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519187-97-4,MFCD13152397
Catalog No.:AA00DKAD

519187-97-4 | Edonerpic maleate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$74.00   $52.00
- +
5mg
≥98%
in stock  
$128.00   $89.00
- +
10mg
≥98%
in stock  
$230.00   $161.00
- +
25mg
≥98%
in stock  
$508.00   $355.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DKAD
Chemical Name:
Edonerpic maleate
CAS Number:
519187-97-4
Molecular Formula:
C20H25NO6S
Molecular Weight:
407.4806
MDL Number:
MFCD13152397
SMILES:
OC(=O)/C=C\C(=O)O.OC1CN(C1)CCCOCCc1ccc2c(c1)ccs2
Properties
Computed Properties
 
Complexity:
415  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  

Downstream Synthesis Route

[1]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1437353,2004,A1Locationinpatent:Page62;63

[2]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1437353,2004,A1Locationinpatent:Page63

[3]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1437353,2004,A1Locationinpatent:Page63

[4]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn39

[5]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn39-40

[6]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn40

[7]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn40-41

[8]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn40

[9]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn41

[10]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn40

[11]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn41

[12]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn42

[13]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1864978,2007,A1Locationinpatent:Page/Pagecolumn41

[1]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1437353,2004,A1Locationinpatent:Page50

[2]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP1614419,2006,A1Locationinpatent:Page/Pagecolumn22-23

[1]CurrentPatentAssignee:FUJIFILMHOLDINGSCORP.-EP2287160,2011,A1Locationinpatent:Page/Pagecolumn6-7

Literature

Title: T-817MA, a novel neurotrophic agent, ameliorates loss of GABAergic parvalbumin-positive neurons and sensorimotor gating deficits in rats transiently exposed to MK-801 in the neonatal period.

Journal: Journal of psychiatric research 20120501

Title: T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice.

Journal: Biochemical and biophysical research communications 20110422

Title: [Pharmacological properties of T-817MA, a novel neurotrophic agent, for treatment of Alzheimer's disease.].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100701

Title: T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide.

Journal: British journal of pharmacology 20090601

Title: A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.

Journal: Neuropharmacology 20081001

Title: Neuroprotective effects of T-817MA against noise-induced hearing loss.

Journal: Neuroscience research 20080501

Title: T-817MA, a novel neurotrophic compound, ameliorates phencyclidine-induced disruption of sensorimotor gating.

Journal: Psychopharmacology 20080401

Title: Ameliorative effects of a neuroprotective agent, T-817MA, on place learning deficits induced by continuous infusion of amyloid-beta peptide (1-40) in rats.

Journal: Hippocampus 20070101

Title: T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons.

Journal: Neurochemistry international 20060101

Title: A novel neurotrophic agent, T-817MA [1-{3-[2-(1-benzothiophen-5-yl) ethoxy] propyl}-3-azetidinol maleate], attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20050701

Title: Hirata K, et al. A novel neurotrophic agent, T-817MA -{3--(1-benzothiophen-5-yl) ethoxy propyl}-3-azetidinol maleate, attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons. J Pharmacol Exp Ther. 2005 Jul;314(1):252-9.

Title: Kimura T, et al. T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide. Br J Pharmacol. 2009 Jun;157(3):451-63.

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