Title: Simultaneous determination of intestinal permeability and potential drug interactions of complex mixtures using Caco-2 cells and high-resolution mass spectrometry: Studies with Rauwolfia serpentina extract.
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Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: Should all individuals with a nondiagnostic Brugada-electrocardiogram undergo sodium-channel blocker test?
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Title: Alstiphyllanines I-O, ajmaline type alkaloids from Alstonia macrophylla showing vasorelaxant activity.
Journal: Bioorganic & medicinal chemistry 20120601
Title: Haemochromatosis, sinus node dysfunction and Brugada syndrome--a ménage a trois of findings in one and the same patient: coincidence or causality?
Journal: Acta cardiologica 20120401
Title: Anything to declare? Possible risks for patients' health resulting from undeclared plants in herbal supplements.
Journal: British journal of clinical pharmacology 20120301
Title: Chest pain, shortness of breath, and palpitations unmask an unexpected diagnosis.
Journal: Circulation 20120214
Title: Ajmaline attenuates electrocardiogram characteristics of inferolateral early repolarization.
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Title: Functional analysis of B7-H3 in colonic carcinoma cells.
Journal: Asian Pacific journal of cancer prevention : APJCP 20120101
Title: New electrocardiographic criteria for discriminating between Brugada types 2 and 3 patterns and incomplete right bundle branch block.
Journal: Journal of the American College of Cardiology 20111122
Title: Prevalence of the type 1 Brugada electrocardiogram in Caucasian patients with suspected coronary spasm.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20111101
Title: Full neurological recovery following cardiac arrest during percutaneous coronary intervention due to accidentally intracoronary administration of ajmaline.
Journal: Resuscitation 20110901
Title: Ajmaline challenge in young individuals with suspected Brugada syndrome.
Journal: Pacing and clinical electrophysiology : PACE 20110601
Title: Beamforming for directional sources: additional estimator and evaluation of performance under different acoustic scenarios.
Journal: The Journal of the Acoustical Society of America 20110401
Title: ST segment elevation by current-to-load mismatch: an experimental and computational study.
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Title: Current-to-load mismatch, Brugada ECG pattern, and the associated arrhythmogenesis.
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Title: Dynamic downsloping ST-segment depression in the left precordial leads: acute myocardial ischemia or ...?
Journal: Journal of electrocardiology 20110101
Title: Utility of high and standard right precordial leads during ajmaline testing for the diagnosis of Brugada syndrome.
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Title: A phenotypic combination of idiopathic VF and Brugada syndrome.
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Title: [Life-threatening brady- and tachyarrhythmias].
Journal: Der Internist 20100801
Title: Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome.
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Title: Enantiospecific total synthesis of the important biogenetic intermediates along the ajmaline pathway, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epivellosimine and macusine A.
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Journal: Giornale italiano di cardiologia (2006) 20100401
Title: [Ajmaline test].
Journal: Deutsche medizinische Wochenschrift (1946) 20100301
Title: Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation.
Journal: Journal of the American College of Cardiology 20100223
Title: Tpeak-Tend interval and Tpeak-Tend/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20100201
Title: Diagnostic value of bipolar precordial leads in Brugada syndrome: more accurate, more simple, or more theoretical?
Journal: Heart rhythm 20100101
Title: Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch.
Journal: Heart rhythm 20100101
Title: An alternative hypothesis for right precordial ST-segment elevation in structural heart disease with diminished sodium current.
Journal: Heart rhythm 20100101
Title: Diagnostic utility of bipolar precordial leads during ajmaline testing for suspected Brugada syndrome.
Journal: Heart rhythm 20100101
Title: Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.
Journal: PloS one 20100101
Title: Ajmaline challenge for the diagnosis of Brugada syndrome: which protocol?
Journal: Archives of cardiovascular diseases 20100101
Title: Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20091001
Title: The ajmaline challenge and a strange ECG.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20091001
Title: Non-invasive imaging of cardiac activation and recovery.
Journal: Annals of biomedical engineering 20090901
Title: The validity of the recommended criteria for termination of the ajmaline test in diagnosing Brugada syndrome.
Journal: Heart rhythm 20090801
Title: Brugada-like changes in the peripheral leads during diagnostic ajmaline test in patients with suspected Brugada syndrome.
Journal: Pacing and clinical electrophysiology : PACE 20090601
Title: Significance of QRS prolongation during diagnostic ajmaline test in patients with suspected Brugada syndrome.
Journal: Heart rhythm 20090501
Title: Ajmaline challenge: to stop or not to stop..
Journal: Heart rhythm 20090501
Title: In vitro propagation of Rauwolfia serpentina using liquid medium, assessment of genetic fidelity of micropropagated plants, and simultaneous quantitation of reserpine, ajmaline, and ajmalicine.
Journal: Methods in molecular biology (Clifton, N.J.) 20090101
Title: [Bio-objects and biological methods of space radiation effects evaluation].
Journal: Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine 20090101
Title: [Studies on predict of absorption of corynanthine, yohimbine, ajmalicine and ajmaline across human intestinal epithelial by using human Caco-2 cells monolayers].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081001
Title: [Arrhythmias during pregnancy].
Journal: Deutsche medizinische Wochenschrift (1946) 20080901
Title: Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.
Journal: Circulation research 20080815
Title: Arrhythmogenic right ventricular dysplasia-cardiomyopathy and provocable coved-type ST-segment elevation in right precordial leads: clues from long-term follow-up.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20080701
Title: Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel.
Journal: Cardiovascular research 20080301
Title: Ajmaline challenge in Brugada syndrome.
Journal: Resuscitation 20070801
Title: The type species of Apiognomonia, A. veneta, with its Discula anamorph is distinct from A. errabunda.
Journal: Mycological research 20070601
Title: NA+- and K+-channels as molecular targets of the alkaloid ajmaline in skeletal muscle fibres.
Journal: British journal of pharmacology 20070501
Title: Peculiarities of nerve conduction block produced by lidocaine and ajmaline.
Journal: Bulletin of experimental biology and medicine 20070301
Title: Syncopal monomorphic ventricular tachycardia with pleomorphism, sensitive to antitachycardia pacing in a patient with Brugada syndrome.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20061201
Title: Quantitative determination of reserpine, ajmaline, and ajmalicine in Rauvolfia serpentina by reversed-phase high-performance liquid chromatography.
Journal: Journal of chromatographic science 20061001
Title: Brugada syndrome in childhood: a potential fatal arrhythmia not always recognised by paediatricians. A case report and review of the literature.
Journal: European journal of pediatrics 20060801
Title: Monomorphic and propafenone-induced polymorphic ventricular tachycardia in Brugada syndrome: a case report.
Journal: Acta cardiologica 20060801
Title: Recording of high V1-V3 precordial leads may be essential to the diagnosis of Brugada syndrome during the ajmaline test.
Journal: Journal of cardiovascular pharmacology and therapeutics 20060601
Title: Paradoxical effect of ajmaline in a patient with Brugada syndrome.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20060401
Title: Localized and dynamic repolarization alternans in Ajmaline accentuated Brugada syndrome.
Journal: International journal of cardiology 20060104
Title: Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system.
Journal: Planta 20051101
Title: Electrocardiographic predictors of Brugada type response during Na channel blockade challenge.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20050901
Title: A novel nonsense mutation in the SCN5A gene leads to Brugada syndrome and a silent gene mutation carrier state.
Journal: The Canadian journal of cardiology 20050901
Title: Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes.
Journal: General physiology and biophysics 20050901
Title: Brugada-like electrocardiographic pattern induced by an episode of anemia.
Journal: Zeitschrift fur Kardiologie 20050801
Title: Typical ECG changes unmasked by ajmaline in a patient with Brugada syndrome and left bundle branch block.
Journal: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20050701
Title: Crystal structure of vinorine synthase, the first representative of the BAHD superfamily.
Journal: The Journal of biological chemistry 20050408
Title: True right bundle branch block masking the typical ECG in Brugada syndrome.
Journal: Pacing and clinical electrophysiology : PACE 20050301
Title: Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome.
Journal: Heart rhythm 20050301
Title: Are all sodium channel blockers created equal? Clinical-basic correlations based on observations in Brugada syndrome.
Journal: Heart rhythm 20050301
Title: Effect of ajmaline on transient outward current in rat ventricular myocytes.
Journal: General physiology and biophysics 20050301
Title: Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041201
Title: Value of electrocardiographic parameters and ajmaline test in the diagnosis of Brugada syndrome caused by SCN5A mutations.
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Title: [Recurrent ventricular fibrillation during a febrile illness as the first manifestation of Brugada syndrome--a case report].
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Title: Prevalence of drug-induced electrocardiographic pattern of the Brugada syndrome in a healthy population.
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Title: Role of sodium and calcium channel block in unmasking the Brugada syndrome.
Journal: Heart rhythm 20040701
Title: Results of ajmaline testing in patients with arrhythmogenic right ventricular dysplasia-cardiomyopathy.
Journal: International journal of cardiology 20040601
Title: Purification and partial amino acid sequences of the enzyme vinorine synthase involved in a crucial step of ajmaline biosynthesis.
Journal: Bioorganic & medicinal chemistry 20040515
Title: [Atypical behavior of QTc and ST-T intervals in a patient with the Brugada syndrome].
Journal: Revista espanola de cardiologia 20040301
Title: Phenotypic characterization of a large European family with Brugada syndrome displaying a sudden unexpected death syndrome mutation in SCN5A:
Journal: Journal of cardiovascular electrophysiology 20040101
Title: Gender difference and drug challenge in Brugada syndrome.
Journal: Journal of cardiovascular electrophysiology 20040101
Title: Total synthesis of (-)-raumacline.
Journal: Chemical communications (Cambridge, England) 20031121
Title: Unusual response to the ajmaline test in a patient with Brugada syndrome.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20031001
Title: In vivo monitoring of alkaloid metabolism in hybrid plant cell cultures by 2D cryo-NMR without labelling.
Journal: Bioorganic & medicinal chemistry 20030901
Title: Enantiospecific total synthesis of (-)-(E)16-epiaffinisine, (+)-(E)16-epinormacusine B, and (+)-dehydro-16-epiaffinisine as well as the stereocontrolled total synthesis of alkaloid G.
Journal: The Journal of organic chemistry 20030725
Title: The ajmaline challenge in Brugada syndrome: a useful tool or misleading information?
Journal: European heart journal 20030601
Title: The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol.
Journal: European heart journal 20030601
Title: Production of ajmalicine and ajmaline in hairy root cultures of Rauvolfia micrantha Hook f., a rare and endemic medicinal plant.
Journal: Biotechnology letters 20030401
Title: A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline.
Journal: Planta medica 20021001
Title: Vomilenine reductase--a novel enzyme catalyzing a crucial step in the biosynthesis of the therapeutically applied antiarrhythmic alkaloid ajmaline.
Journal: Bioorganic & medicinal chemistry 20020601
Title: Aborted sudden death in a patient with a structurally normal heart: the Brugada syndrome.
Journal: Intensive care medicine 20020601
Title: [Tachycardic patient, hemodynamically stable. What can I do without ECG?].
Journal: MMW Fortschritte der Medizin 20020404
Title: Body surface potential mapping in patients with Brugada syndrome: right precordial ST segment variations and reverse changes in left precordial leads.
Journal: Cardiovascular research 20020401
Title: Wolff-Parkinson-White syndrome associated with Brugada syndrome.
Journal: Pacing and clinical electrophysiology : PACE 20010901
Title: Torsade de pointes induced by ajmaline.
Journal: Zeitschrift fur Kardiologie 20010801
Title: Effect of experimental renal dysfunction on bioavailability of ajmaline in rats.
Journal: The Journal of pharmacy and pharmacology 20010601
Title: Revision of the structure of ajmalimine.
Journal: Journal of natural products 20010501
Title: Stereocontrolled total synthesis of alkaloid G via the oxy-anion Cope rearrangement and improved total synthesis of (+)-ajmaline.
Journal: Organic letters 20010208
Title: Effects of ajmaline on rate-dependent atrioventricular node properties. Potential role in experimental atrioventricular re-entrant tachycardia.
Journal: European journal of pharmacology 20010119
Title: [Sequential isolation of superoxide dismutase and ajmaline from a tissue culture of Rauwolfia serpentina Benth].
Journal: Prikladnaia biokhimiia i mikrobiologiia 20010101
Title: The ajmaline group of indole alkaloids.
Journal: The Alkaloids. Chemistry and biology 20010101
Title: His-Purkinje system reentry as a proarrhythmic effect of flecainide.
Journal: Pacing and clinical electrophysiology : PACE 20000401
Title: Spontaneous sustained monomorphic ventricular tachycardia after administration of ajmaline in a patient with Brugada syndrome.
Journal: Pacing and clinical electrophysiology : PACE 20000301
Title: Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts.
Journal: Circulation 20000208
Title: [Progression to 2d and 3d grade atrioventricular block in patients after electrostimulation for bundle-branch block and syncope: a long-term study].
Journal: Giornale italiano di cardiologia 19940401
Title: Pharmacokinetics and electrophysiological effects of intravenous ajmaline.
Journal: Clinical pharmacokinetics 19931101
Title: Dual inhibition of platelet-activating factor and arachidonic acid metabolism by ajmaline and effect on carrageenan-induced rat paw oedema.
Journal: The Journal of pharmacy and pharmacology 19930801
Title: Electrophysiological and haemodynamic effects of lidocaine and ajmaline in the management of sustained ventricular tachycardia.
Journal: European heart journal 19920801
Title: Provocation of supraventricular tachycardias by an intravenous class I antiarrhythmic drug.
Journal: International journal of cardiology 19920201
Title: In vivo evidence that ethosuximide is a substrate for cytochrome P450IIIA.
Journal: Pharmacology 19920101
Title: [Preajmaline-induced cholestatic hepatitis].
Journal: Harefuah 19911115
Title: [Recurrent ventricular tachyarrhythmias primarily diagnosed as epilepsy].
Journal: Ugeskrift for laeger 19910513
Title: [Arrhythmogenic effect of ajmaline on the atrial level].
Journal: Archives des maladies du coeur et des vaisseaux 19891201
Title: [Bidirectional tachycardia during therapy with lorajmine].
Journal: Cardiologia (Rome, Italy) 19891001
Title: [Prolonged hepatitis due to ajmaline--description of a case and review of the literature].
Journal: Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis 19890516
Title: Regional myocardial ajmaline concentration and antiarrhythmic activity for ischaemia- and reperfusion-induced arrhythmias in rats.
Journal: British journal of pharmacology 19880401
Title: [Intrahepatic cholestasis and aplastic anemia following administration of prajmaline].
Journal: Klinische Wochenschrift 19880315
Title: Ajmaline induced intra-Hisian block.
Journal: International journal of cardiology 19870401
Title: The value of intracardiac electrophysiologic techniques in recurrent syncope of 'unknown cause'.
Journal: International journal of cardiology 19860101
Title: Ajmaline-induced torsade de pointes.
Journal: Cardiology 19860101
Title: Prolonged cholestasis after ajmaline-induced acute hepatitis.
Journal: Journal of hepatology 19860101
Title: Ajmaline-induced torsade de pointes.
Journal: Cardiology 19850101
Title: Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies.
Journal: Hepatology (Baltimore, Md.) 19850101
Title: [Anuria, cholestatic jaundice, thrombocytopenia, hemolysis. Immunoallergic complication due to ajmaline].
Journal: Annales de medecine interne 19850101
Title: Lithium causing a serious sinus-node dysfunction at therapeutic doses.
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Title: [Evaluation of the response to the ajmaline test in the diagnosis of paroxysmal atrioventricular blocks].
Journal: Archives des maladies du coeur et des vaisseaux 19831001
Title: [Acute renal failure caused by ajmaline-butobarbital].
Journal: Presse medicale (Paris, France : 1983) 19830625
Title: [Ajmaline-induced hepatitis. A case report with ultrastructural study].
Journal: Gastroenterologie clinique et biologique 19830501
Title: [Stimulus-dependent blockade of the Na channels of isolated myocardial cells in the rat by the anti-arrhythmia agent N-propyl ajmaline (neogiluritmal)].
Journal: Biulleten' eksperimental'noi biologii i meditsiny 19830401
Title: [Acute anuric hemolysis caused by antiajmaline antibodies].
Journal: Presse medicale (Paris, France : 1983) 19830219
Title: [Neurologic complications of monochloroacetylajmaline poisoning].
Journal: Rivista di neurobiologia : organo ufficiale della Societa dei neurologi, neuroradiologi e neurochirurghi ospedalieri 19820101
Title: [Hepatitis due to ajmaline. Report of cases and review of the literature].
Journal: Gastroenterologie clinique et biologique 19800401
Title: [Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].
Journal: Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete 19800401
Title: [Recurrent anuria, thrombopenia and jaundice: unusual manifestation of hypersensitivity to ajmaline].
Journal: La Nouvelle presse medicale 19780506
Title: [Cholestatic hepatitis due to ajmaline. Lymphatic congestion of the liver. Recovery after spironolactone].
Journal: Medecine & chirurgie digestives 19780101
Title: Severe cerebral confusion produced by prajmalium bitartrate.
Journal: British medical journal 19770910
Title: The antiarrhythmic effect of prostaglandin E2 on catecholamine-induced arrhythmias.
Journal: Acta biologica et medica Germanica 19770101
Title: [Neurological complications during therapy with 17 MDCAA (author's transl)].
Journal: Giornale italiano di cardiologia 19770101
Title: [Experimental anti-arrhythmic effects of a new beta-adrenergic receptor blocking agent, dl-l-(tert. butylamino)-3-[(2-propinyloxy)phenoxy]2-propanol hydrochloride (dl Kö 1400-Cl)].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19760701
Title: [Intrahepatic cholestasis due to N-propyl ajmaline].
Journal: Deutsche medizinische Wochenschrift (1946) 19760430
Title: [Liver damage due to N-propyl-ajmalin bitartrate (NPAB)].
Journal: Zeitschrift fur Gastroenterologie 19750901
Title: [Effect of sparteine sulfate on the predamaged conduction system of the heart].
Journal: Zeitschrift fur Kardiologie 19750501
Title: Effect of procaine amide, quinidine, and ajmaline in the Wolff-Parkinson-White syndrome.
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Title: [Preliminary clinical studies on the antiparkinson effects of 17-monochloroacetylajmaline].
Journal: Minerva medica 19740530
Title: Antiarrhythmic potency of N-propyl ajmaline with untoward response of ventricular fibrillation in excess dose.
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Title: Transient cholestasis during treatment with ajmaline, and chronic xanthomatous cholestasis after administration of ajmaline, methyltestosterone and ethinylestradiol. Two case reports.
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Title: [Some toxic effects of ajmaline with a report of 2 cases].
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Title: [Development of a complete left bundle-branch block in the WPW syndrome following Ajmaline injection].
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