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479-50-5,MFCD00866726
Catalog No.:AA00DJV7

479-50-5 | lucanthone

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50mg
99+%
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$218.00   $153.00
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100mg
99+%
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$318.00   $223.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DJV7
Chemical Name:
lucanthone
CAS Number:
479-50-5
Molecular Formula:
C20H24N2OS
Molecular Weight:
340.4824
MDL Number:
MFCD00866726
SMILES:
CCN(CCNc1ccc(c2c1c(=O)c1c(s2)cccc1)C)CC
Properties
Computed Properties
 
Complexity:
426  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4  

Downstream Synthesis Route

[1]Mauss[ChemischeBerichte,1948,vol.81,p.19,26]Hammick;Munro[JournaloftheChemicalSociety,1952,p.1077,1079]

[1]CurrentPatentAssignee:BAYERAG-DE919107,1940,C

[1]Archer;Suter[JournaloftheAmericanChemicalSociety,1952,vol.74,p.4296,4301]Mauss[ChemischeBerichte,1948,vol.81,p.19,26]Sharp[JournaloftheChemicalSociety,1951,p.2961]

19057-92-2   
CASUnavailable 
  479-50-5 

[1]Mauss[ChemischeBerichte,1948,vol.81,p.19,26]

[1]Mauss[ChemischeBerichte,1948,vol.81,p.19,26]

Literature

Title: [2-Butyl-4-(4-tert-butyl-benz-yl)-1,2,4-triazol-3-yl-idene]chlorido[(1,2,5,6-η)-cyclo-octa-1,5-diene]iridium(I).

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: [(1,2,5,6-η)-Cyclo-octa-1,5-diene]bis-(1-isopropyl-3-methyl-imidazolin-2-yl-idene)rhodium(I) tetra-fluorido-borate.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: 3-(2,6-Dimethyl-anilino)imidazo[1,2-a]pyridin-1-ium perchlorate.

Journal: Acta crystallographica. Section E, Structure reports online 20110501

Title: N,N'-Bis(5-bromo-pyridin-2-yl)methane-diamine.

Journal: Acta crystallographica. Section E, Structure reports online 20110401

Title: Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.

Journal: The Journal of biological chemistry 20110225

Title: 4-(Piperidin-1-yl)-4H-benzo[b]tetra-zolo[1,5-d][1,4]diazepin-5(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20110101

Title: Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.

Journal: PloS one 20110101

Title: Impact of Autophagy on Chemotherapy and Radiotherapy Mediated Tumor Cytotoxicity: 'To Live or not to Live'.

Journal: Frontiers in oncology 20110101

Title: [(1,2,5,6-η)-1,5-Cyclo-octa-diene](1-isopropyl-3-methyl-imidazolin-2-yl-idene)(triphenyl-phosphine)iridium(I) tetra-fluorido-borate dichloro-methane solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: 2-Propyl 3,3-dibromo-2-hydroxy-pyrrolidine-1-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20100301

Title: 2-Butyl-11-phenyl-5,10-dihydro-1H-benzo[e]imidazo[1,5-a][1,4]diazepine-1,3(2H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100301

Title: Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1.

Journal: Journal of radiation research 20100101

Title: The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target.

Journal: Molecular aspects of medicine 20070101

Title: Clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70.

Journal: Cell stress & chaperones 20050301

Title: Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone.

Journal: Anticancer research 20040101

Title: Design of small volume HX and triple-resonance probes for improved limits of detection in protein NMR experiments.

Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20030901

Title: Abasic sites in DNA of HeLa cells induced by lucanthone.

Journal: Cancer investigation 20020101

Title: Accelerated regression of brain metastases in patients receiving whole brain radiation and the topoisomerase II inhibitor, lucanthone.

Journal: International journal of radiation oncology, biology, physics 19990101

Title: Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18.

Title: Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.

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