Home Pyridines 447-05-2
447-05-2,MFCD01941473
Catalog No.:AA00DF59

447-05-2 | 5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DF59
Chemical Name:
5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate
CAS Number:
447-05-2
Molecular Formula:
C8H12NO6P
Molecular Weight:
249.1577
MDL Number:
MFCD01941473
SMILES:
OCc1c(cnc(c1O)C)COP(=O)(O)O
NSC Number:
83119
Properties
Computed Properties
 
Complexity:
269  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
-1.9  

Downstream Synthesis Route

[1]Heyletal.[JournaloftheAmericanChemicalSociety,1951,vol.73,p.3430,3432]

Literature

Title: Characterization of an acid phosphatase responsible for hydrolysis of pyridoxal 5'-phosphate in tobacco plants.

Journal: Plant physiology and biochemistry : PPB 20120801

Title: Toxicological biomarkers of 2,3,4,7,8-pentachlorodibenzofuran in proteins secreted by HepG2 cells.

Journal: Biochimica et biophysica acta 20120401

Title: The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis.

Journal: Nutrition & metabolism 20120101

Title: Interconversions of different forms of vitamin B6 in tobacco plants.

Journal: Phytochemistry 20111201

Title: Expression, in vivo localization and phylogenetic analysis of a pyridoxine 5'-phosphate oxidase in Arabidopsis thaliana.

Journal: Plant physiology and biochemistry : PPB 20110101

Title: Stress response regulators identified through genome-wide transcriptome analysis of the (p)ppGpp-dependent response in Rhizobium etli.

Journal: Genome biology 20110101

Title: Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation.

Journal: BMC genomics 20110101

Title: Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity.

Journal: PloS one 20110101

Title: Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency.

Journal: Developmental medicine and child neurology 20100701

Title: Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics.

Journal: Developmental medicine and child neurology 20100701

Title: Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration.

Journal: Mechanisms of ageing and development 20100601

Title: A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production.

Journal: BMC genomics 20100101

Title: Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder.

Journal: The Journal of biological chemistry 20091106

Title: Enhanced pyridoxal 5'-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus.

Journal: Neuroscience 20090331

Title: Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.

Journal: Hippocampus 20090101

Title: Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.

Journal: PloS one 20090101

Title: Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.

Journal: BMJ case reports 20090101

Title: Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis.

Journal: Neurological research 20080701

Title: Human brain pyridoxal-5'-phosphate phosphatase (PLPP):protein transduction of PEP-1-PLPP into PC12 cells.

Journal: BMB reports 20080531

Title: Potential role of pyridoxal-5'-phosphate phosphatase/chronopin in epilepsy.

Journal: Experimental neurology 20080501

Title: Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.

Journal: Archives of disease in childhood. Fetal and neonatal edition 20080301

Title: The assembly of the plasmodial PLP synthase complex follows a defined course.

Journal: PloS one 20080101

Title: Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order.

Journal: Comparative and functional genomics 20080101

Title: Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.

Journal: Experimental neurology 20070701

Title: Vitamin B6 related epilepsy during childhood.

Journal: Chang Gung medical journal 20070101

Title: Purification and characterization of pyridoxine 5'-phosphate phosphatase from Sinorhizobium meliloti.

Journal: Bioscience, biotechnology, and biochemistry 20051201

Title: [A preliminary proteomic analysis of tauopathies].

Journal: Zhonghua nei ke za zhi 20050501

Title: The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.

Journal: The Journal of biological chemistry 20041210

Title: Dietary antioxidant lack, impaired hepatic glutathione reserve, and cholesterol gallstones.

Journal: Clinica chimica acta; international journal of clinical chemistry 20041101

Title: Structure of the phenazine biosynthesis enzyme PhzG.

Journal: Acta crystallographica. Section D, Biological crystallography 20041101

Title: Vigabatrin inhibits pyridoxine-5'-phosphate oxidase, not pyridoxal kinase in the hippocampus of seizure prone gerbils.

Journal: Neurochemistry international 20040201

Title: Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.

Journal: Biochemistry 20021001

Title: Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis.

Journal: Journal of molecular biology 20020823

Title: Chronological changes in pyridoxine-5'-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus.

Journal: Journal of neuroscience research 20020615

Title: Immunohistochemical studies of brain pyridoxine-5'-phosphate oxidase.

Journal: Brain research 20020125

Title: Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase.

Journal: Journal of molecular biology 20020118

Title: X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate at 2.0 A resolution.

Journal: Journal of molecular biology 20010720

Title: Structural basis for the function of pyridoxine 5'-phosphate synthase.

Journal: Structure (London, England : 1993) 20010307

Title: CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control.

Journal: Brain & development 20010301

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Tags:447-05-2 Molecular Formula|447-05-2 MDL|447-05-2 SMILES|447-05-2 5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate