fractionation.

Journal: Journal of agricultural and food chemistry 20100210

Title: Preserving hesperetin nanosuspensions for dermal application.

Journal: Die Pharmazie 20100201

Title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.

Journal: Nutrients 20100201

Title: Greater apparent absorption of flavonoids is associated with lesser human fecal flavonoid disappearance rates.

Journal: Journal of agricultural and food chemistry 20100113

Title: Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation.

Journal: Journal of agricultural and food chemistry 20100113

Title: Characterization of flavor modulating effects in complex mixtures via high temperature liquid chromatography.

Journal: Journal of agricultural and food chemistry 20100113

Title: Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: Structural activity relationship of flavonoids with estrogen-related receptor gamma.

Journal: FEBS letters 20100104

Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Journal: Bioorganic & medicinal chemistry 20100101

Title: Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats.

Journal: Journal of clinical biochemistry and nutrition 20100101

Title: Acute effects of vinegar intake on some biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits.

Journal: Lipids in health and disease 20100101

Title: Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high cholesterolemic experimental rabbits.

Journal: Lipids in health and disease 20100101

Title: Flavanols and anthocyanins in cardiovascular health: a review of current evidence.

Journal: International journal of molecular sciences 20100101

Title: Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.

Journal: Cellular immunology 20100101

Title: A novel dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha.

Journal: PloS one 20100101

Title: Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen.

Journal: PloS one 20100101

Title: Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats.

Journal: Journal of toxicology and environmental health. Part A 20100101

Title: Effects of Various Flavonoids on the α-Synuclein Fibrillation Process.

Journal: Parkinson's disease 20100101

Title: Glycine tomentella Hayata inhibits IL-1β and IL-6 production, inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells.

Journal: Journal of biomedical science 20100101

Title: Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei).

Journal: Marine drugs 20100101

Title: Inhibitory effect of flavonoids on mutant H-Rasp protein.

Journal: Bioinformation 20100101

Title: Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.

Journal: Journal of agricultural and food chemistry 20091125

Title: 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.

Journal: Journal of medicinal chemistry 20091112

Title: Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone.

Journal: European journal of medicinal chemistry 20091101

Title: Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity.

Journal: Journal of clinical biochemistry and nutrition 20091101

Title: Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats.

Journal: The British journal of nutrition 20091001

Title: Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.

Journal: Diabetes 20091001

Title: Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001

Title: Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics.

Journal: AAPS PharmSciTech 20090901

Title: Major phytochemical composition of 3 native Korean citrus varieties and bioactive activity on V79-4 cells induced by oxidative stress.

Journal: Journal of food science 20090801

Title: Influences of flavonoids on erythrocyte membrane and metabolic implication through anionic exchange modulation.

Journal: The Journal of membrane biology 20090801

Title: [Studies on the chemical constituents from flower of Paulownia fortunei].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090801

Title: Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis.

Journal: Chemico-biological interactions 20090715

Title: Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.

Journal: Journal of natural products 20090701

Title: Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.

Journal: Investigational new drugs 20090601

Title: Bioactivation of flavonoid diglycosides by chicken cecal bacteria.

Journal: FEMS microbiology letters 20090601

Title: Distribution and major sources of flavonoid intakes in the middle-aged Japanese women.

Journal: Journal of clinical biochemistry and nutrition 20090501

Title: Production and characterization of Hesperetin nanosuspensions for dermal delivery.

Journal: International journal of pharmaceutics 20090417

Title: Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Sulfation of dietary flavonoids by human sulfotransferases.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090401

Title: [Effects of Hesperetin on cell activation and proliferation of murine T lymphocytes in vitro].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090401

Title: The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.

Journal: Archives of biochemistry and biophysics 20090401

Title: Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide.

Journal: Journal of agricultural and food chemistry 20090325

Title: Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion.

Journal: The British journal of nutrition 20090301

Title: The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.

Journal: Biomedical chromatography : BMC 20090301

Title: Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.

Journal: Biomedical chromatography : BMC 20090201

Title: Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.

Journal: Molecular and cellular biochemistry 20090101

Title: Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals.

Journal: BMC molecular biology 20090101

Title: Effect of processing on the flavonoid content and antioxidant capacity of Citrus hystrix leaf.

Journal: International journal of food sciences and nutrition 20090101

Title: Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry.

Journal: Chinese medicine 20090101

Title: Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin.

Journal: Bioinorganic chemistry and applications 20090101

Title: Determination of flavonoid and phenolic Acid contents of clover, cotton and citrus floral honeys.

Journal: The Journal of the Egyptian Public Health Association 20090101

Title: Alleviation and prevention of severe allergic rhinitis and conjunctivitis following long-term lemon juice use: a case report.

Journal: Cases journal 20090101

Title: Hesperetin inhibits the maturation and function of monocyte-derived dendritic cells from patients with asthma.

Journal: Molecular medicine reports 20090101

Title: Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt.

Journal: Journal of agricultural and food chemistry 20081210

Title: Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay.

Journal: Phytochemistry 20081201

Title: Essential nutrients suppress inflammation by modulating key inflammatory gene expression.

Journal: International journal of molecular medicine 20081201

Title: Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.

Journal: Nutrition research (New York, N.Y.) 20081201

Title: Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes.

Journal: Journal of agricultural and food chemistry 20081126

Title: Enantiomeric separation of some flavanones using shinorhizobial linear octasaccharides in CE.

Journal: Electrophoresis 20081101

Title: Fast repair activities towards dGMP hydroxyl radical adducts by silybin and its analogues.

Journal: Journal of radiation research 20081101

Title: Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in beta-Oxidation in Mouse White Adipose Tissue.

Journal: Journal of clinical biochemistry and nutrition 20081101

Title: Neuroprotective effects of chronic hesperetin administration in mice.

Journal: Archives of pharmacal research 20081101

Title: Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.

Journal: Phytotherapy research : PTR 20081001

Title: Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.

Journal: The Journal of pharmacy and pharmacology 20081001

Title: Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901

Title: Chemical composition and botanical origin of red propolis, a new type of brazilian propolis.

Journal: Evidence-based complementary and alternative medicine : eCAM 20080901

Title: Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols.

Journal: Archives of biochemistry and biophysics 20080815

Title: Effect of flavonoids on rat splenocytes, a structure-activity relationship study.

Journal: Biochemical pharmacology 20080815

Title: Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein.

Journal: Life sciences 20080815

Title: Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

Journal: Journal of medicinal chemistry 20080724

Title: In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts.

Journal: Journal of agricultural and food chemistry 20080723

Title: Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20080701

Title: Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.

Journal: Neuroscience letters 20080613

Title: Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation.

Journal: Cell biology and toxicology 20080601

Title: Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.

Journal: Journal of microbiology and biotechnology 20080601

Title: Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice.

Journal: Life sciences 20080523

Title: Dietary flavonoid intake and lung cancer--a population-based case-control study.

Journal: Cancer 20080515

Title: Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle.

Journal: Journal of cellular biochemistry 20080501

Title: Auricular acupressure may improve absorption of flavanones in the extracts from Citrus aurantium L. in the human body.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20080501

Title: [Studies on chemical constituents from herbs of Taraxacum mongolicum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

Title: Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.

Journal: The Journal of biological chemistry 20080404

Title: Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects - variability and possible use as biomarkers of polyphenol intake.

Journal: European journal of clinical nutrition 20080401

Title: Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.

Journal: Bioorganic & medicinal chemistry 20080401

Title: Phytoestrogens and breast cancer prevention: possible mechanisms of action.

Journal: Environmental health perspectives 20080401

Title: Transepithelial transport of flavanone in intestinal Caco-2 cell monolayers.

Journal: Biochemical and biophysical research communications 20080328

Title: Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.

Journal: Biopharmaceutics & drug disposition 20080301

Title: Glycosylation of hesperetin by plant cell cultures.

Journal: Phytochemistry 20080301

Title: Analysis of food allergen structures and development of foods for allergic patients.

Journal: Bioscience, biotechnology, and biochemistry 20080301

Title: [Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301

Title: Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells.

Journal: Journal of agricultural and food chemistry 20080213

Title: Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells.

Journal: Journal of agricultural and food chemistry 20080213

Title: Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens.

Journal: Archives of animal nutrition 20080201

Title: Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.

Journal: Journal of nutritional science and vitaminology 20080201

Title: Estrogenic constituents of the heartwood of Dalbergia parviflora.

Journal: Phytochemistry 20080101

Title: Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers.

Journal: Biochimica et biophysica acta 20080101

Title: Inhibition of oral carcinogenesis by citrus flavonoids.

Journal: Nutrition and cancer 20080101

Title: Development of a potential reference material for evaluating antioxidant activity.

Journal: Journal of AOAC International 20080101

Title: Dietary flavonoid sources in Australian adults.

Journal: Nutrition and cancer 20080101

Title: Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.

Journal: British journal of biomedical science 20080101

Title: Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.

Journal: Journal of applied microbiology 20071201

Title: [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20071201

Title: Enzymatic acylation of flavonoids: effect of the nature of the substrate, origin of lipase, and operating conditions on conversion yield and regioselectivity.

Journal: Journal of agricultural and food chemistry 20071114

Title: Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20071101

Title: Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons.

Journal: Journal of neurochemistry 20071101

Title: Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols.

Journal: Biochemical and biophysical research communications 20071019

Title: Comparison of two sample preconcentration strategies for the sensitivity enhancement of flavonoids found in Chinese herbal medicine in micellar electrokinetic chromatography with UV detection.

Journal: Journal of chromatography. A 20070928

Title: Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.

Journal: Atherosclerosis 20070901

Title: Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa).

Journal: Public health nutrition 20070801

Title: Flavanone plasma pharmacokinetics from blood orange juice in human subjects.

Journal: The British journal of nutrition 20070701

Title: Orange juice or fructose intake does not induce oxidative and inflammatory response.

Journal: Diabetes care 20070601

Title: Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits.

Journal: Journal of chromatography. A 20070511

Title: Enantioseparation of some chiral flavanones using microbial cyclic beta-(1-->3),(1-->6)-glucans as novel chiral additives in capillary electrophoresis.

Journal: Carbohydrate research 20070409

Title: Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.

Journal: Journal of agricultural and food chemistry 20070404

Title: Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.

Journal: European journal of clinical nutrition 20070401

Title: Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits.

Journal: Biological & pharmaceutical bulletin 20070401

Title: Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS.

Journal: Journal of separation science 20070401

Title: Analysis of flavonoids by CE using capacitively coupled contactless conductivity detection.

Journal: Electrophoresis 20070301

Title: Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL.

Journal: The British journal of nutrition 20070301

Title: Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070201

Title: Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential.

Journal: Amino acids 20070101

Title: Predicting the biological activities of 2-methoxyphenol antioxidants: effects of dimers.

Journal: In vivo (Athens, Greece) 20070101

Title: A liquid chromatography/atmospheric pressure ionization tandem mass spectrometry quantitation method for nevirapine and its two oxidative metabolites, 2-hydroxynevirapine and nevirapine 4-carboxylic acid, and pharmacokinetics in baboons.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Lemon juice has protective activity in a rat urolithiasis model.

Journal: BMC urology 20070101

Title: Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.

Journal: Nutrition and cancer 20070101

Title: Flavonoid content of U.S. fruits, vegetables, and nuts.

Journal: Journal of agricultural and food chemistry 20061227

Title: The reaction of flavonoid metabolites with peroxynitrite.

Journal: Biochemical and biophysical research communications 20061201

Title: Age-related variations in flavonoid intake and sources in the Australian population.

Journal: Public health nutrition 20061201

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship.

Journal: Biochemical pharmacology 20061016

Title: Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin.

Journal: Aging cell 20061001

Title: Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.

Journal: Biochemical and biophysical research communications 20060908

Title: Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20060901

Title: Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin.

Journal: Archives of pharmacal research 20060801

Title: Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods.

Journal: The British journal of nutrition 20060701

Title: Bioavailability of glucosyl hesperidin in rats.

Journal: Bioscience, biotechnology, and biochemistry 20060601

Title: Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Potential antivirals and antiviral strategies against SARS coronavirus infections.

Journal: Expert review of anti-infective therapy 20060401

Title: The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites.

Journal: European journal of nutrition 20060301

Title: Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.

Journal: International journal of molecular medicine 20060301

Title: Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20060301

Title: Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.

Journal: The Journal of pharmacy and pharmacology 20060301

Title: Inhibition of rat vas deferens contractions by flavonoids in-vitro.

Journal: The Journal of pharmacy and pharmacology 20060301

Title: Capillary electrochromatography of biologically relevant flavonoids.

Journal: Electrophoresis 20060201

Title: Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans.

Journal: Journal of nutritional science and vitaminology 20060201

Title: The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth.

Journal: Free radical biology & medicine 20060115

Title: Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction.

Journal: Journal of agricultural and food chemistry 20060111

Title: Interactive effects of polyphenols, tocopherol and ascorbic acid on the Cu2+-mediated oxidative modification of human low density lipoproteins.

Journal: European journal of nutrition 20051001

Title: Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.

Journal: Antiviral research 20051001

Title: Polyphenol levels in human urine after intake of six different polyphenol-rich beverages.

Journal: The British journal of nutrition 20051001

Title: Determination of active components in rosemary by capillary electrophoresis with electrochemical detection.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-beta-cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

Journal: The FEBS journal 20050901

Title: Xanthine oxidase activity in vitro: effects of food extracts and components.

Journal: Journal of agricultural and food chemistry 20050810

Title: Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.

Journal: Biochemical pharmacology 20050715

Title: Interaction between hesperetin and human serum albumin revealed by spectroscopic methods.

Journal: Biochimica et biophysica acta 20050620

Title: Impact of high pressure and pulsed electric fields on bioactive compounds and antioxidant activity of orange juice in comparison with traditional thermal processing.

Journal: Journal of agricultural and food chemistry 20050601

Title: High-performance liquid chromatographic separation and chiroptical properties of the enantiomers of naringenin and other flavanones.

Journal: Journal of chromatography. A 20050527

Title: Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.

Journal: The British journal of nutrition 20050501

Title: (-)Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis.

Journal: The Journal of nutrition 20050401

Title: Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis 20050309

Title: Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.

Journal: Journal of cellular physiology 20050201

Title: Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.

Journal: Atherosclerosis 20050101

Title: Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata.

Journal: Planta medica 20050101

Title: Protection by food-derived antioxidants from UV-A1-induced photodamage, measured using living skin equivalents.

Journal: Photochemistry and photobiology 20050101

Title: Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression.

Journal: Anticancer research 20050101

Title: Antiradical and anti-H2O2 properties of polyphenolic compounds from an aqueous peppermint extract.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

Title: Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041201

Title: Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships.

Journal: Biochemical pharmacology 20041115

Title: Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma.

Journal: Journal of agricultural and food chemistry 20041020

Title: Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041001

Title: A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine.

Journal: Journal of pharmaceutical and biomedical analysis 20040921

Title: Reactions of the flavonoid hesperetin with chlorine: a spectroscopic study of the reaction pathways.

Journal: Environmental science & technology 20040901

Title: The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.

Journal: Molecular nutrition & food research 20040901

Title: [Interaction between AM fungi and Rhizobium and effects of flavonoids on it].

Journal: Ying yong sheng tai xue bao = The journal of applied ecology 20040901

Title: The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells.

Journal: Biochemical pharmacology 20040815

Title: Antiallergic activity of hesperidin is activated by intestinal microflora.

Journal: Pharmacology 20040801

Title: Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats.

Journal: Bioorganic & medicinal chemistry 20040701

Title: Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport.

Journal: Pharmaceutical research 20040701

Title: Hesperetin: a potent antioxidant against peroxynitrite.

Journal: Free radical research 20040701

Title: Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.

Journal: Cancer research 20040615

Title: Determination of hesperetin, cinnamic acid and nicotinic acid in propolis with micellar electrokinetic capillary chromatography.

Journal: Fitoterapia 20040601

Title: Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.

Journal: Molecular pharmacology 20040501

Title: Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040501

Title: Interaction of the breast cancer resistance protein with plant polyphenols.

Journal: Biochemical and biophysical research communications 20040423

Title: Improvement in solubility and dissolution rate of flavonoids by complexation with beta-cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis 20040416

Title: Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.

Journal: Journal of agricultural and food chemistry 20040407

Title: Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis.

Journal: Journal of chromatography. A 20040402

Title: Effects of some natural flavonoids on retinal function recovery after ischemic insult in the rat.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040401

Title: Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040305

Title: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens.

Journal: Planta medica 20040301

Title: Structure-activity relationship (SAR) between some natural flavonoids and ocular blood flow in the rabbit.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040201

Title: Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice.

Journal: Journal of agricultural and food chemistry 20040128

Title: Apple phytochemicals and their health benefits.

Journal: Nutrition journal 20040101

Title: Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity.

Journal: Nutrition and cancer 20040101

Title: High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara.

Journal: Phytochemical analysis : PCA 20040101

Title: Reports: plasma and dietary phytoestrogens and risk of premalignant lesions of the cervix.

Journal: Nutrition and cancer 20040101

Title: Comparative study of flavonoids in experimental models of inflammation.

Journal: Pharmacological research 20031201

Title: Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Biological & pharmaceutical bulletin 20031201

Title: Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate.

Journal: Journal of agricultural and food chemistry 20031119

Title: Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.

Journal: Biochemical pharmacology 20031001

Title: Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation.

Journal: Archives of pharmacal research 20031001

Title: Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts.

Journal: Photochemistry and photobiology 20030901

Title: Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.).

Journal: Journal of plant physiology 20030901

Title: Hypocholesterolemic activity of hesperetin derivatives.

Journal: Bioorganic & medicinal chemistry letters 20030818

Title: Separation of some chiral flavanones by micellar electrokinetic chromatography.

Journal: Electrophoresis 20030801

Title: New potent antioxidative hydroxyflavanones produced with Aspergillus saitoi from flavanone glycoside in citrus fruit.

Journal: Bioscience, biotechnology, and biochemistry 20030701

Title: Pro-oxidative properties of flavonoids in human lymphocytes.

Journal: Bioscience, biotechnology, and biochemistry 20030601

Title: Degradation of flavonoid aglycones by rabbit, rat and human fecal flora.

Journal: Biological & pharmaceutical bulletin 20030501

Title: Interaction between flavonoids and the blood-brain barrier: in vitro studies.

Journal: Journal of neurochemistry 20030401

Title: Activation of the aryl hydrocarbon receptor by some vegetable constituents determined using in vitro reporter gene assay.

Journal: Biological & pharmaceutical bulletin 20030401

Title: Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.

Journal: Journal of agricultural and food chemistry 20030312

Title: Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice.

Journal: European journal of clinical nutrition 20030201

Title: Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.

Journal: Clinica chimica acta; international journal of clinical chemistry 20030101

Title: Anti-Sindbis activity of flavanones hesperetin and naringenin.

Journal: Biological & pharmaceutical bulletin 20030101

Title: Flavonoids and nitric oxide synthase.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201

Title: [Prediction of eluotropic sequence of solutes in countercurrent chromatography].

Journal: Se pu = Chinese journal of chromatography 20021101

Title: Fasting plasma concentrations of selected flavonoids as markers of their ordinary dietary intake.

Journal: European journal of nutrition 20021001

Title: Kinetic evaluation of the reactivity of flavonoids as radical scavengers.

Journal: SAR and QSAR in environmental research 20021001

Title: Liquid chromatographic-photodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020925

Title: Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.

Journal: European journal of clinical nutrition 20020901

Title: Enantiomer separation of flavour and fragrance compounds by liquid chromatography using novel urea-covalent bonded methylated beta-cyclodextrins on silica.

Journal: Journal of chromatography. A 20020830

Title: Study of flavonoids/beta-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation.

Journal: Journal of pharmaceutical and biomedical analysis 20020801

Title: Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).

Journal: Journal of experimental botany 20020801

Title: In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020501

Title: Flavonoids in human urine as biomarkers for intake of fruits and vegetables.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020501

Title: Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: relationship between structure and activity.

Journal: Melanoma research 20020401

Title: Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.

Journal: Clinical pharmacology and therapeutics 20020101

Title: Effects of prenylflavanones from Sophora species on growth and activation of mouse macrophage-like cell line.

Journal: Anticancer research 20020101

Title: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin.

Journal: Phytotherapy research : PTR 20011201

Title: Degradation of natural polyphenols by methanogenic consortia enriched from digested municipal sludge.

Journal: Water research 20010801

Title: Flavanone glycosides from Citrus junos and their anti-influenza virus activity.

Journal: Planta medica 20010801

Title: Specific flavonoids induced nod gene expression and pre-activated nod genes of Rhizobium leguminosarum increased pea (Pisum sativum L.) and lentil (Lens culinaris L.) nodulation in controlled growth chamber environments.

Journal: Journal of experimental botany 20010701

Title: Enzymatic halogenation of flavanones and flavones.

Journal: Phytochemistry 20010601

Title: Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.

Journal: Journal of lipid research 20010501

Title: Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens.

Journal: Chemical research in toxicology 20010301

Title: Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.

Journal: The Journal of pharmacology and experimental therapeutics 20010101

Title: In vitro biological activity of prenylflavanones.

Journal: Anticancer research 20010101

Title: Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20010101

Title: Antimicrobial activity of prenylflavanones.

Journal: In vivo (Athens, Greece) 20010101

Title: Inhibition of aromatase activity by flavonoids.

Journal: Archives of pharmacal research 19990601

Title: Inhibition of HIV activation in latently infected cells by flavonoid compounds.

Journal: AIDS research and human retroviruses 19960101

Title: Inhibition of HIV infection by flavanoids.

Journal: Antiviral research 19931001

Title: Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

Journal: European journal of biochemistry 19900705

Title: Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964

Title: Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059.

Title: Oo A, et al. In silico study on anti-Chikungunya virus activity of hesperetin. PeerJ. 2016 Oct 26;4:e2602. eCollection 2016.

Title: Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301

Title: Bai X, et al. The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. Br J Pharmacol. 2017 Jan;174(1):41-56

Title: Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.

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SDS
Tags:520-33-2 Molecular Formula|520-33-2 MDL|520-33-2 SMILES|520-33-2 (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
Catalog No.: AA00DED8
520-33-2,MFCD00075646
520-33-2 | (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
Pack Size: 1g
Purity: 97%
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$7.00 $5.00
Pack Size: 5g
Purity: 97%
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$11.00 $8.00
Pack Size: 10g
Purity: 97%
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$13.00 $9.00
Pack Size: 25g
Purity: ≥98%
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$28.00 $19.00
Pack Size: 500g
Purity: 97%
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$393.00 $275.00
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Technical Information
Catalog Number: AA00DED8
Chemical Name: (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
CAS Number: 520-33-2
Molecular Formula: C16H14O6
Molecular Weight: 302.2788
MDL Number: MFCD00075646
SMILES: COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O
FEMA Number: 4313
Properties
Complexity: 413  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.4  
Literature fold

Title: Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.

Journal: Toxicology letters20180915

Title: Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl(4)-induced acute liver injury and LPS-treated RAW264.7 cells.

Journal: Toxicology letters20170515

Title: Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway.

Journal: Toxicology20170415

Title: Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.

Journal: Chemico-biological interactions20151205

Title: Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.

Journal: Journal of biochemical and molecular toxicology20150301

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20150201

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters20150105

Title: Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity.

Journal: Pharmacology, biochemistry, and behavior20140901

Title: Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.

Journal: Mediators of inflammation20140101

Title: Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

Journal: Journal of pharmaceutical sciences20130901

Title: Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.

Journal: Food chemistry20121215

Title: Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori.

Journal: Food chemistry20121215

Title: Iron reduction potentiates hydroxyl radical formation only in flavonols.

Journal: Food chemistry20121215

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.

Journal: Journal of molecular recognition : JMR20121101

Title: The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

Journal: The Journal of nutritional biochemistry20121001

Title: Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells.

Journal: Food & function20121001

Title: Evaluation of matrix effect in determination of some bioflavonoids in food samples by LC-MS/MS method.

Journal: Talanta20120915

Title: Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins.

Journal: Food chemistry20120915

Title: Composition of native Australian herbs polyphenolic-rich fractions and in vitro inhibitory activities against key enzymes relevant to metabolic syndrome.

Journal: Food chemistry20120915

Title: Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120901

Title: Rapid assessment of endpoint antioxidant capacity of red wines through microchemical methods using a kinetic matching approach.

Journal: Talanta20120815

Title: Evaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography.

Journal: Analytica chimica acta20120813

Title: Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie20120701

Title: Synergy of flavone with vancomycin and oxacillin against vancomycin-intermediate Staphyloccus aureus.

Journal: Pakistan journal of pharmaceutical sciences20120701

Title: Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

Journal: Toxicology mechanisms and methods20120601

Title: A prenylated flavanone from Dalea elegans inhibits rhodamine 6 G efflux and reverses fluconazole-resistance in Candida albicans.

Journal: Planta medica20120601

Title: In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.

Journal: Molecular nutrition & food research20120601

Title: Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells.

Journal: Journal of agricultural and food chemistry20120509

Title: In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8).

Journal: Naunyn-Schmiedeberg's archives of pharmacology20120501

Title: An investigation on the interaction of DNA with hesperetin/apigenin in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical application.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20120501

Title: Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.

Journal: Journal of natural products20120427

Title: Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.

Journal: Bioorganic & medicinal chemistry20120415

Title: Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.

Journal: Journal of pharmaceutical and biomedical analysis20120407

Title: Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: effect of dose and physicochemical properties.

Journal: Journal of pharmaceutical sciences20120401

Title: Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.

Journal: Food & function20120401

Title: Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.

Journal: Molecular nutrition & food research20120401

Title: Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120301

Title: Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120301

Title: Autophagy and cancer.

Journal: Experimental & molecular medicine20120227

Title: Interference of selected flavonoid aglycons in platelet aggregation assays.

Journal: Clinical chemistry and laboratory medicine20120227

Title: Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations.

Journal: Biochemical and biophysical research communications20120217

Title: Neuroprotective effects of citrus flavonoids.

Journal: Journal of agricultural and food chemistry20120201

Title: Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption.

Journal: Journal of the Academy of Nutrition and Dietetics20120201

Title: Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20120125

Title: Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach.

Journal: Journal of agricultural and food chemistry20120111

Title: UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis20120105

Title: Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.

Journal: International journal of biological macromolecules20120101

Title: Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes.

Journal: The Journal of pharmacy and pharmacology20120101

Title: Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Study of lipid profile and parieto-temporal lipid peroxidation in AlCl₃ mediated neurotoxicity. Modulatory effect of fenugreek seeds.

Journal: Lipids in health and disease20120101

Title: Multiple functions of microsomal triglyceride transfer protein.

Journal: Nutrition & metabolism20120101

Title: Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.

Journal: BMC complementary and alternative medicine20120101

Title: Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.

Journal: Bioscience, biotechnology, and biochemistry20120101

Title: Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus.

Journal: Bioinformation20120101

Title: Does dietary inulin affect biological activity of a grapefruit flavonoid-rich extract?

Journal: Nutrition & metabolism20120101

Title: Characterisation of flavonoid aglycones by negative ion chip-based nanospray tandem mass spectrometry.

Journal: International journal of analytical chemistry20120101

Title: Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents.

Journal: Asian Pacific journal of cancer prevention : APJCP20120101

Title: Antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of Punica granatum in alloxan-induced non-insulin-dependent diabetes mellitus albino rats.

Journal: Indian journal of pharmacology20120101

Title: Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Journal: Frontiers in microbiology20120101

Title: Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.

Journal: Mediators of inflammation20120101

Title: Computational prediction of protein-protein interactions of human tyrosinase.

Journal: Enzyme research20120101

Title: The effects of jiang-zhi-ning and its main components on cholesterol metabolism.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: The chemotherapeutic potential of Terminalia ferdinandiana: Phytochemistry and bioactivity.

Journal: Pharmacognosy reviews20120101

Title: Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation.

Journal: PPAR research20120101

Title: Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.

Journal: Oxidative medicine and cellular longevity20120101

Title: [Study on chemical constituents of Artemisia sphaerocephala].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20120101

Title: Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats.

Journal: Vascular pharmacology20120101

Title: Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.

Journal: Biopharmaceutics & drug disposition20111201

Title: Toxicological aspects of the use of phenolic compounds in disease prevention.

Journal: Interdisciplinary toxicology20111201

Title: Study on the interference of rat feed to pharmacokinetics of flavonoids.

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20111201

Title: Analysis of flavonoids by capillary zone electrophoresis with electrokinetic supercharging.

Journal: The Analyst20111107

Title: Evaluation of binding and thermodynamic characteristics of interactions between a citrus flavonoid hesperitin with protein and effects of metal ions on binding.

Journal: Molecular biology reports20111101

Title: Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats.

Journal: Ecotoxicology and environmental safety20111001

Title: Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.

Journal: Cell biology and toxicology20111001

Title: Microbial metabolism. Part 13. Metabolites of hesperetin.

Journal: Bioorganic & medicinal chemistry letters20111001

Title: Binding of citrus flavanones and their glucuronides and chalcones to human serum albumin.

Journal: Food & function20111001

Title: Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7.

Journal: Molecular and cellular endocrinology20110915

Title: Hesperidin promotes cyclobutane pyrimidine dimer repair in UVB-exposed mice epidermis.

Journal: Irish journal of medical science20110901

Title: Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.

Journal: Cardiovascular toxicology20110901

Title: Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents.

Journal: Pharmacology, biochemistry, and behavior20110901

Title: Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study.

Journal: European review for medical and pharmacological sciences20110901

Title: Flavonoids in prevention of diseases with respect to modulation of Ca-pump function.

Journal: Interdisciplinary toxicology20110901

Title: Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.

Journal: European journal of medicinal chemistry20110801

Title: Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey.

Journal: Molecules (Basel, Switzerland)20110727

Title: Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry.

Journal: Analytical and bioanalytical chemistry20110601

Title: Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.

Journal: Journal of agricultural and food chemistry20110525

Title: Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion.

Journal: Journal of agricultural and food chemistry20110511

Title: Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.

Journal: The Journal of clinical endocrinology and metabolism20110501

Title: Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.

Journal: Diabetes20110501

Title: Intrinsic and extrinsic regulation of innate immune receptors.

Journal: Yonsei medical journal20110501

Title: Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFκB, p38 and caspase-3.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20110401

Title: Analysis of isoflavones and flavonoids in human urine by UHPLC.

Journal: Analytical and bioanalytical chemistry20110301

Title: Hesperetin, a potential therapy for carcinoid cancer.

Journal: American journal of surgery20110301

Title: Assessment of Antioxidant and Phenolic Compound Concentrations as well as Xanthine Oxidase and Tyrosinase Inhibitory Properties of Different Extracts of Pleurotus citrinopileatus Fruiting Bodies.

Journal: Mycobiology20110301

Title: Prenylated flavanones with anti-tyrosinase activity from Dalea boliviana.

Journal: Journal of natural products20110225

Title: Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals.

Journal: Oncology reports20110201

Title: Stereoisomeric separation of some flavanones using highly succinate-substituted α-cyclosophoro-octadecaoses as chiral additives in capillary electrophoresis.

Journal: Carbohydrate research20110103

Title: Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of piper sarmentosum on experimental rabbits fed with cholesterol diet.

Journal: Lipids in health and disease20110101

Title: Identification of chemical constituents in extracts and rat plasma from Fructus Aurantii by UPLC-PDA-Q-TOF/MS.

Journal: Phytochemical analysis : PCA20110101

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences20110101

Title: Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.

Journal: Lipids in health and disease20110101

Title: [Aromatic constituents of Heteroplexis micocephal and their bioactivities].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20110101

Title: Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin. [corrected].

Journal: PloS one20110101

Title: Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.

Journal: International journal of medical sciences20110101

Title: C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent.

Journal: PloS one20110101

Title: Inhibitory effect of phthalic Acid on tyrosinase: the mixed-type inhibition and docking simulations.

Journal: Enzyme research20110101

Title: Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.

Journal: Journal of biomedicine & biotechnology20110101

Title: Towards Al-induced manganese-containing superoxide dismutase inactivation and conformational changes: an integrating study with docking simulations.

Journal: Enzyme research20110101

Title: Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice.

Journal: Genetics and molecular biology20110101

Title: Evaluation of antiaggregatory activity of flavonoid aglycone series.

Journal: Nutrition journal20110101

Title: Diet-induced metabolic hamster model of nonalcoholic fatty liver disease.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy20110101

Title: To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial.

Journal: BMC gastroenterology20110101

Title: Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma.

Journal: Mediators of inflammation20110101

Title: Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.

Journal: Drug metabolism and pharmacokinetics20110101

Title: Development and validation of a UHPLC method for the determination of flavonoids in red wine.

Journal: Journal of AOAC International20110101

Title: Tissue distribution of hesperetin in rats after a dietary intake.

Journal: Bioscience, biotechnology, and biochemistry20110101

Title: High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis.

Journal: BMC complementary and alternative medicine20110101

Title: Role of phenolic compounds in peptic ulcer: An overview.

Journal: Journal of pharmacy & bioallied sciences20110101

Title: Adaptation of Rhizobium leguminosarum to pea, alfalfa and sugar beet rhizospheres investigated by comparative transcriptomics.

Journal: Genome biology20110101

Title: Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice.

Journal: Pharmacognosy research20110101

Title: Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.

Journal: PloS one20110101

Title: Antioxidant Activities of Plumbagin and Its Cu (II) Complex.

Journal: Bioinorganic chemistry and applications20110101

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science20110101

Title: Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease.

Journal: Journal of inflammation (London, England)20110101

Title: Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study.

Journal: PloS one20110101

Title: Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia.

Journal: International journal of molecular sciences20110101

Title: Antiviral activity of four types of bioflavonoid against dengue virus type-2.

Journal: Virology journal20110101

Title: Potential of herbs in skin protection from ultraviolet radiation.

Journal: Pharmacognosy reviews20110101

Title: 7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation.

Journal: Phytotherapy research : PTR20101201

Title: Carboxymethylated cyclosophoraose as a novel chiral additive for the stereoisomeric separation of some flavonoids by capillary electrophoresis.

Journal: Carbohydrate research20101102

Title: Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.

Journal: Acta tropica20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Polyphenols and human health: prevention of disease and mechanisms of action.

Journal: Nutrients20101101

Title: Free fruit at workplace intervention increases total fruit intake: a validation study using 24 h dietary recall and urinary flavonoid excretion.

Journal: European journal of clinical nutrition20101001

Title: Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.

Journal: European journal of medicinal chemistry20101001

Title: Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.

Journal: Journal of separation science20101001

Title: Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media.

Journal: Archives of biochemistry and biophysics20100901

Title: Selective inhibition of methoxyflavonoids on human CYP1B1 activity.

Journal: Bioorganic & medicinal chemistry20100901

Title: Micronutrient synergy--a new tool in effective control of metastasis and other key mechanisms of cancer.

Journal: Cancer metastasis reviews20100901

Title: Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity.

Journal: Nutrition research (New York, N.Y.)20100901

Title: Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis.

Journal: Journal of food science20100901

Title: Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters.

Journal: Journal of medicinal food20100801

Title: Chemical synthesis of citrus flavanone glucuronides.

Journal: Journal of agricultural and food chemistry20100728

Title: Passive asymmetric transport of hesperetin across isolated rabbit cornea.

Journal: International journal of pharmaceutics20100715

Title: Hesperidin and hesperetin membrane interaction: understanding the role of 7-O-glycoside moiety in flavonoids.

Journal: Archives of biochemistry and biophysics20100701

Title: Protective effects of silybin and analogues against X-ray radiation-induced damage.

Journal: Acta biochimica et biophysica Sinica20100701

Title: Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.

Journal: The British journal of nutrition20100601

Title: The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.

Journal: Molecular nutrition & food research20100601

Title: Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.

Journal: Journal of agricultural and food chemistry20100526

Title: Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.

Journal: Journal of agricultural and food chemistry20100526

Title: Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway.

Journal: The Journal of nutritional biochemistry20100501

Title: Extracellular monoenzyme deglycosylation system of 7-O-linked flavonoid beta-rutinosides and its disaccharide transglycosylation activity from Stilbella fimetaria.

Journal: Archives of microbiology20100501

Title: The effect of component of cream for topical delivery of hesperetin.

Journal: Chemical & pharmaceutical bulletin20100501

Title: Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.

Journal: Natural product communications20100501

Title: Cytotoxic activities of several geranyl-substituted flavanones.

Journal: Journal of natural products20100423

Title: Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.

Journal: Journal of ethnopharmacology20100421

Title: The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.

Journal: Biochemical and biophysical research communications20100409

Title: Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

Journal: Drug metabolism and disposition: the biological fate of chemicals20100401

Title: Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.

Journal: European journal of clinical nutrition20100401

Title: In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system.

Journal: International journal of pharmaceutics20100330

Title: Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions.

Journal: Drug development and industrial pharmacy20100301

Title: Influence of oryzanol and ferulic Acid on the lipid metabolism and antioxidative status in high fat-fed mice.

Journal: Journal of clinical biochemistry and nutrition20100301

Title: Enzyme technology for precision functional food ingredient processes.

Journal: Annals of the New York Academy of Sciences20100301

Title: Optical isomer separation of flavanones and flavanone glycosides by nano-liquid chromatography using a phenyl-carbamate-propyl-beta-cyclodextrin chiral stationary phase.

Journal: Journal of chromatography. A20100212

Title: Identification of bisprenylated benzoic acid derivatives from yerba santa (Eriodictyon ssp.) using sensory-guided fractionation.

Journal: Journal of agricultural and food chemistry20100210

Title: Preserving hesperetin nanosuspensions for dermal application.

Journal: Die Pharmazie20100201

Title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.

Journal: Nutrients20100201

Title: Greater apparent absorption of flavonoids is associated with lesser human fecal flavonoid disappearance rates.

Journal: Journal of agricultural and food chemistry20100113

Title: Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation.

Journal: Journal of agricultural and food chemistry20100113

Title: Characterization of flavor modulating effects in complex mixtures via high temperature liquid chromatography.

Journal: Journal of agricultural and food chemistry20100113

Title: Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20100105

Title: Structural activity relationship of flavonoids with estrogen-related receptor gamma.

Journal: FEBS letters20100104

Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Journal: Bioorganic & medicinal chemistry20100101

Title: Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats.

Journal: Journal of clinical biochemistry and nutrition20100101

Title: Acute effects of vinegar intake on some biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits.

Journal: Lipids in health and disease20100101

Title: Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high cholesterolemic experimental rabbits.

Journal: Lipids in health and disease20100101

Title: Flavanols and anthocyanins in cardiovascular health: a review of current evidence.

Journal: International journal of molecular sciences20100101

Title: Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.

Journal: Cellular immunology20100101

Title: A novel dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes.

Journal: Oxidative medicine and cellular longevity20100101

Title: Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha.

Journal: PloS one20100101

Title: Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen.

Journal: PloS one20100101

Title: Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.

Journal: Drug metabolism and pharmacokinetics20100101

Title: Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats.

Journal: Journal of toxicology and environmental health. Part A20100101

Title: Effects of Various Flavonoids on the α-Synuclein Fibrillation Process.

Journal: Parkinson's disease20100101

Title: Glycine tomentella Hayata inhibits IL-1β and IL-6 production, inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells.

Journal: Journal of biomedical science20100101

Title: Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei).

Journal: Marine drugs20100101

Title: Inhibitory effect of flavonoids on mutant H-Rasp protein.

Journal: Bioinformation20100101

Title: Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.

Journal: Journal of agricultural and food chemistry20091125

Title: 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.

Journal: Journal of medicinal chemistry20091112

Title: Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone.

Journal: European journal of medicinal chemistry20091101

Title: Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity.

Journal: Journal of clinical biochemistry and nutrition20091101

Title: Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats.

Journal: The British journal of nutrition20091001

Title: Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.

Journal: Diabetes20091001

Title: Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20091001

Title: Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics.

Journal: AAPS PharmSciTech20090901

Title: Major phytochemical composition of 3 native Korean citrus varieties and bioactive activity on V79-4 cells induced by oxidative stress.

Journal: Journal of food science20090801

Title: Influences of flavonoids on erythrocyte membrane and metabolic implication through anionic exchange modulation.

Journal: The Journal of membrane biology20090801

Title: [Studies on the chemical constituents from flower of Paulownia fortunei].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20090801

Title: Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis.

Journal: Chemico-biological interactions20090715

Title: Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.

Journal: Journal of natural products20090701

Title: Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.

Journal: Investigational new drugs20090601

Title: Bioactivation of flavonoid diglycosides by chicken cecal bacteria.

Journal: FEMS microbiology letters20090601

Title: Distribution and major sources of flavonoid intakes in the middle-aged Japanese women.

Journal: Journal of clinical biochemistry and nutrition20090501

Title: Production and characterization of Hesperetin nanosuspensions for dermal delivery.

Journal: International journal of pharmaceutics20090417

Title: Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression.

Journal: Bioorganic & medicinal chemistry letters20090415

Title: Sulfation of dietary flavonoids by human sulfotransferases.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20090401

Title: [Effects of Hesperetin on cell activation and proliferation of murine T lymphocytes in vitro].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology20090401

Title: The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.

Journal: Archives of biochemistry and biophysics20090401

Title: Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide.

Journal: Journal of agricultural and food chemistry20090325

Title: Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion.

Journal: The British journal of nutrition20090301

Title: The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.

Journal: Biomedical chromatography : BMC20090301

Title: Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.

Journal: Biomedical chromatography : BMC20090201

Title: Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.

Journal: Molecular and cellular biochemistry20090101

Title: Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals.

Journal: BMC molecular biology20090101

Title: Effect of processing on the flavonoid content and antioxidant capacity of Citrus hystrix leaf.

Journal: International journal of food sciences and nutrition20090101

Title: Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry.

Journal: Chinese medicine20090101

Title: Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin.

Journal: Bioinorganic chemistry and applications20090101

Title: Determination of flavonoid and phenolic Acid contents of clover, cotton and citrus floral honeys.

Journal: The Journal of the Egyptian Public Health Association20090101

Title: Alleviation and prevention of severe allergic rhinitis and conjunctivitis following long-term lemon juice use: a case report.

Journal: Cases journal20090101

Title: Hesperetin inhibits the maturation and function of monocyte-derived dendritic cells from patients with asthma.

Journal: Molecular medicine reports20090101

Title: Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt.

Journal: Journal of agricultural and food chemistry20081210

Title: Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay.

Journal: Phytochemistry20081201

Title: Essential nutrients suppress inflammation by modulating key inflammatory gene expression.

Journal: International journal of molecular medicine20081201

Title: Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.

Journal: Nutrition research (New York, N.Y.)20081201

Title: Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes.

Journal: Journal of agricultural and food chemistry20081126

Title: Enantiomeric separation of some flavanones using shinorhizobial linear octasaccharides in CE.

Journal: Electrophoresis20081101

Title: Fast repair activities towards dGMP hydroxyl radical adducts by silybin and its analogues.

Journal: Journal of radiation research20081101

Title: Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in beta-Oxidation in Mouse White Adipose Tissue.

Journal: Journal of clinical biochemistry and nutrition20081101

Title: Neuroprotective effects of chronic hesperetin administration in mice.

Journal: Archives of pharmacal research20081101

Title: Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.

Journal: Phytotherapy research : PTR20081001

Title: Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.

Journal: The Journal of pharmacy and pharmacology20081001

Title: Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.

Journal: Drug metabolism and disposition: the biological fate of chemicals20080901

Title: Chemical composition and botanical origin of red propolis, a new type of brazilian propolis.

Journal: Evidence-based complementary and alternative medicine : eCAM20080901

Title: Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols.

Journal: Archives of biochemistry and biophysics20080815

Title: Effect of flavonoids on rat splenocytes, a structure-activity relationship study.

Journal: Biochemical pharmacology20080815

Title: Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein.

Journal: Life sciences20080815

Title: Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

Journal: Journal of medicinal chemistry20080724

Title: In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts.

Journal: Journal of agricultural and food chemistry20080723

Title: Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry.

Journal: Biomedical chromatography : BMC20080701

Title: Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.

Journal: Neuroscience letters20080613

Title: Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation.

Journal: Cell biology and toxicology20080601

Title: Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.

Journal: Journal of microbiology and biotechnology20080601

Title: Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice.

Journal: Life sciences20080523

Title: Dietary flavonoid intake and lung cancer--a population-based case-control study.

Journal: Cancer20080515

Title: Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle.

Journal: Journal of cellular biochemistry20080501

Title: Auricular acupressure may improve absorption of flavanones in the extracts from Citrus aurantium L. in the human body.

Journal: Journal of alternative and complementary medicine (New York, N.Y.)20080501

Title: [Studies on chemical constituents from herbs of Taraxacum mongolicum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20080501

Title: Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.

Journal: The Journal of biological chemistry20080404

Title: Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects - variability and possible use as biomarkers of polyphenol intake.

Journal: European journal of clinical nutrition20080401

Title: Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.

Journal: Bioorganic & medicinal chemistry20080401

Title: Phytoestrogens and breast cancer prevention: possible mechanisms of action.

Journal: Environmental health perspectives20080401

Title: Transepithelial transport of flavanone in intestinal Caco-2 cell monolayers.

Journal: Biochemical and biophysical research communications20080328

Title: Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.

Journal: Biopharmaceutics & drug disposition20080301

Title: Glycosylation of hesperetin by plant cell cultures.

Journal: Phytochemistry20080301

Title: Analysis of food allergen structures and development of foods for allergic patients.

Journal: Bioscience, biotechnology, and biochemistry20080301

Title: [Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20080301

Title: Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells.

Journal: Journal of agricultural and food chemistry20080213

Title: Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells.

Journal: Journal of agricultural and food chemistry20080213

Title: Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens.

Journal: Archives of animal nutrition20080201

Title: Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.

Journal: Journal of nutritional science and vitaminology20080201

Title: Estrogenic constituents of the heartwood of Dalbergia parviflora.

Journal: Phytochemistry20080101

Title: Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers.

Journal: Biochimica et biophysica acta20080101

Title: Inhibition of oral carcinogenesis by citrus flavonoids.

Journal: Nutrition and cancer20080101

Title: Development of a potential reference material for evaluating antioxidant activity.

Journal: Journal of AOAC International20080101

Title: Dietary flavonoid sources in Australian adults.

Journal: Nutrition and cancer20080101

Title: Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.

Journal: British journal of biomedical science20080101

Title: Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.

Journal: Journal of applied microbiology20071201

Title: [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

Journal: Ai zheng = Aizheng = Chinese journal of cancer20071201

Title: Enzymatic acylation of flavonoids: effect of the nature of the substrate, origin of lipase, and operating conditions on conversion yield and regioselectivity.

Journal: Journal of agricultural and food chemistry20071114

Title: Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD20071101

Title: Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons.

Journal: Journal of neurochemistry20071101

Title: Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols.

Journal: Biochemical and biophysical research communications20071019

Title: Comparison of two sample preconcentration strategies for the sensitivity enhancement of flavonoids found in Chinese herbal medicine in micellar electrokinetic chromatography with UV detection.

Journal: Journal of chromatography. A20070928

Title: Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.

Journal: Atherosclerosis20070901

Title: Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa).

Journal: Public health nutrition20070801

Title: Flavanone plasma pharmacokinetics from blood orange juice in human subjects.

Journal: The British journal of nutrition20070701

Title: Orange juice or fructose intake does not induce oxidative and inflammatory response.

Journal: Diabetes care20070601

Title: Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits.

Journal: Journal of chromatography. A20070511

Title: Enantioseparation of some chiral flavanones using microbial cyclic beta-(1-->3),(1-->6)-glucans as novel chiral additives in capillary electrophoresis.

Journal: Carbohydrate research20070409

Title: Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.

Journal: Journal of agricultural and food chemistry20070404

Title: Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.

Journal: European journal of clinical nutrition20070401

Title: Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits.

Journal: Biological & pharmaceutical bulletin20070401

Title: Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS.

Journal: Journal of separation science20070401

Title: Analysis of flavonoids by CE using capacitively coupled contactless conductivity detection.

Journal: Electrophoresis20070301

Title: Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL.

Journal: The British journal of nutrition20070301

Title: Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

Journal: Drug metabolism and disposition: the biological fate of chemicals20070201

Title: Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential.

Journal: Amino acids20070101

Title: Predicting the biological activities of 2-methoxyphenol antioxidants: effects of dimers.

Journal: In vivo (Athens, Greece)20070101

Title: A liquid chromatography/atmospheric pressure ionization tandem mass spectrometry quantitation method for nevirapine and its two oxidative metabolites, 2-hydroxynevirapine and nevirapine 4-carboxylic acid, and pharmacokinetics in baboons.

Journal: Rapid communications in mass spectrometry : RCM20070101

Title: Lemon juice has protective activity in a rat urolithiasis model.

Journal: BMC urology20070101

Title: Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.

Journal: Nutrition and cancer20070101

Title: Flavonoid content of U.S. fruits, vegetables, and nuts.

Journal: Journal of agricultural and food chemistry20061227

Title: The reaction of flavonoid metabolites with peroxynitrite.

Journal: Biochemical and biophysical research communications20061201

Title: Age-related variations in flavonoid intake and sources in the Australian population.

Journal: Public health nutrition20061201

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling20061101

Title: Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship.

Journal: Biochemical pharmacology20061016

Title: Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin.

Journal: Aging cell20061001

Title: Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.

Journal: Biochemical and biophysical research communications20060908

Title: Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20060901

Title: Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin.

Journal: Archives of pharmacal research20060801

Title: Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods.

Journal: The British journal of nutrition20060701

Title: Bioavailability of glucosyl hesperidin in rats.

Journal: Bioscience, biotechnology, and biochemistry20060601

Title: Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Potential antivirals and antiviral strategies against SARS coronavirus infections.

Journal: Expert review of anti-infective therapy20060401

Title: The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites.

Journal: European journal of nutrition20060301

Title: Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.

Journal: International journal of molecular medicine20060301

Title: Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry.

Journal: Journal of mass spectrometry : JMS20060301

Title: Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.

Journal: The Journal of pharmacy and pharmacology20060301

Title: Inhibition of rat vas deferens contractions by flavonoids in-vitro.

Journal: The Journal of pharmacy and pharmacology20060301

Title: Capillary electrochromatography of biologically relevant flavonoids.

Journal: Electrophoresis20060201

Title: Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans.

Journal: Journal of nutritional science and vitaminology20060201

Title: The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth.

Journal: Free radical biology & medicine20060115

Title: Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction.

Journal: Journal of agricultural and food chemistry20060111

Title: Interactive effects of polyphenols, tocopherol and ascorbic acid on the Cu2+-mediated oxidative modification of human low density lipoproteins.

Journal: European journal of nutrition20051001

Title: Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.

Journal: Antiviral research20051001

Title: Polyphenol levels in human urine after intake of six different polyphenol-rich beverages.

Journal: The British journal of nutrition20051001

Title: Determination of active components in rosemary by capillary electrophoresis with electrochemical detection.

Journal: Journal of pharmaceutical and biomedical analysis20050915

Title: The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-beta-cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis20050915

Title: Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

Journal: The FEBS journal20050901

Title: Xanthine oxidase activity in vitro: effects of food extracts and components.

Journal: Journal of agricultural and food chemistry20050810

Title: Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.

Journal: Biochemical pharmacology20050715

Title: Interaction between hesperetin and human serum albumin revealed by spectroscopic methods.

Journal: Biochimica et biophysica acta20050620

Title: Impact of high pressure and pulsed electric fields on bioactive compounds and antioxidant activity of orange juice in comparison with traditional thermal processing.

Journal: Journal of agricultural and food chemistry20050601

Title: High-performance liquid chromatographic separation and chiroptical properties of the enantiomers of naringenin and other flavanones.

Journal: Journal of chromatography. A20050527

Title: Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.

Journal: The British journal of nutrition20050501

Title: (-)Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis.

Journal: The Journal of nutrition20050401

Title: Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis20050309

Title: Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.

Journal: Journal of cellular physiology20050201

Title: Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.

Journal: Atherosclerosis20050101

Title: Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata.

Journal: Planta medica20050101

Title: Protection by food-derived antioxidants from UV-A1-induced photodamage, measured using living skin equivalents.

Journal: Photochemistry and photobiology20050101

Title: Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression.

Journal: Anticancer research20050101

Title: Antiradical and anti-H2O2 properties of polyphenolic compounds from an aqueous peppermint extract.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20050101

Title: Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20041201

Title: Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships.

Journal: Biochemical pharmacology20041115

Title: Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma.

Journal: Journal of agricultural and food chemistry20041020

Title: Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20041001

Title: A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine.

Journal: Journal of pharmaceutical and biomedical analysis20040921

Title: Reactions of the flavonoid hesperetin with chlorine: a spectroscopic study of the reaction pathways.

Journal: Environmental science & technology20040901

Title: The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.

Journal: Molecular nutrition & food research20040901

Title: [Interaction between AM fungi and Rhizobium and effects of flavonoids on it].

Journal: Ying yong sheng tai xue bao = The journal of applied ecology20040901

Title: The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells.

Journal: Biochemical pharmacology20040815

Title: Antiallergic activity of hesperidin is activated by intestinal microflora.

Journal: Pharmacology20040801

Title: Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats.

Journal: Bioorganic & medicinal chemistry20040701

Title: Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport.

Journal: Pharmaceutical research20040701

Title: Hesperetin: a potent antioxidant against peroxynitrite.

Journal: Free radical research20040701

Title: Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.

Journal: Cancer research20040615

Title: Determination of hesperetin, cinnamic acid and nicotinic acid in propolis with micellar electrokinetic capillary chromatography.

Journal: Fitoterapia20040601

Title: Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.

Journal: Molecular pharmacology20040501

Title: Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology20040501

Title: Interaction of the breast cancer resistance protein with plant polyphenols.

Journal: Biochemical and biophysical research communications20040423

Title: Improvement in solubility and dissolution rate of flavonoids by complexation with beta-cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis20040416

Title: Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.

Journal: Journal of agricultural and food chemistry20040407

Title: Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis.

Journal: Journal of chromatography. A20040402

Title: Effects of some natural flavonoids on retinal function recovery after ischemic insult in the rat.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20040401

Title: Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20040305

Title: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens.

Journal: Planta medica20040301

Title: Structure-activity relationship (SAR) between some natural flavonoids and ocular blood flow in the rabbit.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20040201

Title: Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice.

Journal: Journal of agricultural and food chemistry20040128

Title: Apple phytochemicals and their health benefits.

Journal: Nutrition journal20040101

Title: Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity.

Journal: Nutrition and cancer20040101

Title: High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara.

Journal: Phytochemical analysis : PCA20040101

Title: Reports: plasma and dietary phytoestrogens and risk of premalignant lesions of the cervix.

Journal: Nutrition and cancer20040101

Title: Comparative study of flavonoids in experimental models of inflammation.

Journal: Pharmacological research20031201

Title: Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Biological & pharmaceutical bulletin20031201

Title: Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate.

Journal: Journal of agricultural and food chemistry20031119

Title: Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.

Journal: Biochemical pharmacology20031001

Title: Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation.

Journal: Archives of pharmacal research20031001

Title: Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts.

Journal: Photochemistry and photobiology20030901

Title: Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.).

Journal: Journal of plant physiology20030901

Title: Hypocholesterolemic activity of hesperetin derivatives.

Journal: Bioorganic & medicinal chemistry letters20030818

Title: Separation of some chiral flavanones by micellar electrokinetic chromatography.

Journal: Electrophoresis20030801

Title: New potent antioxidative hydroxyflavanones produced with Aspergillus saitoi from flavanone glycoside in citrus fruit.

Journal: Bioscience, biotechnology, and biochemistry20030701

Title: Pro-oxidative properties of flavonoids in human lymphocytes.

Journal: Bioscience, biotechnology, and biochemistry20030601

Title: Degradation of flavonoid aglycones by rabbit, rat and human fecal flora.

Journal: Biological & pharmaceutical bulletin20030501

Title: Interaction between flavonoids and the blood-brain barrier: in vitro studies.

Journal: Journal of neurochemistry20030401

Title: Activation of the aryl hydrocarbon receptor by some vegetable constituents determined using in vitro reporter gene assay.

Journal: Biological & pharmaceutical bulletin20030401

Title: Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.

Journal: Journal of agricultural and food chemistry20030312

Title: Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice.

Journal: European journal of clinical nutrition20030201

Title: Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.

Journal: Clinica chimica acta; international journal of clinical chemistry20030101

Title: Anti-Sindbis activity of flavanones hesperetin and naringenin.

Journal: Biological & pharmaceutical bulletin20030101

Title: Flavonoids and nitric oxide synthase.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20021201

Title: [Prediction of eluotropic sequence of solutes in countercurrent chromatography].

Journal: Se pu = Chinese journal of chromatography20021101

Title: Fasting plasma concentrations of selected flavonoids as markers of their ordinary dietary intake.

Journal: European journal of nutrition20021001

Title: Kinetic evaluation of the reactivity of flavonoids as radical scavengers.

Journal: SAR and QSAR in environmental research20021001

Title: Liquid chromatographic-photodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20020925

Title: Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.

Journal: European journal of clinical nutrition20020901

Title: Enantiomer separation of flavour and fragrance compounds by liquid chromatography using novel urea-covalent bonded methylated beta-cyclodextrins on silica.

Journal: Journal of chromatography. A20020830

Title: Study of flavonoids/beta-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation.

Journal: Journal of pharmaceutical and biomedical analysis20020801

Title: Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).

Journal: Journal of experimental botany20020801

Title: In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20020501

Title: Flavonoids in human urine as biomarkers for intake of fruits and vegetables.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology20020501

Title: Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: relationship between structure and activity.

Journal: Melanoma research20020401

Title: Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.

Journal: Clinical pharmacology and therapeutics20020101

Title: Effects of prenylflavanones from Sophora species on growth and activation of mouse macrophage-like cell line.

Journal: Anticancer research20020101

Title: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin.

Journal: Phytotherapy research : PTR20011201

Title: Degradation of natural polyphenols by methanogenic consortia enriched from digested municipal sludge.

Journal: Water research20010801

Title: Flavanone glycosides from Citrus junos and their anti-influenza virus activity.

Journal: Planta medica20010801

Title: Specific flavonoids induced nod gene expression and pre-activated nod genes of Rhizobium leguminosarum increased pea (Pisum sativum L.) and lentil (Lens culinaris L.) nodulation in controlled growth chamber environments.

Journal: Journal of experimental botany20010701

Title: Enzymatic halogenation of flavanones and flavones.

Journal: Phytochemistry20010601

Title: Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.

Journal: Journal of lipid research20010501

Title: Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens.

Journal: Chemical research in toxicology20010301

Title: Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.

Journal: The Journal of pharmacology and experimental therapeutics20010101

Title: In vitro biological activity of prenylflavanones.

Journal: Anticancer research20010101

Title: Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands)20010101

Title: Antimicrobial activity of prenylflavanones.

Journal: In vivo (Athens, Greece)20010101

Title: Inhibition of aromatase activity by flavonoids.

Journal: Archives of pharmacal research19990601

Title: Inhibition of HIV activation in latently infected cells by flavonoid compounds.

Journal: AIDS research and human retroviruses19960101

Title: Inhibition of HIV infection by flavanoids.

Journal: Antiviral research19931001

Title: Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

Journal: European journal of biochemistry19900705

Title: Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964

Title: Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059.

Title: Oo A, et al. In silico study on anti-Chikungunya virus activity of hesperetin. PeerJ. 2016 Oct 26;4:e2602. eCollection 2016.

Title: Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301

Title: Bai X, et al. The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. Br J Pharmacol. 2017 Jan;174(1):41-56

Title: Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.

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