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444723-13-1,MFCD09264153
Catalog No.:AA00DGQ0

444723-13-1 | NU6140

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$82.00   $57.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
10mg
≥98%
in stock  
$306.00   $214.00
- +
50mg
98%
in stock  
$1,188.00   $832.00
- +
100mg
98%
in stock  
$1,913.00   $1,339.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DGQ0
Chemical Name:
NU6140
CAS Number:
444723-13-1
Molecular Formula:
C23H30N6O2
Molecular Weight:
422.5233
MDL Number:
MFCD09264153
SMILES:
CCN(C(=O)c1ccc(cc1)Nc1nc(OCC2CCCCC2)c2c(n1)nc[nH]2)CC
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
560  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
4.8  

Downstream Synthesis Route
Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.

Journal: Bioorganic & medicinal chemistry letters 20110701

Title: Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.

Journal: Molecular cancer therapeutics 20050901

Title: Pennati M, et al. Potentiation of apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37.

Title: Jorda R, et al. How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases? Med Chem. 2018 Oct 25;61(20):9105-9120.

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SDS
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